Fabrication of polymeric Janus particles by droplet microfluidics

Janus particles (JPs), with their fascinating property of asymmetry, have received considerable attention in recent years in the fields of colloidal and particulate chemistry. The particles offer a range of exciting potential applications as they possess two distinctive parts with different chemistry, colors, polarities, and/or surfaces. Currently, a number of methodologies are available for the synthesis of JPs. This review presents a short description of polymeric JPs synthesized by droplet microfluidics.

[1]  W. Liu,et al.  Generation of Janus alginate hydrogel particles with magnetic anisotropy for cell encapsulation. , 2009, Lab on a chip.

[2]  H. Hofmann,et al.  Superparamagnetic nanoparticles for biomedical applications: Possibilities and limitations of a new drug delivery system , 2005 .

[3]  Chang-Soo Lee,et al.  Generation of Monodisperse Inorganic–Organic Janus Microspheres in a Microfluidic Device , 2009 .

[4]  Wei Li,et al.  Janus and ternary particles generated by microfluidic synthesis: design, synthesis, and self-assembly. , 2006, Journal of the American Chemical Society.

[5]  Toru Torii,et al.  Synthesis of Monodisperse Bicolored Janus Particles with Electrical Anisotropy Using a Microfluidic Co‐Flow System , 2006 .

[6]  O. Velev,et al.  Anisotropic particle synthesis in dielectrophoretically controlled microdroplet reactors , 2004, Nature materials.

[7]  Lin He,et al.  Barcoding the microworld. , 2004, Analytical chemistry.

[8]  P. Wust,et al.  Magnetic fluid hyperthermia (MFH): Cancer treatment with AC magnetic field induced excitation of biocompatible superparamagnetic nanoparticles , 1999 .

[9]  M. Ersoz,et al.  Fabrication of novel anisotropic magnetic microparticles , 2009 .

[10]  Saifullah Lone,et al.  Microfluidic preparation of dual stimuli-responsive microparticles and light-directed clustering. , 2010, Langmuir : the ACS journal of surfaces and colloids.

[11]  A. Lösch.  Nano , 2012, Ortsregister.

[12]  D. Weitz,et al.  Janus microgels produced from functional precursor polymers. , 2010, Langmuir : the ACS journal of surfaces and colloids.

[13]  O. Velev,et al.  Fabrication of asymmetrically coated colloid particles by microcontact printing techniques , 2003 .

[14]  Kevin Barraclough,et al.  I and i , 2001, BMJ : British Medical Journal.

[15]  O. Velev,et al.  Fabrication of dipolar colloid particles by microcontact printing. , 2003, Chemical communications.

[16]  K. Rissanen,et al.  Bisfunctionalized Janus molecules. , 2004, Organic letters.

[17]  Younan Xia,et al.  Template-assisted self-assembly: a practical route to complex aggregates of monodispersed colloids with well-defined sizes, shapes, and structures. , 2001, Journal of the American Chemical Society.

[18]  Yadong Yin,et al.  Template‐Assisted Self‐Assembly of Spherical Colloids into Complex and Controllable Structures , 2003 .

[19]  M. R. Imam,et al.  Self-assembly of semifluorinated janus-dendritic benzamides into bilayered pyramidal columns. , 2005, Angewandte Chemie.

[20]  A. Fernández-Nieves.  Engineering colloids with optical and geometrical anisotropies: de-coupling size monodispersity and particle properties. , 2006, Soft Matter.

[21]  M. Gao,et al.  Magnetic Janus Particles Prepared by a Flame Synthetic Approach: Synthesis, Characterizations and Properties , 2009 .

[22]  I. Cho,et al.  Morphology of latex particles formed by poly(methyl methacrylate)-seeded emulsion polymerization of styrene , 1985 .

[23]  H. Kawaguchi,et al.  Preparation of unsymmetrical microspheres at the interfaces , 1999 .

[24]  Joerg Lahann,et al.  Biphasic Janus particles with nanoscale anisotropy , 2005, Nature materials.

[25]  Shirley Dex,et al.  JR 旅客販売総合システム（マルス）における運用及び管理について , 1991 .

[26]  Everett E. Carpenter,et al.  Iron nanoparticles as potential magnetic carriers , 2001 .

[27]  A. Müller,et al.  Amphiphilic Janus micelles with polystyrene and poly(methacrylic acid) hemispheres. , 2003, Journal of the American Chemical Society.

[28]  Bing Xu,et al.  Facile one-pot synthesis of bifunctional heterodimers of nanoparticles: a conjugate of quantum dot and magnetic nanoparticles. , 2004, Journal of the American Chemical Society.

[29]  Younan Xia,et al.  Three‐Dimensional Photonic Crystals with Non‐spherical Colloids as Building Blocks , 2001 .

[30]  P. Fabre,et al.  «Janus beads»: realization and behaviour at water/oil interfaces , 1989 .

[31]  Miss A.O. Penney.  (b) , 1974, The New Yale Book of Quotations.

[32]  A. Abate,et al.  Microfluidic Assembly of Magnetic Hydrogel Particles with Uniformly Anisotropic Structure , 2009 .

[33]  Bartosz A. Grzybowski,et al.  Self-assembly of polymeric microspheres of complex internal structures , 2004 .

[34]  Shouheng Sun,et al.  Dumbbell-like bifunctional Au-Fe3O4 nanoparticles. , 2005, Nano letters.

[35]  Dae Kun Hwang,et al.  Multifunctional superparamagnetic Janus particles. , 2010, Langmuir : the ACS journal of surfaces and colloids.

[36]  Kishan Dholakia,et al.  Optically Anisotropic Colloids of Controllable Shape , 2005 .

[37]  David A. Weitz,et al.  Janus Supraparticles by Induced Phase Separation of Nanoparticles in Droplets , 2009 .

[38]  D. Balding,et al.  HLA Sequence Polymorphism and the Origin of Humans , 2006 .

[39]  Andreas F. M. Kilbinger,et al.  Polymeric janus particles. , 2009, Angewandte Chemie.

[40]  Orlin D. Velev,et al.  Reconfigurable responsive structures assembled from magnetic Janus particles , 2009 .

[41]  G. Rivas,et al.  Encoded beads for electrochemical identification. , 2003, Analytical chemistry.

[42]  Younan Xia,et al.  A self-assembly approach to the formation of asymmetric dimers from monodispersed spherical colloids. , 2001, Journal of the American Chemical Society.

[43]  H. Takei and,et al.  Gradient Sensitive Microscopic Probes Prepared by Gold Evaporation and Chemisorption on Latex Spheres , 1997 .

[44]  Daeyeon Lee,et al.  Photoreactive coating for high-contrast spatial patterning of microfluidic device wettability. , 2008, Lab on a chip.

[45]  Seung-Man Yang,et al.  Optofluidic Synthesis of Electroresponsive Photonic Janus Balls with Isotropic Structural Colors , 2008 .

[46]  O. Cayre,et al.  Supraparticles and “Janus” Particles Fabricated by Replication of Particle Monolayers at Liquid Surfaces Using a Gel Trapping Technique , 2004 .

[47]  L. Liz‐Marzán,et al.  Asymmetric Functional Colloids Through Selective Hemisphere Modification , 2005 .

[48]  André R Studart,et al.  Droplet microfluidics for fabrication of non-spherical particles. , 2010, Macromolecular rapid communications.

[49]  George M. Whitesides,et al.  Fabrication and Wetting Properties of Metallic Half-Shells with Submicron Diameters , 2002 .

[50]  K. Tsujii,et al.  Adsorption of disk-shaped janus beads at liquid-liquid interfaces. , 2004, Langmuir : the ACS journal of surfaces and colloids.

[51]  Sung Hoon Kim,et al.  Microfluidic synthesis of Janus particles by UV-directed phase separation. , 2011, Chemical communications.

[52]  Curtis W. Frank,et al.  An Interfacial Stress Rheometer To Study Rheological Transitions in Monolayers at the Air-Water Interface , 1999 .

[53]  R. K. Shah,et al.  Janus particles templated from double emulsion droplets generated using microfluidics. , 2009, Langmuir : the ACS journal of surfaces and colloids.

[54]  F. Stillinger,et al.  Improving the Density of Jammed Disordered Packings Using Ellipsoids , 2004, Science.

[55]  Tien,et al.  Forming electrical networks in three dimensions by self-assembly , 2000, Science.

[56]  G. G. Stokes.  "J." , 1890, The New Yale Book of Quotations.

[57]  M. Delville,et al.  Smart surface dissymmetrization of microparticles driven by laser photochemical deposition , 2003 .

[58]  Toshiro Higuchi,et al.  Novel microreactors for functional polymer beads , 2004 .

[59]  Serge Ravaine,et al.  Design and synthesis of Janus micro- and nanoparticles , 2005 .

[60]  É. Duguet,et al.  Syntheses of raspberrylike silica/polystyrene materials , 2002 .

[61]  Kaler,et al.  A class of microstructured particles through colloidal crystallization , 2000, Science.

[62]  C. Mirkin,et al.  Scanometric DNA array detection with nanoparticle probes. , 2000, Science.

[63]  Yongzhong Du,et al.  Biotinylated and enzyme-immobilized carrier prepared by hetero-bifunctional latex beads. , 2004, Chemical communications.

[64]  S. Margel,et al.  New micrometer-sized monodispersed self-assembled amphiphilic polystyrene/poly(n-butyl methacrylate) composite particles of hemispherical morphology: synthesis and characterization , 2005 .