Two cases of gingival hyperplasia induced by administration of nifedipine and/or cyclosporine

Two cases of gingival hyperplasia induced by nifedipine and both nifedipine and cyclosporine were presented. In a 46 year old woman, gingival hyperplasia developed 1 year and 1 month after nifedipine administration. Gingival hyperplasia covered lower 1/3 of dental crown and was not seen in the edentulous portion. In a 47 year old man, gingival hyperplasia had not been observed during 4 years after nifedipine administration. It occurred 1 year and 4 months after administration of both nifedipine and cyclosporine due to renal transplantation. Additive effects of nifedipine and cyclosporine were considered in the latter case. Reported cases of gingival hyperplasia induced by nifedipine and/or cyclosporine were reviewed. First choice of treatment is change of drugs and plaque control and then gingivectomy should be chosen, if no improvement is found after a few months' observation.

[1]  D. B. Gower,et al.  Androgen metabolism in gingival hyperplasia induced by nifedipine and cyclosporin. , 1990, Journal of periodontal research.

[2]  J. L. López Colomés,et al.  [Gingival hyperplasia associated with nifedipine]. , 1989, Revista clinica espanola.

[3]  S. Menni,et al.  Severe Cingival Hyperplasia Following Cyclosporin and Ketoconazole Therapy , 1988, International journal of dermatology.

[4]  I Kaplan,et al.  The CO2 laser in the excision of gingival hyperplasia caused by nifedipine. , 1988, Journal of clinical periodontology.

[5]  W. Z. Yusof.  Gingival hyperplasia: an intra-oral side effect of phenytoin, nifedipine and cyclosporine therapies. , 1988, Singapore medical journal.

[6]  J. Weddell,et al.  Incidence and indications for surgical management of phenytoin-induced gingival overgrowth in a cerebral palsy population. , 1988, Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons.

[7]  W. Qunibi,et al.  Kaposi's sarcoma in cyclosporine-induced gingival hyperplasia. , 1988, American journal of kidney diseases : the official journal of the National Kidney Foundation.

[8]  P. G. Raman,et al.  Nifedipine induced gingival hyperplasia. , 1988, The Journal of the Association of Physicians of India.

[9]  P. Bartold.  Cyclosporine and gingival overgrowth. , 1987, Journal of oral pathology.

[10]  J. Taylor,et al.  CYCLOSPORIN, NIFEDIPINE, AND GINGIVAL HYPERPLASIA , 1987, The Lancet.

[11]  J. Hiss,et al.  Gingival Hyperplasia Caused by Nifedipine , 1987 .

[12]  T. McGaw,et al.  Cyclosporin-induced gingival overgrowth: correlation with dental plaque scores, gingivitis scores, and cyclosporin levels in serum and saliva. , 1987, Oral surgery, oral medicine, and oral pathology.

[13]  N. Savage,et al.  Cyclosporin-A-induced gingival enlargement. A case report. , 1987, Journal of periodontology.

[14]  B. Rodu,et al.  New developments in understanding phenytoin-induced gingival hyperplasia. , 1987, Journal of the American Dental Association.

[15]  J. Collins,et al.  Phenytoin-induced gingival hyperplasia of edentulous spaces: a case report. , 1987, Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry.

[16]  J. Hiss,et al.  Gingival hyperplasia caused by nifedipine. Histopathologic findings. , 1987, Journal of periodontology.

[17]  K. Kalkwarf,et al.  Drug-induced gingival hyperplasia: phenytoin, cyclosporine, and nifedipine. , 1987, Journal of the American Dental Association.

[18]  D. B. Tuinzing,et al.  Gingival hyperplasia induced by nifedipine, an arterial vasodilating drug. , 1985, Oral surgery, oral medicine, and oral pathology.

[19]  P. Bencini,et al.  Gingival hyperplasia by nifedipine. Report of a case. , 1985, Acta dermato-venereologica.

[20]  T. Daley,et al.  Cyclosporine therapy. Its significance to the periodontist. , 1984, Journal of periodontology.

[21]  H. Lumerman,et al.  Gingival hyperplasia associated with nifedipine therapy. Report of a case. , 1984, Oral surgery, oral medicine, and oral pathology.

[22]  S. Behar,et al.  Gingival hyperplasia caused by nifedipine--a preliminary report. , 1984, International journal of cardiology.

[23]  T. Hassell,et al.  Phenytoin sensitivity of fibroblasts as the basis for susceptibility to gingival enlargement. , 1983, The American journal of pathology.

[24]  A. Hefti,et al.  Initial observation that cyclosporin-A induces gingival enlargement in man. , 1983, Journal of clinical periodontology.

[25]  J. McElnay,et al.  Risk factors in phenytoin-induced gingival hyperplasia. , 1983, Journal of periodontology.

[26]  A. Laupacis,et al.  Fibrous hyperplasia of the gingiva: a side effect of cyclosporin A therapy. , 1983, Oral surgery, oral medicine, and oral pathology.

[27]  T. Hassell.  Epilepsy and the oral manifestations of phenytoin therapy. , 1981, Monographs in oral science.

[28]  D. Dunn,et al.  CYCLOSPORIN A INITIALLY AS THE ONLY IMMUNOSUPPRESSANT IN 34 RECIPIENTS OF CADAVERIC ORGANS: 32 KIDNEYS, 2 PANCREASES, AND 2 LIVERS , 1979, The Lancet.

[29]  R. Coope,et al.  TREATMENT OF EPILEPSY WITH SODIUM DIPHENYL HYDANTOINATE , 1940 .