论文信息 - Inhibition of Vertebrate Telomerases by the Triphosphate Derivatives of Some Biologically Active Nucleosides

Inhibition of Vertebrate Telomerases by the Triphosphate Derivatives of Some Biologically Active Nucleosides

Abstract In order to clarify the effect of the base moiety of nucleotide analogs on telomerase inhibition, triphosphate derivatives of biologically active nucleosides, 3′-azido-3′-deoxythymidine (AZT), 2′-deoxy-2′-fluoroarafuranosylthymine (FaraT), acycloguanosine (ACG) and their guanine or thymine counterparts (AZdG, FaraG and ACT, respectively) were investigated. In all of the present cases, guanine derivatives showed more potent inhibition than their thymine counterparts.

Hazuki Takahashi | M. Saneyoshi | Toyofumi Yamaguchi | Yuko Takayama | Hiroshi Jinmei

[1] F. Ishikawa,et al. Recognition of 2'-deoxy-l-ribonucleoside 5'-triphosphates by human telomerase. , 2000, Biochemical and biophysical research communications.

[2] J. Montgomery,et al. 9-(2-Deoxy-2-fluoro-beta-D-arabinofuranosyl)guanine: a metabolically stable cytotoxic analogue of 2'-deoxyguanosine. , 1986, Journal of medicinal chemistry.

[3] F. Eckstein,et al. SYNTHESIS OF 3′‐AZIDO‐2′,3′‐DIDEOXYRIBOFURANOSYLPURINES , 1978 .