Inhibition of sonic hedgehog signaling via MAPK activation controls chemotherapy-induced alopecia.

[1]  W. Banlunara,et al.  Increasing the percutaneous absorption and follicular penetration of retinal by topical application of proretinal nanoparticles , 2019, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[2]  M. Lacouture,et al.  Hair disorders in cancer survivors. , 2019, Journal of the American Academy of Dermatology.

[3]  M. Lacouture,et al.  Hair disorders in patients with cancer. , 2019, Journal of the American Academy of Dermatology.

[4]  Sung-Jan Lin,et al.  How chemotherapy and radiotherapy damage the tissue: Comparative biology lessons from feather and hair models , 2018, Experimental dermatology.

[5]  X. Lim,et al.  Identifying novel strategies for treating human hair loss disorders: Cyclosporine A suppresses the Wnt inhibitor, SFRP1, in the dermal papilla of human scalp hair follicles , 2018, PLoS biology.

[6]  M. Lacouture,et al.  Scalp hypothermia as a preventative measure for chemotherapy‐induced alopecia: a review of controlled clinical trials , 2018, Journal of the European Academy of Dermatology and Venereology : JEADV.

[7]  Sung-Jan Lin,et al.  Mobilizing Transit-Amplifying Cell-Derived Ectopic Progenitors Prevents Hair Loss from Chemotherapy or Radiation Therapy. , 2017, Cancer research.

[8]  F. F. Sahle,et al.  Synthesis and Validation of Functional Nanogels as pH-Sensors in the Hair Follicle. , 2017, Macromolecular bioscience.

[9]  C. Antoniou,et al.  From basal cell carcinoma morphogenesis to the alopecia induced by hedgehog inhibitors: connecting the dots , 2017, The British journal of dermatology.

[10]  W. Huber,et al.  The Shh Topological Domain Facilitates the Action of Remote Enhancers by Reducing the Effects of Genomic Distances , 2016, Developmental cell.

[11]  X. Li,et al.  Disturbed MEK/ERK signaling increases osteoclast activity via the Hedgehog-Gli pathway in postmenopausal osteoporosis. , 2016, Progress in biophysics and molecular biology.

[12]  Y. Hsu,et al.  Hair follicles’ transit-amplifying cells govern concurrent dermal adipocyte production through Sonic Hedgehog , 2016, Genes & development.

[13]  O. Kwon,et al.  Development of a Model for Chemotherapy-Induced Alopecia: Profiling of Histological Changes in Human Hair Follicles after Chemotherapy. , 2016, The Journal of investigative dermatology.

[14]  M. Lacouture,et al.  Alopecia in patients treated with molecularly targeted anticancer therapies. , 2015, Annals of oncology : official journal of the European Society for Medical Oncology.

[15]  R. Paus,et al.  Human hair follicle organ culture: theory, application and perspectives , 2015, Experimental dermatology.

[16]  N. Farber,et al.  Hedgehog regulates cerebellar progenitor cell and medulloblastoma apoptosis , 2015, Neurobiology of Disease.

[17]  L. Vahdat,et al.  Efficacy of Scalp Cooling in Preventing Chemotherapy-Induced Alopecia in Breast Cancer Patients Receiving Adjuvant Docetaxel and Cyclophosphamide Chemotherapy. , 2015, Clinical breast cancer.

[18]  Guojiang Xie,et al.  Testing chemotherapeutic agents in the feather follicle identifies a selective blockade of cell proliferation and a key role for sonic hedgehog signaling in chemotherapy-induced tissue damage. , 2015, The Journal of investigative dermatology.

[19]  L. Lettice,et al.  Mapping the Shh long-range regulatory domain , 2014, Development.

[20]  A. Joyner,et al.  Roles for Hedgehog signaling in adult organ homeostasis and repair , 2014, Development.

[21]  H. Roe Scalp cooling: management option for chemotherapy-induced alopecia. , 2014, British journal of nursing.

[22]  J. Spiegel,et al.  Complex changes in the apoptotic and cell differentiation programs during initiation of the hair follicle response to chemotherapy , 2014, The Journal of investigative dermatology.

[23]  S. Lee,et al.  Cyclopamine: from cyclops lambs to cancer treatment. , 2014, Journal of agricultural and food chemistry.

[24]  Xiaohu Zhang,et al.  Cyclopamine, a naturally occurring alkaloid, and its analogues may find wide applications in cancer therapy. , 2013, Current topics in medicinal chemistry.

[25]  P. Watson,et al.  Role for the Epidermal Growth Factor Receptor in Chemotherapy-Induced Alopecia , 2013, PloS one.

[26]  H. H. Ryu,et al.  Pretreatment of epidermal growth factor promotes primary hair recovery via the dystrophic anagen pathway after chemotherapy‐induced alopecia , 2013, Experimental dermatology.

[27]  Ralf Paus,et al.  Pathobiology of chemotherapy-induced hair loss. , 2013, The Lancet. Oncology.

[28]  Benjamin D. Yu,et al.  Negative regulation of Shh levels by Kras and Fgfr2 during hair follicle development. , 2013, Developmental biology.

[29]  H. Zhen,et al.  Shh maintains dermal papilla identity and hair morphogenesis via a Noggin-Shh regulatory loop. , 2012, Genes & development.

[30]  A. Joyner,et al.  Nerve-derived sonic hedgehog defines a niche for hair follicle stem cells capable of becoming epidermal stem cells. , 2011, Cell stem cell.

[31]  V. Rotter,et al.  p53‐dependent transcriptional regulation of EDA2R and its involvement in chemotherapy‐induced hair loss , 2010, FEBS letters.

[32]  J. Blenis,et al.  ERK2 but not ERK1 induces epithelial-to-mesenchymal transformation via DEF motif-dependent signaling events. , 2010, Molecular cell.

[33]  R. Paus,et al.  Methods in hair research: how to objectively distinguish between anagen and catagen in human hair follicle organ culture , 2010, Experimental dermatology.

[34]  C. Tabin,et al.  Fgf-dependent Etv4/5 activity is required for posterior restriction of Sonic Hedgehog and promoting outgrowth of the vertebrate limb. , 2009, Developmental cell.

[35]  D. Tobin,et al.  Dissecting the impact of chemotherapy on the human hair follicle: a pragmatic in vitro assay for studying the pathogenesis and potential management of hair follicle dystrophy. , 2007, The American journal of pathology.

[36]  T. Schlake,et al.  Localization of Shh expression by Wnt and Eda affects axial polarity and shape of hairs. , 2007, Developmental biology.

[37]  B. Ducommun,et al.  Identification of an unexpected link between the Shh pathway and a G2/M regulator, the phosphatase CDC25B. , 2006, Developmental biology.

[38]  B. Morgan,et al.  Distinct stem cell populations regenerate the follicle and interfollicular epidermis. , 2005, Developmental cell.

[39]  C. Hui,et al.  Shh controls epithelial proliferation via independent pathways that converge on N-Myc. , 2005, Developmental cell.

[40]  J. Blenis,et al.  Spatially Separate Docking Sites on ERK2 Regulate Distinct Signaling Events In Vivo , 2005, Current Biology.

[41]  R. Paus,et al.  A guide to assessing damage response pathways of the hair follicle: lessons from cyclophosphamide-induced alopecia in mice. , 2005, The Journal of investigative dermatology.

[42]  B. Gilchrest,et al.  Fas Signaling Is Involved in the Control of Hair Follicle Response to Chemotherapy , 2004, Cancer Research.

[43]  Robert J. Wechsler-Reya,et al.  Transcriptional profiling of the Sonic hedgehog response: A critical role for N-myc in proliferation of neuronal precursors , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[44]  C. Hui,et al.  Sonic hedgehog-dependent activation of Gli2 is essential for embryonic hair follicle development. , 2003, Genes & development.

[45]  Michael D. Cole,et al.  Nmyc upregulation by sonic hedgehog signaling promotes proliferation in developing cerebellar granule neuron precursors , 2003, Development.

[46]  R. Crystal,et al.  Effect of adenovirus-mediated expression of Sonic hedgehog gene on hair regrowth in mice with chemotherapy-induced alopecia. , 2001, Journal of the National Cancer Institute.

[47]  B. Gilchrest,et al.  p53 is essential for chemotherapy-induced hair loss. , 2000, Cancer research.

[48]  Y. Barrandon,et al.  Conditional Disruption of Hedgehog Signaling Pathway Defines its Critical Role in Hair Development and Regeneration , 2000 .

[49]  R. Paus,et al.  Overexpression of Bcl-2 protects from ultraviolet B-induced apoptosis but promotes hair follicle regression and chemotherapy-induced alopecia. , 2000, The American journal of pathology.

[50]  M V Chernov,et al.  A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy. , 1999, Science.

[51]  D. Tobin,et al.  Do hair bulb melanocytes undergo apoptosis during hair follicle regression (catagen)? , 1998, The Journal of investigative dermatology.

[52]  R. Paus,et al.  Reduction of intrafollicular apoptosis in chemotherapy-induced alopecia by topical calcitriol-analogs. , 1998, The Journal of investigative dermatology.

[53]  R. Paus,et al.  Sonic hedgehog signaling is essential for hair development , 1998, Current Biology.

[54]  Carina,et al.  Analysis of apoptosis during hair follicle regression (catagen) , 1997, The American journal of pathology.

[55]  S. Eichmüller,et al.  Chemotherapy-induced alopecia in mice. Induction by cyclophosphamide, inhibition by cyclosporine A, and modulation by dexamethasone. , 1994, The American journal of pathology.

[56]  A. Collett,et al.  A Clinical and Biological Guide for Understanding Chemotherapy-Induced Alopecia and Its Prevention. , 2018, The oncologist.

[57]  V. Garelli,et al.  ON Chemotherapy-induced alopecia management : Clinical experience and practical advice , 2017 .

[58]  B. Gilchrest,et al.  p53 Involvement in the control of murine hair follicle regression. , 2001, The American journal of pathology.

[59]  W Gaffield,et al.  Essential role for Sonic hedgehog during hair follicle morphogenesis. , 1999, Developmental biology.