论文信息 - A novel urocanic acid derivative from skin tissue extracts; (E)-3-[1-(1,1-dimethyl-3-oxobutyl)imidazol-4-yl]propenoic acid

A novel urocanic acid derivative from skin tissue extracts; (E)-3-[1-(1,1-dimethyl-3-oxobutyl)imidazol-4-yl]propenoic acid

A novel derivative of urocanic acid (1) had been isolated from acetone extracts of rabbit skin tissue. It proved to be (E)-3-[1-(1,1-dimethyl-3-oxobutyl)imidazol-4-yl]propenoic acid (3c), potentially a much better ultraviolet screening agent than urocanic acid. Sterical effect of dimethyl groups in the side chain adjacent to the imidazole ring of 3c on its solubility is also discussed.

Toshio Yamada | K. Ienaga | A. Yamamoto | Y. Joh

[1] T. Goto,et al. Bioactive compounds produced in animal tissues (I); two diketopiperadine plant growth regulators containing hydroxyproline isolated from rabbit skin tissue extract , 1987 .

[2] T. Goto,et al. Bioactive compounds produced in animal tissues. II: Two hydantoin plant growth regulators isolated from inflamed rabbit skin tissue , 1987 .

[3] J. Macleod,et al. The synthesis of the isomeric N-methyl derivatives of murexine , 1981 .

[4] Y. Kohama,et al. [Studies on biologically active substances from rabbit skin tissues infected with vaccinia virus.--Isolation and properties of inhibitor to gastric acid secretion (author's transl)]. , 1976, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.