[Ectopic mediastinal parathyroid adenoma. Detection with a radioisotopic probe and resolution with videothoracoscopy].

We report a 66 years old woman with a diagnosis of primary hyperparathyroidism. Localization to mediastinum was obtained with parathyroid scintigraphy using 99mtc-methoxy-isobutyl-isonitrite (Tc99-MIBI). The patient was successfully operated upon by means of a videothora-coscopic approach. During the procedure serum parathormone was measured before and 10 minutes after adenomectomy, showing a more than 50% reduction from the basal level. An attempt to detect the precise site of the adenoma with a Tc99-MIBI probe was unsuccessful because of its proximity to the myocardium, but radioactivity was confirmed on the surgical specimen after resection. The patient's calcemia and parathormone levels became normal during the postoperative course and she remains normocalcemic 9 months after the procedure. In our case, preoperative localization and intraoperative parathormone measurements were both very useful for confirming surgical success; the intraoperative localization with a radioactive probe was not useful, but radioactivity was confirmed after resection on the surgical specimen. The endoscopic surgical procedure with videothoracoscopy was well tolerated, less painful than a thoracotomy, and it shortened the hospitalization period.

[1]  M. Ishibashi,et al.  Mediastinal parathyroid adenoma detected by99mTc-methoxyisobutylisonitrile: Report of a case , 2005, Surgery Today.

[2]  D. Farley,et al.  Focused Cervical Exploration for Primary Hyperparathyroidism without Intraoperative Parathyroid Hormone Monitoring or Use of the Gamma Probe , 2004, World Journal of Surgery.

[3]  M. Shindo Intraoperative rapid parathyroid hormone monitoring in parathyroid surgery. , 2004, Otolaryngologic clinics of North America.

[4]  J. Chabot,et al.  The impact of sestamibi scanning on the outcome of parathyroid surgery. , 2003, The Journal of clinical endocrinology and metabolism.

[5]  S. Libutti,et al.  Persistent Primary Hyperparathyroidism Caused by Adenomas Identified in Pharyngeal or Adjacent Structures , 2003, World Journal of Surgery.

[6]  I. Adalet,et al.  Efficiency of Gamma Probe and Dual-Phase Tc-99m Sestamibi Scintigraphy in Surgery for Patients with Primary Hyperparathyroidism , 2003, Clinical nuclear medicine.

[7]  K. Waxman,et al.  Preoperative Sestamibi Localization Combined with Intraoperative Parathyroid Hormone Assay Predicts Successful Focused Unilateral Neck Exploration during Surgery for Primary Hyperparathyroidism , 2003, The American surgeon.

[8]  S. Schell,et al.  Clinical outcomes and fiscal consequences of bilateral neck exploration for primary idiopathic hyperparathyroidism without preoperative radionuclide imaging or minimally invasive techniques. , 2003, Surgery.

[9]  J. Rastad,et al.  Summary statement from a workshop on asymptomatic primary hyperparathyroidism: a perspective for the 21st century. , 2002, The Journal of clinical endocrinology and metabolism.

[10]  A. Piotto,et al.  Ectopic Parathyroid Adenomas Located at the Carotid Bifurcation: The Role of Preoperative Tc-99m MIBI Scintigraphy and the Intraoperative Gamma Probe Procedure in Surgical Treatment Planning , 2001, Clinical nuclear medicine.

[11]  Oscar D. Bruno,et al.  USO DEL TC-99M-SESTAMIBI EN LA LOCALIZACION PREOPERATORIA DE PARATIROIDES ANORMALES HIPERFUNCIONANTES , 1996 .

[12]  C. Proye,et al.  Thoracoscopic excision of enlarged mediastinal parathyroid glands. , 1994, Surgery.

[13]  C. Higgins,et al.  Localization procedures in patients with persistent or recurrent hyperparathyroidism. , 1994, Archives of surgery.

[14]  M. Brennan,et al.  NIH conference. Diagnosis and management of asymptomatic primary hyperparathyroidism: consensus development conference statement. , 1991, Annals of internal medicine.