Genetic loci and prioritization of genes for kidney function decline derived from a meta-analysis of 62 longitudinal genome-wide association studies

Karsten B. Sieber | Laurent F. Thomas | Pashupati P. Mishra | Audrey Y. Chu | M. Nalls | C. Gieger | F. Kronenberg | M. Waldenberger | J. Cook | A. Morris | T. Lehtimäki | D. Gudbjartsson | U. Thorsteinsdóttir | K. Stefánsson | E. Boerwinkle | C. Lindgren | M. Laakso | J. O’Connell | K. Strauch | A. Zonderman | M. Evans | H. White | A. Köttgen | Qiong Yang | Shih-Jen Hwang | J. Coresh | P. Sulem | Gardar Sveinbjornsson | I. Olafsson | T. Ahluwalia | T. Meitinger | S. Szymczak | W. Lieb | B. Psaty | B. Penninx | H. Snieder | Michael H. Preuss | C. Meisinger | K. Stark | C. Willer | H. Stringham | O. Melander | M. Orho-Melander | K. Taylor | J. Rotter | I. Heid | J. Ärnlöv | B. Schöttker | K. Rice | A. Mahajan | H. Hólm | N. Bansal | S. Pendergrass | C. Sabanayagam | H. Schmidt | A. Teumer | U. Völker | A. Franke | W. Koenig | N. Mononen | E. Bottinger | M. Kähönen | M. Feitosa | T. Winkler | Ching-Yu Cheng | X. Sim | Jin-Fang Chai | B. Kühnel | I. Nolte | B. Tayo | P. J. van der Most | M. Ghanbari | C. Khor | J. Kuusisto | Y. Milaneschi | M. Sims | P. van der Harst | A. Parsa | R. Loos | Man Li | K. Hveem | L. Lyytikäinen | L. Wallentin | Martina E. Zimmermann | R. Carroll | C. Shaffer | C. Fuchsberger | M. Nauck | P. Hamet | E. Salvi | D. Cusi | D. Waterworth | G. Nadkarni | A. Chu | V. Giedraitis | N. Verweij | S. Bakker | R. Gansevoort | B. Banas | C. Böger | M. Cocca | M. Gorski | L. Lange | K. Nikus | L. Yerges-Armstrong | B. Åsvold | K. Wakai | S. Hallan | S. Freitag-Wolf | K. Ryan | S. Graham | E. Hofer | K. Eckardt | A. Hishida | M. Naito | C. Pattaro | M. Nakatochi | Markus Scholz | P. Rossing | B. Brumpton | M. O’Donoghue | J. Mychaleckyj | Kevin Ho | L. Chaker | H. Rasheed | L. Thomas | Yong Li | Sahar Ghasemi | M. Wuttke | A. Tin | A. Hoppmann | K. Horn | T. Nutile | S. Sedaghat | M. Biggs | M. Chee | Miao-Ling Chee | F. Degenhardt | K. Endlich | N. Josyula | B. Jung | H. Kramer | M. Rheinberger | M. D. de Borst | B. Ning | L. Raffield | C. Thio | F. Rizzi | M. Pirastu | T. Wong | M. Ciullo | D. Ruggiero | G. Biino | B. Holleczek | S. Wallner | S. Vaccargiu | N. Hutri-Kähönen | A. Rosenkranz | F. Günther | Judy Wang | M. Ikram | Christina-Alexandra Schulz | Michael H Preuss | P. Matías-García | Peter J. van der Most | M. Lukas | Piyush G Gampawar | T. Bergler | G. Sveinbjornsson | J. Chalmers | Lars Lind | Irma Karabegović | H. Stocker | H. Brenner | Reinhold Schmidt | Kira-Julia Stanzick | M. Woodward | Michael Böhnke | Bernhard K. Krämer | O. Raitakari | Johanne Tremblay | L. Lind | R. Schmidt | P. van der harst | Anselm Hoppmann | M. Zimmermann | M. Preuss | M. Kähönen | J. Coresh | Mathias Gorski | B. Psaty | A. Morris | Brigitte Kühnel | R. Loos | Olli T. Raitakari | C. Shaffer | K. Taylor | P. Gampawar | K. Taylor | A. Morris

[1]  K. Abrams,et al.  Treatments for Chronic Kidney Disease: A Systematic Literature Review of Randomized Controlled Trials , 2021, Advances in Therapy.

[2]  M. Woodward,et al.  Changes in GFR and Albuminuria in Routine Clinical Practice and the Risk of Kidney Disease Progression. , 2021, American journal of kidney diseases : the official journal of the National Kidney Foundation.

[3]  B. Caramelli,et al.  Empagliflozin Inhibits Proximal Tubule NHE3 Activity, Preserves GFR, and Restores Euvolemia in Nondiabetic Rats with Induced Heart Failure. , 2021, Journal of the American Society of Nephrology : JASN.

[4]  M. Nalls,et al.  Trans-ethnic meta-analysis identifies new loci associated with longitudinal blood pressure traits , 2021, Scientific Reports.

[5]  M. Nangaku,et al.  SHROOM3, the gene associated with chronic kidney disease, affects the podocyte structure , 2020, Scientific Reports.

[6]  G. Navis,et al.  Methylmalonic acid, vitamin B12, renal function, and risk of all-cause mortality in the general population: results from the prospective Lifelines-MINUTHE study , 2020, BMC Medicine.

[7]  Lyanne M. Kieneker,et al.  Muscle mass heavily influences creatinine-based renal function estimation: a 12-year longitudinal general population-based cohort study , 2020 .

[8]  M. D. de Borst,et al.  Identifying donors with no recovery of kidney function. , 2020, Kidney International.

[9]  Karsten B. Sieber,et al.  Meta-analysis uncovers genome-wide significant variants for rapid kidney function decline. , 2020, Kidney international.

[10]  S. Bakker,et al.  Long‐term magnesium supplementation improves glucocorticoid metabolism: A post‐hoc analysis of an intervention trial , 2020, Clinical Endocrinology.

[11]  Eun Sug Park,et al.  Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019 , 2020, Lancet.

[12]  J. McMurray,et al.  Dapagliflozin in Patients with Chronic Kidney Disease. , 2020, The New England journal of medicine.

[13]  M. Vervloet,et al.  Comparison of two methods for the assessment of intra-erythrocyte magnesium and its determinants: Results from the LifeLines cohort study. , 2020, Clinica chimica acta; international journal of clinical chemistry.

[14]  Laurent F. Thomas,et al.  Discovery and prioritization of variants and genes for kidney function in >1.2 million individuals , 2020, Nature Communications.

[15]  R. Gans,et al.  Thyroid function and risk of all-cause and cardiovascular mortality: a prospective population-based cohort study , 2020, Endocrine.

[16]  J. Geleijnse,et al.  Effects of Potassium or Sodium Supplementation on Mineral Homeostasis: A Controlled Dietary Intervention Study , 2020, The Journal of clinical endocrinology and metabolism.

[17]  M. D. de Borst,et al.  Low serum magnesium as a risk factor for peripheral artery disease in chronic kidney disease: an open verdict , 2020, Nephrology, Dialysis and Transplantation.

[18]  G. Navis,et al.  Fibroblast growth factor 23 and new-onset chronic kidney disease in the general population: the Prevention of Renal and Vascular Endstage Disease (PREVEND) study , 2020, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[19]  A. Köttgen,et al.  The CKDGen Consortium: ten years of insights into the genetic basis of kidney function. , 2020, Kidney international.

[20]  J. Coresh,et al.  Measured and estimated glomerular filtration rate: current status and future directions , 2019, Nature Reviews Nephrology.

[21]  Karsten B. Sieber,et al.  Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria , 2019, Nature Communications.

[22]  Jacob M. Keaton,et al.  Mapping eGFR loci to the renal transcriptome and phenome in the VA Million Veteran Program , 2019, Nature Communications.

[23]  Sara M. Willems,et al.  Genome-wide Association Study of Change in Fasting Glucose over time in 13,807 non-diabetic European Ancestry Individuals , 2019, Scientific Reports.

[24]  K. Faber,et al.  Levels of serum free thiols are superior to fecal calprotectin in predicting endoscopic disease activity in Inflammatory Bowel Disease , 2019 .

[25]  Karsten B. Sieber,et al.  A catalog of genetic loci associated with kidney function from analyses of a million individuals , 2019, Nature Genetics.

[26]  I. Nolte,et al.  Galectin-3 and Long-Term Graft Failure in Renal Transplant Recipients: A Prospective Cohort Study. , 2019 .

[27]  Jacob F. Degner,et al.  Are drug targets with genetic support twice as likely to be approved? Revised estimates of the impact of genetic support for drug mechanisms on the probability of drug approval , 2019, bioRxiv.

[28]  Helen E. Parkinson,et al.  The NHGRI-EBI GWAS Catalog of published genome-wide association studies, targeted arrays and summary statistics 2019 , 2018, Nucleic Acids Res..

[29]  G. Navis,et al.  Influence of exogenous growth hormone administration on circulating concentrations of α-klotho in healthy and chronic kidney disease subjects: a prospective, single-center open case-control pilot study , 2018, BMC Nephrology.

[30]  Christian Gieger,et al.  Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits , 2018, Nature Genetics.

[31]  Paul J. Hoover,et al.  An eQTL landscape of kidney tissue in human nephrotic syndrome , 2018, bioRxiv.

[32]  E. Hoorn,et al.  Rationale and Design of a Randomized Placebo-Controlled Clinical Trial Assessing the Renoprotective Effects of Potassium Supplementation in Chronic Kidney Disease , 2018, Nephron.

[33]  S. Bakker,et al.  Pre-Transplant Duration of Dialysis, N-Terminal Pro-Brain Natriuretic Peptide and Post-Transplant Mortality in Renal Transplant Recipients. , 2018 .

[34]  G. Navis,et al.  Estimated GFR at Donor Screening and Achieved Measured GFR after Living Kidney Donation. , 2018 .

[35]  Z. Kutalik,et al.  Addendum: A joint view on genetic variants for adiposity differentiates subtypes with distinct metabolic implications , 2018, Nature Communications.

[36]  A. Israni,et al.  NPHP1 (Nephrocystin-1) Gene Deletions Cause Adult-Onset ESRD. , 2018, Journal of the American Society of Nephrology : JASN.

[37]  G. Navis,et al.  Dietary Approach to Stop Hypertension (DASH) diet and risk of renal function decline and all‐cause mortality in renal transplant recipients , 2018, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

[38]  G. Remuzzi,et al.  Moderate salt restriction with or without paricalcitol in type 2 diabetes and losartan-resistant macroalbuminuria (PROCEED): a randomised, double-blind, placebo-controlled, crossover trial. , 2018, The lancet. Diabetes & endocrinology.

[39]  W. Y. van der Plas,et al.  Effect of parathyroidectomy and cinacalcet on quality of life in patients with end-stage renal disease-related hyperparathyroidism: a systematic review , 2017, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[40]  G. Davey Smith,et al.  Genetic epidemiology and Mendelian randomization for informing disease therapeutics: Conceptual and methodological challenges , 2017, bioRxiv.

[41]  D. Tsikas,et al.  Low plasma homoarginine concentration is associated with high rates of all-cause mortality in renal transplant recipients , 2017, Amino Acids.

[42]  G. Navis,et al.  Vitamin D inhibits lymphangiogenesis through VDR-dependent mechanisms , 2017, Scientific Reports.

[43]  Janina M. Jeff,et al.  Genome-Wide Association of CKD Progression: The Chronic Renal Insufficiency Cohort Study. , 2017, Journal of the American Society of Nephrology : JASN.

[44]  Caroline Relton,et al.  When Will Mendelian Randomization Become Relevant for Clinical Practice and Public Health? , 2017, JAMA.

[45]  Lyanne M. Kieneker,et al.  Urinary Calcium Excretion and Risk of Chronic Kidney Disease in the General Population , 2016, Kidney international reports.

[46]  S. Bakker,et al.  Serum free sulfhydryl status is associated with patient and graft survival in renal transplant recipients. , 2016, Free radical biology & medicine.

[47]  J. van den Born,et al.  Interferon gamma peptidomimetic targeted to interstitial myofibroblasts attenuates renal fibrosis after unilateral ureteral obstruction in mice , 2016, Oncotarget.

[48]  M. Vervloet,et al.  Phosphate Binding Therapy to Lower Serum Fibroblast-Growth-Factor-23 Concentrations in Chronic Kidney Disease: Rationale and Study Design of the Sevelamer on FGF23 Trial (SoFT) , 2016, Nephron.

[49]  G. Navis,et al.  Vitamin D receptor activator and dietary sodium restriction to reduce residual urinary albumin excretion in chronic kidney disease (ViRTUE study): rationale and study protocol. , 2016, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[50]  A. V. Roon,et al.  ARTERIAL STIFFNESS CALCULATED FROM PERIPHERAL ARTERIAL PULSE PRESSURE IS INDEPENDENTLY ASSOCIATED WITH ALL-CAUSE MORTALITY IN THE GENERAL POPULATION , 2016 .

[51]  Aihua Li,et al.  Developmental Origins for Kidney Disease Due to Shroom3 Deficiency. , 2016, Journal of the American Society of Nephrology : JASN.

[52]  Po-Ru Loh,et al.  A Robust Example of Collider Bias in a Genetic Association Study. , 2016, American journal of human genetics.

[53]  M. D. de Borst,et al.  Vitamin D analogues to target residual proteinuria: potential impact on cardiorenal outcomes. , 2015, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[54]  M. Vervloet,et al.  Membrane-bound Klotho is not expressed endogenously in healthy or uraemic human vascular tissue. , 2015, Cardiovascular research.

[55]  D. Tsikas,et al.  High urinary homoarginine excretion is associated with low rates of all-cause mortality and graft failure in renal transplant recipients , 2015, Amino Acids.

[56]  G. Navis,et al.  Plasma ADMA associates with all-cause mortality in renal transplant recipients , 2015, Amino Acids.

[57]  P. Elliott,et al.  UK Biobank: An Open Access Resource for Identifying the Causes of a Wide Range of Complex Diseases of Middle and Old Age , 2015, PLoS medicine.

[58]  Peter Kraft,et al.  Adjusting for heritable covariates can bias effect estimates in genome-wide association studies. , 2015, American journal of human genetics.

[59]  Andrew D. Johnson,et al.  Genome-wide association study of kidney function decline in individuals of European descent , 2014, Kidney international.

[60]  N. C. Yeo,et al.  Shroom3 contributes to the maintenance of the glomerular filtration barrier integrity , 2015, Genome research.

[61]  Martin T. Wells,et al.  Large-Scale Genome-Wide Association Studies and Meta-Analyses of Longitudinal Change in Adult Lung Function , 2014, PloS one.

[62]  M. Vervloet,et al.  Dietary and pharmacological modification of fibroblast growth factor-23 in chronic kidney disease. , 2014, Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation.

[63]  R. Schoevers,et al.  Antidepressants differentially related to 1,25-(OH)2 vitamin D3 and 25-(OH) vitamin D3 in late-life depression , 2014, Translational Psychiatry.

[64]  H. Comijs,et al.  Calcitriol, the biologically active from of vitamin D-3, in late-life depression , 2014 .

[65]  Barry I. Freedman,et al.  APOL1 risk variants, race, and progression of chronic kidney disease. , 2013, The New England journal of medicine.

[66]  K. Andrassy,et al.  Comments on 'KDIGO 2012 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease'. , 2013, Kidney international.

[67]  Kai-Uwe Eckardt,et al.  Evolving importance of kidney disease: from subspecialty to global health burden , 2013, The Lancet.

[68]  G. Navis,et al.  Improving the efficacy of RAAS blockade in patients with chronic kidney disease , 2013, Nature Reviews Nephrology.

[69]  Brenda R. Hemmelgarn,et al.  Notice , 2012, Kidney International Supplements.

[70]  H. Snieder,et al.  Association of Complement C3 Gene Variants with Renal Transplant Outcome of Deceased Cardiac Dead Donor Kidneys , 2012, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

[71]  Sylvia Stracke,et al.  Genome-Wide Association and Functional Follow-Up Reveals New Loci for Kidney Function , 2012, PLoS genetics.

[72]  R. Gans,et al.  Antiproteinuric treatment reduces urinary loss of vitamin D-binding protein but does not affect vitamin D status in patients with chronic kidney disease , 2012, The Journal of Steroid Biochemistry and Molecular Biology.

[73]  M. Borst,et al.  Towards Tailored Treatment - New Organ-Specific Drug Strategies Interfering in Signal Transduction , 2011 .

[74]  Mark N. Wass,et al.  Genetic loci influencing kidney function and chronic kidney disease , 2010, Nature Genetics.

[75]  G. Navis,et al.  Possible renoprotection by vitamin D in chronic renal disease: beyond mineral metabolism , 2009, Nature Reviews Nephrology.

[76]  S. Vansteelandt,et al.  On the adjustment for covariates in genetic association analysis: a novel, simple principle to infer direct causal effects , 2009, Genetic epidemiology.

[77]  C. Schmid,et al.  A new equation to estimate glomerular filtration rate. , 2009, Annals of internal medicine.

[78]  G. Navis,et al.  Vitamin D: the key to regression of renal fibrosis? , 2009 .

[79]  R. Kok,et al.  Cell-specific Delivery of a Transforming Growth Factor-beta Type I Receptor Kinase Inhibitor to Proximal Tubular Cells for the Treatment of Renal Fibrosis , 2008, Pharmaceutical Research.

[80]  M. Jarvelin,et al.  A Common Variant in the FTO Gene Is Associated with Body Mass Index and Predisposes to Childhood and Adult Obesity , 2007, Science.

[81]  M. Borst Protein kinase signaling : Intracellular messengers as potential targets for intervention in renal disease , 2007 .

[82]  H. Bakker,et al.  Mannose-6-Phosphate/Insulin-Like Growth Factor-II Receptors may Represent a Target for the Selective Delivery of Mycophenolic Acid to Fibrogenic Cells , 2006, Pharmaceutical Research.

[83]  Raymond J. Carroll,et al.  Measurement error in nonlinear models: a modern perspective , 2006 .

[84]  M. Tonelli,et al.  Progression of kidney dysfunction in the community-dwelling elderly. , 2006, Kidney international.

[85]  J. Robins,et al.  When is baseline adjustment useful in analyses of change? An example with education and cognitive change. , 2005, American journal of epidemiology.

[86]  A. Bello,et al.  Chronic kidney disease: the global challenge , 2005, The Lancet.

[87]  D. Levy,et al.  Genomewide linkage analysis to serum creatinine, GFR, and creatinine clearance in a community-based population: the Framingham Heart Study. , 2004, Journal of the American Society of Nephrology : JASN.

[88]  G. Navis,et al.  Potentiating effect of sodium restriction on ACE-Inhibition is associated. with increased renal COX-2, nNOS and renin expression in normal and nephrotic rats. , 2003 .

[89]  J. Leij,et al.  ADAM19 expression in chronic renal transplant failure. , 2003 .

[90]  G. Navis,et al.  Potentiating effect of sodium restriction on ACE-inhibition in experimental nephrosis is associated with increased renal cortical COX-2 expression. , 2002 .

[91]  G. Navis,et al.  Renoprotective effects of specific MAP-kinase blockade in homozygous TGR(mRen2)27 rats. , 2002 .

[92]  Kristopher J Preacher,et al.  On the practice of dichotomization of quantitative variables. , 2002, Psychological methods.

[93]  D. Altman,et al.  Analysing controlled trials with baseline and follow up measurements , 2001, BMJ : British Medical Journal.

[94]  R A Kronmal,et al.  The effects of measurement error in response variables and tests of association of explanatory variables in change models. , 1998, Statistics in medicine.

[95]  R. Peto THE HORSE-RACING EFFECT , 1981, The Lancet.