Molecular Imaging: Looking at Problems, Seeing Solutions

Noninvasive molecular-imaging technologies are providing researchers with exciting new opportunities to study small-animal models of human disease. With continued improvements in instrumentation, identification of better imaging targets by genome-based approaches, and design of better imaging probes by innovative chemistry, these technologies promise to play increasingly important roles in disease diagnosis and therapy.

[1]  Jos Jonkers,et al.  Noninvasive imaging of spontaneous retinoblastoma pathway-dependent tumors in mice. , 2002, Cancer research.

[2]  B. Gulyás,et al.  PET studies with carbon-11 radioligands in neuropsychopharmacological drug development. , 2001, Current pharmaceutical design.

[3]  C. Contag,et al.  Advances in in vivo bioluminescence imaging of gene expression. , 2002, Annual review of biomedical engineering.

[4]  Michel Sadelain,et al.  Serial in vivo imaging of the targeted migration of human HSV-TK-transduced antigen-specific lymphocytes , 2003, Nature Biotechnology.

[5]  S. Gambhir,et al.  Molecular imaging in living subjects: seeing fundamental biological processes in a new light. , 2003, Genes & development.

[6]  R. Weissleder,et al.  Molecular imaging in drug discovery and development , 2003, Nature Reviews Drug Discovery.

[7]  S. Cherry,et al.  MicroPET II: design, development and initial performance of an improved microPET scanner for small-animal imaging. , 2003, Physics in medicine and biology.

[8]  Yu-Shin Ding,et al.  Imaging brain cholinergic activity with positron emission tomography: its role in the evaluation of cholinergic treatments in Alzheimer’s dementia , 2001, Biological Psychiatry.

[9]  R Weissleder,et al.  Glossary of molecular imaging terminology. , 2001, Academic radiology.

[10]  David K. Stevenson,et al.  Rapid in vivo functional analysis of transgenes in mice using whole body imaging of luciferase expression , 2001, Transgenic Research.

[11]  Ralph Weissleder,et al.  Feasibility of in vivo multichannel optical imaging of gene expression: experimental study in mice. , 2002, Radiology.

[12]  H. Burns,et al.  Positron emission tomography neuroreceptor imaging as a tool in drug discovery, research and development. , 1999, Current opinion in chemical biology.

[13]  Vasilis Ntziachristos,et al.  Shedding light onto live molecular targets , 2003, Nature Medicine.

[14]  J. Barrio,et al.  Noninvasive, repetitive, quantitative measurement of gene expression from a bicistronic message by positron emission tomography, following gene transfer with adenovirus. , 2002, Molecular therapy : the journal of the American Society of Gene Therapy.

[15]  S. Gambhir,et al.  Visualization of advanced human prostate cancer lesions in living mice by a targeted gene transfer vector and optical imaging , 2002, Nature Medicine.

[16]  Thomas L. Chenevert,et al.  Noninvasive real-time imaging of apoptosis , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[17]  David T. Curiel,et al.  Vector Targeting for Therapeutic Gene Delivery , 2002 .

[18]  Sanjiv S Gambhir,et al.  Quantitative imaging of the T cell antitumor response by positron-emission tomography , 2003, Proceedings of the National Academy of Sciences of the United States of America.