Multiple‐fibre low‐power interstitial laser hyperthermia: studies in the normal liver

Multiple four‐fibre low‐power interstitial laser hyperthermia was performed in the canine liver to establish the parameters with which large areas of thermal necrosis could be made. Using 1.5 W for 670s (4020 J in total) and a fibre spacing of 1.5 cm, lesions with dimensions of 3.6 × 3.1 × 2.8 cm were achieved in 75 per cent of those attempted. There was no mortality and a low morbidity rate. These lesions could be visualized in both their development and resolution using ultrasonography. Healing occurred by 1 year. Temperatures in the centre of the heated region were 60°C, which is more than enough to cause thermal cell death. There was good correlation between the temperatures recorded, the sonographic changes seen, and the pathological evidence of necrosis. Multiple‐fibre low‐power interstitial laser hyperthermia performed with ultrasonic guidance may be of use in the treatment of liver tumours.

[1]  M. Baggish,et al.  Death caused by air embolism associated with neodymium:yttrium-aluminum-garnet laser surgery and artificial sapphire tips. , 1989, American journal of obstetrics and gynecology.

[2]  H. Barr,et al.  Low power interstitial Nd YAG laser photocoagulation: Studies in a transplantable fibrosarcoma , 1989, The British journal of surgery.

[3]  J. Frazer,et al.  Mechanisms of synergism between arteriolar embolization and hyperthermia in a rabbit V-2 model of solitary hepatic metastasis. , 1986, Cancer research.

[4]  Wr Lees,et al.  Interstitial laser hyperthermia: a new approach to local destruction of tumours. , 1989 .

[5]  H D Suit,et al.  Time-temperature relationship th hyperthermic treatment of malignant and normal tissue in vivo. , 1979, Cancer research.

[6]  D. Franco.  Malignancy of the liver , 1990 .

[7]  I. Taylor,et al.  Hepatic resection for colorectal secondaries , 1990, The British journal of surgery.

[8]  A. C. Steger,et al.  The Use Of Multiple Fibreoptic Systems In The Medical Application Of Lasers , 1989, Photonics West - Lasers and Applications in Science and Engineering.

[9]  T. Cetas,et al.  Introduction to hyperthermia device evaluation. , 1988, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

[10]  U. Stenram,et al.  Local hyperthermia in treatment of experimental liver tumors , 1984, Cancer.

[11]  Y. Osaki,et al.  Clinical effects of total‐body hyperthermia combined with anticancer chemotherapy for far‐advanced gastrointestinal cancer , 1985, Cancer.

[12]  G. Hahn,et al.  Thermal sensitivity to single and double heat treatments in normal canine liver. , 1985, Cancer research.

[13]  A. B. Barnes,et al.  Comparison of Histologic and Colposcopic Findings in DES-Exposed Females , 1978, Obstetrics and gynecology.

[14]  J. P. O'sullivan,et al.  Biological effects of intrahepatic neodymium:yttrium-aluminum-garnet laser photocoagulation in rats. , 1987, Gastroenterology.

[15]  A. Simjee,et al.  Serial ultrasound in amoebic liver abscess. , 1985, Clinical radiology.

[16]  I. Taylor.  Colorectal liver metastases — to treat or not to treat? , 1985, The British journal of surgery.

[17]  H. Ohnacker,et al.  Liver damage in heatstroke and its regression. A biopsy study. , 1972, Human pathology.

[18]  F. Moffat,et al.  Thermochemotherapy for unresectable hepatic cancer. , 1986, Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer.

[19]  A. Milligan,et al.  Biochemical and cellular effects of radiofrequency induced interstitial hyperthermia on normal canine liver. , 1988, International journal of radiation oncology, biology, physics.

[20]  I. Gore,et al.  The pathology of hyperpyrexia; observations at autopsy in 17 cases of fever therapy. , 1949, The American journal of pathology.

[21]  C. McArdle,et al.  Occult hepatic metastases in colorectal carcinoma , 1986, The British journal of surgery.

[22]  S Shiina,et al.  Percutaneous ethanol injection therapy for the treatment of hepatocellular carcinoma. , 1990, AJR. American journal of roentgenology.

[23]  M. Baggish,et al.  A ten-year experience treating cervical intraepithelial neoplasia with the CO2 laser. , 1989, American journal of obstetrics and gynecology.

[24]  T. Ravikumar,et al.  Hepatic cryosurgery with intraoperative ultrasound monitoring for metastatic colon carcinoma. , 1987, Archives of surgery.

[25]  R. Dickinson,et al.  The practical use of thermocouples for temperature measurement in clinical hyperthermia. , 1986, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

[26]  P. Vaupel,et al.  Pathophysiology of tumors in hyperthermia. , 1988, Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer.

[27]  R. Condon,et al.  Hyperthermic isolation‐perfusion in vivo of the canine liver , 1983, Cancer.

[28]  H. C. Nauts,et al.  The treatment of malignant tumors by bacterial toxins as developed by the late William B. Coley, M.D., reviewed in the light of modern research. , 1946, Cancer research.

[29]  J. P. O'sullivan,et al.  Low power interstitial Nd YAG laser photocoagulation in normal and neoplastic rat colon. , 1988, Gut.

[30]  C. McArdle,et al.  Growth rate of hepatic metastases in colorectal carcinoma , 1988, The British journal of surgery.

[31]  The Necessity for Staging Liver Metastases and Standardizing Treatment-Response Criteria. The Case of Secondaries of Colo-Rectal Origin , 1984 .

[32]  D N Wheatley,et al.  Heat-induced damage to HeLa-S3 cells: correlation of viability, permeability, osmosensitivity, phase-contrast light-, scanning electron- and transmission electron-microscopical findings. , 1989, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

[33]  Edwin M. Smith,et al.  The Edwin Smith surgical papyrus , 1984 .