Loss of anchorage in checkpoint-deficient cells increases genomic instability and promotes oncogenic transformation
暂无分享,去创建一个
[1] J. Julian Blow,et al. Replication licensing and cancer — a fatal entanglement? , 2008, Nature Reviews Cancer.
[2] R. Assoian,et al. Growth control by intracellular tension and extracellular stiffness. , 2008, Trends in cell biology.
[3] Ludger Hengst,et al. The Cdk inhibitor p27 in human cancer: prognostic potential and relevance to anticancer therapy , 2008, Nature Reviews Cancer.
[4] Jiri Bartek,et al. An Oncogene-Induced DNA Damage Model for Cancer Development , 2008, Science.
[5] R. Eils,et al. Systemic spread is an early step in breast cancer. , 2008, Cancer cell.
[6] James R Bischoff,et al. CDK inhibitors in cancer therapy: what is next? , 2008, Trends in pharmacological sciences.
[7] A. Porter. Preventing DNA over-replication: a Cdk perspective , 2008, Cell Division.
[8] B. Aronow,et al. Loss of the retinoblastoma tumor suppressor: differential action on transcriptional programs related to cell cycle control and immune function , 2007, Oncogene.
[9] E. Knudsen,et al. RB Loss Promotes Aberrant Ploidy by Deregulating Levels and Activity of DNA Replication Factors* , 2007, Journal of Biological Chemistry.
[10] S. Henderson,et al. Transformation of human mesenchymal stem cells increases their dependency on oxidative phosphorylation for energy production , 2007, Proceedings of the National Academy of Sciences.
[11] Richard W. Kriwacki,et al. Cdk-Inhibitory Activity and Stability of p27 Kip1 Are Directly Regulated by Oncogenic Tyrosine Kinases , 2007, Cell.
[12] Aaron Bensimon,et al. Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication , 2006, Nature.
[13] Dimitris Kletsas,et al. Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints , 2006, Nature.
[14] J. Bartek,et al. Retinoblastoma pathway defects show differential ability to activate the constitutive DNA damage response in human tumorigenesis. , 2006, Cancer research.
[15] K. Pumiglia,et al. Focal Adhesion Kinase Controls Cellular Levels of p27/Kip1 and p21/Cip1 through Skp2-Dependent and -Independent Mechanisms , 2006, Molecular and Cellular Biology.
[16] L. Coussens,et al. Tumor stroma and regulation of cancer development. , 2006, Annual review of pathology.
[17] Jiri Bartek,et al. ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks , 2006, Nature Cell Biology.
[18] T. Ørntoft,et al. DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis , 2005, Nature.
[19] Dimitris Kletsas,et al. Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions , 2005, Nature.
[20] W. D. Cress,et al. Efficient Down-Regulation of Cyclin A-Associated Activity and Expression in Suspended Primary Keratinocytes Requires p21Cip111This work was supported by the Cortner-Couch Endowed Chair for Cancer Research (W. J. P.) and NIH Grants CA73780 (W. J. P.) and CA90489 (W. D. C.) , 2004 .
[21] W. D. Cress,et al. Efficient down-regulation of cyclin A-associated activity and expression in suspended primary keratinocytes requires p21(Cip1). , 2004, Molecular cancer research : MCR.
[22] Anindya Dutta,et al. A p53-dependent checkpoint pathway prevents rereplication. , 2003, Molecular cell.
[23] E. Pérez-Nadales,et al. Dissecting the Contribution of p16INK4A and the Rb Family to the Ras Transformed Phenotype , 2003, Molecular and Cellular Biology.
[24] E. Harlow,et al. The retinoblastoma tumour suppressor in development and cancer , 2002, Nature Reviews Cancer.
[25] William C Hahn,et al. Rules for making human tumor cells. , 2002, The New England journal of medicine.
[26] F. McCormick,et al. The RB and p53 pathways in cancer. , 2002, Cancer cell.
[27] M. Schwartz,et al. Integrins and cell proliferation: regulation of cyclin-dependent kinases via cytoplasmic signaling pathways. , 2001, Journal of cell science.
[28] R. Weinberg,et al. Heterotypic signaling between epithelial tumor cells and fibroblasts in carcinoma formation. , 2001, Experimental cell research.
[29] J. Shay,et al. Putative telomere-independent mechanisms of replicative aging reflect inadequate growth conditions. , 2001, Genes & development.
[30] M. Schwartz,et al. Coordinate signaling by integrins and receptor tyrosine kinases in the regulation of G1 phase cell-cycle progression. , 2001, Current opinion in genetics & development.
[31] A. Lloyd,et al. Lack of Replicative Senescence in Normal Rodent Glia , 2001, Science.
[32] D. Hanahan,et al. The Hallmarks of Cancer , 2000, Cell.
[33] S. Sen,et al. Aneuploidy and cancer , 2000, Current opinion in oncology.
[34] M. Bottazzi,et al. α5β1 Integrin Controls Cyclin D1 Expression by Sustaining Mitogen-activated Protein Kinase Activity in Growth Factor-treated Cells , 1999 .
[35] Robert A. Weinberg,et al. Creation of human tumour cells with defined genetic elements , 1999, Nature.
[36] M. Bottazzi,et al. Alpha5beta1 integrin controls cyclin D1 expression by sustaining mitogen-activated protein kinase activity in growth factor-treated cells. , 1999, Molecular biology of the cell.
[37] T. Tsuruo,et al. Up‐regulation of p27Kip1 Correlates Inversely with Anchorage‐independent Growth of Human Cancer Cell Lines , 1998, Japanese journal of cancer research : Gann.
[38] M. Kawada,et al. Induction of p27Kip1 degradation and anchorage independence by Ras through the MAP kinase signaling pathway , 1997, Oncogene.
[39] R. Kerr. Ice Rhythms—Core Reveals a Plethora of Climate Cycles , 1996, Science.
[40] K. Manova-Todorova,et al. Enhanced Growth of Mice Lacking the Cyclin-Dependent Kinase Inhibitor Function of p27 Kip1 , 1996, Cell.
[41] James M. Roberts,et al. Adhesion-dependent cell cycle progression linked to the expression of cyclin D1, activation of cyclin E-cdk2, and phosphorylation of the retinoblastoma protein , 1996, The Journal of cell biology.
[42] N. Jones,et al. E2F-1 but not E2F-4 can overcome p16-induced G1 cell-cycle arrest , 1996, Current Biology.
[43] T. Hunter,et al. Dependence of Cyclin E-CDK2 Kinase Activity on Cell Anchorage , 1996, Science.
[44] S. Frisch,et al. Disruption of epithelial cell-matrix interactions induces apoptosis , 1994, The Journal of cell biology.
[45] James M. Roberts,et al. A link between cyclin A expression and adhesion-dependent cell cycle progression. , 1993, Science.
[46] V. Freedman,et al. Cellular tumorigenicity in nude mice: correlation with cell growth in semi-solid medium. , 1974, Cell.