Metabolic rewiring in melanoma
暂无分享,去创建一个
[1] L. Galluzzi,et al. Mitochondrial metabolism and cancer , 2017, Cell Research.
[2] Eugenia G. Giannopoulou,et al. Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH , 2015, Science.
[3] M. Bergo,et al. Antioxidants can increase melanoma metastasis in mice , 2015, Science Translational Medicine.
[4] S. Leung,et al. PDK1-Dependent Metabolic Reprogramming Dictates Metastatic Potential in Breast Cancer. , 2015, Cell metabolism.
[5] R. Deberardinis,et al. Oxidative stress inhibits distant metastasis by human melanoma cells , 2015, Nature.
[6] N. Dhomen,et al. Resistance to BRAF inhibitors induces glutamine dependency in melanoma cells , 2015, Molecular oncology.
[7] P. Tamayo,et al. Metabolic Rewiring by Oncogenic BRAF V600E Links Ketogenesis Pathway to BRAF-MEK1 Signaling. , 2015, Molecular cell.
[8] M. V. Heiden,et al. Supporting Aspartate Biosynthesis Is an Essential Function of Respiration in Proliferating Cells , 2015, Cell.
[9] J. Rutter,et al. You Down With ETC? Yeah, You Know D! , 2015, Cell.
[10] A. Bosserhoff,et al. Glucose transporter isoform 1 expression enhances metastasis of malignant melanoma cells , 2015, Oncotarget.
[11] R. Lo,et al. Vemurafenib resistance reprograms melanoma cells towards glutamine dependence , 2015, Journal of Translational Medicine.
[12] M. Feldman,et al. ATF4-dependent induction of heme oxygenase 1 prevents anoikis and promotes metastasis. , 2015, The Journal of clinical investigation.
[13] D. Sabatini,et al. An Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate Synthesis , 2015, Cell.
[14] Steven J. M. Jones,et al. Genomic Classification of Cutaneous Melanoma , 2015, Cell.
[15] Xiaoyu Liang,et al. Upregulation of cytosolic phosphoenolpyruvate carboxykinase is a critical metabolic event in melanoma cells that repopulate tumors. , 2015, Cancer research.
[16] R. Deberardinis,et al. Metabolic pathways promoting cancer cell survival and growth , 2015, Nature Cell Biology.
[17] P. Guldberg,et al. Molecular drivers of cellular metabolic reprogramming in melanoma. , 2015, Trends in molecular medicine.
[18] Boris Ratnikov,et al. Glutamate and asparagine cataplerosis underlie glutamine addiction in melanoma , 2015, Oncotarget.
[19] Xian Chen,et al. Redox regulation of Rac1 by thiol oxidation. , 2015, Free radical biology & medicine.
[20] S. Inoue,et al. Glutathione and thioredoxin antioxidant pathways synergize to drive cancer initiation and progression. , 2015, Cancer cell.
[21] T. Graeber,et al. Low MITF/AXL ratio predicts early resistance to multiple targeted drugs in melanoma , 2014, Nature Communications.
[22] William J. Israelsen,et al. Pyruvate kinase isoform expression alters nucleotide synthesis to impact cell proliferation. , 2014, Molecular cell.
[23] D. Fisher,et al. The melanoma revolution: From UV carcinogenesis to a new era in therapeutics , 2014, Science.
[24] Jianxin Xie,et al. A role for the mitochondrial pyruvate carrier as a repressor of the Warburg effect and colon cancer cell growth. , 2014, Molecular cell.
[25] R. Deberardinis,et al. Glutamine oxidation maintains the TCA cycle and cell survival during impaired mitochondrial pyruvate transport. , 2014, Molecular cell.
[26] Christian M. Metallo,et al. Regulation of substrate utilization by the mitochondrial pyruvate carrier. , 2014, Molecular cell.
[27] E. Cheng,et al. Asparagine plays a critical role in regulating cellular adaptation to glutamine depletion. , 2014, Molecular cell.
[28] Zhandong Liu,et al. Serine catabolism regulates mitochondrial redox control during hypoxia. , 2014, Cancer discovery.
[29] K. Struhl,et al. Metformin and phenformin deplete tricarboxylic acid cycle and glycolytic intermediates during cell transformation and NTPs in cancer stem cells , 2014, Proceedings of the National Academy of Sciences.
[30] K. Vousden,et al. Serine, but not glycine, supports one-carbon metabolism and proliferation of cancer cells. , 2014, Cell Reports.
[31] N. Chandel,et al. ROS Function in Redox Signaling and Oxidative Stress , 2014, Current Biology.
[32] T. Shlomi,et al. Quantitative flux analysis reveals folate-dependent NADPH production , 2014, Nature.
[33] Adam M. Feist,et al. Tracing compartmentalized NADPH metabolism in the cytosol and mitochondria of mammalian cells. , 2014, Molecular cell.
[34] K. Wellen,et al. Pyruvate kinase M2: regulatory circuits and potential for therapeutic intervention. , 2014, Current pharmaceutical design.
[35] Bingying Zhou,et al. Rho GTPases, oxidation, and cell redox control , 2014, Small GTPases.
[36] I. Amelio,et al. Serine and glycine metabolism in cancer☆ , 2014, Trends in biochemical sciences.
[37] K. Flaherty,et al. Pathways and therapeutic targets in melanoma , 2014, Oncotarget.
[38] B. Poljšak,et al. The Role of Antioxidants in Skin Cancer Prevention and Treatment , 2014, Oxidative medicine and cellular longevity.
[39] E. Larsson,et al. Antioxidants Accelerate Lung Cancer Progression in Mice , 2014, Science Translational Medicine.
[40] T. Mak,et al. Modulation of oxidative stress as an anticancer strategy , 2013, Nature Reviews Drug Discovery.
[41] C. Morrison,et al. A purine nucleotide biosynthesis enzyme guanosine monophosphate reductase is a suppressor of melanoma invasion. , 2013, Cell reports.
[42] L. Cantley,et al. Phenformin enhances the therapeutic benefit of BRAFV600E inhibition in melanoma , 2013, Proceedings of the National Academy of Sciences.
[43] J. Sosman,et al. The Society for Immunotherapy of Cancer consensus statement on tumour immunotherapy for the treatment of cutaneous melanoma , 2013, Nature Reviews Clinical Oncology.
[44] Jie Li,et al. PKM2 Isoform-Specific Deletion Reveals a Differential Requirement for Pyruvate Kinase in Tumor Cells , 2013, Cell.
[45] J. Locasale. Serine, glycine and one-carbon units: cancer metabolism in full circle , 2013, Nature Reviews Cancer.
[46] M. Leach,et al. MEK1/2 inhibition decreases lactate in BRAF-driven human cancer cells. , 2013, Cancer research.
[47] M. V. Heiden,et al. Pyruvate as a Pivot Point for Oncogene-Induced Senescence , 2013, Cell.
[48] T. Shlomi,et al. A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence , 2013, Nature.
[49] Jun S. Song,et al. Oncogenic BRAF regulates oxidative metabolism via PGC1α and MITF. , 2013, Cancer cell.
[50] P. Puigserver,et al. PGC1α expression defines a subset of human melanoma tumors with increased mitochondrial capacity and resistance to oxidative stress. , 2013, Cancer cell.
[51] John M. Asara,et al. Glutamine supports pancreatic cancer growth through a Kras-regulated metabolic pathway , 2013, Nature.
[52] S. Campbell,et al. Redox regulation of Ras and Rho GTPases: mechanism and function. , 2013, Antioxidants & redox signaling.
[53] David S. Wishart,et al. HMDB 3.0—The Human Metabolome Database in 2013 , 2012, Nucleic Acids Res..
[54] Boris Ratnikov,et al. Glutamine‐fueled mitochondrial metabolism is decoupled from glycolysis in melanoma , 2012, Pigment cell & melanoma research.
[55] J. Kirkwood,et al. Importance of glycolysis and oxidative phosphorylation in advanced melanoma , 2012, Molecular Cancer.
[56] Abraham J. Khorasani,et al. Loss of 5-Hydroxymethylcytosine Is an Epigenetic Hallmark of Melanoma , 2012, Cell.
[57] Jeffrey W. Smith,et al. Functional Specialization in Proline Biosynthesis of Melanoma , 2012, PloS one.
[58] K. Bachman,et al. Analysis of glutamine dependency in non-small cell lung cancer , 2012, Cancer biology & therapy.
[59] Gerald C. Chu,et al. Abstract A101: Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism. , 2012 .
[60] Gregory Stephanopoulos,et al. Amplification of phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis , 2012, BMC Proceedings.
[61] Wei Liu,et al. Reprogramming of proline and glutamine metabolism contributes to the proliferative and metabolic responses regulated by oncogenic transcription factor c-MYC , 2012, Proceedings of the National Academy of Sciences.
[62] Fabian V. Filipp,et al. Reverse TCA cycle flux through isocitrate dehydrogenases 1 and 2 is required for lipogenesis in hypoxic melanoma cells , 2012, Pigment cell & melanoma research.
[63] J. Rabinowitz,et al. Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation , 2012, Proceedings of the National Academy of Sciences.
[64] Chi V Dang,et al. MYC on the Path to Cancer , 2012, Cell.
[65] P. Ward,et al. Metabolic reprogramming: a cancer hallmark even warburg did not anticipate. , 2012, Cancer cell.
[66] J. McEneny,et al. The biochemistry of ketogenesis and its role in weight management, neurological disease and oxidative stress , 2012, Journal of Physiology and Biochemistry.
[67] T. Fan,et al. The metabolic profile of tumors depends on both the responsible genetic lesion and tissue type. , 2012, Cell metabolism.
[68] A. Cassago,et al. Mitochondrial localization and structure-based phosphate activation mechanism of Glutaminase C with implications for cancer metabolism , 2012, Proceedings of the National Academy of Sciences.
[69] L. Cantley,et al. PHGDH amplification and altered glucose metabolism in human melanoma , 2011, Pigment cell & melanoma research.
[70] K. Brown,et al. A novel recurrent mutation in MITF predisposes to familial and sporadic melanoma , 2011, Nature.
[71] Christian M. Metallo,et al. Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia , 2011, Nature.
[72] S. Puig,et al. A SUMOylation-defective MITF germline mutation predisposes to melanoma and renal carcinoma , 2011, Nature.
[73] Jeffrey W. Smith,et al. Comparative Metabolic Flux Profiling of Melanoma Cell Lines , 2011, The Journal of Biological Chemistry.
[74] M. V. Vander Heiden,et al. Aerobic glycolysis: meeting the metabolic requirements of cell proliferation. , 2011, Annual review of cell and developmental biology.
[75] J. McEneny,et al. The biochemistry of ketogenesis and its role in weight management, neurological disease and oxidative stress , 2011, Journal of Physiology and Biochemistry.
[76] D. Fisher,et al. Biology and clinical relevance of the micropthalmia family of transcription factors in human cancer. , 2011, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[77] Dean P. Jones,et al. Clinical trials of antioxidants as cancer prevention agents: past, present, and future. , 2011, Free radical biology & medicine.
[78] T. Copetti,et al. Anticancer Targets in the Glycolytic Metabolism of Tumors: A Comprehensive Review , 2011, Front. Pharmacol..
[79] Scott E. Kern,et al. Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis , 2011, Nature.
[80] S. Mazurek. Pyruvate kinase type M2: a key regulator of the metabolic budget system in tumor cells. , 2011, The international journal of biochemistry & cell biology.
[81] P. Mischel,et al. Combination therapy with vemurafenib (PLX4032/RG7204) and metformin in melanoma cell lines with distinct driver mutations , 2011, Journal of Translational Medicine.
[82] R. Klose,et al. The oncometabolite 2‐hydroxyglutarate inhibits histone lysine demethylases , 2011, EMBO reports.
[83] H. Grönberg,et al. Dietary supplement use patterns in men with prostate cancer: the Cancer Prostate Sweden study. , 2011, Annals of oncology : official journal of the European Society for Medical Oncology.
[84] D. Hanahan,et al. Hallmarks of Cancer: The Next Generation , 2011, Cell.
[85] T. Shibata,et al. Mutant IDH1 confers an in vivo growth in a melanoma cell line with BRAF mutation. , 2011, The American journal of pathology.
[86] Bin Wang,et al. Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases. , 2011, Cancer cell.
[87] J. O'Brien,et al. Mutations in GNA11 in uveal melanoma. , 2010, The New England journal of medicine.
[88] W. Wong,et al. Hypoxia-inducible factors and the response to hypoxic stress. , 2010, Molecular cell.
[89] C. Thompson,et al. Glutamine addiction: a new therapeutic target in cancer. , 2010, Trends in biochemical sciences.
[90] Alexander Roesch,et al. A Temporarily Distinct Subpopulation of Slow-Cycling Melanoma Cells Is Required for Continuous Tumor Growth , 2010, Cell.
[91] W. Wheaton,et al. Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity , 2010, Proceedings of the National Academy of Sciences.
[92] A. Bosserhoff,et al. Constitutive HIF-1 activity in malignant melanoma. , 2010, European journal of cancer.
[93] Derek Y. Chiang,et al. The landscape of somatic copy-number alteration across human cancers , 2010, Nature.
[94] R. Deberardinis,et al. Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer , 2010, Oncogene.
[95] V. Vacic,et al. Immune profile and mitotic index of metastatic melanoma lesions enhance clinical staging in predicting patient survival , 2009, Proceedings of the National Academy of Sciences.
[96] A. Colell,et al. Mitochondrial glutathione, a key survival antioxidant. , 2009, Antioxidants & redox signaling.
[97] Peng Huang,et al. Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach? , 2009, Nature Reviews Drug Discovery.
[98] Zhon-Yin Zhang. Faculty Opinions recommendation of Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha. , 2009 .
[99] Kun-Liang Guan,et al. Glioma-Derived Mutations in IDH1 Dominantly Inhibit IDH1 Catalytic Activity and Induce HIF-1α , 2009, Science.
[100] Irving L. Weissman,et al. Association of reactive oxygen species levels and radioresistance in cancer stem cells , 2009, Nature.
[101] R. DePinho,et al. BRafV600E cooperates with Pten silencing to elicit metastatic melanoma , 2009, Nature Genetics.
[102] J. Mackey,et al. Dichloroacetate (DCA) as a potential metabolic-targeting therapy for cancer , 2008, British Journal of Cancer.
[103] N. Denko,et al. Hypoxia, HIF1 and glucose metabolism in the solid tumour , 2008, Nature Reviews Cancer.
[104] Guido Kroemer,et al. Tumor cell metabolism: cancer's Achilles' heel. , 2008, Cancer cell.
[105] David D. Smith,et al. Detection of Copy Number Alterations in Metastatic Melanoma by a DNA Fluorescence In situ Hybridization Probe Panel and Array Comparative Genomic Hybridization: A Southwest Oncology Group Study (S9431) , 2008, Clinical Cancer Research.
[106] Ralph J Deberardinis,et al. Brick by brick: metabolism and tumor cell growth. , 2008, Current opinion in genetics & development.
[107] R. Deberardinis,et al. Beyond aerobic glycolysis: Transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis , 2007, Proceedings of the National Academy of Sciences.
[108] B. Spiegelman,et al. Skeletal Muscle Fiber-type Switching, Exercise Intolerance, and Myopathy in PGC-1α Muscle-specific Knock-out Animals* , 2007, Journal of Biological Chemistry.
[109] D. Guttridge. Faculty Opinions recommendation of Skeletal muscle fiber-type switching, exercise intolerance, and myopathy in PGC-1alpha muscle-specific knock-out animals. , 2007 .
[110] R. Sachidanandam,et al. Deficiency in glutamine but not glucose induces MYC-dependent apoptosis in human cells , 2007, The Journal of cell biology.
[111] Suzanne Schubbert,et al. Hyperactive Ras in developmental disorders and cancer , 2007, Nature Reviews Cancer.
[112] D. Fisher,et al. Melanocyte biology and skin pigmentation , 2007, Nature.
[113] Jiandie D. Lin,et al. Suppression of Reactive Oxygen Species and Neurodegeneration by the PGC-1 Transcriptional Coactivators , 2006, Cell.
[114] J. Herman,et al. Dysfunctional KEAP1–NRF2 Interaction in Non-Small-Cell Lung Cancer , 2006, PLoS medicine.
[115] M. Patel,et al. Regulation of the pyruvate dehydrogenase complex. , 2006, Biochemical Society transactions.
[116] Tsutomu Ohta,et al. Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer. , 2006, Molecular cell.
[117] N. Denko,et al. HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption. , 2006, Cell metabolism.
[118] G. Semenza,et al. HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia. , 2006, Cell metabolism.
[119] J. Shay,et al. BRAFE600-associated senescence-like cell cycle arrest of human naevi , 2005, Nature.
[120] T. Golub,et al. Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma , 2005, Nature.
[121] G. Catignani,et al. Antioxidants and Prevention of Chronic Disease , 2004, Critical reviews in food science and nutrition.
[122] M. Stratton,et al. The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website , 2004, British Journal of Cancer.
[123] M. Daly,et al. PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes , 2003, Nature Genetics.
[124] P. Puigserver,et al. Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulator. , 2003, Endocrine reviews.
[125] D. Theodorescu,et al. Cell density mediated pericellular hypoxia leads to induction of HIF-1α via nitric oxide and Ras/MAP kinase mediated signaling pathways , 2001, Oncogene.
[126] J. Utikal,et al. Extra c-myc oncogene copies in high risk cutaneous malignant melanoma and melanoma metastases , 2001, British Journal of Cancer.
[127] G. Semenza,et al. V-SRC induces expression of hypoxia-inducible factor 1 (HIF-1) and transcription of genes encoding vascular endothelial growth factor and enolase 1: involvement of HIF-1 in tumor progression. , 1997, Cancer research.
[128] J. Challem. Re: Risk factors for lung cancer and for intervention effects in CARET, the Beta-Carotene and Retinol Efficacy trial. , 1997, Journal of the National Cancer Institute.
[129] A. Giaccia,et al. Oncogenic transformation and hypoxia synergistically act to modulate vascular endothelial growth factor expression. , 1996, Cancer research.
[130] B. Ebert,et al. Hypoxic Regulation of Lactate Dehydrogenase A , 1995, The Journal of Biological Chemistry.
[131] H. Lodish,et al. Elevated levels of glucose transport and transporter messenger RNA are induced by ras or src oncogenes. , 1987, Science.
[132] M. Harris. Pyruvate blocks expression of sensitivity to antimycin A and chloramphenicol , 1980, Somatic cell genetics.
[133] M. Roizen,et al. Hallmarks of Cancer: The Next Generation , 2012 .
[134] 이연수. Functional genomics reveal that the serine synthesis pathway is essential in breast cancer , 2011 .
[135] D. Albanes,et al. The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. , 1994, The New England journal of medicine.
[136] S. Weinhouse. On respiratory impairment in cancer cells. , 1956, Science.
[137] Sozen,et al. Mutations in GNA 11 in Uveal Melanoma , 2022 .