Lecithin and choline in human health and disease.

Choline is involved in methyl group metabolism and lipid transport and is a component of a number of important biological compounds including the membrane phospholipids lecithin, sphingomyelin, and plasmalogen; the neurotransmitter acetylcholine; and platelet activating factor. Although a required nutrient for several animal species, choline is not currently designated as essential for humans. However, recent clinical studies show it to be essential for normal liver function. Additionally, a large body of evidence from the fields of molecular and cell biology shows that certain phospholipids play a critical role in generating second messengers for cell membrane signal transduction. This process involves a cascade of reactions that translate an external cell stimulus such as a hormone or growth factor into a change in cell transport, metabolism, growth, function, or gene expression. Disruptions in phospholipid metabolism can interfere with this process and may underlie certain disease states such as cancer and Alzheimer's disease. These recent findings may be appropriate in the consideration of choline as an essential nutrient for humans.

[1]  A. Merrill.  Lipid modulators of cell function. , 2009, Nutrition reviews.

[2]  S. Zeisel.  Choline phospholipids: signal transduction and carcinogenesis. , 1993, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[3]  S. C. Garner,et al.  Accumulation of 1,2-sn-diradylglycerol with increased membrane-associated protein kinase C may be the mechanism for spontaneous hepatocarcinogenesis in choline-deficient rats. , 1993, The Journal of biological chemistry.

[4]  Y. Nishizuka.  Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. , 1992, Science.

[5]  J. Growdon,et al.  Release of Alzheimer amyloid precursor derivatives stimulated by activation of muscarinic acetylcholine receptors. , 1992, Science.

[6]  S. Younkin,et al.  Secretory processing of the Alzheimer amyloid beta/A4 protein precursor is increased by protein phosphorylation. , 1992, Biochemical and biophysical research communications.

[7]  R. Wurtman.  Choline metabolism as a basis for the selective vulnerability of cholinergic neurons , 1992, Trends in Neurosciences.

[8]  P. Greengard,et al.  Protein phosphorylation regulates secretion of Alzheimer beta/A4 amyloid precursor protein. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[9]  D. Jenden,et al.  Lecithin increases plasma free choline and decreases hepatic steatosis in long-term total parenteral nutrition patients. , 1992, Gastroenterology.

[10]  C. Ezzell.  Alzheimer's Alchemy , 1992 .

[11]  J. Growdon,et al.  Evidence for a membrane defect in Alzheimer disease brain. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[12]  Y. Hannun,et al.  Activation of protein kinase C by oleic acid. Determination and analysis of inhibition by detergent micelles and physiologic membranes: requirement for free oleate. , 1992, The Journal of biological chemistry.

[13]  S. Younkin,et al.  Potentially amyloidogenic, carboxyl-terminal derivatives of the amyloid protein precursor. , 1992, Science.

[14]  D. Selkoe,et al.  Processing of the amyloid protein precursor to potentially amyloidogenic derivatives. , 1992, Science.

[15]  J. Marx.  Boring in on beta-amyloid's role in Alzheimer's. , 1992, Science.

[16]  M. Morotomi,et al.  Fecal excretion, uptake and metabolism by colon mucosa of diacylglycerol in rats. , 1991, Biochemical and biophysical research communications.

[17]  S. Cook,et al.  Regulation of the hydrolysis of phosphatidylcholine in Swiss 3T3 cells. , 1991, Biochemical Society transactions.

[18]  J. Guillem,et al.  Decreased levels of 1,2-sn-diacylglycerol in human colon tumors. , 1991, Cancer research.

[19]  K. Mak,et al.  Attenuation of alcohol‐induced hepatic fibrosis by polyunsaturated lecithin , 1990, Hepatology.

[20]  A. Köppen,et al.  Small Rises in Plasma Choline Reverse the Negative Arteriovenous Difference of Brain Choline , 1990, Journal of neurochemistry.

[21]  P. Greengard,et al.  Processing of Alzheimer beta/A4 amyloid precursor protein: modulation by agents that regulate protein phosphorylation. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[22]  T. Oltersdorf,et al.  Cleavage of amyloid beta peptide during constitutive processing of its precursor. , 1990, Science.

[23]  J. Exton.  Signaling through phosphatidylcholine breakdown. , 1990, The Journal of biological chemistry.

[24]  Kuo-ping Huang,et al.  The mechanism of protein kinase C activation , 1989, Trends in Neurosciences.

[25]  Y. Hannun,et al.  Regulation of protein kinase C by sphingosine and lysosphingolipids. , 1989, Clinica chimica acta; international journal of clinical chemistry.

[26]  D. Ford,et al.  Activation of protein kinase C by naturally occurring ether-linked diglycerides. , 1989, The Journal of biological chemistry.

[27]  R. Wurtman,et al.  Choline increases acetylcholine release and protects against the stimulation-induced decrease in phosphatide levels within membranes of rat corpus striatum , 1989, Brain Research.

[28]  L. Mcphail,et al.  Selective priming of rate and duration of the respiratory burst of neutrophils by 1,2-diacyl and 1-O-alkyl-2-acyl diglycerides. Possible relation to effects on protein kinase C. , 1988, The Journal of biological chemistry.

[29]  Y. Nishizuka,et al.  The molecular heterogeneity of protein kinase C and its implications for cellular regulation , 1988, Nature.

[30]  J. Guillem,et al.  Changes in expression of oncogenes and endogenous retroviral-like sequences during colon carcinogenesis. , 1988, Cancer research.

[31]  K. Dobkins,et al.  Decreased levels of protein kinase C in Alzheimer brain , 1988, Brain Research.

[32]  C. Piantadosi,et al.  Alkyl-linked diglycerides inhibit protein kinase C activation by diacylglycerols. , 1988, Biochemical and biophysical research communications.

[33]  J. Cook,et al.  Parallel changes in amino acid transport and protein kinase C localization in LLC‐PK1 cells treated with TPA or diradylglycerols , 1987, Journal of cellular physiology.

[34]  M. Castagna,et al.  Alkyl analogs of diacylglycerol as activators of protein kinase C , 1987, FEBS letters.

[35]  K. Takahama,et al.  Effects of Extracellular Choline Concentration and K+ Depolarization on Choline Kinase and Choline Acetyltransferase Activities in Superior Cervical Sympathetic Ganglia Excised from Rats , 1987, Journal of neurochemistry.

[36]  M. Berridge,et al.  Inositol Trisphosphate as a Second Messenger in Signal Transduction , 1987, Annals of the New York Academy of Sciences.

[37]  M. Treat,et al.  Altered levels of protein kinase C and Ca2+-dependent protein kinases in human colon carcinomas. , 1987, Cancer research.

[38]  P. Cuatrecasas,et al.  Rapid formation of diacylglycerol from phosphatidylcholine: a pathway for generation of a second messenger. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[39]  Y. Nishizuka.  Studies and perspectives of protein kinase C. , 1986, Science.

[40]  K. L. Hoover,et al.  Hepatic DNA methylation and liver tumor formation in male C3H mice fed methionine- and choline-deficient diets. , 1986, Journal of the National Cancer Institute.

[41]  G. Blackburn,et al.  Plasma choline concentration in humans fed parenterally. , 1986, The American journal of clinical nutrition.

[42]  R. Hall,et al.  The effect of choline supplementation on hepatic steatosis in the parenterally fed rat. , 1985, JPEN. Journal of parenteral and enteral nutrition.

[43]  R. Lévy,et al.  A double-blind, placebo controlled trial of high-dose lecithin in Alzheimer's disease. , 1985, Journal of neurology, neurosurgery, and psychiatry.

[44]  K. Mak,et al.  Choline fails to prevent liver fibrosis in ethanol‐fed baboons but causes toxicity , 1985, Hepatology.

[45]  M. Cabot,et al.  Structural and chemical specificity of diradylglycerols for protein kinase C activation , 1984 .

[46]  E. Farber,et al.  The induction of liver cancer by dietary deficiency of choline and methionine without added carcinogens. , 1984, Carcinogenesis.

[47]  K. L. Hoover,et al.  Hepatocarcinogenesis in rats fed methyl-deficient, amino acid-defined diets. , 1983, Carcinogenesis.

[48]  S. Corkin.  Acetylcholine, aging and Alzheimer's disease Implications for treatment , 1981, Trends in Neurosciences.

[49]  J. Growdon,et al.  Normal plasma choline responses to ingested lecithin , 1980, Neurology.

[50]  R. Wurtman,et al.  Brain acetylcholine: control by dietary choline. , 1976, Science.

[51]  A. E. Rogers.  Variable effects of a lipotrope-deficient, high-fat diet on chemical carcinogenesis in rats. , 1975, Cancer research.

[52]  D. Haubrich.  PARTIAL PURIFICATION AND PROPERTIES OF CHOLINE KINASE (EC 2.7.1.32) FROM RABBIT BRAIN: MEASUREMENT OF ACETYLCHOLINE , 1973, Journal of neurochemistry.

[53]  M. Burns,et al.  Hepatomas in choline deficiency. , 1955, Journal of the National Cancer Institute.

[54]  W. Salmon,et al.  The Occurrence of Neoplasms in the Liver, Lungs, and Other Tissues of Rats as a Result of Prolonged Choline Deficiency. , 1946, The American journal of pathology.

[55]  J. Li,et al.  Phosphatidylcholine protects against fibrosis and cirrhosis in the baboon. , 1994, Gastroenterology.

[56]  A. Merrill,et al.  Fumonisins and other inhibitors of de novo sphingolipid biosynthesis. , 1993, Advances in lipid research.

[57]  Y. Hannun,et al.  Use of sphingosine as inhibitor of protein kinase C. , 1991, Methods in enzymology.

[58]  A. Ullrich,et al.  Protein kinase C , 1987, Journal of cellular physiology. Supplement.

[59]  M. Locniskar,et al.  Inhibition of hepatocarcinogenesis in mice by dietary methyl donors methionine and choline. , 1990, Nutrition and cancer.

[60]  J. Locker,et al.  DNA methylation and hepatocarcinogenesis in rats fed a choline-devoid diet. , 1986, Carcinogenesis.

[61]  A. E. Rogers,et al.  Labile methyl groups and the promotion of cancer. , 1986, Annual review of nutrition.

[62]  S. Zeisel,et al.  Choline, phosphatidylcholine and sphingomyelin in human and bovine milk and infant formulas. , 1986, The Journal of nutrition.

[63]  S. Zeisel.  Dietary choline: biochemistry, physiology, and pharmacology. , 1981, Annual review of nutrition.

[64]  A. Strecker.  Ueber einige neue Bestandtheile der Schweinegalle , 1862 .