Regulation of p53 by Hypoxia: Dissociation of Transcriptional Repression and Apoptosis from p53-Dependent Transactivation
暂无分享,去创建一个
Yoichi Taya | Scott W. Lowe | S. Lowe | P. Sutphin | M. Kastan | M. Murphy | W. Hoffman | Y. Taya | C. Koumenis | Constantinos Koumenis | R. Alarcon | E. Hammond | J. Derr | A. Giaccia | Patrick Sutphin | Maureen Murphy | Rodolfo Alarcon | Ester Hammond | William Hoffman | Jennifer Derr | Michael Kastan | Amato Giaccia | Ester M Hammond | William H. Hoffman
[1] A. Giaccia,et al. Hypoxia induces p53 accumulation through MDM2 down-regulation and inhibition of E6-mediated degradation. , 1999, Cancer research.
[2] L. Bracco,et al. The requirement for the p53 proline‐rich functional domain for mediation of apoptosis is correlated with specific PIG3 gene transactivation and with transcriptional repression , 1998, The EMBO journal.
[3] A. Giaccia,et al. The unique physiology of solid tumors: opportunities (and problems) for cancer therapy. , 1998, Cancer research.
[4] P Vaupel,et al. Intratumoral pO2 predicts survival in advanced cancer of the uterine cervix. , 1993, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.
[5] K. Sakaguchi,et al. DNA damage activates p53 through a phosphorylation-acetylation cascade. , 1998, Genes & development.
[6] M. Karin,et al. p53-Dependent apoptosis in the absence of transcriptional activation of p53-target genes , 1994, Nature.
[7] L. Donehower,et al. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours , 1992, Nature.
[8] Stephen N. Jones,et al. Regulation of p53 stability by Mdm2 , 1997, Nature.
[9] John Calvin Reed,et al. Tumor suppressor p53 is a direct transcriptional activator of the human bax gene , 1995, Cell.
[10] N. Hay,et al. Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21waf1/cip1. , 1994, Genes & development.
[11] C. Harris,et al. The XPB and XPD DNA helicases are components of the p53-mediated apoptosis pathway. , 1996, Genes & development.
[12] D. Livingston,et al. Binding and modulation of p53 by p300/CBP coactivators , 1997, Nature.
[13] D. Meek,et al. Multisite phosphorylation and the integration of stress signals at p53. , 1998, Cellular signalling.
[14] M. Yoshida,et al. Selective Induction of Cyclin‐Dependent Kinase Inhibitors and Their Roles in Cell Cycle Arrest Caused by Trichostatin A, an Inhibitor of Histone Deacetylase , 1999, Annals of the New York Academy of Sciences.
[15] E. Shaulian,et al. Induction of apoptosis in HeLa cells by trans-activation-deficient p53. , 1995, Genes & development.
[16] P. Olive,et al. The comet assay: a comprehensive review. , 1995, Mutation research.
[17] David E. Housman,et al. Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours , 1996, Nature.
[18] Y Taya,et al. DNA damage induces phosphorylation of the amino terminus of p53. , 1997, Genes & development.
[19] T. Unger,et al. Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2 , 1999, The EMBO journal.
[20] K. Gardner,et al. Recruitment of p300/CBP in p53-Dependent Signal Pathways , 1997, Cell.
[21] T. Graeber,et al. Hypoxia induces accumulation of p53 protein, but activation of a G1-phase checkpoint by low-oxygen conditions is independent of p53 status , 1994, Molecular and cellular biology.
[22] S. Schreiber,et al. A role for histone deacetylase activity in HDAC1-mediated transcriptional repression. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[23] C. Prives. Signaling to p53 Breaking the MDM2–p53 Circuit , 1998, Cell.
[24] Yoichi Taya,et al. DNA Damage-Induced Phosphorylation of p53 Alleviates Inhibition by MDM2 , 1997, Cell.
[25] Y Taya,et al. Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. , 1998, Science.
[26] G. Prendergast,et al. The polyproline region of p53 is required to activate apoptosis but not growth arrest , 1997, Oncogene.
[27] E. White,et al. Modulation of p53-mediated transcriptional repression and apoptosis by the adenovirus E1B 19K protein , 1995, Molecular and cellular biology.
[28] B. Vogelstein,et al. A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia , 1992, Cell.
[29] C. Harris,et al. Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis. , 1994, Cancer research.
[30] M. Yoshida,et al. Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A. , 1990, Journal of Biological Chemistry.
[31] K. Kinzler,et al. A model for p53-induced apoptosis , 1997, Nature.
[32] S. Lowe,et al. Apaf-1 and caspase-9 in p53-dependent apoptosis and tumor inhibition. , 1999, Science.
[33] M. Oren,et al. Mdm2 promotes the rapid degradation of p53 , 1997, Nature.
[34] J. Trent,et al. WAF1, a potential mediator of p53 tumor suppression , 1993, Cell.
[35] P. Baeuerle,et al. Hypoxia Induces c-fos Transcription via a Mitogen-activated Protein Kinase-dependent Pathway* , 1997, The Journal of Biological Chemistry.
[36] K. Vousden,et al. Characterization of Structural p53 Mutants Which Show Selective Defects in Apoptosis but Not Cell Cycle Arrest , 1998, Molecular and Cellular Biology.
[37] Wei Gu,et al. Synergistic activation of transcription by CBP and p53 , 1997, Nature.
[38] Y Taya,et al. DNA damage‐inducible phosphorylation of p53 at N‐terminal sites including a novel site, Ser20, requires tetramerization , 1999, The EMBO journal.
[39] A. Giaccia,et al. The complexity of p53 modulation: emerging patterns from divergent signals. , 1998, Genes & development.
[40] A. Levine. p53, the Cellular Gatekeeper for Growth and Division , 1997, Cell.
[41] A. Levine,et al. Transcriptional repression by wild-type p53 utilizes histone deacetylases, mediated by interaction with mSin3a. , 1999, Genes & development.
[42] A. Levine,et al. Down-regulation of the stathmin/Op18 and FKBP25 genes following p53 induction , 1999, Oncogene.
[43] P. Howley,et al. Ubiquitination of p53 and p21 is differentially affected by ionizing and UV radiation , 1997, Molecular and cellular biology.
[44] A. Levine,et al. The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation , 1992, Cell.
[45] A. Levine,et al. Wild-type p53 negatively regulates the expression of a microtubule-associated protein. , 1996, Genes & development.
[46] E. May,et al. Transcriptional activation plays a role in the induction of apoptosis by transiently transfected wild-type p53. , 1995, Oncogene.
[47] C. Prives,et al. Functional interaction between p53, the TATA-binding protein (TBP), andTBP-associated factors in vivo , 1996, Molecular and cellular biology.
[48] Erwin G. Van Meir. Hypoxia-mediated selection of cells with diminished apoptotic potential to solid tumours. , 1996, Neurosurgery.
[49] D. Israeli,et al. p53 Activates the CD95 (APO-1/Fas) Gene in Response to DNA Damage by Anticancer Drugs , 1998, The Journal of experimental medicine.
[50] K. Vousden,et al. Stress Signals Utilize Multiple Pathways To Stabilize p53 , 2000, Molecular and Cellular Biology.
[51] D. Israeli,et al. Inhibition of presenilin 1 expression is promoted by p53 and p21WAF-1 and results in apoptosis and tumor suppression , 1998, Nature Medicine.
[52] P. Howley,et al. Mutations in serines 15 and 20 of human p53 impair its apoptotic activity , 1999, Oncogene.
[53] S. Bhattacharya,et al. Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1. , 1999, Genes & development.
[54] Xinbin Chen,et al. Identification of a Novel p53 Functional Domain That Is Necessary for Mediating Apoptosis* , 1998, The Journal of Biological Chemistry.
[55] X. Chen,et al. p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells. , 1996, Genes & development.