Zinc oxide–engineered nanoparticles: Dissolution and toxicity to marine phytoplankton

It is now widely recognized that dissolution plays an important role in metallic nanoparticle toxicity, but to what extent remains unclear. In the present study, it was found that ZnO-engineered nanoparticle (ZnO-EN) toxicity to the marine diatom Thalassiosira pseudonana could be solely explained by zinc ion (Zn(2+) ) release. This is based on comparable inhibitive effects from ZnO-EN addition media, with or without the ultrafiltration through a 3-kD membrane, and from the media in which only Zn(2+) was added. Considering the importance of dissolution in ZnO-EN toxicity, Zn(2+) release kinetics was systematically examined under different conditions for the first time. It was found to be mainly influenced by pH as well as the specific surface area of the nanoparticles. In contrast, natural organic compounds either enhance or reduce Zn(2+) release, depending on their chemical composition and concentration. Compared with deionized water, ZnO-EN dissolution rates were accelerated in seawater, whereas ZnO-EN concentration itself only had a very small effect on Zn(2+) release. Therefore, dissolution as affected by several physicochemical factors should not be neglected in the effects, behavior, and fate of ENs in the environment.

[1]  T. Xia,et al.  Toxic Potential of Materials at the Nanolevel , 2006, Science.

[2]  U. Azeiteiro,et al.  Differences in the Effects of Metals on Growth of Two Freshwater Green Algae (Pseudokirchneriella subcapitata (Korshikov) Hindak and Gonium pectorale Müller) , 2005, Bulletin of environmental contamination and toxicology.

[3]  Robert Landsiedel,et al.  Acute and chronic effects of nano- and non-nano-scale TiO(2) and ZnO particles on mobility and reproduction of the freshwater invertebrate Daphnia magna. , 2009, Chemosphere.

[4]  Nathalie Tufenkji,et al.  Characterizing manufactured nanoparticles in the environment: multimethod determination of particle sizes. , 2009, Environmental science & technology.

[5]  Xuezhi Zhang,et al.  The impact of ZnO nanoparticle aggregates on the embryonic development of zebrafish (Danio rerio) , 2009, Nanotechnology.

[6]  R. Lim,et al.  Toxicity of metal mixtures to a tropical freshwater alga (Chlorella sp.): The effect of interactions between copper, cadmium, and zinc on metal cell binding and uptake , 2002, Environmental toxicology and chemistry.

[7]  Jae-Hong Kim,et al.  Natural organic matter stabilizes carbon nanotubes in the aqueous phase. , 2007, Environmental science & technology.

[8]  R. Guillard,et al.  Studies of marine planktonic diatoms. I. Cyclotella nana Hustedt, and Detonula confervacea (cleve) Gran. , 1962, Canadian journal of microbiology.

[9]  Enrique Navarro,et al.  Toxicity of silver nanoparticles to Chlamydomonas reinhardtii. , 2008, Environmental science & technology.

[10]  J. Reinfelder,et al.  Metabolic responses to subacute toxicity of trace metals in a marine microalga (Thalassiosira weissflogii) measured by calorespirometry , 2000 .

[11]  Zhiping Luo,et al.  The algal toxicity of silver engineered nanoparticles and detoxification by exopolymeric substances. , 2009, Environmental pollution.

[12]  Fredd,et al.  The Influence of Chelating Agents on the Kinetics of Calcite Dissolution. , 1998, Journal of colloid and interface science.

[13]  Robert N Grass,et al.  Exposure of engineered nanoparticles to human lung epithelial cells: influence of chemical composition and catalytic activity on oxidative stress. , 2007, Environmental science & technology.

[14]  F. Hofer,et al.  Löslichkeitsprodukte von Metalloxiden und ‐hydroxiden. 10. Mitteilung. Löslichkeitsprodukte von Zinkoxid, Kupferhydroxid und Kupferoxid in Abhängigkeit von Teilchengrösse und molarer Oberfläche. Ein Beitrag zur Thermodynamik von Grenzflächen fest‐flüssig , 1965 .

[15]  Kun Yang,et al.  Interactions of humic acid with nanosized inorganic oxides. , 2009, Langmuir : the ACS journal of surfaces and colloids.

[16]  M. Kosec,et al.  Effect of pH and impurities on the surface charge of zinc oxide in aqueous solution , 2000 .

[17]  Jamie R Lead,et al.  Nanomaterials in the environment: Behavior, fate, bioavailability, and effects , 2008, Environmental toxicology and chemistry.

[18]  P. Juneau,et al.  Comparison of Cd, Cu, and Zn toxic effects on four marine phytoplankton by pulse‐amplitude‐modulated fluorometry , 2005, Environmental toxicology and chemistry.

[19]  Baoshan Xing,et al.  Root uptake and phytotoxicity of ZnO nanoparticles. , 2008, Environmental science & technology.

[20]  G. E. Gadd,et al.  Comparative toxicity of nanoparticulate ZnO, bulk ZnO, and ZnCl2 to a freshwater microalga (Pseudokirchneriella subcapitata): the importance of particle solubility. , 2007, Environmental science & technology.

[21]  Bin Xie,et al.  Impact of natural organic matter on the physicochemical properties of aqueous C60 nanoparticles. , 2008, Environmental science & technology.

[22]  Benjamin Gilbert,et al.  Comparison of the mechanism of toxicity of zinc oxide and cerium oxide nanoparticles based on dissolution and oxidative stress properties. , 2008, ACS nano.

[23]  E. Matijević,et al.  Interactions of metal hydrous oxides with chelating agents: VIII. Dissolution of hematite , 1989 .

[24]  Karluss Thomas,et al.  Research strategies for safety evaluation of nanomaterials, part V: role of dissolution in biological fate and effects of nanoscale particles. , 2006, Toxicological sciences : an official journal of the Society of Toxicology.

[25]  P. Campbel.  Interactions between trace metals and aquatic organisms : A critique of the Free-ion Activity Model , 1995 .

[26]  Anne J Anderson,et al.  Antimicrobial activities of commercial nanoparticles against an environmental soil microbe, Pseudomonas putida KT2440 , 2009, Journal of biological engineering.

[27]  C. Hung,et al.  The distribution of biogenic thiols in surface waters of Galveston Bay , 2000 .

[28]  W. Sunda,et al.  Feedback interactions between zinc and phytoplankton in seawater , 1992 .

[29]  M. Orellana,et al.  Spontaneous assembly of marine dissolved organic matter into polymer gels , 1998, Nature.

[30]  Pedro J J Alvarez,et al.  Comparative eco-toxicity of nanoscale TiO2, SiO2, and ZnO water suspensions. , 2006, Water research.

[31]  Serge Stoll,et al.  A Generalized Description of Aquatic Colloidal Interactions: The Three-colloidal Component Approach , 1998 .

[32]  P. Santschi,et al.  Distribution and partitioning of trace metals (Cd, Cu, Ni, Pb, Zn) in Galveston Bay waters , 2002 .

[33]  G. Oberdörster,et al.  Nanotoxicology: An Emerging Discipline Evolving from Studies of Ultrafine Particles , 2005, Environmental health perspectives.

[34]  K. Knauer,et al.  Effects of free Cu2+ and Zn2+ ions on growth and metal accumulation in freshwater algae , 1997 .

[35]  W. Feitknecht,et al.  Löslichkeitsprodukte von Metalloxiden und ‐hydroxiden. 9. Mitteilung. Löslichkeitsprodukte und Freie Bildungsenthalpien von Zinkoxid, amorphem Zinkhydroxid, β11‐,β2‐, γ‐, δ‐ und ϵ‐Zinkhydroxid , 1964 .

[36]  K. Kasemets,et al.  Toxicity of nanoparticles of CuO, ZnO and TiO2 to microalgae Pseudokirchneriella subcapitata. , 2009, The Science of the total environment.

[37]  S. Manahan,et al.  Kinetics of the reactions of EDTA and coal humic acid with CuO , 1977 .

[38]  Wei Jiang,et al.  Bacterial toxicity comparison between nano- and micro-scaled oxide particles. , 2009, Environmental pollution.

[39]  S. Bhatia,et al.  Probing the Cytotoxicity Of Semiconductor Quantum Dots. , 2004, Nano letters.

[40]  Hua Chang.  Interactions of metal hydrous oxides with chelating agents *1IV. Dissolution of hematite , 1983 .