The short term burden of ambient fine particulate matter on chronic obstructive pulmonary disease in Ningbo, China

BackgroundNumerous studies have found associations between ambient fine particulate matter (PM2.5) and increased mortality risk. However, little evidence is available on associations between PM2.5 and years of life lost (YLL). We aimed to estimate the YLL due to chronic obstructive pulmonary disease (COPD) mortality related to ambient PM2.5 exposure.MethodsA time-series study was conducted based on the data on air pollutants, meteorological conditions and 18,472 registered COPD deaths in Ningbo, China, 2011–2015. The effects of PM2.5 on YLL and daily death of COPD were estimated, after controlling long term trend, meteorological index and other confounders.ResultsThe impact of PM2.5 on YLL due to COPD lasted for 5 days (lag 0–4). Per 10 μg/m3 increase in PM2.5 was associated with 0.91 (95%CI: 0.16, 1.66) years increase in YLL. The excess YLL of COPD mortality were 8206 years, and 0.38 day per person in Ningbo from 2011 to 2015. The exposure-response curve of PM2.5 and YLL due to COPD showed a non-linear pattern, with relatively steep at low levels and flattened out at higher exposures.. Furthermore, the effects were significantly higher in the elderly than those in the younger.ConclusionsOur findings explored burden of PM2.5 on YLL due to COPD and highlight the importance and urgency of ambient PM2.5 pollution control and protection of the vulnerable populations.

[1]  Shaowei Wu,et al.  The Relationship between Particulate Matter (PM10) and Hospitalizations and Mortality Of Chronic Obstructive Pulmonary Disease: A Meta-Analysis , 2013, COPD.

[2]  C. Ou,et al.  Estimating years of life lost from cardiovascular mortality related to air pollution in Guangzhou, China. , 2016, The Science of the total environment.

[3]  T. Louis,et al.  Modification of the association between ambient air pollution and lung function by frailty status among older adults in the Cardiovascular Health Study. , 2012, American journal of epidemiology.

[4]  Xiaochuan Pan,et al.  Short-term exposure to air pollution and morbidity of COPD and asthma in East Asian area: A systematic review and meta-analysis. , 2016, Environmental research.

[5]  Tao Liu,et al.  The effects of dust-haze on mortality are modified by seasons and individual characteristics in Guangzhou, China. , 2014, Environmental pollution.

[6]  D. Mannino.  COPD: epidemiology, prevalence, morbidity and mortality, and disease heterogeneity. , 2002, Chest.

[7]  Wei Huang,et al.  Systematic review of Chinese studies of short-term exposure to air pollution and daily mortality. , 2013, Environment international.

[8]  Yuming Guo,et al.  The Impact of Temperature on Mortality in Tianjin, China: A Case-Crossover Design with a Distributed Lag Nonlinear Model , 2011, Environmental health perspectives.

[9]  J. Schwartz,et al.  Associations of Fine Particulate Matter Species with Mortality in the United States: A Multicity Time-Series Analysis , 2014, Environmental health perspectives.

[10]  T. Bateson,et al.  Who is Sensitive to the Effects of Particulate Air Pollution on Mortality?: A Case-Crossover Analysis of Effect Modifiers , 2004, Epidemiology.

[11]  Haidong Kan,et al.  Differentiating the effects of fine and coarse particles on daily mortality in Shanghai, China. , 2007, Environment international.

[12]  Nicolas Roche,et al.  Impact of gender on COPD expression in a real-life cohort , 2014, Respiratory Research.

[13]  Bernadette A. Thomas,et al.  Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010 , 2012, The Lancet.

[14]  I. Annesi-Maesano,et al.  The epidemiological link between ageing and respiratory diseases , 2009 .

[15]  David M Stieb,et al.  Associations between ambient air pollution and daily mortality among elderly persons in Montreal, Quebec. , 2013, The Science of the total environment.

[16]  A. Cohen,et al.  Inappropriate use of daily mortality analyses to estimate longer-term mortality effects of air pollution. , 1998, International journal of epidemiology.

[17]  M. Pihlsgård,et al.  Incidence of airflow limitation in subjects 65–100 years of age , 2015, European Respiratory Journal.

[18]  G. Jiang,et al.  The short term burden of ambient particulate matters on non-accidental mortality and years of life lost: A ten-year multi-district study in Tianjin, China. , 2017, Environmental pollution.

[19]  B. Møller,et al.  Years of life lost as a measure of cancer burden on a national level , 2014, British Journal of Cancer.

[20]  G. Hoek,et al.  Panel studies of air pollution in patients with COPD: Systematic review and meta-analysis. , 2016, Environmental research.

[21]  Jun Liu,et al.  Estimating adult mortality attributable to PM2.5 exposure in China with assimilated PM2.5 concentrations based on a ground monitoring network. , 2016, The Science of the total environment.

[22]  G. Jiang,et al.  Characteristics of the Exposure-Response Relationship of Particulate Matter and Mortality: A Time Series Analysis of 7 Cities in China , 2015, Journal of occupational and environmental medicine.

[23]  Tao Liu,et al.  Ambient air pollution and years of life lost in Ningbo, China , 2016, Scientific Reports.

[24]  Yuming Guo,et al.  The burden of air pollution on years of life lost in Beijing, China, 2004-08: retrospective regression analysis of daily deaths , 2013, BMJ.

[25]  Alan D. Lopez,et al.  The Global Burden of Disease Study , 2003 .

[26]  Daniel Krewski,et al.  Cardiovascular Mortality and Exposure to Airborne Fine Particulate Matter and Cigarette Smoke: Shape of the Exposure-Response Relationship , 2009, Circulation.

[27]  T. To,et al.  Progression from Asthma to Chronic Obstructive Pulmonary Disease. Is Air Pollution a Risk Factor? , 2016, American journal of respiratory and critical care medicine.

[28]  Alan D. Lopez,et al.  Age-specific and sex-specific mortality in 187 countries, 1970–2010: a systematic analysis for the Global Burden of Disease Study 2010 , 2012, The Lancet.

[29]  Wei Huang,et al.  Association of particulate air pollution with daily mortality: the China Air Pollution and Health Effects Study. , 2012, American journal of epidemiology.

[30]  C. Ou,et al.  The burden of COPD mortality due to ambient air pollution in Guangzhou, China , 2016, Scientific Reports.

[31]  Kaarle Hämeri,et al.  Particulate matter air pollution and respiratory symptoms in individuals having either asthma or chronic obstructive pulmonary disease: a European multicentre panel study , 2012, Environmental Health.

[32]  F. Martinez,et al.  Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. , 2007, American journal of respiratory and critical care medicine.