To bloom or not to bloom: role of microRNAs in plant flowering.

During the course of their life cycles, plants undergo various morphological and physiological changes underlying juvenile-to-adult and adult-to-flowering phase transitions. To flower or not to flower is a key step of plasticity of a plant toward the start of its new life cycle. In addition to the previously revealed intrinsic genetic programs, exogenous cues, and endogenous cues, a class of small non-coding RNAs, microRNAs (miRNAs), plays a key role in plants making the decision to flower by integrating into the known flowering pathways. This review highlights the age-dependent flowering pathway with a focus on a number of timing miRNAs in determining such a key process. The contributions of other miRNAs which exist mainly outside the age pathway are also discussed. Approaches to study the flowering-determining miRNAs, their interactions, and applications are presented.

[1]  P. Huijser,et al.  Functional analysis of the Arabidopsis thaliana SBP-box gene SPL3: a novel gene involved in the floral transition. , 1997, The Plant journal : for cell and molecular biology.

[2]  C. Vincent,et al.  Analysis of the Arabidopsis Shoot Meristem Transcriptome during Floral Transition Identifies Distinct Regulatory Patterns and a Leucine-Rich Repeat Protein That Promotes Flowering[C][W][OA] , 2012, Plant Cell.

[3]  Shruti Lal,et al.  Regulation of the SQUAMOSA PROMOTER-BINDING PROTEIN-LIKE genes/microRNA156 module by the homeodomain proteins PENNYWISE and POUND-FOOLISH in Arabidopsis. , 2011, Molecular plant.

[4]  Chentao Lin,et al.  Photoreceptors and regulation of flowering time. , 2000, Plant physiology.

[5]  Detlef Weigel,et al.  The Sequential Action of miR156 and miR172 Regulates Developmental Timing in Arabidopsis , 2009, Cell.

[6]  D. Bartel,et al.  MicroRNAS and their regulatory roles in plants. , 2006, Annual review of plant biology.

[7]  Chung-Mo Park,et al.  Modulation of sugar metabolism by an INDETERMINATE DOMAIN transcription factor contributes to photoperiodic flowering in Arabidopsis. , 2011, The Plant journal : for cell and molecular biology.

[8]  Li Yang,et al.  Sugar promotes vegetative phase change in Arabidopsis thaliana by repressing the expression of MIR156A and MIR156C , 2013, eLife.

[9]  Yan Luo,et al.  Evolutionary conservation of microRNA regulatory programs in plant flower development. , 2013, Developmental biology.

[10]  P. Glazińska,et al.  The putative miR172 target gene InAPETALA2-like is involved in the photoperiodic flower induction of Ipomoea nil. , 2009, Journal of plant physiology.

[11]  Ji Hoon Ahn,et al.  Genetic framework for flowering-time regulation by ambient temperature-responsive miRNAs in Arabidopsis , 2010, Nucleic acids research.

[12]  L. Xiong,et al.  Gradual Increase of miR156 Regulates Temporal Expression Changes of Numerous Genes during Leaf Development in Rice1[C][W][OA] , 2012, Plant Physiology.

[13]  Edwards Allen,et al.  DICER-LIKE 4 functions in trans-acting small interfering RNA biogenesis and vegetative phase change in Arabidopsis thaliana. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[14]  K. Goto,et al.  FD, a bZIP Protein Mediating Signals from the Floral Pathway Integrator FT at the Shoot Apex , 2005, Science.

[15]  R. Poethig,et al.  Small RNAs and developmental timing in plants. , 2009, Current opinion in genetics & development.

[16]  Chenmin Yang,et al.  Conservation and diversity of microRNA-associated copper-regulatory networks in Populus trichocarpa. , 2011, Journal of integrative plant biology.

[17]  Qian Luo,et al.  MicroRNA171c-targeted SCL6-II, SCL6-III, and SCL6-IV genes regulate shoot branching in Arabidopsis. , 2010, Molecular plant.

[18]  F. Gubler,et al.  The Role of GAMYB Transcription Factors in GA-Regulated Gene Expression , 2003, Journal of Plant Growth Regulation.

[19]  P. Chouard.  Vernalization and its Relations to Dormancy , 1960 .

[20]  Xingliang Hou,et al.  Nuclear factor Y-mediated H3K27me3 demethylation of the SOC1 locus orchestrates flowering responses of Arabidopsis , 2014, Nature Communications.

[21]  C. N. Stewart,et al.  Overexpression of miR156 in switchgrass (Panicum virgatum L.) results in various morphological alterations and leads to improved biomass production , 2012, Plant biotechnology journal.

[22]  Jiawei Wang,et al.  Special Topic: Plant Biology: Chromatin, Small Rna and Signaling the Role of Mir156 in Developmental Transitions in Nicotiana Tabacum , 2022 .

[23]  Utpal Nath,et al.  Hyper-activation of the TCP4 transcription factor in Arabidopsis thaliana accelerates multiple aspects of plant maturation. , 2011, The Plant journal : for cell and molecular biology.

[24]  Mark Stitt,et al.  Regulation of Flowering by Trehalose-6-Phosphate Signaling in Arabidopsis thaliana , 2013, Science.

[25]  Heinz Saedler,et al.  The microRNA regulated SBP-box genes SPL9 and SPL15 control shoot maturation in Arabidopsis , 2008, Plant Molecular Biology.

[26]  Jian‐Kang Zhu,et al.  Application of the CRISPR-Cas system for efficient genome engineering in plants. , 2013, Molecular plant.

[27]  Feijie Wu,et al.  BrpSPL9 (Brassica rapa ssp. pekinensis SPL9) controls the earliness of heading time in Chinese cabbage. , 2014, Plant biotechnology journal.

[28]  Jae-Hoon Jung,et al.  Arabidopsis RNA-binding Protein FCA Regulates MicroRNA172 Processing in Thermosensory Flowering* , 2012, The Journal of Biological Chemistry.

[29]  J. Salinas,et al.  Sucrose availability on the aerial part of the plant promotes morphogenesis and flowering of Arabidopsis in the dark. , 1999, The Plant journal : for cell and molecular biology.

[30]  P. Suárez-López,et al.  Graft-transmissible induction of potato tuberization by the microRNA miR172 , 2009, Development.

[31]  Frank Küttner,et al.  Spatial control of flowering by DELLA proteins in Arabidopsis thaliana , 2012, Development.

[32]  Ying-Bo Mao,et al.  Interaction between Two Timing MicroRNAs Controls Trichome Distribution in Arabidopsis , 2014, PLoS genetics.

[33]  N. Chua,et al.  The GIGANTEA-Regulated MicroRNA172 Mediates Photoperiodic Flowering Independent of CONSTANS in Arabidopsis[W][OA] , 2007, The Plant Cell Online.

[34]  Seth J Davis,et al.  Integrating hormones into the floral-transition pathway of Arabidopsis thaliana. , 2009, Plant, cell & environment.

[35]  T. Chiou,et al.  The role of the miR399-PHO2 module in the regulation of flowering time in response to different ambient temperatures in Arabidopsis thaliana , 2011, Molecules and cells.

[36]  C. Helliwell,et al.  A diverse set of microRNAs and microRNA-like small RNAs in developing rice grains. , 2008, Genome research.

[37]  Lizhe An,et al.  Involvement of brassinosteroid signals in the floral-induction network of Arabidopsis. , 2010, Journal of experimental botany.

[38]  S. Jackson,et al.  The role of microRNAs in the control of flowering time. , 2014, Journal of experimental botany.

[39]  Jae-Hoon Jung,et al.  miR172 signals are incorporated into the miR156 signaling pathway at the SPL3/4/5 genes in Arabidopsis developmental transitions , 2011, Plant Molecular Biology.

[40]  Patrick Achard,et al.  Modulation of floral development by a gibberellin-regulated microRNA , 2004, Development.

[41]  J. Messing,et al.  CARPEL FACTORY, a Dicer Homolog, and HEN1, a Novel Protein, Act in microRNA Metabolism in Arabidopsis thaliana , 2002, Current Biology.

[42]  S. Rothstein,et al.  The role of epigenetic processes in controlling flowering time in plants exposed to stress. , 2011, Journal of experimental botany.

[43]  Detlef Weigel,et al.  Dual Effects of miR156-Targeted SPL Genes and CYP78A5/KLUH on Plastochron Length and Organ Size in Arabidopsis thaliana[W][OA] , 2008, The Plant Cell Online.

[44]  Junhui Wang,et al.  Flowering time control in ornamental gloxinia (Sinningia speciosa) by manipulation of miR159 expression. , 2013, Annals of botany.

[45]  Ilha Lee,et al.  SOC1 translocated to the nucleus by interaction with AGL24 directly regulates leafy. , 2008, The Plant journal : for cell and molecular biology.

[46]  G. An,et al.  The rice heterochronic gene SUPERNUMERARY BRACT regulates the transition from spikelet meristem to floral meristem. , 2006, The Plant journal : for cell and molecular biology.

[47]  B. Simmons,et al.  Overexpression of the maize Corngrass1 microRNA prevents flowering, improves digestibility, and increases starch content of switchgrass , 2011, Proceedings of the National Academy of Sciences.

[48]  Gang Wu,et al.  Temporal regulation of shoot development in Arabidopsis thaliana by miR156 and its target SPL3 , 2006, Development.

[49]  Qian-Hao Zhu,et al.  Over-expression of miR172 causes loss of spikelet determinacy and floral organ abnormalities in rice (Oryza sativa) , 2009, BMC Plant Biology.

[50]  D. Weiss,et al.  Mechanisms of Cross Talk between Gibberellin and Other Hormones1 , 2007, Plant Physiology.

[51]  G. Coupland,et al.  SHORT VEGETATIVE PHASE reduces gibberellin biosynthesis at the Arabidopsis shoot apex to regulate the floral transition , 2014, Proceedings of the National Academy of Sciences.

[52]  Olivier Voinnet,et al.  LOST MERISTEMS genes regulate cell differentiation of central zone descendants in Arabidopsis shoot meristems. , 2010, The Plant journal : for cell and molecular biology.

[53]  L. Xiong,et al.  Genomic Organization, Differential Expression, and Interaction of SQUAMOSA Promoter-Binding-Like Transcription Factors and microRNA156 in Rice1[W] , 2006, Plant Physiology.

[54]  L. Hileman,et al.  SQUAMOSA-PROMOTER BINDING PROTEIN 1 initiates flowering in Antirrhinum majus through the activation of meristem identity genes. , 2010, The Plant journal : for cell and molecular biology.

[55]  Qihui Zhu,et al.  Genome-wide identification and evolutionary analysis of the plant specific SBP-box transcription factor family. , 2008, Gene.

[56]  D. Weigel,et al.  A thermosensory pathway controlling flowering time in Arabidopsis thaliana , 2003, Nature Genetics.

[57]  Bing Yang,et al.  Demonstration of CRISPR/Cas9/sgRNA-mediated targeted gene modification in Arabidopsis, tobacco, sorghum and rice , 2013, Nucleic acids research.

[58]  Ilha Lee,et al.  The SOC1 MADS-box gene integrates vernalization and gibberellin signals for flowering in Arabidopsis. , 2003, The Plant journal : for cell and molecular biology.

[59]  Carina Barth,et al.  The role of ascorbic acid in the control of flowering time , 2006 .

[60]  Overexpression of Arabidopsis miR157b induces bushy architecture and delayed phase transition in Torenia fournieri , 2012, Planta.

[61]  S. Park,et al.  Role of SVP in the control of flowering time by ambient temperature in Arabidopsis. , 2007, Genes & development.

[62]  Wei Wei Li,et al.  Stress-induced early flowering is mediated by miR169 in Arabidopsis thaliana. , 2014, Journal of experimental botany.

[63]  G. Bernier,et al.  The role of carbohydrates in the induction of flowering in Arabidopsis thaliana: comparison between the wild type and a starchless mutant , 1998, Planta.

[64]  A. V. Dijken,et al.  Arabidopsis Trehalose-6-Phosphate Synthase 1 Is Essential for Normal Vegetative Growth and Transition to Flowering1 , 2004, Plant Physiology.

[65]  Ju Yun,et al.  The miR172 target TOE3 represses AGAMOUS expression during Arabidopsis floral patterning. , 2014, Plant science : an international journal of experimental plant biology.

[66]  F. Turck,et al.  The impact of chromatin regulation on the floral transition. , 2008, Seminars in cell & developmental biology.

[67]  Fabio Fornara,et al.  Plant Phase Transitions Make a SPLash , 2009, Cell.

[68]  T. Komatsuda,et al.  Cleistogamous flowering in barley arises from the suppression of microRNA-guided HvAP2 mRNA cleavage , 2009, Proceedings of the National Academy of Sciences.

[69]  Detlef Weigel,et al.  A Collection of Target Mimics for Comprehensive Analysis of MicroRNA Function in Arabidopsis thaliana , 2010, PLoS genetics.

[70]  D. Weigel,et al.  GAMYB-like genes, flowering, and gibberellin signaling in Arabidopsis. , 2001, Plant physiology.

[71]  Gang Wu,et al.  The microRNA-regulated SBP-Box transcription factor SPL3 is a direct upstream activator of LEAFY, FRUITFULL, and APETALA1. , 2009, Developmental cell.

[72]  E. Mutasa-Göttgens,et al.  Gibberellin as a factor in floral regulatory networks. , 2009, Journal of experimental botany.

[73]  F. Nagy,et al.  Genetic Analyses of Interactions among Gibberellin, Abscisic Acid, and Brassinosteroids in the Control of Flowering Time in Arabidopsis thaliana , 2010, PloS one.

[74]  Yoshinori Hirano,et al.  Gibberellin-induced DELLA recognition by the gibberellin receptor GID1 , 2008, Nature.

[75]  M. Todesco,et al.  Target mimicry provides a new mechanism for regulation of microRNA activity , 2007, Nature Genetics.

[76]  Xuemei Chen,et al.  Orchestration of the Floral Transition and Floral Development in Arabidopsis by the Bifunctional Transcription Factor APETALA2[W][OA] , 2010, Plant Cell.

[77]  Heinz Saedler,et al.  The miRNA156/157 recognition element in the 3' UTR of the Arabidopsis SBP box gene SPL3 prevents early flowering by translational inhibition in seedlings. , 2007, The Plant journal : for cell and molecular biology.

[78]  G. Coupland,et al.  Spatially distinct regulatory roles for gibberellins in the promotion of flowering of Arabidopsis under long photoperiods , 2012, Development.

[79]  H. Kamada,et al.  Ethylene advances the transition from vegetative growth to flowering in Arabidopsis thaliana. , 2003, Journal of plant physiology.

[80]  Gang Wu,et al.  SGS3 and SGS2/SDE1/RDR6 are required for juvenile development and the production of trans-acting siRNAs in Arabidopsis. , 2004, Genes & development.

[81]  Feijie Wu,et al.  HYL1 controls the miR156-mediated juvenile phase of vegetative growth , 2012, Journal of experimental botany.

[82]  H. Itoh,et al.  The COP1 Ortholog PPS Regulates the Juvenile–Adult and Vegetative–Reproductive Phase Changes in Rice[C][W] , 2011, Plant Cell.

[83]  D. Van Der Straeten,et al.  The plant stress hormone ethylene controls floral transition via DELLA-dependent regulation of floral meristem-identity genes , 2007, Proceedings of the National Academy of Sciences.

[84]  Javier F. Palatnik,et al.  Control of Jasmonate Biosynthesis and Senescence by miR319 Targets , 2008, PLoS biology.

[85]  Yukihisa Shimada,et al.  GAMYB controls different sets of genes and is differentially regulated by microRNA in aleurone cells and anthers. , 2006, The Plant journal : for cell and molecular biology.

[86]  J. Duan,et al.  OsTIR1 and OsAFB2 Downregulation via OsmiR393 Overexpression Leads to More Tillers, Early Flowering and Less Tolerance to Salt and Drought in Rice , 2012, PloS one.

[87]  Jia-Wei Wang,et al.  Molecular Basis of Age-Dependent Vernalization in Cardamine flexuosa , 2013, Science.

[88]  Jae-Hyung Lee,et al.  The SOC1-SPL module integrates photoperiod and gibberellic acid signals to control flowering time in Arabidopsis. , 2012, The Plant journal : for cell and molecular biology.

[89]  A. Mushegian,et al.  Short Integuments1/suspensor1/carpel Factory, a Dicer Homolog, Is a Maternal Effect Gene Required for Embryo Development in Arabidopsis1 , 2002, Plant Physiology.

[90]  M. Schmid,et al.  Regulation of flowering time: all roads lead to Rome , 2011, Cellular and Molecular Life Sciences.

[91]  R. Poethig,et al.  Vegetative phase change is mediated by a leaf-derived signal that represses the transcription of miR156 , 2011, Development.

[92]  P. Huijser,et al.  Molecular characterisation of the Arabidopsis SBP-box genes. , 1999, Gene.

[93]  Xuemei Chen,et al.  Effective Small RNA Destruction by the Expression of a Short Tandem Target Mimic in Arabidopsis[C][W] , 2012, Plant Cell.

[94]  F. Turck,et al.  NATURAL VARIATION IN EPIGENETIC GENE REGULATION AND ITS EFFECTS ON PLANT DEVELOPMENTAL TRAITS , 2014, Evolution; international journal of organic evolution.

[95]  T. Mockler,et al.  Regulation of photoperiodic flowering by Arabidopsis photoreceptors , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[96]  Roberto Tuberosa,et al.  Conserved noncoding genomic sequences associated with a flowering-time quantitative trait locus in maize , 2007, Proceedings of the National Academy of Sciences.

[97]  P. Huijser,et al.  Genomic organization, phylogenetic comparison and differential expression of the SBP-box family of transcription factors in tomato , 2011, Planta.

[98]  L. Mao,et al.  Regulation of FLOWERING LOCUS T by a MicroRNA in Brachypodium distachyon[C][W] , 2013, Plant Cell.

[99]  P. Huijser,et al.  The microRNA156-SQUAMOSA PROMOTER BINDING PROTEIN-LIKE3 Module Regulates Ambient Temperature-Responsive Flowering via FLOWERING LOCUS T in Arabidopsis1[C][W][OA] , 2012, Plant Physiology.

[100]  J. Mathieu,et al.  Repression of Flowering by the miR172 Target SMZ , 2009, PLoS biology.

[101]  M. Schmid,et al.  Gibberellin Regulates the Arabidopsis Floral Transition through miR156-Targeted SQUAMOSA PROMOTER BINDING–LIKE Transcription Factors[W] , 2012, Plant Cell.

[102]  Z. Ye,et al.  Over‐expression of sly‐miR156a in tomato results in multiple vegetative and reproductive trait alterations and partial phenocopy of the sft mutant , 2011, FEBS letters.

[103]  D. Hegedus,et al.  Arabidopsis mutant sk156 reveals complex regulation of SPL15 in a miR156-controlled gene network , 2012, BMC Plant Biology.

[104]  R. Bhalerao,et al.  Daylength mediated control of seasonal growth patterns in perennial trees. , 2013, Current opinion in plant biology.

[105]  G. Coupland,et al.  Control of flowering time: interacting pathways as a basis for diversity. , 2002, The Plant cell.

[106]  Ectopic expression of the apple Md-miRNA156h gene regulates flower and fruit development in Arabidopsis , 2013, Plant Cell, Tissue and Organ Culture (PCTOC).

[107]  P. Huijser,et al.  Comparative analysis of the SBP-box gene families in P. patens and seed plants. , 2007, Gene.

[108]  D. Bartel.  MicroRNAs Genomics, Biogenesis, Mechanism, and Function , 2004, Cell.

[109]  Xuemei Chen,et al.  LEUNIG and SEUSS co-repressors regulate miR172 expression in Arabidopsis flowers , 2011, Development.

[110]  G. Coupland,et al.  Distinct Roles of GIGANTEA in Promoting Flowering and Regulating Circadian Rhythms in Arabidopsis , 2005, The Plant Cell Online.

[111]  Detlef Weigel,et al.  miR156-Regulated SPL Transcription Factors Define an Endogenous Flowering Pathway in Arabidopsis thaliana , 2009, Cell.

[112]  Detlef Weigel,et al.  MiRNA Control of Vegetative Phase Change in Trees , 2011, PLoS genetics.

[113]  C. Helliwell,et al.  Over-expression of microRNA171 affects phase transitions and floral meristem determinancy in barley , 2013, BMC Plant Biology.

[114]  N. Han,et al.  Regulation of auxin response by miR393-targeted transport inhibitor response protein1 is involved in normal development in Arabidopsis , 2011, Plant Molecular Biology.

[115]  Jia-Wei Wang,et al.  Sugar is an endogenous cue for juvenile-to-adult phase transition in plants , 2013, eLife.

[116]  R. Amasino,et al.  Molecular analysis of FRIGIDA, a major determinant of natural variation in Arabidopsis flowering time. , 2000, Science.

[117]  D. Weigel,et al.  MicroRNA networks and developmental plasticity in plants. , 2011, Trends in plant science.

[118]  Michael Q. Zhang,et al.  The effects of carbon dioxide and temperature on microRNA expression in Arabidopsis development , 2013, Nature Communications.

[119]  S. Nandakumar,et al.  Carbohydrate Changes in Shoot Tip and Subtending Leaves During Ontogenetic Development of Pineapple , 1983 .

[120]  M. Schmid,et al.  The control of developmental phase transitions in plants , 2011, Development.

[121]  E. Goldschmidt,et al.  The nature of floral signals in Arabidopsis. I. Photosynthesis and a far-red photoresponse independently regulate flowering by increasing expression of FLOWERING LOCUS T (FT) , 2008, Journal of experimental botany.

[122]  Cristina Martinez,et al.  Salicylic acid regulates flowering time and links defence responses and reproductive development. , 2004, The Plant journal : for cell and molecular biology.

[123]  B. Reinhart,et al.  Prediction of Plant MicroRNA Targets , 2002, Cell.

[124]  S. Ohms,et al.  The MicroRNA159-Regulated GAMYB-like Genes Inhibit Growth and Promote Programmed Cell Death in Arabidopsis1[C][W][OA] , 2010, Plant Physiology.

[125]  H. Vaucheret,et al.  The Nuclear dsRNA Binding Protein HYL1 Is Required for MicroRNA Accumulation and Plant Development, but Not Posttranscriptional Transgene Silencing , 2004, Current Biology.

[126]  Jonathan D. G. Jones,et al.  A Plant miRNA Contributes to Antibacterial Resistance by Repressing Auxin Signaling , 2006, Science.

[127]  Jae-Hoon Jung,et al.  SHORT VEGETATIVE PHASE (SVP) protein negatively regulates miR172 transcription via direct binding to the pri‐miR172a promoter in Arabidopsis , 2012, FEBS letters.

[128]  Shiyou Zhu,et al.  High-throughput screening of a CRISPR/Cas9 library for functional genomics in human cells , 2014, Nature.

[129]  Javier F. Palatnik,et al.  Control of leaf morphogenesis by microRNAs , 2003, Nature.

[130]  Detlef Weigel,et al.  Dissection of floral induction pathways using global expression analysis , 2003, Development.

[131]  E. Lander,et al.  Development and Applications of CRISPR-Cas9 for Genome Engineering , 2014, Cell.

[132]  James E. DiCarlo,et al.  RNA-Guided Human Genome Engineering via Cas9 , 2013, Science.

[133]  D. Weigel,et al.  Gibberellins Promote Flowering of Arabidopsis by Activating the LEAFY Promoter , 1998, Plant Cell.

[134]  Melissa D. Lehti-Shiu,et al.  The MADS domain factors AGL15 and AGL18 act redundantly as repressors of the floral transition in Arabidopsis. , 2007, The Plant journal : for cell and molecular biology.

[135]  M. Axtell,et al.  miR156 and miR390 Regulate tasiRNA Accumulation and Developmental Timing in Physcomitrella patens[C][W][OA] , 2012, Plant Cell.

[136]  K. C. Hamner.  Interrelation of Light and Darkness in Photoperiodic Induction , 1940, Botanical Gazette.

[137]  Hak-Seung Ryu,et al.  Expression of the Floral Repressor miRNA156 is Positively Regulated by the AGAMOUS-like Proteins AGL15 and AGL18 , 2015, Molecules and cells.

[138]  Mizuki Yamada,et al.  Salicylic acid and the flowering gene FLOWERING LOCUS T homolog are involved in poor-nutrition stress-induced flowering of Pharbitis nil. , 2010, Journal of plant physiology.

[139]  R. Amasino,et al.  The molecular basis of vernalization in different plant groups. , 2012, Cold Spring Harbor symposia on quantitative biology.

[140]  Xuemei Chen,et al.  A MicroRNA as a Translational Repressor of APETALA2 in Arabidopsis Flower Development , 2004, Science.

[141]  Yun Zheng,et al.  Identification of novel and candidate miRNAs in rice by high throughput sequencing , 2008, BMC Plant Biology.

[142]  K. Nordström,et al.  Mechanisms of Age-Dependent Response to Winter Temperature in Perennial Flowering of Arabis alpina , 2013, Science.

[143]  Sarah Hake,et al.  The heterochronic maize mutant Corngrass1 results from overexpression of a tandem microRNA , 2007, Nature Genetics.

[144]  F. Turck,et al.  miR824-Regulated AGAMOUS-LIKE16 Contributes to Flowering Time Repression in Arabidopsis[C][W] , 2014, Plant Cell.

[145]  Claire Périlleux,et al.  Cytokinin promotes flowering of Arabidopsis via transcriptional activation of the FT paralogue TSF. , 2011, The Plant journal : for cell and molecular biology.

[146]  Javier F. Palatnik,et al.  Specific effects of microRNAs on the plant transcriptome. , 2005, Developmental cell.

[147]  G. Bernier.  My favourite flowering image: the role of cytokinin as a flowering signal. , 2013, Journal of experimental botany.

[148]  S. Moose,et al.  microRNA172 down-regulates glossy15 to promote vegetative phase change in maize. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[149]  Ilha Lee,et al.  Regulation and function of SOC1, a flowering pathway integrator. , 2010, Journal of experimental botany.

[150]  C. Dean,et al.  Vernalization – a cold-induced epigenetic switch , 2012, Journal of Cell Science.

[151]  Hajime Sakai,et al.  Regulation of Flowering Time and Floral Organ Identity by a MicroRNA and Its APETALA2-Like Target Genes Article, publication date, and citation information can be found at www.plantcell.org/cgi/doi/10.1105/tpc.016238. , 2003, The Plant Cell Online.

[152]  J. Carrington,et al.  Regulation of AUXIN RESPONSE FACTOR3 by TAS3 ta-siRNA Affects Developmental Timing and Patterning in Arabidopsis , 2006, Current Biology.

[153]  D. Weigel,et al.  Move on up, it's time for change--mobile signals controlling photoperiod-dependent flowering. , 2007, Genes & development.

[154]  M. Matsuoka,et al.  Loss-of-function mutations of the rice GAMYB gene impair alpha-amylase expression in aleurone and flower development. , 2004, The Plant cell.

[155]  R. Amasino,et al.  Vernalization: winter and the timing of flowering in plants. , 2009, Annual review of cell and developmental biology.

[156]  Regulation of reproductive development by non-coding RNA in Arabidopsis: to flower or not to flower , 2012, Journal of Plant Research.

[157]  D. Weigel,et al.  Weigel photoperiod-dependent flowering Move on up , it ’ s time for change mobile signals controlling , 2007 .

[158]  Yang Wu,et al.  A repressor complex governs the integration of flowering signals in Arabidopsis. , 2008, Developmental cell.