A sixteen‐year single‐center retrospective chart review of Spitz nevi and spitzoid neoplasms in pediatric patients

Spitzoid neoplasms in pediatric patients pose an interesting challenge for clinicians. More data on the clinical, histologic, and molecular characteristics of these lesions are necessary to distinguish features that may portend recurrence or malignant behavior to help determine future treatment guidelines in pediatric patients.

[1]  D. Elder,et al.  The 2018 World Health Organization Classification of Cutaneous, Mucosal, and Uveal Melanoma: Detailed Analysis of 9 Distinct Subtypes Defined by Their Evolutionary Pathway. , 2020, Archives of pathology & laboratory medicine.

[2]  I. Yeh,et al.  Spitz Melanoma is a Distinct Subset of Spitzoid Melanoma , 2019, Modern Pathology.

[3]  C. Stamoulis,et al.  Clinical features and outcomes of spitzoid proliferations in children and adolescents , 2019, The British journal of dermatology.

[4]  A. Lallas,et al.  Management of Flat Pigmented Spitz and Reed Nevi in Children , 2018, JAMA dermatology.

[5]  M. Megna,et al.  Melanoma frequency among symmetrical Spitzoid-looking lesions: a retrospective study. , 2019, Minerva anestesiologica.

[6]  R. Bakos,et al.  Update on dermoscopy of Spitz/Reed naevi and management guidelines by the International Dermoscopy Society , 2017, The British journal of dermatology.

[7]  A. Wagner Weedon’s Skin Pathology , 2017, Aktuelle Dermatologie.

[8]  R. Halaban,et al.  Spitz nevi and Spitzoid melanomas - Exome sequencing and comparison to conventional melanocytic nevi and melanomas , 2016, Modern Pathology.

[9]  A. Patrizi,et al.  Spitz Nevi and Other Spitzoid Neoplasms in Children: Overview of Incidence Data and Diagnostic Criteria , 2017, Pediatric dermatology.

[10]  N. Palanisamy,et al.  Loss of p16 expression and copy number changes of CDKN2A in a spectrum of spitzoid melanocytic lesions. , 2016, Human pathology.

[11]  K. Stefanaki,et al.  Differential diagnosis of Spitzoid melanocytic neoplasms , 2016, Journal of the European Academy of Dermatology and Venereology : JEADV.

[12]  J. H. Cho-Vega,et al.  A diagnostic algorithm for atypical spitzoid tumors: guidelines for immunohistochemical and molecular assessment , 2016, Modern Pathology.

[13]  B. Wood Paediatric melanoma. , 2016, Pathology.

[14]  M. Mihm,et al.  Genomic aberrations in spitzoid melanocytic tumours and their implications for diagnosis, prognosis and therapy. , 2016, Pathology.

[15]  Giovanni Pellacani,et al.  Clinical and dermoscopic features of atypical Spitz tumors: A multicenter, retrospective, case-control study. , 2015, Journal of the American Academy of Dermatology.

[16]  K. Harms,et al.  Atypical Spitz Tumors: A Diagnostic Challenge. , 2015, Archives of pathology & laboratory medicine.

[17]  J. Schaffer Update on melanocytic nevi in children. , 2015, Clinics in dermatology.

[18]  R. Boldrini,et al.  Atypical Spitz tumors in patients younger than 18 years. , 2015, Journal of the American Academy of Dermatology.

[19]  A. Lallas,et al.  Likelihood of finding melanoma when removing a Spitzoid-looking lesion in patients aged 12 years or older. , 2015, Journal of the American Academy of Dermatology.

[20]  S. Ariyan,et al.  Clinical characteristics associated with Spitz nevi and Spitzoid malignant melanomas: the Yale University Spitzoid Neoplasm Repository experience, 1991 to 2008. , 2014, Journal of the American Academy of Dermatology.

[21]  A. Patrizi,et al.  Spitz nevi: defining features and management in children. , 2014, Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia.

[22]  John Kirkwood,et al.  Atypical Spitzoid neoplasms: a review of potential markers of biological behavior including sentinel node biopsy , 2014, Melanoma research.

[23]  B. B. Weitner,et al.  Histomorphologic Assessment and Interobserver Diagnostic Reproducibility of Atypical Spitzoid Melanocytic Neoplasms With Long-term Follow-up , 2014, The American journal of surgical pathology.

[24]  A. Lallas,et al.  Atypical Spitz tumours and sentinel lymph node biopsy: a systematic review. , 2014, The Lancet. Oncology.

[25]  Iwei Yeh,et al.  Kinase fusions are frequent in Spitz tumours and spitzoid melanomas , 2014, Nature Communications.

[26]  I. Zalaudek,et al.  Spitz nevus, Spitz tumor, and spitzoid melanoma: a comprehensive clinicopathologic overview. , 2013, Dermatologia clinica.

[27]  D. Elder,et al.  Outcomes of Atypical Spitz Tumors With Chromosomal Copy Number Aberrations and Conventional Melanomas in Children , 2013, The American journal of surgical pathology.

[28]  C. Gulmann,et al.  The surgical management of Spitz naevi and atypical spitzoid neoplasms: A review of the literature. , 2013, The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland.

[29]  D. Elder,et al.  Risk Assessment for Atypical Spitzoid Melanocytic Neoplasms Using FISH to Identify Chromosomal Copy Number Aberrations , 2013, The American journal of surgical pathology.

[30]  A. Marghoob,et al.  Spitz nevi: a bridge between dermoscopic morphology and histopathology. , 2013, Dermatologic clinics.

[31]  S. Orlow,et al.  Spitz nevi: beliefs, behaviors, and experiences of pediatric dermatologists. , 2013, JAMA dermatology.

[32]  M. Mihm,et al.  Sentinel lymph node metastasis is not predictive of poor outcome in patients with problematic spitzoid melanocytic tumors. , 2013, Human pathology.

[33]  E. Nagore,et al.  Fluorescence in situ hybridization for the differential diagnosis between Spitz naevus and spitzoid melanoma , 2012, Histopathology.

[34]  Felecia Cerrato,et al.  Outcomes in Pediatric Atypical Spitz Tumors Treated Without Sentinel Lymph Node Biopsy , 2012, Pediatric dermatology.

[35]  P. Gerami,et al.  Fluorescence in situ hybridization for ambiguous melanocytic tumors. , 2012, Histology and histopathology.

[36]  A. Sepehr,et al.  Spitz nevi and other Spitzoid lesions part I. Background and diagnoses. , 2011, Journal of the American Academy of Dermatology.

[37]  A. Sepehr,et al.  Spitz nevi and other Spitzoid lesions part II. Natural history and management. , 2011, Journal of the American Academy of Dermatology.

[38]  T. McCalmont,et al.  Spitz nevi, atypical spitzoid neoplasms, and spitzoid melanoma. , 2011, Clinics in laboratory medicine.

[39]  V. de Giorgi,et al.  Atypical Spitzoid melanocytic tumors: a morphological, mutational, and FISH analysis. , 2011, Journal of the American Academy of Dermatology.

[40]  I. Zalaudek,et al.  Natural Evolution of Spitz Nevi , 2011, Dermatology.

[41]  L. Eichenfield,et al.  Pediatric "STUMP" lesions: evaluation and management of difficult atypical Spitzoid lesions in children. , 2011, Journal of the American Academy of Dermatology.

[42]  M. Garmyn Faculty of 1000 evaluation for Pediatric "STUMP" lesions: evaluation and management of difficult atypical Spitzoid lesions in children. , 2011 .

[43]  W. Tyler,et al.  Statistical Analysis of the Concordance of Immunohistochemical Stains With the Final Diagnosis in Spitzoid Neoplasms , 2011, The American Journal of dermatopathology.

[44]  S. Purcell Melanoma and Melanocytic Tumors of Uncertain Malignant Potential in Children, Adolescents and Young Adults—The Stanford Experience 1995–2008 , 2011 .

[45]  S. Swetter,et al.  Melanoma and Melanocytic Tumors of Uncertain Malignant Potential in Children, Adolescents and Young Adults—The Stanford Experience 1995–2008 , 2010, Pediatric dermatology.

[46]  D. Elder,et al.  Melanocytic Tumors of Uncertain Malignant Potential: Results of a Tutorial Held at the XXIX Symposium of the International Society of Dermatopathology in Graz, October 2008 , 2010, The American journal of surgical pathology.

[47]  D. Jukic The Atypical Spitz Tumor of Uncertain Biologic Potential: A Series of 67 Patients From a Single Institution , 2010 .

[48]  J. Wilmott,et al.  Atypical Spitzoid Melanocytic Tumors With Positive Sentinel Lymph Nodes in Children and Teenagers, and Comparison With Histologically Unambiguous and Lethal Melanomas , 2009, The American journal of surgical pathology.

[49]  L. Morrison,et al.  Fluorescence In Situ Hybridization (FISH) as an Ancillary Diagnostic Tool in the Diagnosis of Melanoma , 2009, The American journal of surgical pathology.

[50]  V. Prieto,et al.  Spitzoid melanoma in children: clinicopathological study and application of immunohistochemistry as an adjunct diagnostic tool , 2009, Journal of cutaneous pathology.

[51]  Jennifer L. Schwartz,et al.  The atypical Spitz tumor of uncertain biologic potential , 2009, Cancer.

[52]  Hideko Kamino Spitzoid melanoma. , 2009, Clinics in dermatology.

[53]  K. Busam,et al.  Sentinel Lymph Node Biopsy for Patients With Diagnostically Controversial Spitzoid Melanocytic Tumors? , 2008, Advances in anatomic pathology.

[54]  Shing M. Lee,et al.  Influence of age on survival in childhood spitzoid melanomas , 2007, Cancer.

[55]  J. Kirkwood,et al.  Sentinel Lymph Node Biopsy for Atypical Melanocytic Lesions with Spitzoid Features , 2006, Annals of Surgical Oncology.

[56]  W. Mooi,et al.  Spitz Nevus Versus Spitzoid Melanoma: Diagnostic Difficulties, Conceptual Controversies , 2006, Advances in anatomic pathology.

[57]  R. Barnhill The Spitzoid Lesion: The Importance of Atypical Variants and Risk Assessment , 2006, The American Journal of dermatopathology.

[58]  R. Barnhill The Spitzoid lesion: rethinking Spitz tumors, atypical variants, ‘Spitzoid melanoma’ and risk assessment , 2006, Modern Pathology.

[59]  E. Sammarco,et al.  Spitz naevus: a proposal for management , 2005, Journal of the European Academy of Dermatology and Venereology : JEADV.

[60]  M. Selim,et al.  Spitz nevi and atypical Spitz nevi/tumors: a histologic and immunohistochemical analysis , 2005, Modern Pathology.

[61]  M. McCarter,et al.  Sentinel lymph node biopsy for melanoma and other melanocytic tumors in adolescents. , 2005, Journal of pediatric surgery.

[62]  J. Mones,et al.  "Atypical" Spitz's nevus, "malignant" Spitz's nevus, and "metastasizing" Spitz's nevus: a critique in historical perspective of three concepts flawed fatally. , 2004, The American Journal of dermatopathology.

[63]  R. Vollmer Patient Age in Spitz Nevus and Malignant Melanoma , 2004 .

[64]  R. Vollmer Patient age in Spitz nevus and malignant melanoma: implication of Bayes rule for differential diagnosis. , 2004, American journal of clinical pathology.

[65]  Daniel Pinkel,et al.  Classifying melanocytic tumors based on DNA copy number changes. , 2003, The American journal of pathology.

[66]  J. Zitelli,et al.  The Surgical Management of Spitz Nevi , 2002, Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.].

[67]  E. K. Mooney,et al.  Pediatric Melanoma: Confirming the Diagnosis With Sentinel Node Biopsy , 2001, Annals of plastic surgery.

[68]  D. Pinkel,et al.  Mutations and copy number increase of HRAS in Spitz nevi with distinctive histopathological features. , 2000, The American journal of pathology.

[69]  C. Cockerell,et al.  Sentinel lymph node biopsy as an adjunct to management of histologically difficult to diagnose melanocytic lesions: a proposal. , 2000, Journal of the American Academy of Dermatology.

[70]  D. Pinkel,et al.  Molecular cytogenetic analysis of Spitz nevi shows clear differences to melanoma. , 1999, The Journal of investigative dermatology.

[71]  M. Mihm,et al.  Atypical Spitz nevi/tumors: lack of consensus for diagnosis, discrimination from melanoma, and prediction of outcome. , 1999, Human pathology.

[72]  C. Benelli,et al.  Clinical review of 247 case records of Spitz nevus (epithelioid cell and/or spindle cell nevus). , 1997, Dermatology.

[73]  E. M. Casso,et al.  Spitz nevi. , 1992, Journal of the American Academy of Dermatology.

[74]  S. Spitz Melanomas of childhood. 1948. , 1991, CA: a cancer journal for clinicians.

[75]  S SPITZ,et al.  Melanomas of childhood. , 1948, The American journal of pathology.

[76]  S. Spitz Classics in oncology: Melanomas of childhood , 2022 .