Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase.
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F. Natt | S. Kim | J. Backer | J. Bos | G. Thomas | M. Roccio | S. Dann | F. Zwartkruis | M. Joaquin | T. Nobukuni | P. Gulati | Maya P Byfield
[1] C. Proud,et al. The Tuberous Sclerosis Protein TSC2 Is Not Required for the Regulation of the Mammalian Target of Rapamycin by Amino Acids and Certain Cellular Stresses* , 2005, Journal of Biological Chemistry.
[2] R. Loewith,et al. Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive , 2004, Nature Cell Biology.
[3] M. Patti,et al. Nutrient sensor links obesity with diabetes risk , 2004, Nature Medicine.
[4] T. Hunter,et al. Inappropriate Activation of the TSC/Rheb/mTOR/S6K Cassette Induces IRS1/2 Depletion, Insulin Resistance, and Cell Survival Deficiencies , 2004, Current Biology.
[5] Johan Auwerx,et al. Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity , 2004, Nature.
[6] N. Sonenberg,et al. Upstream and downstream of mTOR. , 2004, Genes & development.
[7] L. Pelkmans,et al. Not just a sink: endosomes in control of signal transduction. , 2004, Current opinion in cell biology.
[8] D. Guertin,et al. Rictor, a Novel Binding Partner of mTOR, Defines a Rapamycin-Insensitive and Raptor-Independent Pathway that Regulates the Cytoskeleton , 2004, Current Biology.
[9] I. Gout,et al. The TSC1-2 tumor suppressor controls insulin–PI3K signaling via regulation of IRS proteins , 2004, The Journal of cell biology.
[10] M. Bjornsti,et al. The tor pathway: a target for cancer therapy , 2004, Nature Reviews Cancer.
[11] Jean Gruenberg,et al. The biogenesis of multivesicular endosomes , 2004, Nature Reviews Molecular Cell Biology.
[12] S. Kimball,et al. Molecular mechanisms through which amino acids mediate signaling through the mammalian target of rapamycin , 2004, Current opinion in clinical nutrition and metabolic care.
[13] K. Inoki,et al. TSC2: filling the GAP in the mTOR signaling pathway. , 2004, Trends in biochemical sciences.
[14] M. Gonzalez-Gaitan,et al. Endocytosis and Signaling A Relationship under Development , 2003, Cell.
[15] Yoshinori Watanabe,et al. Schizosaccharomyces pombe AGC family kinase Gad8p forms a conserved signaling module with TOR and PDK1‐like kinases , 2003, The EMBO journal.
[16] E. Hafen,et al. Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2. , 2003, Molecular cell.
[17] B. Edgar,et al. Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins , 2003, Nature Cell Biology.
[18] B. Edgar,et al. Rheb promotes cell growth as a component of the insulin/TOR signalling network , 2003, Nature Cell Biology.
[19] C. Kaiser,et al. LST8 negatively regulates amino acid biosynthesis as a component of the TOR pathway , 2003, The Journal of cell biology.
[20] M. Lemmon,et al. Phosphoinositide Recognition Domains , 2003, Traffic.
[21] Steven J. Marygold,et al. Growth Signaling: TSC Takes Its Place , 2002, Current Biology.
[22] A. Hodges,et al. Tuberous sclerosis complex tumor suppressor–mediated S6 kinase inhibition by phosphatidylinositide-3-OH kinase is mTOR independent , 2002, The Journal of cell biology.
[23] S. Emr,et al. Retromer function in endosome-to-Golgi retrograde transport is regulated by the yeast Vps34 PtdIns 3-kinase , 2002, Journal of Cell Science.
[24] J. Crespo,et al. Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control. , 2002, Molecular cell.
[25] O. Hino,et al. Tsc tumour suppressor proteins antagonize amino-acid–TOR signalling , 2002, Nature Cell Biology.
[26] K. Inoki,et al. TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling , 2002, Nature Cell Biology.
[27] Krishnamurthy Natarajan,et al. Gcn4p, a Master Regulator of Gene Expression, Is Controlled at Multiple Levels by Diverse Signals of Starvation and Stress , 2002, Eukaryotic Cell.
[28] A. Jaeschke,et al. Mammalian TOR: A Homeostatic ATP Sensor , 2001, Science.
[29] A. Marette,et al. Amino acid and insulin signaling via the mTOR/p70 S6 kinase pathway. A negative feedback mechanism leading to insulin resistance in skeletal muscle cells. , 2001, The Journal of biological chemistry.
[30] Y. Ohsumi,et al. Beclin–phosphatidylinositol 3‐kinase complex functions at the trans‐Golgi network , 2001, EMBO reports.
[31] Takeshi Noda,et al. Two Distinct Vps34 Phosphatidylinositol 3–Kinase Complexes Function in Autophagy and Carboxypeptidase Y Sorting inSaccharomyces cerevisiae , 2001, The Journal of cell biology.
[32] S. Emr,et al. Autophagy as a regulated pathway of cellular degradation. , 2000, Science.
[33] P. Codogno,et al. Distinct Classes of Phosphatidylinositol 3′-Kinases Are Involved in Signaling Pathways That Control Macroautophagy in HT-29 Cells* , 2000, The Journal of Biological Chemistry.
[34] H. Hibshoosh,et al. Induction of autophagy and inhibition of tumorigenesis by beclin 1 , 1999, Nature.
[35] P. Houghton,et al. Amino acid-dependent control of p70(s6k). Involvement of tRNA aminoacylation in the regulation. , 1999, The Journal of biological chemistry.
[36] M. Mcdaniel,et al. Branched-chain amino acids are essential in the regulation of PHAS-I and p70 S6 kinase by pancreatic beta-cells. A possible role in protein translation and mitogenic signaling. , 1998, The Journal of biological chemistry.
[37] J. Avruch,et al. Amino Acid Sufficiency and mTOR Regulate p70 S6 Kinase and eIF-4E BP1 through a Common Effector Mechanism* , 1998, The Journal of Biological Chemistry.
[38] M. Zvelebil,et al. A human phosphatidylinositol 3‐kinase complex related to the yeast Vps34p‐Vps15p protein sorting system. , 1995, The EMBO journal.
[39] A. Meijer,et al. Phosphorylation of Ribosomal Protein S6 Is Inhibitory for Autophagy in Isolated Rat Hepatocytes (*) , 1995, The Journal of Biological Chemistry.
[40] Y. Ohsumi,et al. Isolation and characterization of autophagy‐defective mutants of Saccharomyces cerevisiae , 1993, FEBS letters.
[41] H. Lane,et al. p70s6k function is essential for G1 progression , 1993, Nature.
[42] S. Emr,et al. A membrane‐associated complex containing the Vps15 protein kinase and the Vps34 PI 3‐kinase is essential for protein sorting to the yeast lysosome‐like vacuole. , 1993, The EMBO journal.