Neolignans from leaves of Nectandra leucantha (Lauraceae) display in vitro antitrypanosomal activity via plasma membrane and mitochondrial damages
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P. Sartorelli | T. Costa-Silva | J. Lago | F. Sousa | C. Andrade | C. Tcacenco | S. Grecco | A. Tempone
[1] R. Azevedo,et al. Neolignans isolated from Nectandra leucantha induce apoptosis in melanoma cells by disturbance in mitochondrial integrity and redox homeostasis. , 2017, Phytochemistry.
[2] C. Andrade,et al. Antitrypanosomal activity and evaluation of the mechanism of action of dehydrodieugenol isolated from Nectandra leucantha (Lauraceae) and its methylated derivative against Trypanosoma cruzi. , 2017, Phytomedicine : international journal of phytotherapy and phytopharmacology.
[3] D. Arcanjo,et al. In Vitro Effects of the Neolignan 2,3‐Dihydrobenzofuran Against Leishmania Amazonensis , 2017, Basic & clinical pharmacology & toxicology.
[4] C. Nakamura,et al. 1,3,4-Thiadiazole derivatives of R-(+)-limonene benzaldehyde-thiosemicarbazones cause death in Trypanosoma cruzi through oxidative stress. , 2016, Microbes and infection.
[5] L. Overman,et al. Analogues of Marine Guanidine Alkaloids Are in Vitro Effective against Trypanosoma cruzi and Selectively Eliminate Leishmania (L.) infantum Intracellular Amastigotes. , 2016, Journal of natural products.
[6] C. Arruda,et al. Antileishmanial Activity and Structure-Activity Relationship of Triazolic Compounds Derived from the Neolignans Grandisin, Veraguensin, and Machilin G , 2016, Molecules.
[7] J. Irwin,et al. An Aggregation Advisor for Ligand Discovery. , 2015, Journal of medicinal chemistry.
[8] Alexander Tropsha,et al. Pred‐hERG: A Novel web‐Accessible Computational Tool for Predicting Cardiac Toxicity , 2015, Molecular informatics.
[9] C. Nakamura,et al. Mitochondrial Dysfunction Induced by N-Butyl-1-(4-Dimethylamino)Phenyl-1,2,3,4-Tetrahydro-β-Carboline-3-Carboxamide Is Required for Cell Death of Trypanosoma cruzi , 2015, PloS one.
[10] A. Satoskar,et al. Immunomodulatory and Antileishmanial Activity of Phenylpropanoid Dimers Isolated from Nectandra leucantha. , 2015, Journal of natural products.
[11] F. Cicora,et al. Cerebral trypanosomiasis in a renal transplant recipient , 2014, Transplant infectious disease : an official journal of the Transplantation Society.
[12] J. Baell,et al. Chemistry: Chemical con artists foil drug discovery , 2014, Nature.
[13] C. Andrade,et al. In silico prediction of drug metabolism by P450. , 2014, Current drug metabolism.
[14] Alexander Tropsha,et al. Tuning HERG out: antitarget QSAR models for drug development. , 2014, Current topics in medicinal chemistry.
[15] Mathias Dunkel,et al. ProTox: a web server for the in silico prediction of rodent oral toxicity , 2014, Nucleic Acids Res..
[16] A. Tempone,et al. Antimicrobial peptides isolated from Phyllomedusa nordestina (Amphibia) alter the permeability of plasma membrane of Leishmania and Trypanosoma cruzi. , 2013, Experimental parasitology.
[17] Márcia R. Oliveira,et al. Neolignan Licarin A presents effect against Leishmania (Leishmania) major associated with immunomodulation in vitro. , 2013, Experimental parasitology.
[18] Sereina Riniker,et al. Open-source platform to benchmark fingerprints for ligand-based virtual screening , 2013, Journal of Cheminformatics.
[19] W. Cunha,et al. Evaluation of the in vivo therapeutic properties of (-)-cubebin and (-)-hinokinin against Trypanosoma cruzi. , 2013, Experimental parasitology.
[20] Jie Shen,et al. admetSAR: A Comprehensive Source and Free Tool for Assessment of Chemical ADMET Properties , 2012, J. Chem. Inf. Model..
[21] C. Nakamura,et al. Trypanocidal action of eupomatenoid-5 is related to mitochondrion dysfunction and oxidative damage in Trypanosoma cruzi. , 2011, Microbes and infection.
[22] Rajarshi Guha,et al. KNIME Workflow to Assess PAINS Filters in SMARTS Format. Comparison of RDKit and Indigo Cheminformatics Libraries , 2011, Molecular informatics.
[23] Tudor I. Oprea,et al. A novel approach for predicting P-glycoprotein (ABCB1) inhibition using molecular interaction fields. , 2011, Journal of medicinal chemistry.
[24] S. Perry,et al. Mitochondrial membrane potential probes and the proton gradient: a practical usage guide. , 2011, BioTechniques.
[25] David Rogers,et al. Extended-Connectivity Fingerprints , 2010, J. Chem. Inf. Model..
[26] A. Tempone,et al. Antitrypanosomal activity of a diterpene and lignans isolated from Aristolochia cymbifera. , 2010, Planta medica.
[27] J. Baell,et al. New substructure filters for removal of pan assay interference compounds (PAINS) from screening libraries and for their exclusion in bioassays. , 2010, Journal of medicinal chemistry.
[28] L. Rivas,et al. Characterization of the leishmanicidal activity of antimicrobial peptides. , 2010, Methods in molecular biology.
[29] Klaus-Robert Müller,et al. Benchmark Data Set for in Silico Prediction of Ames Mutagenicity , 2009, J. Chem. Inf. Model..
[30] Wei Xie,et al. Computer-Aided Prediction of Rodent Carcinogenicity by PASS and CISOC-PSCT , 2009 .
[31] F. Stintzing,et al. Comparative in vitro study on the anti-herpetic effect of phytochemically characterized aqueous and ethanolic extracts of Salvia officinalis grown at two different locations. , 2008, Phytomedicine : international journal of phytotherapy and phytopharmacology.
[32] V. Yardley,et al. Antitrypanosomal and Antileishmanial Activities of Flavonoids and Their Analogues: In Vitro, In Vivo, Structure-Activity Relationship, and Quantitative Structure-Activity Relationship Studies , 2006, Antimicrobial Agents and Chemotherapy.
[33] H. van de Waterbeemd,et al. ADMET in silico modelling: towards prediction paradise? , 2003, Nature reviews. Drug discovery.
[34] H. Vial,et al. Phospholipids in parasitic protozoa. , 2003, Molecular and biochemical parasitology.
[35] D. Ellis. Amphotericin B: spectrum and resistance. , 2002, The Journal of antimicrobial chemotherapy.
[36] A. D. F. Dias. An improved high yield synthesis of dehydrodieugenol , 1988 .
[37] H. Achenbach,et al. Dehydrodieugenols from Nectandra polita , 1983 .
[38] H. Gottlieb,et al. Dehydrodieugenols from Ocotea cymbarum , 1980 .
[39] H. L. Morgan. The Generation of a Unique Machine Description for Chemical Structures-A Technique Developed at Chemical Abstracts Service. , 1965 .