Microfluidics platform for glass capillaries and its application in droplet and nanoparticle fabrication.

The accessibility to microfluidics of a broader scientific community is often limited by the costly and complex manufacture of the chips. In this respect, we present a simple and reusable platform for the flexible and easy assembly of glass capillaries to create a microfluidics chip within minutes, with excellent chemical compatibility and durability, and without the need of using specialized infrastructure. To demonstrate the application of the proposed platform, we have used it to produce microparticles by the double emulsion approach, nanoparticles by nanoprecipitation, and screened the nanoparticles' size and polydispersity obtained upon modification of various parameters.

[1]  Robert Langer,et al.  Microfluidic platform for controlled synthesis of polymeric nanoparticles. , 2008, Nano letters.

[2]  A. Woolley,et al.  Advances in microfluidic materials, functions, integration, and applications. , 2013, Chemical reviews.

[3]  Robert Langer,et al.  Mass production and size control of lipid-polymer hybrid nanoparticles through controlled microvortices. , 2012, Nano letters.

[4]  M. Stuart,et al.  Controlled nanoparticle formation by diffusion limited coalescence. , 2012, Physical review letters.

[5]  Patrick Tabeling,et al.  Recent progress in the physics of microfluidics and related biotechnological applications. , 2014, Current opinion in biotechnology.

[6]  L. R. Arriaga,et al.  Scalable single-step microfluidic production of single-core double emulsions with ultra-thin shells. , 2015, Lab on a chip.

[7]  Shanavaz Nasarabadi,et al.  On-chip single-copy real-time reverse-transcription PCR in isolated picoliter droplets. , 2007, Analytical chemistry.

[8]  Hélder A. Santos,et al.  A Versatile and Robust Microfluidic Platform Toward High Throughput Synthesis of Homogeneous Nanoparticles with Tunable Properties , 2015, Advanced materials.

[9]  Jean-Louis Viovy,et al.  New family of fluorinated polymer chips for droplet and organic solvent microfluidics. , 2011, Lab on a chip.

[10]  Zoltan K. Nagy,et al.  Production of polymeric nanoparticles by micromixing in a co-flow microfluidic glass capillary device , 2015 .

[11]  C. Culbertson,et al.  Sol-gel modified poly(dimethylsiloxane) microfluidic devices with high electroosmotic mobilities and hydrophilic channel wall characteristics. , 2005, Analytical chemistry.

[12]  Robert Langer,et al.  Parallel microfluidic synthesis of size-tunable polymeric nanoparticles using 3D flow focusing towards in vivo study. , 2013, Nanomedicine : nanotechnology, biology, and medicine.

[13]  Liang-Yin Chu,et al.  Designer emulsions using microfluidics , 2008 .

[14]  Hiroyuki Moriguchi,et al.  Droplet formation behavior in a microfluidic device fabricated by hydrogel molding , 2014 .

[15]  Phil Stephens,et al.  Simple and Versatile 3D Printed Microfluidics Using Fused Filament Fabrication , 2016, PloS one.

[16]  Jarno Salonen,et al.  Fabrication of a Multifunctional Nano‐in‐micro Drug Delivery Platform by Microfluidic Templated Encapsulation of Porous Silicon in Polymer Matrix , 2014, Advanced materials.

[17]  Honglong Chang,et al.  Ultra-monodisperse droplet formation using PMMA microchannels integrated with low-pulsation electrolysis micropumps , 2016 .

[18]  Robert Langer,et al.  Synthesis of Size‐Tunable Polymeric Nanoparticles Enabled by 3D Hydrodynamic Flow Focusing in Single‐Layer Microchannels , 2011, Advanced materials.

[19]  R. Mukhopadhyay When PDMS isn't the best , 2007 .

[20]  Hélder A Santos,et al.  Simple Microfluidic Approach to Fabricate Monodisperse Hollow Microparticles for Multidrug Delivery. , 2015, ACS applied materials & interfaces.

[21]  D. Weitz,et al.  Microfluidic assembly of multistage porous silicon-lipid vesicles for controlled drug release. , 2014, Lab on a chip.

[22]  R. Kodzius,et al.  Fabrication of polystyrene microfluidic devices using a pulsed CO2 laser system , 2012 .

[23]  Hatem Fessi,et al.  Nanocapsule formation by interfacial polymer deposition following solvent displacement , 1989 .