Prolonged Color Blindness Induced by Intense Spectral Lights in Rhesus Monkeys

Prolonged exposure of rhesus monkeys to intense blue light produces long-term changes which are consistent with loss of response of those cones that contain a photopigment with peak absorption at 445 nanometers. The 90 percent reduction of spectral sensitivity in the blue region has lasted more than 5 months. Reduced sensitivity to long wavelengths is produced by adaptation to light of 520 nanometers. This reduced sensitivity, which lasts no more than 30 days, is attributed to a temporary loss of response of the cones containing a photopigment with peak absorption at 535 nanometers.

[1]  On Artificial Temporary Colour-Blindness, with an Examination of the Colour Sensations of 109 Persons , 1899 .

[2]  William T. Ham,et al.  Effects of laser radiation on the mammalian eye. , 1966, Transactions of the New York Academy of Sciences.

[3]  H. Sperling,et al.  Photopic spectral sensitivity in the rhesus monkey. , 1967, Journal of the Optical Society of America.

[4]  H. Sperling,et al.  Photopic Spectral Sensitivity in the Monkey: Methods for Determinilng, and Initial Results , 1965, Science.

[5]  T. Kuwabara,et al.  Retinal damage by visible light. An electron microscopic study. , 1968, Archives of ophthalmology.

[6]  T. Kuwabara,et al.  Retinal recovery from exposure to light. , 1970, American journal of ophthalmology.

[7]  A. R. Forsyth.  Memoir on the Integration of Partial Differential Equations of the Second Order in Three Independent Variables When an Intermediary Integral Does Not Exist in General , 1898 .

[8]  G Wald,et al.  Human color vision and color blindness. , 1965, Cold Spring Harbor symposia on quantitative biology.

[9]  D. Bok,et al.  Practical Remarks on Gout, Rheumatic Fever, and Chonic Rheumatism of the Joints; Being the Substance of the Croonian Lectures for the Present Year, Delivered at the College of Physicians , 1844, Edinburgh Medical and Surgical Journal.

[10]  B. Droz,et al.  THE RENEWAL OF PROTEIN IN RETINAL RODS AND CONES , 1968, The Journal of cell biology.

[11]  S Berman,et al.  Retinal damage by light in rats. , 1966, Investigative ophthalmology.

[12]  T. Kuwabara,et al.  The Retinal Pigment Epithelium: IV. The Damaging Effects of Radiant Energy , 1968 .

[13]  R. Harwerth,et al.  Red-Green Cone Interactions in the Increment-Threshold Spectral Sensitivity of Primates , 1971, Science.

[14]  G. Brindley,et al.  The effects on colour vision of adaptation to very bright lights , 1953, The Journal of physiology.

[15]  W C Stebbins,et al.  A technique for measuring the latency of a discriminative operant. , 1961, Journal of the experimental analysis of behavior.

[16]  A. Kroll,et al.  Experimental retinal detachment and reattachment in the rhesus monkey. Electron microscopic comparison of rods and cones. , 1969, American journal of ophthalmology.