Production of the antitumor drug epirubicin (4′-epidoxorubicin) and its precursor by a genetically engineered strain of Streptomyces peucetius
暂无分享,去创建一个
D. Macneil | J. Kennedy | K. Madduri | C. Hutchinson | J. Occi | S. Filippini | K. Gewain | A. L. Colombo | G. Zanuso | G. Rivola | A. Inventi-Solari
[1] J. Sambrook,et al. Molecular Cloning: A Laboratory Manual , 2001 .
[2] C R Hutchinson,et al. Sequencing and mutagenesis of genes from the erythromycin biosynthetic gene cluster of Saccharopolyspora erythraea that are involved in L-mycarose and D-desosamine production. , 1997, Microbiology.
[3] J R Jacobsen,et al. Precursor-directed biosynthesis of erythromycin analogs by an engineered polyketide synthase. , 1997, Science.
[4] K. Madduri,et al. Cloning and characterization of the Streptomyces peucetius dnmZUV genes encoding three enzymes required for biosynthesis of the daunorubicin precursor thymidine diphospho-L-daunosamine , 1997, Journal of bacteriology.
[5] G. Forloni,et al. Effectiveness of anthracycline against experimental prion disease in Syrian hamsters. , 1997, Science.
[6] R. Thompson,et al. Production of hybrid glycopeptide antibiotics in vitro and in Streptomyces toyocaensis. , 1997, Chemistry & biology.
[7] C. Hutchinson,et al. Enhanced antibiotic production by manipulation of the Streptomyces peucetius dnrH and dnmT genes involved in doxorubicin (adriamycin) biosynthesis , 1996, Journal of bacteriology.
[8] C. Khosla,et al. Generation of polyketide libraries via combinatorial biosynthesis. , 1996, Trends in biotechnology.
[9] M. Araake,et al. Cladinose analogues of sixteen-membered macrolide antibiotics. I. Synthesis of 4-O-alkyl-L-cladinose analogues via glycosylation. , 1996, The Journal of antibiotics.
[10] J. Ward,et al. The dnrM gene in Streptomyces peucetius contains a naturally occurring frameshift mutation that is suppressed by another locus outside of the daunorubicin-production gene cluster. , 1996, Microbiology.
[11] C. Hutchinson,et al. Cloning and characterization of the Streptomyces peucetius dnrQS genes encoding a daunosamine biosynthesis enzyme and a glycosyl transferase involved in daunorubicin biosynthesis , 1995, Journal of bacteriology.
[12] T. Stachelhaus,et al. Rational design of peptide antibiotics by targeted replacement of bacterial and fungal domains. , 1995, Science.
[13] K. Madduri,et al. Functional characterization and transcriptional analysis of the dnrR1 locus, which controls daunorubicin biosynthesis in Streptomyces peucetius , 1995, Journal of bacteriology.
[14] C. Hutchinson,et al. Functional analysis of putative beta-ketoacyl:acyl carrier protein synthase and acyltransferase active site motifs in a type II polyketide synthase of Streptomyces glaucescens , 1995, Journal of bacteriology.
[15] M. Bibb,et al. The mRNA for the 23S rRNA methylase encoded by the ermE gene of Saccharopolyspora erythraea is translated in the absence of a conventional ribosome‐binding site , 1994, Molecular microbiology.
[16] H. Tsunekawa,et al. Cloning of the macrolide antibiotic biosynthesis gene acyA, which encodes 3-O-acyltransferase, from Streptomyces thermotolerans and its use for direct fermentative production of a hybrid macrolide antibiotic , 1994, Applied and environmental microbiology.
[17] R. Morona,et al. Characterization of the dTDP‐rhamnose biosynthetic genes encoded in the rfb iocus of Shigella flexneri , 1994, Molecular microbiology.
[18] J B McAlpine,et al. An erythromycin analog produced by reprogramming of polyketide synthesis. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[19] R. Weiss. The anthracyclines: will we ever find a better doxorubicin? , 1992, Seminars in oncology.
[20] C. Hutchinson,et al. A macrolide 3-O-acyltransferase gene from the midecamycin-producing species Streptomyces mycarofaciens , 1992, Journal of bacteriology.
[21] W R Strohl,et al. Compilation and analysis of DNA sequences associated with apparent streptomycete promoters. , 1992, Nucleic acids research.
[22] C. Hutchinson,et al. A bacterial analog of the mdr gene of mammalian tumor cells is present in Streptomyces peucetius, the producer of daunorubicin and doxorubicin. , 1991, Proceedings of the National Academy of Sciences of the United States of America.
[23] J. McAlpine,et al. An erythromycin derivative produced by targeted gene disruption in Saccharopolyspora erythraea. , 1991, Science.
[24] P. Reeves,et al. Structure and sequence of the rfb (O antigen) gene cluster of Salmonella serovar typhimurium (strain LT2) , 1991, Molecular microbiology.
[25] A. Pühler,et al. Gene disruption and gene replacement in Streptomyces via single stranded DNA transformation of integration vectors. , 1991, Nucleic acids research.
[26] T. Goodson,et al. Production of a hybrid macrolide antibiotic in Streptomyces ambofaciens and Streptomyces lividans by introduction of a cloned carbomycin biosynthetic gene from Streptomyces thermotolerans. , 1989, Gene.
[27] S. Donadio,et al. Cloning of genes governing the deoxysugar portion of the erythromycin biosynthesis pathway in Saccharopolyspora erythraea (Streptomyces erythreus) , 1989, Journal of bacteriology.
[28] K. Grébner,et al. New antibiotics from genetically engineered actinomycetes. I. 2-Norerythromycins, isolation and structural determinations. , 1987, The Journal of antibiotics.
[29] P. Dephillips,et al. Actinoidin A2, a novel glycopeptide: production, preparative HPLC separation and characterization. , 1987, The Journal of antibiotics.
[30] J. Devereux,et al. A comprehensive set of sequence analysis programs for the VAX , 1984, Nucleic Acids Res..
[31] F. Formelli,et al. Synthesis and antitumor properties of new glycosides of daunomycinone and adriamycinone. , 1975, Journal of medicinal chemistry.
[32] C. Hutchinson. ANTIBIOTICS FROM GENETICALLY ENGINEERED MICROORGANISMS , 1997 .
[33] D. Macneil. CHAPTER 15 – Avermectins , 1995 .
[34] S. Donadio,et al. Macrolides. , 1995, Biotechnology.
[35] C. Hutchinson,et al. Polyketide synthase gene manipulation: a structure-function approach in engineering novel antibiotics. , 1995, Annual review of microbiology.
[36] J. Thorson,et al. Pathways and mechanisms in the biogenesis of novel deoxysugars by bacteria. , 1994, Annual review of microbiology.
[37] D. Hopwood. Genetic manipulation of Streptomyces : a laboratory manual , 1985 .
[38] C. Yanisch-Perron,et al. Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mp18 and pUC19 vectors. , 1985, Gene.