Combined Immunodeficiency Rag1/2 Knockout Pigs with Severe

[1]  D. Merlin,et al.  Nanoparticles with surface antibody against CD98 and carrying CD98 small interfering RNA reduce colitis in mice. , 2014, Gastroenterology.

[2]  E. Cozzi,et al.  Immunological challenges and therapies in xenotransplantation. , 2014, Cold Spring Harbor perspectives in medicine.

[3]  W. Tian,et al.  Generation of knockout rabbits using transcription activator-like effector nucleases , 2014, Cell Regeneration.

[4]  L. Lai,et al.  Highly Efficient Generation of GGTA1 Biallelic Knockout Inbred Mini-Pigs with TALENs , 2013, PloS one.

[5]  Peng Li,et al.  Generation of RAG 1- and 2-deficient rabbits by embryo microinjection of TALENs , 2013, Cell Research.

[6]  Huimin Zhao,et al.  Transcription activator‐like effector nucleases (TALENs): A highly efficient and versatile tool for genome editing , 2013, Biotechnology and bioengineering.

[7]  Daniel R. Richards,et al.  Genomic responses in mouse models poorly mimic human inflammatory diseases , 2013, Proceedings of the National Academy of Sciences.

[8]  Ignacio Anegon,et al.  Generation of Rag1‐knockout immunodeficient rats and mice using engineered meganucleases , 2013, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[9]  D. Voytas,et al.  Efficient TALEN-mediated gene knockout in livestock , 2012, Proceedings of the National Academy of Sciences.

[10]  Y. Kashiwakura,et al.  Il2rg gene-targeted severe combined immunodeficiency pigs. , 2012, Cell stem cell.

[11]  Ya-Jen Chang,et al.  Innate lymphoid cells mediate influenza-induced airway hyper-reactivity independently of adaptive immunity , 2011, Nature Immunology.

[12]  Erin L. Doyle,et al.  Efficient design and assembly of custom TALEN and other TAL effector-based constructs for DNA targeting , 2011, Nucleic acids research.

[13]  Kyle A. Barlow,et al.  A TALE nuclease architecture for efficient genome editing , 2011, Nature Biotechnology.

[14]  I. Weissman,et al.  T-cell receptor-driven lymphomagenesis in mice derived from a reprogrammed T cell , 2010, Proceedings of the National Academy of Sciences.

[15]  R. Buckley,et al.  Why Newborn Screening for Severe Combined Immunodeficiency Is Essential: A Case Report , 2010, Pediatrics.

[16]  Shihua Li,et al.  Expression of Huntington's disease protein results in apoptotic neurons in the brains of cloned transgenic pigs. , 2010, Human molecular genetics.

[17]  J. Leigh,et al.  Early, microbially driven follicular reactions in the neonatal piglet do not contribute to expansion of the immunoglobulin heavy chain V-D-J repertoire. , 2007, Veterinary immunology and immunopathology.

[18]  Markus G. Manz,et al.  Development of a Human Adaptive Immune System in Cord Blood Cell-Transplanted Mice , 2004, Science.

[19]  C. Hughes,et al.  Of Mice and Not Men: Differences between Mouse and Human Immunology , 2004, The Journal of Immunology.

[20]  A. Fischer,et al.  The mechanisms of immune diversification and their disorders , 2003, Nature Reviews Immunology.

[21]  R. Flavell,et al.  Immune-Mediated Eradication of Tumors through the Blockade of Transforming Growth Factor-beta Signaling in T Cells , 2002 .

[22]  Sandro Santagata,et al.  Partial V(D)J Recombination Activity Leads to Omenn Syndrome , 1998, Cell.

[23]  U. Pannicke,et al.  RAG Mutations in Human B Cell-Negative SCID , 1996, Science.

[24]  Christina A. Cuomo,et al.  Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps , 1995, Cell.

[25]  V. Stewart,et al.  RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement , 1992, Cell.

[26]  Susumu Tonegawa,et al.  RAG-1-deficient mice have no mature B and T lymphocytes , 1992, Cell.

[27]  D. Schatz,et al.  RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination. , 1990, Science.

[28]  E. Brooks,et al.  V(D)J recombination defects in lymphocytes due to RAG mutations: severe immunodeficiency with a spectrum of clinical presentations. , 2001, Blood.