Studies On the Synthesis of Coronamic Acid, Norcoronamic Acid and Allocoronamic Acid From 2,3 -Methanohomoserine

Abstract Coronamic acid and norcoronamic acid have been prepared in racemic form in 11% and 20% overall yields, respectively, from (E)- methanohomoserine, while the (1S,2R)-isomer of the latter allows the preparation of enantiomerically pure (1S,2R)- allocoronamic acid in 37% overall yield. Care is required to avoid intramolecular cyclisation reactions during side chain manipulation.

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