论文信息 - Genomics: Massively parallel sequencing

Genomics: Massively parallel sequencing

A sequencing system has been developed that can read 25 million bases of genetic code — the entire genome of some fungi — within four hours. The technique may provide an alternative approach to DNA sequencing.Speed sequencingThe race is on for a big prize: the job of providing the world's DNA sequencing laboratories with the successor to the ‘Sanger-based’ technology that gave us the first wave of genome sequences. One technology in the frame is that produced by 454 Life Sciences Corporation of Branford, Connecticut. Today's technology reads 67,000 base pairs per hour; this new approach is 100 times faster, reading 6 million base pairs per hour. The improved performance results from using picolitre-sized chemical reactors, enhanced light-emitting sequencing chemistries and complex informatics. Further miniaturization of the system is planned. Such leaps in technology may one day make it possible to analyse an individual's genome before designing therapy: the ultimate in personalized medicine.

Y. Rogers | J. Venter | J. Venter | Yu-Hui Rogers | J. Craig Venter

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