The Time Course of Signaling at Central Glutamatergic Synapses.

Glutamate is the main excitatory transmitter in the mammalian CNS, mediating fast synaptic transmission primarily by activation of AMPA-type glutamate receptor channels. Both synaptic structure and a cell-specific molecular switch in the AMPA receptor subunit expression are involved in the regulation of the synaptic signaling time course.

[1]  D. Brutsaert,et al.  Influence of loading patterns on peak length-tension relation and on relaxation in cardiac muscle. , 1989, Journal of the American College of Cardiology.

[2]  L. Trussell,et al.  Delayed clearance of transmitter and the role of glutamate transporters at synapses with multiple release sites , 1996, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[3]  B. Sakmann,et al.  Quantal components of unitary EPSCs at the mossy fibre synapse on CA3 pyramidal cells of rat hippocampus. , 1993, The Journal of physiology.

[4]  B. Walmsley,et al.  Counting quanta: Direct measurements of transmitter release at a central synapse , 1995, Neuron.

[5]  Jeffrey S. Diamond,et al.  Asynchronous release of synaptic vesicles determines the time course of the AMPA receptor-mediated EPSC , 1995, Neuron.

[6]  L. Trussell,et al.  Desensitization of AMPA receptors upon multiquantal neurotransmitter release , 1993, Neuron.

[7]  E L Yellin,et al.  Left ventricular filling dynamics and diastolic function. , 1990, Progress in cardiovascular diseases.

[8]  H. Monyer,et al.  A molecular determinant for submillisecond desensitization in glutamate receptors. , 1994, Science.

[9]  B. Sakmann,et al.  Relative abundance of subunit mRNAs determines gating and Ca2+ permeability of AMPA receptors in principal neurons and interneurons in rat CNS , 1995, Neuron.

[10]  D. Chemla,et al.  Major alterations in relaxation during cardiac hypertrophy induced by aortic stenosis in guinea pig. , 1987, Circulation research.

[11]  Shaul Hestrin,et al.  Different glutamate receptor channels mediate fast excitatory synaptic currents in inhibitory and excitatory cortical neurons , 1993, Neuron.

[12]  C. Jahr,et al.  Transporters Buffer Synaptically Released Glutamate on a Submillisecond Time Scale , 1997, The Journal of Neuroscience.

[13]  D. Chemla,et al.  Relaxant effects of isoproterenol in isolated cardiac muscle: influence of loading patterns. , 1994, The American journal of physiology.

[14]  B. Sakmann,et al.  Pre‐ and postsynaptic whole‐cell recordings in the medial nucleus of the trapezoid body of the rat. , 1995, The Journal of physiology.

[15]  M. Mayer,et al.  Cyclothiazide differentially modulates desensitization of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor splice variants. , 1994, Molecular pharmacology.

[16]  W. Gaasch,et al.  Mechanical loads and the isovolumic and filling indices of left ventricular relaxation. , 1990, Progress in cardiovascular diseases.

[17]  B. Sakmann,et al.  Action of brief pulses of glutamate on AMPA/kainate receptors in patches from different neurones of rat hippocampal slices. , 1992, The Journal of physiology.

[18]  Arnd Roth,et al.  Submillisecond AMPA Receptor-Mediated Signaling at a Principal Neuron–Interneuron Synapse , 1997, Neuron.

[19]  P. Jonas,et al.  Ionotropic Glutamate Receptors in the CNS , 1999, Handbook of Experimental Pharmacology.

[20]  R. Wenthold,et al.  Glutamate Receptors Are Selectively Targeted to Postsynaptic Sites in Neurons , 1997, Neuron.

[21]  R. Bonow,et al.  Minimum left ventricular pressure during beta-adrenergic stimulation in human subjects. Evidence for elastic recoil and diastolic "suction" in the normal heart. , 1990, Circulation.