Towards the reconstruction of central nervous system white matter using neural precursor cells.

Epidermal growth factor-responsive neural precursor cells were used as donor cells for transplantation into wild-type and myelin-deficient shiverer (shi) mice. The cells engrafted robustly within the CNS following intracerebroventricular and cisternal transplantation in neonatal mice. The cells adopted glial phenotypes, and some functioned as oligodendrocytes, producing myelin basic protein and morphologically normal internodal myelin sheaths. When individual shi mice received two transplants (on post-natal days 1 and 3), donor-derived cells disseminated widely and expressed myelin basic protein in central white matter tracts throughout the brain.

[1]  J. Goldman,et al.  Endogenous Progenitors Remyelinate Demyelinated Axons in the Adult CNS , 1997, Neuron.

[2]  T. Ben-Hur,et al.  Polysialylated Neural Cell Adhesion Molecule-Positive CNS Precursors Generate Both Oligodendrocytes and Schwann Cells to Remyelinate the CNS after Transplantation , 1999, The Journal of Neuroscience.

[3]  E. Barbarese,et al.  Stage specific, (O4+GalC-) isolated oligodendrocyte progenitors produce MBP+ myelin in vivo. , 1992, Developmental neuroscience.

[4]  Yasuzo Tsukada,et al.  Fine structure of the central myelin sheath in the myelin deficient mutant Shiverer mouse, with special reference to the pattern of myelin formation by oligodendroglia , 1981, Brain Research.

[5]  I. Duncan,et al.  Myelination Following Transplantation of EGF-Responsive Neural Stem Cells into a Myelin-Deficient Environment , 1997, Experimental Neurology.

[6]  R. Sidman,et al.  Engraftable human neural stem cells respond to development cues, replace neurons, and express foreign genes , 1998, Nature Biotechnology.

[7]  A. Gansmuller,et al.  Tracing transplanted oligodendrocytes during migration and maturation in the shiverer mouse brain , 1991, Glia.

[8]  R L Sidman,et al.  Morphometric Analysis of Normal, Mutant, and Transgenic CNS: Correlation of Myelin Basic Protein Expression to Myelinogenesis , 1992, Journal of neurochemistry.

[9]  E. Barbarese,et al.  Differential myelinogenic capacity of specific developmental stages of the oligodendrocyte lineage upon transplantation into hypomyelinating hosts , 1993, Journal of neuroscience research.

[10]  N. Baumann,et al.  Remyelination by transplanted oligodendrocytes of a demyelinated lesion in the spinal cord of the adult shiverer mouse , 1988, Neuroscience Letters.

[11]  A. Björklund,et al.  Incorporation and Glial Differentiation of Mouse EGF-Responsive Neural Progenitor Cells after Transplantation into the Embryonic Rat Brain , 1998, Molecular and Cellular Neuroscience.

[12]  R. McKay,et al.  In vitro-generated neural precursors participate in mammalian brain development. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[13]  Naoki Takahashi,et al.  Chromosomal mapping of mouse myelin basic protein gene and structure and transcription of the partially deleted gene in shiverer mutant mice , 1985, Cell.

[14]  Carol Readhead,et al.  Expression of a myelin basic protein gene in transgenic shiverer mice: Correction of the dysmyelinating phenotype , 1987, Cell.

[15]  I. Duncan,et al.  Intraventricular transplantation of oligodendrocyte progenitors into a fetal myelin mutant results in widespread formation of myelin , 1999, Annals of neurology.

[16]  R. J. Mullen,et al.  NeuN, a neuronal specific nuclear protein in vertebrates. , 1992, Development.

[17]  I. Duncan,et al.  Transplantation of an oligodendrocyte cell line leading to extensive myelination. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[18]  K. Mikoshiba,et al.  Transplantation of bulk-separated oligodendrocytes into the brains of shiverer mutant mice: Immunohistochemical and electron microscopic studies on the myelination , 1986, Brain Research.

[19]  A. Björklund,et al.  Generation and Transplantation of EGF-Responsive Neural Stem Cells Derived from GFAP–hNGF Transgenic Mice , 1997, Experimental Neurology.

[20]  P. Quesenberry,et al.  In VitroCell Density-Dependent Clonal Growth of EGF-Responsive Murine Neural Progenitor Cells under Serum-Free Conditions , 1997, Experimental Neurology.

[21]  B. Nait-Oumesmar,et al.  Expansion of rat oligodendrocyte progenitors into proliferative “oligospheres” that retain differentiation potential , 1996, Journal of neuroscience research.

[22]  L. Decker,et al.  Progenitor cells of the adult mouse subventricular zone proliferate, migrate and differentiate into oligodendrocytes after demyelination , 1999, The European journal of neuroscience.

[23]  T. Holekamp,et al.  Embryonic stem cells differentiate into oligodendrocytes and myelinate in culture and after spinal cord transplantation. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[24]  I. Duncan,et al.  Generation of oligodendroglial progenitors from neural stem cells , 1998, Journal of neurocytology.

[25]  F. Gage,et al.  Survival and differentiation of adult neuronal progenitor cells transplanted to the adult brain. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[26]  A. B. Evercooren,et al.  Transplanted Transgenically Marked Oligodendrocytes Survive, Migrate and Myelinate in the Normal Mouse Brain as They Do in the Shiverer Mouse Brain , 1994, The European journal of neuroscience.

[27]  C. Lubetzki,et al.  Myelination by oligodendrocytes isolated from 4–6-week-old rat central nervous system and transplanted into newborn shiverer brain , 1988, Journal of the Neurological Sciences.

[28]  R. McKay,et al.  Chimeric brains generated by intraventricular transplantation of fetal human brain cells into embryonic rats , 1998, Nature Biotechnology.

[29]  M. Ikawa,et al.  A rapid and non‐invasive selection of transgenic embryos before implantation using green fluorescent protein (GFP) , 1995, FEBS letters.

[30]  J. Rosenbluth,et al.  Central myelin in the mouse mutant shiverer , 1980, The Journal of comparative neurology.

[31]  A. Álvarez-Buylla,et al.  Stem cells in the developing and adult nervous system. , 1998, Journal of neurobiology.

[32]  G. Nilaver,et al.  Myelination by transplanted fetal and neonatal oligodendrocytes in a dysmyelinating mutant , 1986, Brain Research.

[33]  S. Dunnett,et al.  Long-Term Survival of Human Central Nervous System Progenitor Cells Transplanted into a Rat Model of Parkinson's Disease , 1997, Experimental Neurology.

[34]  J. Rosenbluth,et al.  Myelin formation following transplantation of normal fetal glia into myelin-deficient rat spinal cord , 1990, Journal of neurocytology.

[35]  F. Lachapelle,et al.  Mouse oligospheres: From pre‐progenitors to functional oligodendrocytes , 1999, Journal of neuroscience research.

[36]  I. Duncan,et al.  Isolation and transplantation of multipotential populations of epidermal growth factor–responsive, neural progenitor cells from the canine brain , 1997, Journal of neuroscience research.

[37]  S. Weiss,et al.  Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system. , 1992, Science.

[38]  N. Baumann,et al.  Absence of the major dense line in myelin of the mutant mouse ‘shiverer’ , 1979, Neuroscience Letters.

[39]  D L Price,et al.  A vector for expressing foreign genes in the brains and hearts of transgenic mice. , 1996, Genetic analysis : biomolecular engineering.

[40]  S. Weiss,et al.  A multipotent EGF-responsive striatal embryonic progenitor cell produces neurons and astrocytes , 1992, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[41]  L A Herzenberg,et al.  Disruption of overlapping transcripts in the ROSA beta geo 26 gene trap strain leads to widespread expression of beta-galactosidase in mouse embryos and hematopoietic cells. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[42]  I. Duncan,et al.  Repair of myelin disease: strategies and progress in animal models. , 1997, Molecular medicine today.

[43]  E. Parati,et al.  Epidermal and Fibroblast Growth Factors Behave as Mitogenic Regulators for a Single Multipotent Stem Cell-Like Population from the Subventricular Region of the Adult Mouse Forebrain , 1999, The Journal of Neuroscience.

[44]  H. O. de la Iglesia,et al.  Constructing Suprachiasmatic Nucleus Chimeras In Vivo , 2001 .

[45]  R. McKay,et al.  Embryonic stem cell-derived glial precursors: a source of myelinating transplants. , 1999, Science.

[46]  N. Baumann,et al.  Survival and differentiation of oligodendrocytes from neural tissue transplanted into new-born mouse brain , 1983, Neuroscience Letters.

[47]  R. Franklin,et al.  Repair of demyelinated lesions by transplantation of purified 0-2A progenitor cells , 1993, Nature.

[48]  R. Franklin,et al.  Transplantation of glial cells into the CNS , 1991, Trends in Neurosciences.

[49]  R. Franklin,et al.  Transplanted CG4 Cells (an Oligodendrocyte Progenitor Cell Line) Survive, Migrate, and Contribute to Repair of Areas of Demyelination in X-Irradiated and Damaged Spinal Cord but Not in Normal Spinal Cord , 1996, Experimental Neurology.

[50]  R. Thompson,et al.  Molecular Structure, Localization, and Possible Functions of the Myelin‐Associated Enzyme 2′,3′‐Cyclic Nucleotide 3′‐Phosphodiesterase , 1988, Journal of neurochemistry.

[51]  S. Weiss,et al.  Clonal and population analyses demonstrate that an EGF-responsive mammalian embryonic CNS precursor is a stem cell. , 1996, Developmental biology.

[52]  M. Rao,et al.  Gliogenesis in the central nervous system , 2000, Glia.

[53]  F. Gage,et al.  Differentiation of adult hippocampus-derived progenitors into olfactory neurons in vivo , 1996, Nature.

[54]  I. Duncan,et al.  Adult brain retains the potential to generate oligodendroglial progenitors with extensive myelination capacity. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[55]  E. Snyder,et al.  "Global" cell replacement is feasible via neural stem cell transplantation: evidence from the dysmyelinated shiverer mouse brain. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[56]  F. Gage,et al.  Widespread Integration and Survival of Adult-Derived Neural Progenitor Cells in the Developing Optic Retina , 1998, Molecular and Cellular Neuroscience.

[57]  R. McKinnon,et al.  Motor function analysis of myelin mutant mice using a rotarod , 1995, International Journal of Developmental Neuroscience.

[58]  S. Dunnett,et al.  Survival and Differentiation of Rat and Human Epidermal Growth Factor-Responsive Precursor Cells Following Grafting into the Lesioned Adult Central Nervous System , 1996, Experimental Neurology.

[59]  M. Schachner,et al.  Formation of myelin after transplantation of neural precursor cells into the retina of young postnatal mice , 2000, Glia.

[60]  Yamamura Ken-ichi,et al.  Efficient selection for high-expression transfectants with a novel eukaryotic vector , 1991 .

[61]  R. Franklin,et al.  Glial-cell transplantation and plasticity in the O-2A lineage — implications for CNS repair , 1995, Trends in Neurosciences.

[62]  C. Svendsen,et al.  Neural Stem Cells: From Cell Biology to Cell Replacement , 2000, Cell transplantation.