Interaction of the Clostridium difficile Binary Toxin CDT and its Host Cell Receptor LSR*

Background: Clostridium difficile binary toxin CDT enters host cells via its receptor LSR. Results: Regions responsible for the CDT-LSR interaction were identified. Conclusion: An immunoglobulin-like domain of LSR and amino acids 757 to 866 of the binding component of CDT determine the toxin-receptor interaction. Significance: Knowledge of the toxin-receptor interaction is key to the development of anti-toxin strategies. ABSTRACT CDT ( Clostridium difficile transferase) is a binary, actin ADP-ribosylating toxin frequently associated with hypervirulent strains of the human enteric pathogen C.

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