Optofluidic microcavities: Dye-lasers and biosensors.

Optofluidic microcavities are integrated elements of microfluidics that can be explored for a large variety of applications. In this review, we first introduce the physics basis of optical microcavities and microflow control. Then, we describe four types of optofluidic dye lasers developed so far based on both simple and advanced device fabrication technologies. To illustrate the application potential of such devices, we present two types of laser intracavity measurements for chemical solution and single cell analyses. In addition, the possibility of single molecule detection is discussed. All these recent achievements demonstrated the great importance of the topics in biology and several other disciplines.

[1]  S. Quake,et al.  Monolithic microfabricated valves and pumps by multilayer soft lithography. , 2000, Science.

[2]  Walter Koechner,et al.  Solid-State Laser Engineering , 1976 .

[3]  Qingli Kou,et al.  Microfluidic dye laser intracavity absorption , 2006 .

[4]  X. Ni,et al.  Patterning biomolecules with a water-soluble release and protection interlayer. , 2007, Langmuir : the ACS journal of surfaces and colloids.

[5]  Demetri Psaltis,et al.  Mechanically tunable optofluidic distributed feedback dye laser. , 2006 .

[6]  Luke P. Lee,et al.  Optofluidics: Fundamentals, Devices, and Applications , 2009 .

[7]  Hydrodynamic focusing controlled microfluidic laser emission , 2009 .

[8]  K. Jensen,et al.  Cells on chips , 2006, Nature.

[9]  Jian Shi,et al.  Compact dye laser on a chip fabricated by ultraviolet nanoimprint lithography , 2006 .

[10]  Microfluidic devices for optical determination of ethanol concentration , 2008 .

[11]  H. Craighead Future lab-on-a-chip technologies for interrogating individual molecules , 2006, Nature.

[12]  Andrea M. Armani,et al.  Ultra-high-Q microcavity operation in H2O and D2O , 2005 .

[13]  M. Guttmann,et al.  Integration of organic semiconductor lasers and single-mode passive waveguides into a PMMA substrate , 2010 .

[14]  Demetri Psaltis,et al.  Optofluidic evanescent dye laser based on a distributed feedback circular grating , 2009 .

[15]  C. Divya,et al.  Nanoscience and Nanotechnology , 2007 .

[16]  Y Chen,et al.  Nanofabrication: Conventional and nonconventional methods , 2001, Electrophoresis.

[17]  A. Kristensen,et al.  Optofluidic dye laser in a foil. , 2010, Optics express.

[18]  Christelle Monat,et al.  Integrated optofluidics: A new river of light , 2007 .

[19]  Demetri Psaltis,et al.  Single mode optofluidic distributed feedback dye laser. , 2006, Optics express.

[20]  Sindy K. Y. Tang,et al.  A multi-color fast-switching microfluidic droplet dye laser. , 2009, Lab on a chip.

[21]  C. Weisbuch,et al.  Observation of the coupled exciton-photon mode splitting in a semiconductor quantum microcavity. , 1992, Physical review letters.

[22]  George M Whitesides,et al.  A low-threshold, high-efficiency microfluidic waveguide laser. , 2005, Journal of the American Chemical Society.

[23]  Qingli Kou,et al.  Collinear dual-color laser emission from a microfluidic dye laser , 2006 .

[24]  Yong Chen,et al.  Enhanced UV imprint ability with a tri-layer stamp configuration , 2005 .

[25]  Ai Qun Liu,et al.  Determination of single living cell’s dry/water mass using optofluidic chip , 2007 .

[26]  M. Belotti,et al.  Microfluidic tunable dye laser with integrated mixer and ring resonator , 2005 .

[27]  Vincent Studer,et al.  Nanoembossing of thermoplastic polymers for microfluidic applications , 2002 .

[28]  Jian Shi,et al.  Microfluidic refractometer with integrated optical fibers and end-facet transmission gratings. , 2010, The Review of scientific instruments.

[29]  Xudong Fan,et al.  PDMS embedded opto-fluidic microring resonator lasers. , 2008, Optics express.

[30]  J. Hao,et al.  Differential single living cell refractometry using grating resonant cavity with optical trap , 2007 .

[31]  A. Kristensen,et al.  A micro-cavity fluidic dye laser , 2003 .

[32]  G. Whitesides The origins and the future of microfluidics , 2006, Nature.

[33]  Anders Kristensen,et al.  Optofluidic third order distributed feedback dye laser , 2006, physics/0605047.

[34]  Jian Shi,et al.  High resolution and hybrid patterning for single cell attachment , 2010 .

[35]  H. Lezec,et al.  Extraordinary optical transmission through sub-wavelength hole arrays , 1998, Nature.

[36]  P. H. Yap,et al.  Determining refractive index of single living cell using an integrated microchip , 2007 .

[37]  Chen,et al.  Bulk exciton polaritons in GaAs microcavities. , 1995, Physical review. B, Condensed matter.

[38]  P. H. Yap,et al.  Refractive index measurement of single living cells using on-chip Fabry-Pérot cavity , 2006 .

[39]  M. Galli,et al.  Fabrication of SOI photonic crystal slabs by soft UV-nanoimprint lithography , 2006 .

[40]  Steven G. Johnson,et al.  Photonic Crystals: Molding the Flow of Light , 1995 .

[41]  D. Psaltis,et al.  Nanofluidic tuning of photonic crystal circuits , 2006 .

[42]  D. Wiersma,et al.  Local nanofluidic light sources in silicon photonic crystal microcavities. , 2008, Physical review. E, Statistical, nonlinear, and soft matter physics.

[43]  Vincent Studer,et al.  Nanoimprint lithography for the fabrication of DNA electrophoresis chips , 2002 .

[44]  S. Balslev,et al.  Microfluidic single-mode laser using high-order Bragg grating and antiguiding segments. , 2005, Optics express.

[45]  T. Ebbesen,et al.  Light in tiny holes , 2007, Nature.

[46]  K.L. Lear,et al.  Single-Cell Detection Using Optofluidic Intracavity Spectroscopy , 2006, IEEE Sensors Journal.

[47]  Lucio Claudio Andreani,et al.  Replication of photonic crystals by soft ultraviolet-nanoimprint lithography , 2006 .

[48]  Alexander V. Tikhonravov,et al.  Basics of Optics of Multilayer Systems , 1996 .

[49]  Rajan P Kulkarni,et al.  Label-Free, Single-Molecule Detection with Optical Microcavities , 2007, Science.

[50]  Cinzia Sada,et al.  Integrated Ring Resonators , 2020 .

[51]  S. Quake,et al.  Microfluidics: Fluid physics at the nanoliter scale , 2005 .

[52]  Andreas Manz,et al.  Scaling and the design of miniaturized chemical-analysis systems , 2006, Nature.

[53]  Demetri Psaltis,et al.  Optofluidic dye lasers , 2008 .

[54]  A. Kristensen,et al.  Polymer photonic crystal dye lasers as optofluidic cell sensors , 2009, 2009 Conference on Lasers and Electro-Optics and 2009 Conference on Quantum electronics and Laser Science Conference.

[55]  D. Psaltis,et al.  Optofluidic Distributed Feedback Dye Lasers , 2007, IEEE Journal of Selected Topics in Quantum Electronics.

[56]  D. Psaltis,et al.  Developing optofluidic technology through the fusion of microfluidics and optics , 2006, Nature.

[57]  Yuze Sun,et al.  Robust integrated optofluidic-ring-resonator dye lasers. , 2009, Optics letters.

[58]  Laurent Coureau,et al.  Microfluidic dye laser integration in a lab-on-a-chip device , 2004, SPIE/COS Photonics Asia.

[59]  A. deMello Control and detection of chemical reactions in microfluidic systems , 2006, Nature.

[60]  G. Whitesides,et al.  Dynamic control of liquid-core/liquid-cladding optical waveguides , 2004, (CLEO). Conference on Lasers and Electro-Optics, 2005..

[61]  A. Fang,et al.  Highly parallel mix-and-match fabrication of nanopillar arrays integrated in microfluidic channels for long DNA molecule separation , 2007 .

[62]  Demetri Psaltis,et al.  Pneumatically tunable optofluidic dye laser , 2010 .

[63]  J. Eberly,et al.  Cavity Quantum Electrodynamics , 1996 .

[64]  S. Haroche Entanglement, mesoscopic superpositions and decoherence studies with atoms and photons in a cavity , 1998 .

[65]  P. H. Yap,et al.  An optofluidic volume refractometer using Fabry-Pérot resonator with tunable liquid microlenses. , 2010, Biomicrofluidics.