European evidence-based Consensus on the diagnosis and management of ulcerative colitis: Definitions and diagnosis.

### 1.1 Introduction Ulcerative colitis is a life long disease arising from an interaction between genetic and environmental factors, but observed predominantly in the developed countries of the world. The precise aetiology is unknown and therefore medical therapy to cure the disease is not yet available. Within Europe there is a North–South gradient, but the incidence appears to have increased in Southern and developing countries in recent years.1,2 Patients may live with a considerable symptom burden despite medical treatment (66% describe interference with work and 73% with leisure activities3) in the hope that the aetiology of ulcerative colitis will shortly be revealed and a cure emerges. Although this is conceivable in the next decade, clinicians have to advise patients on the basis of information available today. Despite randomized trials there will always be many questions that can only be answered by the exercise of judgement and opinion. This leads to differences in practice between clinicians, which may be brought into sharp relief by differences in emphasis between countries. The Consensus endeavours to address these differences. The Consensus is not meant to supersede the guidelines of different countries (such as those from the UK,4 or Germany5), which reach broadly the same conclusions since they are, after all, based on the same evidence. Rather, the aim of the Consensus is to promote a European perspective on the management of ulcerative colitis (UC) and its dilemmas. Since the development of guidelines is an expensive and time-consuming process, it may help to avoid duplication of effort in the future. A European Consensus is also considered important because an increasing number of therapeutic trials recruit from Central and Eastern European countries where practice guidelines have yet to be published. This document sets out the current European Consensus on the diagnosis and management …

[1]  W. Sandborn.  Pouchitis following heal pouch-anal anastomosis: Definition, pathogenesis, and treatment , 1994 .

[2]  M. Regueiro,et al.  Infliximab for Hospitalized Patients With Severe Ulcerative Colitis , 2006, Journal of clinical gastroenterology.

[3]  C. Griffiths,et al.  Treatment of pyoderma gangrenosum with cyclosporine. , 1992, Archives of dermatology.

[4]  A. Forbes,et al.  European evidence based consensus on the diagnosis and management of Crohn’s disease: current management , 2006, Gut.

[5]  A. Gasbarrini,et al.  Extraintestinal manifestations in inflammatory bowel disease. , 2005, World journal of gastroenterology.

[6]  Thomas Lengauer,et al.  Genetic variation in DLG5 is associated with inflammatory bowel disease , 2004, Nature Genetics.

[7]  A. Griffiths,et al.  The natural history of corticosteroid therapy for ulcerative colitis in children. , 2006, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[8]  A. Schreyer,et al.  MR colonography in inflammatory bowel disease , 2006, Abdominal Imaging.

[9]  W. Reinisch,et al.  An open‐label trial of the selective cyclo‐oxygenase‐2 inhibitor, rofecoxib, in inflammatory bowel disease‐associated peripheral arthritis and arthralgia , 2003, Alimentary pharmacology & therapeutics.

[10]  A. J. Robertson,et al.  Observer variability in the histopathological reporting of abnormal rectal biopsy specimens. , 1994, Journal of clinical pathology.

[11]  N. Read,et al.  Symptoms and stool patterns in patients with ulcerative colitis. , 1988, Gut.

[12]  H. Tilg,et al.  Infliximab in severe steroid-refractory ulcerative colitis: a pilot study. , 2001, Wiener klinische Wochenschrift.

[13]  G. Triadafilopoulos,et al.  Fish oil fatty acid supplementation in active ulcerative colitis: a double-blind, placebo-controlled, crossover study. , 1992, The American journal of gastroenterology.

[14]  D. Present,et al.  Consensus conference: Colorectal cancer screening and surveillance in inflammatory bowel disease. , 2005, Inflammatory bowel diseases.

[15]  H. Appelman,et al.  Histopathology differentiates acute self-limited colitis from ulcerative colitis. , 1987, Gastroenterology.

[16]  D. Jewell,et al.  Randomized, double‐blind, placebo‐controlled trial of oral aloe vera gel for active ulcerative colitis , 2004, Alimentary pharmacology & therapeutics.

[17]  H. Lindahl,et al.  Proctocolectomy and J-pouch ileo-anal anastomosis in children. , 2002, Journal of pediatric surgery.

[18]  G. Feifel,et al.  Conversion of the failing ileoanal pouch to reservoir-ileostomy rather than to ileostomy alone , 1996, Diseases of the colon and rectum.

[19]  A. D. Rodgers,et al.  CRP Correlates with Clinical Score in Ulcerative Colitis but Not in Crohn’s Disease , 2007, Digestive Diseases and Sciences.

[20]  G. Porro,et al.  Azathioprine in steroid-resistant and steroid-dependent ulcerative colitis. , 1997, Journal of clinical gastroenterology.

[21]  P. Gionchetti,et al.  Problematic proctitis and distal colitis , 2004 .

[22]  B. Drumm,et al.  Colonoscopy Under General Anesthesia in Children , 1998, Pediatrics.

[23]  Robert H. Anderson,et al.  On Technical Considerations , 1995, Writing Ethnography (Second Edition).

[24]  B. Nilsson,et al.  Obstetric sphincter tears and anal incontinence: an observational follow‐up study , 2003, Acta obstetricia et gynecologica Scandinavica.

[25]  P. Söderkvist,et al.  Pharmacogenetics during standardised initiation of thiopurine treatment in inflammatory bowel disease , 2006, Gut.

[26]  Christoph Meisner,et al.  Determinants of Life Satisfaction in Inflammatory Bowel Disease , 2005, Inflammatory bowel diseases.

[27]  M. Stolte,et al.  Maintaining remission of ulcerative colitis with the probiotic Escherichia coli Nissle 1917 is as effective as with standard mesalazine , 2004, Gut.

[28]  C. Rubio,et al.  A quantitative method of estimating inflammation in the rectal mucosa. IV. Ulcerative colitis in remission. , 1984, Scandinavian journal of gastroenterology.

[29]  D. Drossman,et al.  Ulcerative colitis and Crohn's disease health status scales for research and clinical practice. , 1992, Journal of clinical gastroenterology.

[30]  P. Rutgeerts,et al.  Is Ileoscopy With Biopsy Worthwhile in Patients Presenting With Symptoms of Inflammatory Bowel Disease? , 1998, American Journal of Gastroenterology.

[31]  K. Petraki,et al.  Intermittent therapy with high-dose 5-aminosalicylic acid enemas maintains remission in ulcerative proctitis and proctosigmoiditis , 1994, Diseases of the colon and rectum.

[32]  W. Sandborn.  Serologic markers in inflammatory bowel disease: state of the art. , 2004, Reviews in gastroenterological disorders.

[33]  D. Schaid,et al.  Familial predisposition for colorectal cancer in chronic ulcerative colitis: a case-control study. , 1998, Gastroenterology.

[34]  B. Wiedenmann,et al.  Rescue therapy with tacrolimus is effective in patients with severe and refractory inflammatory bowel disease , 2003, Alimentary pharmacology & therapeutics.

[35]  M. Kamm,et al.  MMX Multi Matrix System® mesalazine for the induction of remission in patients with mild‐to‐moderate ulcerative colitis: a combined analysis of two randomized, double‐blind, placebo‐controlled trials , 2007, Alimentary pharmacology & therapeutics.

[36]  E. Seidman,et al.  Mesalamine in Pediatric Inflammatory Bowel Disease: A 10‐Year Experience , 1996, Inflammatory bowel diseases.

[37]  J. Bai,et al.  Budesonide enema in pouchitis—a double‐blind, double‐dummy, controlled trial , 2002, Alimentary pharmacology & therapeutics.

[38]  G. Radford-Smith,et al.  Appendectomy For Ulcerative Colitis — A Therapeutic Option? , 2007 .

[39]  C. Bartram,et al.  Depth of ulceration in acute colitis: correlation with outcome and clinical and radiologic features. , 1980, Gastroenterology.

[40]  R. Willén,et al.  Histologic and colonoscopic assessment of disease extension in ulcerative colitis. , 1987, Scandinavian journal of gastroenterology.

[41]  O. Maeda,et al.  Pit patterns in rectal mucosa assessed by magnifying colonoscope are predictive of relapse in patients with quiescent ulcerative colitis , 2006, Gut.

[42]  Kathryn Roeder,et al.  Genome-wide association identifies multiple ulcerative colitis susceptibility loci , 2010, Nature Genetics.

[43]  J. Markowitz,et al.  Growth failure in pediatric inflammatory bowel disease. , 1993, Journal of pediatric gastroenterology and nutrition.

[44]  R. Burakoff,et al.  Use of antibiotics in the treatment of inflammatory bowel disease , 2006, Inflammatory bowel diseases.

[45]  D. Drossman,et al.  Health status and health care use in persons with inflammatory bowel disease , 1991, Digestive Diseases and Sciences.

[46]  Ralph,et al.  A Clinicopathologic Study , 2006 .

[47]  E. Fuller-Thomson,et al.  Depression and inflammatory bowel disease: Findings from two nationally representative Canadian surveys , 2006, Inflammatory bowel diseases.

[48]  A. Forbes,et al.  Infliximab in moderately severe glucocorticoid resistant ulcerative colitis: a randomised controlled trial , 2003, Gut.

[49]  H. Yan,et al.  Observation of the efficacy of acupuncture and moxibustion in 62 cases of chronic colitis. , 1999, Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan.

[50]  D. Thompson,et al.  Psychological disorder and severity of inflammatory bowel disease predict health-related quality of life in ulcerative colitis and Crohn's disease , 2002, American Journal of Gastroenterology.

[51]  R. Motson,et al.  Incidence of third‐degree perineal tears in labour and outcome after primary repair , 1996, The British journal of surgery.

[52]  Hubert G M Leufkens,et al.  5-aminosalicylic acids and the risk of renal disease: a large British epidemiologic study. , 2004, Gastroenterology.

[53]  R. Farouk,et al.  J ileal pouch–anal anastomosis for chronic ulcerative colitis: complications and long‐term outcome in 1310 patients , 1998, The British journal of surgery.

[54]  A. De Gaetano,et al.  Effects of propionyl-L-carnitine topical irrigation in distal ulcerative colitis: a preliminary report. , 2001, Hepato-gastroenterology.

[55]  M. Crowell,et al.  Coping strategies and interpersonal support in patients with irritable bowel syndrome and inflammatory bowel disease. , 2006, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[56]  S. Lledó,et al.  A Prospective Audit of the Complications of Loop Ileostomy Construction and Takedown , 2005, Digestive Surgery.

[57]  C. Bernstein,et al.  Are we telling patients the truth about surveillance colonoscopy in ulcerative colitis? , 1994, The Lancet.

[58]  B F Warren,et al.  European evidence based consensus on the diagnosis and management of Crohn’s disease: definitions and diagnosis , 2006, Gut.

[59]  R. Caprilli,et al.  GI distension in severe ulcerative colitis , 2002, American Journal of Gastroenterology.

[60]  A. Thakur,et al.  Ileoanal pouch procedures in children. , 2001, Journal of pediatric surgery.

[61]  O. Maeda,et al.  Rebamipide enema therapy as a treatment for patients with active distal ulcerative colitis , 2007, Journal of gastroenterology and hepatology.

[62]  R. Brook,et al.  Consensus methods: characteristics and guidelines for use. , 1984, American journal of public health.

[63]  P. Dodero,et al.  Total colectomy and straight ileo-anal soave endorectal pull-through: personal experience with 42 cases. , 2001, European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie.

[64]  L. Lix,et al.  The relationship of inflammatory bowel disease type and activity to psychological functioning and quality of life. , 2006, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[65]  M. Scheurlen,et al.  Microbic Superinfection in Relapse of Inflammatory Bowel Disease , 1992, Journal of clinical gastroenterology.

[66]  M. Karoui,et al.  Results of Surgical Removal of the Pouch After Failed Restorative Proctocolectomy , 2004, Diseases of the colon and rectum.

[67]  Paul Rutgeerts,et al.  C-Reactive Protein as a Marker for Inflammatory Bowel Disease , 2004, Inflammatory bowel diseases.

[68]  R. Thirlby,et al.  Risk Factors and True Incidence of Pouchitis in Patients after Ileal Pouch–Anal Anastomoses , 2000, World Journal of Surgery.

[69]  F. Bochner,et al.  Olsalazine in the Treatment of Active Ulcerative Colitis: A Placebo Controlled Clinical Trial and Assessment of Drug Disposition , 1988 .

[70]  J. Pembérton.  The problem with pouchitis. , 1993, Gastroenterology.

[71]  E. Adeyemi,et al.  Faecal elastase reflects disease activity in active ulcerative colitis. , 1992, Scandinavian journal of gastroenterology.

[72]  S. Candy,et al.  Sucralfate and Methylprednisolone Enemas in Active Ulcerative Colitis (A Prospective, Single-Blind Study) , 1999, Digestive Diseases and Sciences.

[73]  S. Targan,et al.  Anti-neutrophil cytoplasmic antibodies in ulcerative colitis. Comparison with other colitides/diarrheal illnesses. , 1991, Gastroenterology.

[74]  J. Hunter,et al.  A double‐blind, randomized, placebo‐controlled trial of essential fatty acid supplementation in the maintenance of remission of ulcerative colitis , 2002, Alimentary pharmacology & therapeutics.

[75]  A. Cohen,et al.  Psychological distress, social support, and disease activity in patients with inflammatory bowel disease. , 2001 .

[76]  F. Manguso,et al.  Oral beclometasone dipropionate in the treatment of extensive and left‐sided active ulcerative colitis: a multicentre randomised study , 2003, Alimentary pharmacology & therapeutics.

[77]  Bernhard Nafe,et al.  Methylene blue-aided chromoendoscopy for the detection of intraepithelial neoplasia and colon cancer in ulcerative colitis. , 2003, Gastroenterology.

[78]  J. Church.  Functional outcome and quality of life in an elderly patient with an ileal pouch-anal anastomosis: a 10-year follow up. , 2000, The Australian and New Zealand journal of surgery.

[79]  C. Herfarth,et al.  One- or Two-stage Procedure for Restorative Proctocolectomy: Rationale for a Surgical Strategy in Ulcerative Colitis , 2001, Annals of surgery.

[80]  J. Hugot,et al.  Inflammatory bowel disease in children and adolescents: recommendations for diagnosis--the Porto criteria. , 2005, Journal of pediatric gastroenterology and nutrition.

[81]  P. Sagar,et al.  Ileo-anal pouch function and dysfunction. , 1997, Digestive diseases.

[82]  D. V. van Thiel,et al.  Tacrolimus (FK 506), a treatment for primary sclerosing cholangitis: results of an open-label preliminary trial. , 1995, The American journal of gastroenterology.

[83]  E. Kouroumalis,et al.  Active inflammatory bowel disease: evaluation with 99mTc (V) DMSA scintigraphy. , 2003, Radiology.

[84]  R. Playford,et al.  Epidermal growth factor enemas with oral mesalamine for mild-to-moderate left-sided ulcerative colitis or proctitis. , 2003, The New England journal of medicine.

[85]  J. Lennard-jones,et al.  Controlled trial of azathioprine in chronic ulcerative colitis. , 1982, British medical journal.

[86]  A. Griffiths,et al.  A Prospective Multicenter Study: Development and Validation of a Pediatric Ulcerative Colitis Activity Index , 2006 .

[87]  Nancy Xiaonan Yu,et al.  The prevalence of extraintestinal diseases in inflammatory bowel disease: a population-based study , 2001, American Journal of Gastroenterology.

[88]  P. Rutgeerts,et al.  The value of serologic markers in indeterminate colitis: a prospective follow-up study. , 2003, Gastroenterology.

[89]  S. Targan,et al.  Antibodies to CBir1 flagellin define a unique response that is associated independently with complicated Crohn's disease. , 2005, Gastroenterology.

[90]  J. Cangemi,et al.  Oral mesalamine and clinical remission are associated with a decrease in the extent of long‐standing ulcerative colitis , 2006, Inflammatory bowel diseases.

[91]  Samir A. Shah,et al.  Psychosocial determinants of relapse in ulcerative colitis: a longitudinal study , 2003, American Journal of Gastroenterology.

[92]  Samir A. Shah,et al.  Ocular Manifestations of Inflammatory Bowel Disease , 2004, Inflammatory bowel diseases.

[93]  H. Winter,et al.  Azathioprine in the treatment of children with inflammatory bowel disease. , 1990, The Journal of pediatrics.

[94]  S. Riley,et al.  Comparison of delayed-release 5-aminosalicylic acid (mesalazine) and sulfasalazine as maintenance treatment for patients with ulcerative colitis. , 1988, Gastroenterology.

[95]  Å. Danielsson,et al.  Oral budesonide versus prednisolone in patients with active extensive and left-sided ulcerative colitis. , 1996, Gastroenterology.

[96]  R. Grand,et al.  Combined use of cyclosporine and azathioprine or 6-mercaptopurine in pediatric inflammatory bowel disease. , 1996, Journal of pediatric gastroenterology and nutrition.

[97]  A. Kennedy,et al.  A randomised controlled trial to assess the effectiveness and cost of a patient orientated self management approach to chronic inflammatory bowel disease , 2004, Gut.

[98]  G. Lichtenstein.  Mucosal Healing in Inflammatory Bowel Disease: Results From a Norwegian Population-Based Cohort , 2008 .

[99]  W. Petritsch,et al.  Effect of oral tacrolimus (FK 506) on steroid‐refractory moderate/severe ulcerative colitis , 2003, Alimentary pharmacology & therapeutics.

[100]  K. Van Steen,et al.  Interassay and interobserver variability in the detection of anti-neutrophil cytoplasmic antibodies in patients with ulcerative colitis. , 2004, Clinical chemistry.

[101]  H. Zeidler,et al.  Treatment of active ankylosing spondylitis with infliximab: a randomised controlled multicentre trial , 2002, The Lancet.

[102]  A. Griffiths,et al.  Response to corticosteroids in severe ulcerative colitis: a systematic review of the literature and a meta-regression. , 2007, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[103]  L. A. Buie.  CHRONIC ULCERATIVE COLITIS , 1926 .

[104]  U. Böcker,et al.  Inflammatory Bowel Disease and Smoking: A Review of Epidemiology, Pathophysiology, and Therapeutic Implications , 2004, Inflammatory bowel diseases.

[105]  M. Vatn,et al.  Dysplasia and Cancer in Inflammatory Bowel Disease 10 Years after Diagnosis: Results of a Population-Based European Collaborative Follow-Up Study , 2007, Digestion.

[106]  E. O'Keefe,et al.  Olsalazine in maintenance of clinical remission in patients with ulcerative colitis , 1993, Digestive diseases and sciences.

[107]  G. Makin,et al.  Mortality, morbidity and functional outcome after ileorectal anastomosis , 2003, The British journal of surgery.

[108]  R. Löfberg,et al.  Long-term results of ileorectal anastomosis in ulcerative colitis in Stockholm County , 1990, Diseases of the colon and rectum.

[109]  B. Sands.  From symptom to diagnosis: clinical distinctions among various forms of intestinal inflammation. , 2004, Gastroenterology.

[110]  K. Motil,et al.  Growth failure in children with inflammatory bowel disease: a prospective study. , 1993, Gastroenterology.

[111]  A. Forbes,et al.  Review article: oral, modified‐release mesalazine formulations — proprietary versus generic , 2003, Alimentary pharmacology & therapeutics.

[112]  J. Achkar,et al.  A Randomized Clinical Trial of Ciprofloxacin and Metronidazole to Treat Acute Pouchitis , 2001, Inflammatory bowel diseases.

[113]  S. Cucchiara,et al.  Azathioprine in paediatric inflammatory bowel disease: an Italian multicentre survey , 2002, Alimentary pharmacology & therapeutics.

[114]  A. Zinsmeister,et al.  Azathioprine or 6-Mercaptopurine Before Colectomy for Ulcerative Colitis Is Not Associated With Increased Postoperative Complications , 2002, Inflammatory bowel diseases.

[115]  N. Harpaz,et al.  Adenocarcinoma in strictures of ulcerative colitis without antecedent dysplasia by colonoscopy. , 1994, The American journal of gastroenterology.

[116]  L. Hultén,et al.  Incidence and characteristics of pouchitis in the Kock continent ileostomy and the pelvic pouch. , 1993, Scandinavian journal of gastroenterology.

[117]  S. Cross,et al.  Indigo carmine-assisted high-magnification chromoscopic colonoscopy for the detection and characterisation of intraepithelial neoplasia in ulcerative colitis: a prospective evaluation. , 2005, Endoscopy.

[118]  G. Kaplan,et al.  A National Survey of the Prevalence and Impact of Clostridium difficile Infection Among Hospitalized Inflammatory Bowel Disease Patients , 2008, The American Journal of Gastroenterology.

[119]  M. Therkildsen,et al.  The final outcome of patients presenting with their first episode of acute diarrhoea and an inflamed rectal mucosa with preserved crypt architecture. A clinicopathologic study. , 1989, Scandinavian journal of gastroenterology.

[120]  S. Cross,et al.  High-magnification chromoscopic colonoscopy in ulcerative colitis: a valid tool for in vivo optical biopsy and assessment of disease extent , 2006, Endoscopy.

[121]  D. Richards,et al.  Patient quality of life after successful restorative proctocolectomy is normal , 2001, Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland.

[122]  G. Ferry,et al.  Guided self-management and patient-directed follow-up of ulcerative colitis: a randomised trial. , 2002, Journal of pediatric gastroenterology and nutrition.

[123]  C. Rubio,et al.  A quantitative method of estimating inflammation in the rectal mucosa. II. Normal limits in symptomatic patients. , 1982, Scandinavian journal of gastroenterology.

[124]  A. Forbes,et al.  Safety and efficacy of acetarsol suppositories in unresponsive proctitis , 1989, Alimentary pharmacology & therapeutics.

[125]  V. Ponti,et al.  Colonoscopy in inflammatory bowel disease. Diagnostic accuracy and proposal of an endoscopic score. , 1987, Gastroenterology.

[126]  A. Forbes,et al.  Cancer surveillance in longstanding ulcerative colitis: endoscopic appearances help predict cancer risk , 2004, Gut.

[127]  M. Kamm,et al.  Bacterial and fungal microbiota in relation to probiotic therapy (VSL#3) in pouchitis , 2006, Gut.

[128]  G. Järnerot,et al.  Intensive intravenous treatment of ulcerative colitis. , 1985, Gastroenterology.

[129]  J. G. Walker,et al.  Balsalazide in the maintenance treatment of patients with ulcerative colitis, a double‐blind comparison with sulphasalazine , 1988, Alimentary pharmacology & therapeutics.

[130]  Z. Halpern,et al.  Antibodies against laminaribioside and chitobioside are novel serologic markers in Crohn's disease. , 2006, Gastroenterology.

[131]  M. Russel,et al.  Muscoloskeletal manifestations in inflammatory bowel disease. , 2001, Canadian journal of gastroenterology = Journal canadien de gastroenterologie.

[132]  S. Grosso,et al.  Psychiatric Predictors of Noncompliance in Inflammatory Bowel Disease: Psychiatry and Compliance , 2001, Journal of clinical gastroenterology.

[133]  S. Hanauer,et al.  Update on the etiology, pathogenesis and diagnosis of ulcerative colitis , 2004, Nature Clinical Practice Gastroenterology &Hepatology.

[134]  Heidi D Nelson,et al.  Postmenopausal hormone replacement therapy: scientific review. , 2002, JAMA.

[135]  H. Ogata,et al.  Cytomegalovirus Is Frequently Reactivated and Disappears Without Antiviral Agents in Ulcerative Colitis Patients , 2007, The American Journal of Gastroenterology.

[136]  J. Colombel,et al.  [What is the prognosis in unclassified colitis? Results of a cohort study of 104 patients in the Northern-Pas-de-Calais region]. , 1993, Gastroenterologie clinique et biologique.

[137]  S. Leeder,et al.  A population based study , 1993, The Medical journal of Australia.

[138]  P. Rutgeerts,et al.  Mucosal healing in inflammatory bowel disease: impossible ideal or therapeutic target? , 2007, Gut.

[139]  T. Yao,et al.  An index of disease activity in patients with ulcerative colitis. , 1992, The American journal of gastroenterology.

[140]  B. Fretheim.  [Surgery in children]. , 1961, Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke.

[141]  R. Lüdtke,et al.  Effects of Boswellia serrata gum resin in patients with ulcerative colitis. , 1997, European journal of medical research.

[142]  E. Lindberg,et al.  Inflammatory bowel disease in children and adolescents in Sweden, 1984-1995. , 2000, Journal of pediatric gastroenterology and nutrition.

[143]  Judy H. Cho,et al.  A Genome-Wide Association Study Identifies IL23R as an Inflammatory Bowel Disease Gene , 2006, Science.

[144]  C. Calabrese,et al.  Oral budesonide in the treatment of chronic refractory pouchitis , 2007, Alimentary pharmacology & therapeutics.

[145]  S. Danese,et al.  Inflammation and Coagulation in Inflammatory Bowel Disease: The Clot Thickens , 2007, The American Journal of Gastroenterology.

[146]  G. Lee,et al.  Clinical Course of Distal Ulcerative Colitis in Relation to Appendiceal Orifice Inflammation Status , 2005, Inflammatory bowel diseases.

[147]  I. Vlachonikolis,et al.  Appendectomy and the development of ulcerative colitis: results of a metaanalysis of published case-control studies , 2000, American Journal of Gastroenterology.

[148]  S. Vermeire.  Review article: genetic susceptibility and application of genetic testing in clinical management of inflammatory bowel disease , 2006, Alimentary pharmacology & therapeutics.

[149]  A. Dahlström,et al.  Treatment of distal colitis with local anaesthetic agents. , 2002, Pharmacology & toxicology.

[150]  S. Krane,et al.  Metabolic bone disease , 1977 .

[151]  D. Jewell,et al.  Uveitis and erythema nodosum in inflammatory bowel disease: clinical features and the role of HLA genes. , 2002, Gastroenterology.

[152]  B. Feagan,et al.  Oral 5-aminosalicylic acid for maintenance of remission in ulcerative colitis. , 2016, The Cochrane database of systematic reviews.

[153]  L. Fishman,et al.  Educate, communicate, anticipate‐practical recommendations for transitioning adolescents with IBD to adult health care , 2006, Inflammatory bowel diseases.

[154]  W. Kremers,et al.  Ursodeoxycholic acid as a chemopreventive agent in patients with ulcerative colitis and primary sclerosing cholangitis. , 2001, Gastroenterology.

[155]  K. Fellermann,et al.  Mesenteric blood flow is related to disease activity and risk of relapse in ulcerative colitis: a prospective follow up study , 1999, Gut.

[156]  S. Targan,et al.  Anti-Saccharomyces cerevisiae mannan antibodies combined with antineutrophil cytoplasmic autoantibodies in inflammatory bowel disease: prevalence and diagnostic role , 1998, Gut.

[157]  G. Porro,et al.  Ultrasonography in the evaluation of extension, activity, and follow-up of ulcerative colitis. , 1999, Scandinavian journal of gastroenterology.

[158]  D. Jewell,et al.  Intensive intravenous regimen for severe attacks of ulcerative colitis. , 1974, Lancet.

[159]  G. Radford-Smith,et al.  Protective role of appendicectomy on onset and severity of ulcerative colitis and Crohn’s disease , 2002, Gut.

[160]  S. Levenstein,et al.  Stress and exacerbation in ulcerative colitis: a prospective study of patients enrolled in remission , 2000, American Journal of Gastroenterology.

[161]  J. Schölmerich,et al.  [Nutritional deficiencies and complications in chronic inflammatory bowel diseases]. , 1998, Medizinische Klinik.

[162]  A. Cohen,et al.  Treatment of ulcerative colitis with a humanized antibody to the alpha4beta7 integrin. , 2005, The New England journal of medicine.

[163]  C. Kleer,et al.  Endoscopic and histological patchiness in treated ulcerative colitis , 1999, American Journal of Gastroenterology.

[164]  P. Munkholm,et al.  Long-term risk of cancer in ulcerative colitis: a population-based cohort study from Copenhagen County. , 2004, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[165]  J. H. Baron,et al.  CONTROLLED TRIAL OF SULPHASALAZINE IN MAINTENANCE THERAPY FOR ULCERATIVE COLITIS , 1965 .

[166]  A. Cohen,et al.  Clinical, biological, and histologic parameters as predictors of relapse in ulcerative colitis. , 2001, Gastroenterology.

[167]  B. Rembacken,et al.  Non-pathogenic Escherichia coli versus mesalazine for the treatment of ulcerative colitis: a randomised trial , 1999, The Lancet.

[168]  A. Poullis,et al.  Faecal markers in the assessment of activity in inflammatory bowel disease , 2002 .

[169]  W. Mojica,et al.  Systematic review of the effects of n-3 fatty acids in inflammatory bowel disease. , 2005, The American journal of clinical nutrition.

[170]  J. Rhodes,et al.  Ulcerative colitis: diagnosis and management , 2006, BMJ : British Medical Journal.

[171]  E. Blanchard,et al.  Evaluation of a psychological treatment for inflammatory bowel disease. , 1991, Behaviour research and therapy.

[172]  D. Altman,et al.  Outcome measurement in clinical trials for Ulcerative Colitis: towards standardisation , 2007, Trials.

[173]  J. Achkar,et al.  Comprehensive Evaluation of Inflammatory and Noninflammatory Sequelae of Ileal Pouch-Anal Anastomoses , 2005, The American Journal of Gastroenterology.

[174]  R. Möllby,et al.  Occurrence of Clostridium difficile toxin in inflammatory bowel disease. , 1983, Scandinavian journal of gastroenterology.

[175]  E. B. Nye.  GYNAECOLOGICAL SYMPTOMS FOLLOWING RECTAL EXCISION , 1973, The Journal of obstetrics and gynaecology of the British Commonwealth.

[176]  J. Heppell,et al.  Toxic megacolon , 1986, Diseases of the colon and rectum.

[177]  A. Olson,et al.  Colonoscopy or sigmoidoscopy as the initial evaluation of pediatric patients with colitis: a survey of physician behavior and a cost analysis. , 1997, Journal of pediatric gastroenterology and nutrition.

[178]  X. Zhang.  23 cases of chronic nonspecific ulcerative colitis treated by acupuncture and moxibustion. , 1998, Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan.

[179]  R. Hubbard,et al.  Hip fractures in patients with inflammatory bowel disease and their relationship to corticosteroid use: a population based cohort study , 2004, Gut.

[180]  D. Jewell,et al.  Small bowel gas in severe ulcerative colitis. , 1991, Gut.

[181]  A. Öst,et al.  Cancer surveillance of patients with longstanding ulcerative colitis: a clinical, endoscopical, and histological study. , 1986, Gut.

[182]  A. Rizzo,et al.  Severe acute colitis associated with CMV: a prevalence study. , 2004, Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver.

[183]  R. Baldassano,et al.  Growth failure in the child with inflammatory bowel disease. , 2001, Seminars in gastrointestinal disease.

[184]  B. Milne,et al.  A stress management programme for inflammatory bowel disease patients. , 1986, Journal of advanced nursing.

[185]  K. Ewe,et al.  N-3 fatty acids only delay early relapse of ulcerative colitis in remission , 1996, Digestive Diseases and Sciences.

[186]  H. Steinhart,et al.  Medical management of left‐sided ulcerative colitis and ulcerative proctitis: Critical evaluation of therapeutic trials , 2006, Inflammatory bowel diseases.

[187]  D. Bjorkman,et al.  Short‐term adverse effects of 5‐aminosalicylic acid agents in the treatment of ulcerative colitis , 2004 .

[188]  S. Murch,et al.  Indications for investigation of chronic gastrointestinal symptoms. , 1995, Archives of disease in childhood.

[189]  V. Medici,et al.  Prognosis of severe attacks in ulcerative colitis: effect of intensive medical treatment. , 2004, Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver.

[190]  P. Heidenreich,et al.  Increased risk of colorectal neoplasia in patients with primary sclerosing cholangitis and ulcerative colitis: a meta-analysis. , 2002, Gastrointestinal endoscopy.

[191]  C. Kleer,et al.  Ulcerative colitis: patterns of involvement in colorectal biopsies and changes with time. , 1998, The American journal of surgical pathology.

[192]  H. Ishikawa,et al.  Randomized controlled trial of the effect of bifidobacteria-fermented milk on ulcerative colitis. , 2000, Journal of the American College of Nutrition.

[193]  D. Drossman,et al.  Inflammatory bowel disease versus irritable bowel syndrome: a hospital‐based, case‐control study of disease impact on quality of life , 2003, Scandinavian journal of gastroenterology.

[194]  P. Rutgeerts,et al.  Patchy cecal inflammation associated with distal ulcerative colitis: a prospective endoscopic study. , 1997, The American journal of gastroenterology.

[195]  C. Spicer,et al.  Assessment of severity in colitis: a preliminary study. , 1975, Gut.

[196]  P. Beck,et al.  A new look at toxic megacolon: an update and review of incidence, etiology, pathogenesis, and management , 2003, American Journal of Gastroenterology.

[197]  P. Gionchetti,et al.  Comparison of oral with rectal mesalazine in the treatment of ulcerative proctitis , 1998, Diseases of the colon and rectum.

[198]  S. Auvin,et al.  Incidence, Clinical Presentation and Location at Diagnosis of Pediatric Inflammatory Bowel Disease: A Prospective Population-Based Study in Northern France (1988-1999) , 2005, Journal of pediatric gastroenterology and nutrition.

[199]  F. Autschbach,et al.  Diagnosing Pouchitis , 2002, Diseases of the colon and rectum.

[200]  S. Truelove,et al.  Intensive intravenous regimen for membranous colitis. , 1976, British medical journal.

[201]  Yunni-Yi Chen,et al.  Gross Versus Microscopic Pancolitis and the Occurrence of Neoplasia in Ulcerative Colitis , 2003, Inflammatory bowel diseases.

[202]  J. Olsen,et al.  Psychological Stress and Inflammatory Bowel Disease: A Follow-up Study in Parents Who Lost a Child in Denmark , 2004, American Journal of Gastroenterology.

[203]  J. Olsen,et al.  Appendectomy and subsequent risk of inflammatory bowel diseases. , 2001, Surgery.

[204]  S. Plevy.  Do Serological Markers and Cytokines Determine the Indeterminate? , 2004, Journal of clinical gastroenterology.

[205]  J. Tjandra,et al.  Similar functional results after restorative proctocolectomy in patients with familial adenomatous polyposis and mucosal ulcerative colitis. , 1993, American journal of surgery.

[206]  Paul Rutgeerts,et al.  Infliximab for induction and maintenance therapy for ulcerative colitis. , 2005, The New England journal of medicine.

[207]  M. Arrese,et al.  Saccharomyces cerevisiae fungemia after Saccharomyces boulardii treatment in immunocompromised patients. , 2003, Journal of Clinical Gastroenterology.

[208]  Mark Avigan,et al.  Hepatosplenic T cell lymphoma associated with infliximab use in young patients treated for inflammatory bowel disease. , 2007, Journal of pediatric gastroenterology and nutrition.

[209]  C. O'Morain,et al.  The prevalence of genetic and serologic markers in an unselected European population‐based cohort of IBD patients , 2007, Inflammatory bowel diseases.

[210]  R. Mitchell,et al.  P037 Results of the European Federation of Crohn's and Ulcerative Colitis Associations (Efcca) Patient Survey: Prevalence and Impact on Quality of Life , 2007 .

[211]  H. Tilg,et al.  European evidence-based Consensus on the prevention, diagnosis and management of opportunistic infections in inflammatory bowel disease. , 2009, Journal of Crohn's & colitis.

[212]  J. Church,et al.  IIeal Pouch‐Anal Anastomoses Complications and Function in 1005 Patients , 1995, Annals of surgery.

[213]  P. Gionchetti,et al.  Comparison of mesalazine suppositories in proctitis and distal proctosigmoiditis , 1997, Alimentary pharmacology & therapeutics.

[214]  M. Mutinga,et al.  The Clinical Significance of Right-sided Colonic Inflammation in Patients with Left-sided Chronic Ulcerative Colitis , 2004, Inflammatory bowel diseases.

[215]  T. Mussack,et al.  Polymorphisms of the lipopolysaccharide-signaling complex in inflammatory bowel disease: association of a mutation in the Toll-like receptor 4 gene with ulcerative colitis. , 2004, Clinical immunology.

[216]  M. Vatn,et al.  Change of diagnosis during the first five years after onset of inflammatory bowel disease: Results of a prospective follow-up study (the IBSEN Study) , 2006, Scandinavian journal of gastroenterology.

[217]  S. Targan,et al.  Anti‐flagellin (CBir1) phenotypic and genetic Crohn's disease associations , 2007, Inflammatory bowel diseases.

[218]  J. Hyams,et al.  Cyclosporine for the treatment of fulminant ulcerative colitis in children , 1995, Diseases of the colon and rectum.

[219]  G. Radford-Smith,et al.  Epidemiology of appendicectomy in primary sclerosing cholangitis and ulcerative colitis: its influence on the clinical behaviour of these diseases , 2004, Gut.

[220]  L. Melton,et al.  Risk of intestinal cancer in inflammatory bowel disease: a population-based study from olmsted county, Minnesota. , 2006, Gastroenterology.

[221]  P. Munkholm,et al.  Course of ulcerative colitis: analysis of changes in disease activity over years. , 1994, Gastroenterology.

[222]  J. Colombel,et al.  Que deviennent les colites aiguës inclassées? Résultats d'une étude de cohorte de 104 malades dans la région Nord-Pas-de-Calais. Registre des Maladies Inflammatoires du Tube Digestif du Nord-Quest de la France. , 1993 .

[223]  Louis J. Cohen,et al.  Infliximab in Pediatric Ulcerative Colitis: Two-year Follow-up , 2004, Journal of pediatric gastroenterology and nutrition.

[224]  H. Watts,et al.  National Cooperative Crohn's Disease Study: extraintestinal manifestations and perianal complications. , 1979, Gastroenterology.

[225]  I. Engström.  Inflammatory bowel disease in children and adolescents: mental health and family functioning. , 1999 .

[226]  S. Huang,et al.  Treatment of mucous membrane diseases of the digestive tract with jing jie lian qiao tang--therapeutic effect in 168 cases. , 1989, Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan.

[227]  J. Mary,et al.  Infliximab plus azathioprine for steroid-dependent Crohn's disease patients: a randomized placebo-controlled trial. , 2006, Gastroenterology.

[228]  D. Jewell,et al.  Short-chain fatty acid irrigation in severe pouchitis. , 1989, The New England journal of medicine.

[229]  M. Kamm,et al.  Effect of once- or twice-daily MMX mesalamine (SPD476) for the induction of remission of mild to moderately active ulcerative colitis. , 2007, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[230]  N. Shepherd,et al.  Distribution of mucosal pathology and an assessment of colonic phenotypic change in the pelvic ileal reservoir. , 1993, Gut.

[231]  M. Verhoef,et al.  Why patients with inflammatory bowel disease use or do not use complementary and alternative medicine: a Canadian national survey. , 2005, Canadian journal of gastroenterology = Journal canadien de gastroenterologie.

[232]  M. Seo,et al.  Correlation between endoscopic severity and the clinical activity index in ulcerative colitis. , 1998 .

[233]  S. Hanauer,et al.  Intravenous cyclosporin in ulcerative colitis: a five-year experience , 1999, American Journal of Gastroenterology.

[234]  A. Zinsmeister,et al.  Dysplasia in chronic ulcerative colitis: Implications for colonoscopic surveillance , 1992, Diseases of the colon and rectum.

[235]  J. Mate,et al.  Fecal calprotectin and lactoferrin for the prediction of inflammatory bowel disease relapse , 2009, Inflammatory bowel diseases.

[236]  N. LeLeiko,et al.  Distinct Phenotype of Early Childhood Inflammatory Bowel Disease , 2006, Journal of clinical gastroenterology.

[237]  M. Stringer,et al.  Endoscopic Rectal Sparing in Children With Untreated Ulcerative Colitis , 2004, Journal of pediatric gastroenterology and nutrition.

[238]  A. Forbes,et al.  Most dysplasia in ulcerative colitis is visible at colonoscopy. , 2004, Gastrointestinal endoscopy.

[239]  W. Harmsen,et al.  Effect of infliximab on short-term complications in patients undergoing operation for chronic ulcerative colitis. , 2007, Journal of the American College of Surgeons.

[240]  M. Iida,et al.  Chromoscopy might improve diagnostic accuracy in cancer surveillance for ulcerative colitis , 2003, American Journal of Gastroenterology.

[241]  A. Gasbarrini,et al.  Infliximab in the treatment of steroid-dependent ulcerative colitis. , 2004, European review for medical and pharmacological sciences.

[242]  E. Loftus.  Epidemiology and risk factors for colorectal dysplasia and cancer in ulcerative colitis. , 2006, Gastroenterology clinics of North America.

[243]  M. Grootenhuis,et al.  Quality of life in paediatric inflammatory bowel disease measured by a generic and a disease‐specific questionnaire , 2002, Acta paediatrica.

[244]  G. Corrao,et al.  Long-term oral plus topical mesalazine in frequently relapsing ulcerative colitis. , 2005, Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver.

[245]  B. Sandhu,et al.  Presenting features of inflammatory bowel disease in Great Britain and Ireland , 2003, Archives of disease in childhood.

[246]  Philippe Marteau,et al.  A review of activity indices and efficacy end points for clinical trials of medical therapy in adults with ulcerative colitis. , 2007, Gastroenterology.

[247]  M. Schwartz,et al.  Patient defined dichotomous end points for remission and clinical improvement in ulcerative colitis , 2005, Gut.

[248]  P. Davies,et al.  Performance of blood tests in diagnosis of inflammatory bowel disease in a specialist clinic. , 2004, Archives of disease in childhood.

[249]  K. Nordin,et al.  A group-based patient education programme for high-anxiety patients with Crohn disease or ulcerative colitis. , 2003, Scandinavian journal of gastroenterology.

[250]  S. Phillips,et al.  Chronic pouchitis after ileal pouch-anal anastomosis: responses to butyrate and glutamine suppositories in a pilot study. , 1993, Mayo Clinic proceedings.

[251]  J. von Wietersheim,et al.  [The significance of recurrence-inducing events for patients with chronic inflammatory bowel diseases. Results of a prospective longitudinal study over three years]. , 1994, Psychotherapie, Psychosomatik, medizinische Psychologie.

[252]  R. Pollok,et al.  Systematic review of postoperative complications in patients with inflammatory bowel disease treated with immunomodulators , 2006, The British journal of surgery.

[253]  Yoshio Araki,et al.  Germinated barley foodstuff prolongs remission in patients with ulcerative colitis. , 2004, International journal of molecular medicine.

[254]  A. Akobeng,et al.  Tumour necrosis factor alpha blocking agents for induction of remission in ulcerative colitis. , 2006, The Cochrane database of systematic reviews.

[255]  C. Rubio,et al.  A quantitative method of estimating inflammation in the rectal mucosa. III. Chronic ulcerative colitis. , 1982, Scandinavian journal of gastroenterology.

[256]  C. Williams,et al.  Factors affecting the outcome of endoscopic surveillance for cancer in ulcerative colitis. , 1994, Gastroenterology.

[257]  S. Cross,et al.  High-magnification chromoscopic pouchoscopy: a novel in vivo technique for surveillance of the anal transition zone and columnar cuff following ileal pouch-anal anastomosis , 2004, Techniques in Coloproctology.

[258]  G. Greenberg,et al.  High-Level Serum Antibodies to Bacterial Antigens Are Associated with Antibiotic-Induced Clinical Remission in Crohn's Disease: A Pilot Study , 2004, Digestive Diseases and Sciences.

[259]  Joel V Weinstock,et al.  Trichuris suis therapy for active ulcerative colitis: a randomized controlled trial. , 2005, Gastroenterology.

[260]  A. Michalsen,et al.  Comparison of 4 Neutrophil‐Derived Proteins in Feces As Indicators of Disease Activity in Ulcerative Colitis , 2005, Inflammatory bowel diseases.

[261]  Amy K Hara,et al.  A Meta-Analysis of the Yield of Capsule Endoscopy Compared to Other Diagnostic Modalities in Patients with Non-Stricturing Small Bowel Crohn's Disease , 2006, The American Journal of Gastroenterology.

[262]  L. Shaw,et al.  Relaxation training as a treatment for chronic pain caused by ulcerative colitis , 1987, Pain.

[263]  A. Cohen,et al.  Psychosocial correlates of patient-physician discordance in inflammatory bowel disease. , 2002 .

[264]  R. Chapman,et al.  The medical management of primary sclerosing cholangitis. , 2006, Seminars in liver disease.

[265]  A. Konstantinidou,et al.  Frequent detection of cytomegalovirus in the intestine of patients with inflammatory bowel disease , 2006, Inflammatory bowel diseases.

[266]  M. Pfefferkorn,et al.  Patient-reported Symptoms After Pediatric Outpatient Colonoscopy or Flexible Sigmoidoscopy Under General Anesthesia , 2006, Journal of pediatric gastroenterology and nutrition.

[267]  M. Oliva-Hemker,et al.  Infliximab Efficacy in Pediatric Ulcerative Colitis , 2005, Inflammatory bowel diseases.

[268]  A. Zinsmeister,et al.  Risk Factors for Colorectal Neoplasia in Inflammatory Bowel Disease: A Nested Case–Control Study From Copenhagen County, Denmark and Olmsted County, Minnesota , 2007, The American Journal of Gastroenterology.

[269]  A. Kornbluth,et al.  Ulcerative Colitis Practice Guidelines in Adults: American College of Gastroenterology, Practice Parameters Committee , 2010, The American Journal of Gastroenterology.

[270]  Prevalence of nonadherence with maintenance mesalamine in quiescent ulcerative colitis , 2001 .

[271]  M. Dixon,et al.  An analysis of the reliability of detection and diagnostic value of various pathological features in Crohn's disease and ulcerative colitis , 1973, Gut.

[272]  W. Reinisch,et al.  Assessing the Demand for Psychological Care in Chronic Diseases: Development and Validation of a Questionnaire Based on the Example of Inflammatory Bowel Disease , 2004, Inflammatory bowel diseases.

[273]  S. Targan,et al.  Infliximab in the Treatment of Severe, Steroid-Refractory Ulcerative Colitis: A Pilot Study , 2001, Inflammatory bowel diseases.

[274]  J. Satsangi,et al.  The Montreal classification of inflammatory bowel disease: controversies, consensus, and implications , 2006, Gut.

[275]  M. Daly,et al.  IBD5 is a general risk factor for inflammatory bowel disease: replication of association with Crohn disease and identification of a novel association with ulcerative colitis. , 2003, American journal of human genetics.

[276]  W. Chey,et al.  Ulcerative colitis associated enteritis: is ulcerative colitis always confined to the colon? , 2004, Journal of clinical gastroenterology.

[277]  S. Vermeire,et al.  Inflammatory bowel disease in spouses and their offspring. , 2001, Gastroenterology.

[278]  Konstantinos H. Katsanos,et al.  Predictors of early response to infliximab in patients with ulcerative colitis , 2007, Inflammatory bowel diseases.

[279]  J. Church,et al.  Functional Outcome, Quality of Life, and Complications After Ileal Pouch-Anal Anastomosis in Selected Septuagenarians , 2002, Diseases of the colon and rectum.

[280]  M. Kamm,et al.  Four‐week open‐label trial of metronidazole and ciprofloxacin for the treatment of recurrent or refractory pouchitis , 2002, Alimentary pharmacology & therapeutics.

[281]  J. Lennard-jones,et al.  Incidence of inflammatory bowel disease across Europe: is there a difference between north and south? Results of the European Collaborative Study on Inflammatory Bowel Disease (EC-IBD). , 1996, Gut.

[282]  G. L. Engel.  The need for a new medical model: a challenge for biomedicine , 1977 .

[283]  P. Brigidi,et al.  Oral bacteriotherapy as maintenance treatment in patients with chronic pouchitis: a double-blind, placebo-controlled trial. , 2000, Gastroenterology.

[284]  W. Bemelman,et al.  European Evidence-based Consensus on the Management of Ulcerative Colitis: Current Management , 2007 .

[285]  G. Nordström,et al.  Anxiety, Functional Health Status, and Coping Ability in Patients with Ulcerative Colitis Who Are Undergoing Colonoscopic Surveillance , 2004, Inflammatory bowel diseases.

[286]  L. Hultén,et al.  The failed pelvic pouch: conversion to a continent ileostomy , 2004, Techniques in Coloproctology.

[287]  D. Jewell,et al.  Ciclosporin use in acute ulcerative colitis: a long-term experience , 2005, European journal of gastroenterology & hepatology.

[288]  M. Pocard,et al.  Long-term results of ileal pouch-anal anastomosis for colorectal Crohn's disease , 2001, Diseases of the colon and rectum.

[289]  M. Molinari,et al.  Prospective study of the incidence, timing and treatment of pouchitis in 104 consecutive patients after restorative proctocolectomy. , 1996, Archives of surgery.

[290]  Performing a cost-effectiveness analysis: surveillance of patients with ulcerative colitis , 1998 .

[291]  C. Meijer,et al.  Histopathological evaluation of colonic mucosal biopsy specimens in chronic inflammatory bowel disease: diagnostic implications. , 1991, Gut.

[292]  R. Riddell,et al.  Morphologic criteria applicable to biopsy specimens for effective distinction of inflammatory bowel disease from other forms of colitis and of Crohn's disease from ulcerative colitis. , 1999, Scandinavian journal of gastroenterology.

[293]  B C Morson,et al.  Restorative proctocolectomy with ileal reservoir: pathological and histochemical study of mucosal biopsy specimens. , 1987, Journal of clinical pathology.

[294]  H. Drummond,et al.  Increasing incidence of both juvenile-onset Crohn's disease and ulcerative colitis in Scotland , 2001, European journal of gastroenterology & hepatology.

[295]  W. Crandall,et al.  Long-Term Psychosocial Outcomes Reported by Children and Adolescents with Inflammatory Bowel Disease , 2005, The American Journal of Gastroenterology.

[296]  Simon Smale,et al.  Prevalence and mechanism of nonsteroidal anti-inflammatory drug-induced clinical relapse in patients with inflammatory bowel disease. , 2006, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[297]  R. Willén,et al.  The risk of dysplasia and cancer in the ileal pouch mucosa after restorative proctocolectomy for ulcerative proctocolitis is low: A long‐term term follow‐up study , 2004, Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland.

[298]  B. Sandstedt,et al.  A prospective study of first attacks of inflammatory bowel disease and infectious colitis. Histologic course during the 1st year after presentation. , 1994, Scandinavian journal of gastroenterology.

[299]  C. Smith,et al.  Relationship between disease activity indices and colonoscopic findings in patients with colonic inflammatory bowel disease. , 1986, Gut.

[300]  N. Greenberger,et al.  5-Aminosalicylic acid enemas: effective agent in maintaining remission in left-sided ulcerative colitis. , 1988, Gastroenterology.

[301]  S. Kuriyama,et al.  Effect of weekend 5‐aminosalicylic acid (mesalazine) enema as maintenance therapy for ulcerative colitis: Results from a randomized controlled study , 2007, Inflammatory bowel diseases.

[302]  S. Truelove,et al.  ULCERATIVE COLITIS COURSE AND PROGNOSIS , 1950 .

[303]  P. Desreumaux,et al.  Review article: mode of action and delivery of 5‐aminosalicylic acid – new evidence , 2006, Alimentary pharmacology & therapeutics.

[304]  K. Lindor,et al.  Primary sclerosing cholangitis: Diagnosis and management , 2006, Current gastroenterology reports.

[305]  D. Jewell,et al.  Controlled trial of intravenous metronidazole as an adjunct to corticosteroids in severe ulcerative colitis. , 1986, Gut.

[306]  Feza H. Remzi,et al.  Evaluation of the Learning Curve in Ileal Pouch–Anal Anastomosis Surgery , 2005, Annals of surgery.

[307]  S. Targan,et al.  Diagnostic accuracy of serological assays in pediatric inflammatory bowel disease. , 1998, Gastroenterology.

[308]  J. Barkin.  Impact of Clostridium difficile on Inflammatory Bowel Disease , 2008 .

[309]  C. Brensinger,et al.  A meta-analysis of the placebo rates of remission and response in clinical trials of active ulcerative colitis. , 2007, Gastroenterology.

[310]  J. Achkar,et al.  Endoscopic and histologic evaluation together with symptom assessment are required to diagnose pouchitis. , 2001, Gastroenterology.

[311]  E. Arlander,et al.  Ropivacaine gel in active distal ulcerative colitis and proctitis—a pharmacokinetic and exploratory clinical study , 1996, Alimentary pharmacology & therapeutics.

[312]  E. Oldfield.  Clostridium difficile-associated diarrhea: resurgence with a vengeance. , 2006, Reviews in gastroenterological disorders.

[313]  Anne Lavergne,et al.  Colonoscopy of acute colitis , 1994, Digestive Diseases and Sciences.

[314]  F. Campbell,et al.  How could pathologists improve the initial diagnosis of colitis? Evidence from an international workshop , 2002, Journal of clinical pathology.

[315]  M. Kamm,et al.  Once daily high dose probiotic therapy (VSL#3) for maintaining remission in recurrent or refractory pouchitis , 2003, Gut.

[316]  M. Cheang,et al.  A Population-Based Case Control Study of Potential Risk Factors for IBD , 2006, The American Journal of Gastroenterology.

[317]  C. Prantera,et al.  Anti-tumour necrosis factor alpha (infliximab) in the treatment of severe ulcerative colitis: result of an open study on 13 patients. , 2002, Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver.

[318]  R. Hoffmann,et al.  Epidemiologic and clinical characteristics of children with newly diagnosed inflammatory bowel disease in Wisconsin: a statewide population-based study. , 2003, The Journal of pediatrics.

[319]  B. Scott,et al.  How effective are the usual treatments for ulcerative colitis? , 2004, Alimentary pharmacology & therapeutics.

[320]  E. Björnsson,et al.  Quality of life in inflammatory bowel disease in remission: the impact of IBS-like symptoms and associated psychological factors , 2002, American Journal of Gastroenterology.

[321]  M. Al-Haddad,et al.  Differentiating risk factors for acute and chronic pouchitis. , 2005, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[322]  K. Batts,et al.  A placebo-controlled trial of cyclosporine enemas for mildly to moderately active left-sided ulcerative colitis. , 1994, Gastroenterology.

[323]  P. Renzulli,et al.  Ulcerative colitis: Correlation of the Rachmilewitz endoscopic activity index with fecal calprotectin, clinical activity, C‐reactive protein, and blood leukocytes , 2009, Inflammatory bowel diseases.

[324]  J. Evans,et al.  Non-steroidal anti-inflammatory drugs are associated with emergency admission to hospital for colitis due to inflammatory bowel disease. , 1997, Gut.

[325]  M. Bellini,et al.  Role of faecal calprotectin as non-invasive marker of intestinal inflammation. , 2003, Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver.

[326]  E. Cabré,et al.  Azathioprine is useful in maintaining long-term remission induced by intravenous cyclosporine in steroid-refractory severe ulcerative colitis. , 1996, The American journal of gastroenterology.

[327]  R. May,et al.  Sexual dysfunction following rectal excision for ulcerative colitis , 1966, The British journal of surgery.

[328]  H. Drummond,et al.  The efficacy of corticosteroid therapy in inflammatory bowel disease: analysis of a 5‐year UK inception cohort , 2006, Alimentary pharmacology & therapeutics.

[329]  H. Brambs,et al.  [Diagnosis and therapy of ulcerative colitis: results of an evidence based consensus conference by the German society of Digestive and Metabolic Diseases and the competence network on inflammatory bowel disease]. , 2004, Zeitschrift fur Gastroenterologie.

[330]  N. Harpaz,et al.  Colonoscopic polypectomy in chronic colitis: conservative management after endoscopic resection of dysplastic polyps. , 1999, Gastroenterology.

[331]  A. Forbes,et al.  Multicentre randomized‐controlled clinical trial of Ipocol, a new enteric‐coated form of mesalazine, in comparison with Asacol in the treatment of ulcerative colitis , 2005, Alimentary pharmacology & therapeutics.

[332]  A. Lazenby,et al.  Preoperative terminal ileal and colonic resection histopathology predicts risk of pouchitis in patients after ileoanal pull-through procedure. , 1998, Annals of surgery.

[333]  W. Crandall,et al.  Anxiety and Pain Symptoms in Children With Inflammatory Bowel Disease and Functional Gastrointestinal Disorders Undergoing Colonoscopy , 2007, Journal of pediatric gastroenterology and nutrition.

[334]  W. Hong,et al.  Appendiceal orifice inflammation as a skip lesion in ulcerative colitis: an analysis in relation to medical therapy and disease extent. , 1999, Gastrointestinal endoscopy.

[335]  A. Michalsen,et al.  Effects of Mind-Body Therapy on Quality of Life and Neuroendocrine and Cellular Immune Functions in Patients with Ulcerative Colitis , 2005, Psychotherapy and Psychosomatics.

[336]  A. Griffiths.  Specificities of inflammatory bowel disease in childhood. , 2004, Best practice & research. Clinical gastroenterology.

[337]  A. Forbes,et al.  Thirty-year analysis of a colonoscopic surveillance program for neoplasia in ulcerative colitis. , 2006, Gastroenterology.

[338]  M. Reyes-Múgica,et al.  Patterns of Inflammation in Mucosal Biopsies of Ulcerative Colitis: Perceived Differences in Pediatric Populations Are Limited to Children Younger Than 10 Years , 2004, The American journal of surgical pathology.

[339]  C. Mittermaier,et al.  Impact of Depressive Mood on Relapse in Patients With Inflammatory Bowel Disease: A Prospective 18-Month Follow-Up Study , 2004, Psychosomatic medicine.

[340]  M. Shimizu,et al.  Significance of appendiceal involvement in patients with ulcerative colitis. , 2002, Gastrointestinal endoscopy.

[341]  K. Fellermann,et al.  Mesenteric Pulsatility Index Analysis Predicts Response to Azathioprine in Patients with Crohn's Disease , 2005, Inflammatory bowel diseases.

[342]  F. Casellas,et al.  Impairment of Health‐Related Quality of Life in Patients With Inflammatory Bowel Disease: a Spanish Multicenter Study , 2005, Inflammatory bowel diseases.

[343]  D. Drossman.  Gastrointestinal Illness and the Biopsychosocial Model , 1998, Psychosomatic medicine.

[344]  K. Gauvreau,et al.  Depressive Symptoms and Inflammatory Bowel Disease in Children and Adolescents: A Cross-Sectional Study , 2004, Journal of pediatric gastroenterology and nutrition.

[345]  V. Binder.  Epidemiology of IBD during the twentieth century: an integrated view. , 2004, Best practice & research. Clinical gastroenterology.

[346]  J. Colombel,et al.  Colectomy with ileorectal anastomosis preserves female fertility in ulcerative colitis. , 2006, Gastroenterologie clinique et biologique.

[347]  S Gallivan,et al.  Guidelines for the initial biopsy diagnosis of suspected chronic idiopathic inflammatory bowel disease. The British Society of Gastroenterology Initiative. , 1997, Journal of clinical pathology.

[348]  G. D'Haens,et al.  Advances in biologic therapy for ulcerative colitis and Crohn’s disease , 2006, Current gastroenterology reports.

[349]  C. H. Mason,et al.  Controlled trial comparing olsalazine and sulphasalazine for the maintenance treatment of ulcerative colitis. , 1988, Scandinavian journal of gastroenterology. Supplement.

[350]  A. Auvinen,et al.  Incidence of inflammatory bowel disease in finnish children, 1987–2003 , 2006, Inflammatory bowel diseases.

[351]  F. Reinholt,et al.  Cancer risk assessment in long-standing pouchitis , 2002, International Journal of Colorectal Disease.

[352]  D. Drossman,et al.  The rating form of IBD patient concerns: a new measure of health status. , 1991, Psychosomatic medicine.

[353]  T. Matsui,et al.  A randomised dose finding study of oral tacrolimus (FK506) therapy in refractory ulcerative colitis , 2006, Gut.

[354]  C. Fundarò,et al.  [Utility and safety endoscopic digestive procedure in pediatric age]. , 2005, La Pediatria medica e chirurgica : Medical and surgical pediatrics.

[355]  E. Rondonotti,et al.  Gender and disease activity influence health-related quality of life in inflammatory bowel diseases. , 2005, Hepato-gastroenterology.

[356]  S. Hanauer,et al.  European evidence-based consensus on the diagnosis and management of Crohn’s disease , 2007, Gut.

[357]  A. Sood,et al.  The beneficial effect of azathioprine on maintenance of remission in severe ulcerative colitis , 2002, Journal of Gastroenterology.

[358]  S. Hansen,et al.  Bioavailability of 5-aminosalicylic acid from slow release 5-aminosalicylic acid drug and sulfasalazine in normal children , 1993, Digestive Diseases and Sciences.

[359]  J. Achkar,et al.  Treatment of Rectal Cuff Inflammation (Cuffitis) in Patients with Ulcerative Colitis Following Restorative Proctocolectomy and Ileal Pouch-Anal Anastomosis , 2004, American Journal of Gastroenterology.

[360]  H. Tilg,et al.  A randomized placebo-controlled trial of pegylated interferon alpha in active ulcerative colitis , 2003 .

[361]  J. Andrews,et al.  Antidepressants and inflammatory bowel disease: a systematic review , 2006, Clinical practice and epidemiology in mental health : CP & EMH.

[362]  M. Vatn,et al.  Ulcerative Colitis: Patient Characteristics May Predict 10-Yr Disease Recurrence in a European-Wide Population-Based Cohort , 2007, The American Journal of Gastroenterology.

[363]  R. Xavier,et al.  Unravelling the pathogenesis of inflammatory bowel disease , 2007, Nature.

[364]  D. F. Berg,et al.  Acute surgical emergencies in inflammatory bowel disease. , 2002, American journal of surgery.

[365]  T. Byers,et al.  Relevance of major stress events as an indicator of disease activity prevalence in inflammatory bowel disease. , 1991, Behavioral medicine.

[366]  M. Benninga,et al.  Pharmacokinetics of Mesalazine Pellets in Children With Inflammatory Bowel Disease , 2004, Inflammatory bowel diseases.

[367]  A. V. van Bodegraven,et al.  Distribution of mesalazine enemas in active and quiescent ulcerative colitis. , 1996, Alimentary pharmacology & therapeutics.

[368]  M. Wallander,et al.  Risk factors for inflammatory bowel disease in the general population , 2005, Alimentary pharmacology & therapeutics.

[369]  S. Kreiner,et al.  Clinical appearance at diagnosis of ulcerative colitis and Crohn's disease in a regional patient group. , 1983, Scandinavian journal of gastroenterology.

[370]  S. Verloove-vanhorick,et al.  Long-term outcome , 1998 .

[371]  M. Verhoef,et al.  Complementary medicine use by patients with inflammatory bowel disease , 1998, American Journal of Gastroenterology.

[372]  M. Vatn,et al.  Health‐related Quality of Life in Patients with Inflammatory Bowel Disease Measured with the Short Form‐36: Psychometric Assessments and a Comparison with General Population Norms , 2005, Inflammatory bowel diseases.

[373]  D. Rampton,et al.  Review article: complementary and alternative therapies for inflammatory bowel disease , 2006, Alimentary pharmacology & therapeutics.

[374]  P. Fockens,et al.  Beclomethasone dipropionate (3 mg) versus 5-aminosalicylic acid (2 g) versus the combination of both (3 mg/2 g) as retention enemas in active ulcerative proctitis. , 1996, European journal of gastroenterology & hepatology.

[375]  G. Dunnill,et al.  Diagnosis and treatment of pyoderma gangrenosum , 2006, BMJ : British Medical Journal.

[376]  D. Day,et al.  Correlations between defined sigmoidoscopic appearances and other measures of disease activity in ulcerative colitis , 1982, Digestive Diseases and Sciences.

[377]  Jolles,et al.  Combination oral and topical tacrolimus in therapy‐resistant pyoderma gangrenosum , 1999, The British journal of dermatology.

[378]  R. Prescott,et al.  Predicting the outcome of severe ulcerative colitis: development of a novel risk score to aid early selection of patients for second‐line medical therapy or surgery , 2004, Alimentary pharmacology & therapeutics.

[379]  J. Satsangi,et al.  Genetic markers may predict disease behavior in patients with ulcerative colitis. , 1997, Gastroenterology.

[380]  Noam Harpaz,et al.  Progression of flat low-grade dysplasia to advanced neoplasia in patients with ulcerative colitis. , 2003, Gastroenterology.

[381]  J. Walker-smith,et al.  Mesalazine in childhood inflammatory bowel disease , 1989, Alimentary pharmacology & therapeutics.

[382]  P. Rutgeerts,et al.  Appendectomy protects against ulcerative colitis. , 1994, Gastroenterology.

[383]  P. Munkholm,et al.  Treatment of active distal ulcerative colitis with immunoglobulin G enemas , 1993, Alimentary pharmacology & therapeutics.

[384]  D. Orenstein,et al.  Maternal psychiatric disorders in pediatric inflammatory bowel disease and cystic fibrosis , 1994, Child psychiatry and human development.

[385]  J. Stockman.  Treatment of Ulcerative Colitis With a Humanized Antibody to the α4β7 Integrin , 2007 .

[386]  L. van Lieshout,et al.  Pouchitis: result of microbial imbalance? , 1994, Gut.

[387]  P. J. Smith,et al.  Dose‐response Effect , 1987, Acta paediatrica Scandinavica. Supplement.

[388]  H. Janowitz,et al.  The "natural history" of ulcerative colitis: an analysis of the placebo response. , 1989, Journal of clinical gastroenterology.

[389]  Å. Danielsson,et al.  Infliximab as rescue therapy in severe to moderately severe ulcerative colitis: a randomized, placebo-controlled study. , 2005, Gastroenterology.

[390]  E. Irvine.  Quality of Life--measurement in inflammatory bowel disease. , 1993, Scandinavian journal of gastroenterology. Supplement.

[391]  A. Petrie,et al.  Serum levels of C‐reactive protein in Crohn's disease and ulcerative colitis , 1982, European journal of clinical investigation.

[392]  B. Nordlinger,et al.  Function of ileal J pouch‐anal anastomosis in patients with familial adenomatous polyposis , 1993, The British journal of surgery.

[393]  S. Laurberg,et al.  Ulcerative colitis: female fecundity before diagnosis, during disease, and after surgery compared with a population sample. , 2002, Gastroenterology.

[394]  A. Darzi,et al.  Diagnostic Precision of Fecal Calprotectin for Inflammatory Bowel Disease and Colorectal Malignancy , 2007, The American Journal of Gastroenterology.

[395]  R. Yantiss,et al.  Histologic Predictors of Pouchitis in Patients with Chronic Ulcerative Colitis , 2004, The American journal of surgical pathology.

[396]  J. Bartelsman,et al.  Predictors of health care utilization in patients with inflammatory bowel disease: a longitudinal study , 1998, European journal of gastroenterology & hepatology.

[397]  C. Rubio,et al.  Low-Grade Dysplasia in Extensive, Long-Standing Inflammatory Bowel Disease , 2002, Diseases of the colon and rectum.

[398]  A. Price.  Overlap in the spectrum of non-specific inflammatory bowel disease--'colitis indeterminate'. , 1978, Journal of clinical pathology.

[399]  V. Fazio,et al.  Combined Ciprofloxacin and Tinidazole Therapy in the Treatment of Chronic Refractory Pouchitis , 2007, Diseases of the colon and rectum.

[400]  F. Jones,et al.  An Assessment of Prednisone, Salazopyrin, and Topical Hydrocortisone Hemisuccinate Used as Out-patient Treatment for Ulcerative Colitis , 1960, Gut.

[401]  R. Farmer,et al.  Clinical patterns, natural history, and progression of ulcerative colitis , 1993, Digestive Diseases and Sciences.

[402]  G. Lichtenstein.  Development, Validation, and Evaluation of a Pediatric Ulcerative Colitis Activity Index: A Prospective Multicenter Study , 2008 .

[403]  D. Jewell,et al.  High‐Dose Methylprednisolone in the Treatment of Active Ulcerative Colitis , 1988, Journal of clinical gastroenterology.

[404]  E. Cameron,et al.  Oral Prednisolone Metasulphobenzoate in the Treatment of Active Ulcerative Colitis , 2003, Scandinavian journal of gastroenterology.

[405]  W. Kruis,et al.  Chronic inflammatory bowel disease and cancer. , 2000, Hepato-gastroenterology.

[406]  R. Löfberg,et al.  Pouchitis following pelvic pouch operation for ulcerative colitis , 1996, Diseases of the colon and rectum.

[407]  A. Watson,et al.  Gastrin increases murine intestinal crypt regeneration following injury. , 2006, Gastroenterology.

[408]  J. von Wietersheim,et al.  [Education of patients with inflammatory bowel diseases]. , 1999, Wiener medizinische Wochenschrift.

[409]  E. Loftus.  Does Monitoring Prevent Cancer in Inflammatory Bowel Disease? , 2003, Journal of clinical gastroenterology.

[410]  N. Crona,et al.  Gynaecological and sexual function related to anatomical changes in the female pelvis after restorative proctocolectomy , 1994, International Journal of Colorectal Disease.

[411]  M F Neurath,et al.  Surveillance colonoscopy in ulcerative colitis: magnifying chromoendoscopy in the spotlight , 2004, Gut.

[412]  Katherine S. Virgo,et al.  Patterns of disease and surgical treatment among United States veterans more than 50 years of age with ulcerative colitis. , 2003, American journal of surgery.

[413]  H. Büller,et al.  Value of Rectosigmoidoscopy with Biopsies for Diagnosis of Inflammatory Bowel Disease in Children , 2002, Inflammatory bowel diseases.

[414]  P. Hellström,et al.  A 2-year follow-up of the swedish-danish Infliximab/Placebo trial in steroid resistant acute ulcerative colitis , 2007 .

[415]  J. Marshall,et al.  Successful therapy of refractory erythema nodosum associated with Crohn's disease using potassium iodide. , 1997, Canadian journal of gastroenterology = Journal canadien de gastroenterologie.

[416]  P. Miner,et al.  An enema formulation of alicaforsen, an antisense inhibitor of intercellular adhesion molecule‐1, in the treatment of chronic, unremitting pouchitis , 2004, Alimentary pharmacology & therapeutics.

[417]  P. Skipworth,et al.  Reliability of rectal biopsy in distinguishing between chronic inflammatory bowel disease and acute self‐limiting colitis , 1997, Histopathology.

[418]  W. Tremaine,et al.  Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. , 1987, The New England journal of medicine.

[419]  J. Lennard-jones,et al.  Clinical uniformity of inflammatory bowel disease at presentation and during the first year of disease in the north and south of Europe , 1997 .

[420]  E. Tiret,et al.  [Ileal pouch anal-anastomosis without protective ileostomy]. , 2002, Gastroenterologie clinique et biologique.

[421]  M. Donnelly,et al.  Providing Disease-Related Information Worsens Health-Related Quality of Life in Inflammatory Bowel Disease , 2002, Inflammatory bowel diseases.

[422]  B. Sands,et al.  Prevention and treatment of osteoporosis in inflammatory bowel disease , 2006, Inflammatory bowel diseases.

[423]  B. Phillips.  GRADE: levels of evidence and grades of recommendation. , 2004, Archives of disease in childhood.

[424]  M. Vatn,et al.  Low colectomy rates in ulcerative colitis in an unselected European cohort followed for 10 years. , 2007, Gastroenterology.

[425]  L. Mackillop,et al.  European evidenced-based consensus on reproduction in inflammatory bowel disease. , 2010, Journal of Crohn's & colitis.

[426]  H. Nagawa,et al.  Cytomegalovirus infection in ulcerative colitis , 2006, Scandinavian journal of gastroenterology.

[427]  C. Bartram.  Radiology in the current assessment of ulcerative colitis , 1976, Gastrointestinal Radiology.

[428]  F. Zijlstra,et al.  Ridogrel enemas in distal ulcerative colitis. , 1998 .

[429]  A. Schoepfer,et al.  Comparison of Interferon-Gamma Release Assay Versus Tuberculin Skin Test for Tuberculosis Screening in Inflammatory Bowel Disease , 2008, The American Journal of Gastroenterology.

[430]  P. Rutgeerts,et al.  Randomized, double-blind comparison of 4 mg/kg versus 2 mg/kg intravenous cyclosporine in severe ulcerative colitis. , 2003, Gastroenterology.

[431]  K. Das,et al.  Double-blind placebo-controlled study of olsalazine in the treatment of ulcerative colitis. , 1990, The American journal of gastroenterology.

[432]  S. Travis,et al.  The Management of Acute Severe Colitis: ACPGBI Position Statement , 2008, Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland.

[433]  P. Brigidi,et al.  Prophylaxis of pouchitis onset with probiotic therapy: A double‐blind, placebo‐controlled trial , 2000, Gastroenterology.

[434]  D. Jewell,et al.  Cancer surveillance in ulcerative colitis , 2005, The British journal of surgery.

[435]  Z. Cohen,et al.  Subtotal colectomy for ulcerative colitis: Complications related to the rectal remnant , 1991, Diseases of the colon and rectum.

[436]  M. Camilleri,et al.  Fecal Lactoferrin Is a Sensitive and Specific Marker in Identifying Intestinal Inflammation , 2003, American Journal of Gastroenterology.

[437]  C. Feyerabend,et al.  Nicotine enemas for active ulcerative colitis—a pilot study , 1997, Alimentary pharmacology & therapeutics.

[438]  D. Blondin,et al.  Multi-detector CT-colonography in inflammatory bowel disease: prospective analysis of CT-findings to high-resolution video colonoscopy. , 2006, European journal of radiology.

[439]  D. Bartolo,et al.  Comparison of the Moskowitz criteria and the pouchitis disease activity index (PDAI) for diagnosis of ileoanal pouch inflammation , 2001, Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland.

[440]  A. Zinsmeister,et al.  Incidence and Prognosis of Colorectal Dysplasia in Inflammatory Bowel Disease: A Population‐based Study from Olmsted County, Minnesota , 2006, Inflammatory bowel diseases.

[441]  F. Farrokhyar,et al.  Functional gastrointestinal disorders and mood disorders in patients with inactive inflammatory bowel disease: Prevalence and impact on health , 2006, Inflammatory bowel diseases.

[442]  O. Bouché,et al.  Complementary and alternative medicine use by patients with inflammatory bowel disease: results from a postal survey. , 2006, Gastroenterologie clinique et biologique.

[443]  S. Hanauer,et al.  Cyclosporine in severe ulcerative colitis refractory to steroid therapy. , 1994, The New England journal of medicine.

[444]  P. Blok,et al.  Double-blind comparison of slow-release 5-aminosalicylate and sulfasalazine in remission maintenance in ulcerative colitis. , 1988, Gastroenterology.

[445]  J. A. Leighton,et al.  Role of small-bowel endoscopy in the management of patients with inflammatory bowel disease: an international OMED–ECCO consensus , 2009, Endoscopy.

[446]  D. M. van der Heijde,et al.  Analysing chronic spinal changes in ankylosing spondylitis: a systematic comparison of conventional x rays with magnetic resonance imaging using established and new scoring systems , 2004, Annals of the rheumatic diseases.

[447]  S. Heys,et al.  Distal procto-colitis, natural cytotoxicity, and essential fatty acids , 1998, American Journal of Gastroenterology.

[448]  J. Lennard-jones,et al.  Clinical uniformity of inflammatory bowel disease a presentation and during the first year of disease in the north and south of Europe. EC-IBD Study Group. , 1997, European journal of gastroenterology & hepatology.

[449]  J. Lennard-jones,et al.  Controlled trial of bowel rest in the treatment of severe acute colitis. , 1986, Gut.

[450]  S. Gallus,et al.  Are Colonoscopy and Bowel Ultrasound Useful for Assessing Response to Short-Term Therapy and Predicting Disease Outcome of Moderate-to-Severe Forms of Ulcerative Colitis?: A Prospective Study , 2010, The American Journal of Gastroenterology.

[451]  J. Lennard-jones,et al.  Precancer and cancer in extensive ulcerative colitis: findings among 401 patients over 22 years. , 1990, Gut.

[452]  K. Ladefoged,et al.  Skip inflammation of the appendiceal orifice: A prospective endoscopic study , 2005, Scandinavian journal of gastroenterology.

[453]  Å. Danielsson,et al.  Olsalazine versus sulphasalazine for relapse prevention in ulcerative colitis: a multicenter study. , 1995, The American journal of gastroenterology.

[454]  J. Achkar,et al.  Risk factors for diseases of ileal pouch-anal anastomosis after restorative proctocolectomy for ulcerative colitis. , 2006, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[455]  Y. Mahida,et al.  Clostridium difficile associated diarrhoea in hospitalised patients: onset in the community and hospital and role of flexible sigmoidoscopy , 2004, Gut.

[456]  D. Glavač,et al.  Polymorphisms in multidrug resistance 1 (MDR1) gene are associated with refractory Crohn disease and ulcerative colitis , 2004, Genes and Immunity.

[457]  H. Ikeuchi,et al.  Preoperative Steroid-Related Complications in Japanese Pediatric Patients With Ulcerative Colitis , 2006, Diseases of the colon and rectum.

[458]  A. Gasbarrini,et al.  Efficacy of Lactobacillus GG in maintaining remission of ulcerative colitis , 2006, Alimentary pharmacology & therapeutics.

[459]  Fraser Cummings,et al.  Clinical and molecular characteristics of isolated colonic Crohn's disease , 2008, Inflammatory bowel diseases.

[460]  N. LaRusso,et al.  Pouchitis after ileal pouch-anal anastomosis for ulcerative colitis occurs with increased frequency in patients with associated primary sclerosing cholangitis. , 1996, Gut.

[461]  S. Truelove,et al.  Cortisone in Ulcerative Colitis , 1954 .

[462]  Adler Dj,et al.  The therapeutic efficacy of 6-mercaptopurine in refractory ulcerative colitis. , 1990 .

[463]  A. Zinsmeister,et al.  Predictive and protective factors associated with colorectal cancer in ulcerative colitis: A case-control study. , 2006, Gastroenterology.

[464]  A. Griffiths,et al.  Olsalazine versus sulfasalazine in mild to moderate childhood ulcerative colitis: results of the Pediatric Gastroenterology Collaborative Research Group Clinical Trial. , 1993, Journal of pediatric gastroenterology and nutrition.

[465]  D. James.  Erythema Nodosum , 1961, British medical journal.

[466]  P. Munkholm,et al.  Increasing Incidences of Inflammatory Bowel Disease and Decreasing Surgery Rates in Copenhagen City and County, 2003–2005: A Population-Based Study from the Danish Crohn Colitis Database , 2006, The American Journal of Gastroenterology.

[467]  A. Katz,et al.  Infliximab Is Effective in Acute but not Chronic Childhood Ulcerative Colitis , 2004, Journal of pediatric gastroenterology and nutrition.

[468]  D. Hommes,et al.  The Pathogenicity of Cytomegalovirus in Inflammatory Bowel Disease: A Systematic Review and Evidence-based Recommendations for Future Research , 2004, Inflammatory bowel diseases.

[469]  J. Jahnsen,et al.  Pediatric Inflammatory Bowel Disease in Southeastern Norway: A Five-Year Follow-Up Study , 2005, Digestion.

[470]  R. Newcombe,et al.  Transdermal nicotine as maintenance therapy for ulcerative colitis. , 1995, The New England journal of medicine.

[471]  A. H. Zwinderman,et al.  Effect of vaginal delivery on long‐term pouch function , 2006, The British journal of surgery.

[472]  A. Poullis,et al.  Review article: faecal markers in the assessment of activity in inflammatory bowel disease. , 2002, Alimentary pharmacology & therapeutics.

[473]  Naveen Kumar,et al.  Hydrocolonic sonography in the evaluation of colonic lesions , 1999, Abdominal Imaging.

[474]  M. Kimmey,et al.  DNA aneuploidy in colonic biopsies predicts future development of dysplasia in ulcerative colitis. , 1992, Gastroenterology.

[475]  J. Marshall,et al.  Rectal aminosalicylate therapy for distal ulcerative colitis: a meta‐analysis , 1995, Alimentary pharmacology & therapeutics.

[476]  S. Travis,et al.  Infliximab for the treatment of ulcerative colitis: outcomes in Oxford from 2000 to 2006 , 2007, Alimentary pharmacology & therapeutics.

[477]  M. Singer,et al.  Reducing psychological distress in patients with inflammatory bowel disease by cognitive-behavioural treatment: exploratory study of effectiveness. , 2003, Scandinavian journal of gastroenterology.

[478]  W. Sandborn,et al.  Management of Crohn's disease of the ileoanal pouch with infliximab , 2003, American Journal of Gastroenterology.

[479]  H. Ishikawa,et al.  Randomized Controlled Trial of the Effect of Bifidobacteria-Fermented Milk on Ulcerative Colitis , 2003 .

[480]  J. McDonnell,et al.  Important cutaneous manifestations of inflammatory bowel disease , 2005, Postgraduate Medical Journal.

[481]  P. Balladur,et al.  Restorative proctocolectomy for distal ulcerative colitis , 1999, Gut.

[482]  M. Casparie,et al.  The Incidence of Pediatric Inflammatory Bowel Disease in the Netherlands: 1999–2001 , 2004, Journal of pediatric gastroenterology and nutrition.

[483]  C. Folwaczny,et al.  Methotrexate in ulcerative colitis , 2003, Alimentary pharmacology & therapeutics.

[484]  F. Casellas,et al.  Practicality of 5-aminosalicylic suppositories for long-term treatment of inactive distal ulcerative colitis. , 1999, Hepato-gastroenterology.

[485]  M Sculpher,et al.  A randomised controlled trial to assess the impact of a package comprising a patient-orientated, evidence-based self-help guidebook and patient-centred consultations on disease management and satisfaction in inflammatory bowel disease. , 2003, Health technology assessment.

[486]  D. Forman,et al.  Ten year follow up of ulcerative colitis patients with and without low grade dysplasia , 2003, Gut.

[487]  L. Melton,et al.  Primary sclerosing cholangitis is associated with nonsmoking: a case-control study. , 1996, Gastroenterology.

[488]  W. Kruis,et al.  Olsalazine versus placebo in the treatment of mild to moderate ulcerative colitis: a randomised double blind trial. , 1989, Gut.

[489]  S. Hollerbach,et al.  The accuracy of abdominal ultrasound in the assessment of bowel disorders. , 1998, Scandinavian journal of gastroenterology.

[490]  K. Batts,et al.  Pouchitis after ileal pouch-anal anastomosis: a Pouchitis Disease Activity Index. , 1994, Mayo Clinic proceedings.

[491]  A. Kornbluth,et al.  Prevention of Colorectal Cancer in Inflammatory Bowel Disease: Value of Screening and 5-Aminosalicylates , 2006, Digestion.

[492]  P. Rutgeerts,et al.  Incidence of colectomy during long-term follow-up after cyclosporine-induced remission of severe ulcerative colitis. , 2006, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[493]  R. Beart,et al.  Ileal pouch-anal anastomosis without ileostomy , 1991, Diseases of the colon and rectum.

[494]  A. Andriulli,et al.  Continuous Infusion Versus Bolus Administration of Steroids in Severe Attacks of Ulcerative Colitis: A Randomized, Double-Blind Trial , 2007, The American Journal of Gastroenterology.

[495]  R. Goldberg,et al.  Colorectal cancer prognosis among patients with inflammatory bowel disease. , 2006, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[496]  G. Corrao,et al.  Short‐chain fatty acid topical treatment in distal ulcerative colitis , 1995, Alimentary pharmacology & therapeutics.

[497]  R. Baldassano,et al.  Experiences with 6-mercaptopurine and azathioprine therapy in pediatric patients with severe ulcerative colitis. , 1999, Journal of pediatric gastroenterology and nutrition.

[498]  K. Koganei,et al.  Restorative Proctocolectomy for Pediatric Patients with Ulcerative Colitis , 2006, Surgery Today.

[499]  A. Axon,et al.  The role of azathioprine in the management of ulcerative colitis , 1990, Diseases of the colon and rectum.

[500]  V. Litle,et al.  The continent ileostomy: Long-term durability and patient satisfaction , 1998, Journal of Gastrointestinal Surgery.

[501]  S. Hanauer,et al.  Safety and efficacy of controlled-release mesalamine for maintenance of remission in ulcerative colitis , 1995, Digestive Diseases and Sciences.

[502]  G. Sachs,et al.  Relationship between the use of unconventional therapies and disease-related concerns: a study of patients with inflammatory bowel disease. , 1996, Journal of psychosomatic research.

[503]  R. Newcombe,et al.  Transdermal nicotine compared with oral prednisolone therapy for active ulcerative colitis. , 1996, European journal of gastroenterology & hepatology.

[504]  D. Baeten,et al.  Infliximab in patients who have spondyloarthropathy: clinical efficacy, safety, and biological immunomodulation. , 2003, Rheumatic diseases clinics of North America.

[505]  W. Sandborn,et al.  Safety of celecoxib in patients with ulcerative colitis in remission: a randomized, placebo-controlled, pilot study. , 2006, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[506]  J. Galmiche,et al.  Value of wireless capsule endoscopy in patients with indeterminate colitis (inflammatory bowel disease type unclassified) , 2007, Inflammatory bowel diseases.

[507]  J. Korzenik,et al.  Selective use of selective nonsteroidal anti-inflammatory drugs in inflammatory bowel disease. , 2006, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[508]  M. Kamm,et al.  Once-daily, high-concentration MMX mesalamine in active ulcerative colitis. , 2007, Gastroenterology.

[509]  A. Zinsmeister,et al.  The natural history of corticosteroid therapy for inflammatory bowel disease: a population-based study. , 2001, Gastroenterology.

[510]  N. Mortensen,et al.  Smoking may prevent pouchitis in patients with restorative proctocolectomy for ulcerative colitis. , 1996, Gut.

[511]  D. Gudbjartsson,et al.  Subclinical intestinal inflammation and sacroiliac changes in relatives of patients with ankylosing spondylitis. , 2003, Gastroenterology.

[512]  R. Farrell,et al.  Endoscopy in inflammatory bowel disease: indications, surveillance, and use in clinical practice. , 2005, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[513]  A Price,et al.  Observer variation and discriminatory value of biopsy features in inflammatory bowel disease. , 1994, Gut.

[514]  J. Achkar,et al.  Irritable pouch syndrome: a new category of diagnosis for symptomatic patients with ileal pouch-anal anastomosis. , 2002 .

[515]  Z. Cohen,et al.  Female Infertility After Ileal Pouch-Anal Anastomosis for Ulcerative Colitis , 2004, Diseases of the colon and rectum.

[516]  T. Orchard.  Extraintestinal complications of inflammatory bowel disease , 2003, Current gastroenterology reports.

[517]  D. Johnston,et al.  The efficacy of tobramycin in the treatment of ulcerative colitis , 1990, Alimentary pharmacology & therapeutics.

[518]  Judy H. Cho,et al.  MDR1 Ala893 polymorphism is associated with inflammatory bowel disease. , 2003, American journal of human genetics.

[519]  R. Odze,et al.  Long-term follow-up after polypectomy treatment for adenoma-like dysplastic lesions in ulcerative colitis. , 2004, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[520]  T. Thomas,et al.  Meta‐analysis: cancer risk of low‐grade dysplasia in chronic ulcerative colitis , 2007, Alimentary pharmacology & therapeutics.

[521]  Z. Cohen,et al.  Restorative proctocolectomy with ileal reservoir , 1986, International Journal of Colorectal Disease.

[522]  N. Shafiq,et al.  Drug treatment of ulcerative colitis: unfractionated heparin, low molecular weight heparins and beyond , 2004, Expert opinion on pharmacotherapy.

[523]  T. Yamamoto,et al.  Granulocyte and monocyte adsorptive apheresis in the treatment of active distal ulcerative colitis: a prospective, pilot study , 2004, Alimentary pharmacology & therapeutics.

[524]  A. Berstad,et al.  Guidelines on the diagnosis and management of iron deficiency and anemia in inflammatory bowel diseases. , 2007, Inflammatory bowel diseases.

[525]  Oldfield Ec rd.  Clostridium difficile-associated diarrhea: resurgence with a vengeance. , 2006 .

[526]  P. Keeling,et al.  High multidrug resistance (P-glycoprotein 170) expression in inflammatory bowel disease patients who fail medical therapy. , 2000, Gastroenterology.

[527]  Pedro Figueiredo,et al.  Capsule endoscopy in inflammatory bowel disease type unclassified and indeterminate colitis serologically negative , 2010, Inflammatory bowel diseases.

[528]  J. Goldblum,et al.  Interobserver Variability in the Diagnosis of Ulcerative Colitis-Associated Dysplasia by Telepathology , 2002, Modern Pathology.

[529]  R. Motley,et al.  Does smoking improve colitis? , 1989, Scandinavian journal of gastroenterology. Supplement.

[530]  A. Keshavarzian,et al.  Heightened Responses to Stressors in Patients with Inflammatory Bowel Disease , 2005, The American Journal of Gastroenterology.

[531]  N. Kneteman,et al.  Peak cyclosporine levels (Cmax) correlate with freedom from liver graft rejection: results of a prospective, randomized comparison of neoral and sandimmune for liver transplantation (NOF-8). , 1999, Transplantation.

[532]  C. Herfarth,et al.  Outcome after septic complications in J pouch procedures , 2002, The British journal of surgery.

[533]  L. Sutherland,et al.  5-Aminosalicylic acid enemas in treatment of distal ulcerative colitis and proctitis in Canada , 1987, Digestive Diseases and Sciences.

[534]  R. Woods,et al.  Pseudomembranous panenteritis and septicaemia in a patient with ulcerative colitis. , 1996, The Australian and New Zealand journal of surgery.

[535]  P. Munkholm,et al.  Changes in Clinical Characteristics, Course, and Prognosis of Inflammatory Bowel Disease during the Last 5 Decades: A Population‐Based Study from Copenhagen, Denmark , 2007, Inflammatory bowel diseases.

[536]  T. Breidenbach,et al.  Drug interaction of St John's wort with cyclosporin. , 2000, Lancet.

[537]  T. Hibi,et al.  Multicenter randomized controlled trial for the treatment of ulcerative colitis with a leukocytapheresis column. , 2003, Current pharmaceutical design.

[538]  Geraint T. Williams,et al.  Comparison of bismuth citrate and 5-aminosalicylic acid enemas in distal ulcerative colitis: a controlled trial. , 1993, Gut.

[539]  A. Griffiths,et al.  Omega 3 fatty acids (fish oil) for maintenance of remission in ulcerative colitis. , 2007, The Cochrane database of systematic reviews.

[540]  G. Sachs,et al.  Disease-related worries and concerns: a study on out-patients with inflammatory bowel disease. , 1995, European journal of gastroenterology & hepatology.

[541]  A. Kornbluth,et al.  Ulcerative Colitis Practice Guidelines in Adults (Update): American College of Gastroenterology, Practice Parameters Committee , 2004, American Journal of Gastroenterology.

[542]  A. Ekbom.  Ulcerative Colitis and Colorectal Cancer , 1991 .

[543]  D. Gozal,et al.  Complicated endoscopic pediatric procedures using deep sedation and general anesthesia are safe in the endoscopy suite , 2004, Scandinavian journal of gastroenterology.

[544]  G. Costa,et al.  Familial and psychological risk factors of ulcerative colitis. , 1997, Italian journal of gastroenterology and hepatology.

[545]  P. Testoni,et al.  A pilot trial of Saccharomyces boulardii in ulcerative colitis , 2003, European journal of gastroenterology & hepatology.

[546]  J. Goldblum,et al.  Patterns of colonic involvement at initial presentation in ulcerative colitis: a retrospective study of 46 newly diagnosed cases. , 2004, American journal of clinical pathology.

[547]  D. Symmons,et al.  Systematic review: is ingestion of paracetamol or non‐steroidal anti‐inflammatory drugs associated with exacerbations of inflammatory bowel disease? , 2004, Alimentary pharmacology & therapeutics.

[548]  Laurent Beaugerie,et al.  The second European evidence-based Consensus on the diagnosis and management of Crohn's disease: Definitions and diagnosis. , 2006, Journal of Crohn's & colitis.

[549]  L. Schiller,et al.  AGA technical review on the evaluation and management of chronic diarrhea. , 1999, Gastroenterology.

[550]  S. Leveson,et al.  Rifaximin‐ciprofloxacin combination therapy is effective in chronic active refractory pouchitis , 2005, Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland.

[551]  M. Charron,et al.  CT and 99mTc-WBC vs colonoscopy in the evaluation of inflammation and complications of inflammatory bowel diseases , 2002, Journal of Gastroenterology.

[552]  P. Testoni,et al.  Distal ulcerative colitis refractory to rectal mesalamine: role of transdermal nicotine versus oral mesalamine. , 2002, Canadian journal of gastroenterology = Journal canadien de gastroenterologie.

[553]  D. Jewell,et al.  Cyclosporin A retention enemas in refractory distal ulcerative colitis and 'pouchitis'. , 1993, Scandinavian journal of gastroenterology.

[554]  S. Hanauer,et al.  Review article: high‐dose aminosalicylates to induce and maintain remissions in ulcerative colitis , 2006, Alimentary pharmacology & therapeutics.

[555]  D. Jewell,et al.  Predicting outcome in severe ulcerative colitis. , 1996, Gut.

[556]  M. Plebani,et al.  Enzymes in feces: useful markers of chronic inflammatory bowel disease. , 2007, Clinica chimica acta; international journal of clinical chemistry.

[557]  M. Portella,et al.  Life Events and Inflammatory Bowel Disease Relapse: A Prospective Study of Patients Enrolled in Remission , 2006, The American Journal of Gastroenterology.

[558]  S. Targan,et al.  A double-blind comparison of oral versus rectal mesalamine versus combination therapy in the treatment of distal ulcerative colitis. , 1997, The American journal of gastroenterology.

[559]  M. Vatn,et al.  Mucosal healing in inflammatory bowel disease: results from a Norwegian population-based cohort. , 2007, Gastroenterology.

[560]  R. Beart,et al.  Effect of high-dose steroids on anastomotic complications after proctocolectomy with ileal pouch–anal anastomosis , 2004, Journal of Gastrointestinal Surgery.

[561]  D. Bloomquist.  Other systems , 2002, Proceedings of the 2002 Workshop on Autonomous Underwater Vehicles, 2002..

[562]  S. Schreiber,et al.  Immunoregulatory role of interleukin 10 in patients with inflammatory bowel disease. , 1995, Gastroenterology.

[563]  J. Satsangi,et al.  IBD: a family affair. , 2004, Best practice & research. Clinical gastroenterology.

[564]  A. Zinsmeister,et al.  Correlation of C‐Reactive Protein With Clinical, Endoscopic, Histologic, and Radiographic Activity in Inflammatory Bowel Disease , 2005, Inflammatory bowel diseases.

[565]  P. Rutgeerts,et al.  Long-term Outcome of Treatment with Intravenous Cyclosporin in Patients With Severe Ulcerative Colitis , 2004, Inflammatory bowel diseases.

[566]  L. Melton,et al.  Risk of fracture in ulcerative colitis: a population-based study from Olmsted County, Minnesota. , 2003, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[567]  F. Ajayi,et al.  Delayed-Release Oral Mesalamine at 4.8 g/day (800 mg tablet) for the Treatment of Moderately Active Ulcerative Colitis: The ASCEND II Trial , 2005, The American Journal of Gastroenterology.

[568]  Z H Khan,et al.  Retrospective Case Series Analysis of Patients with Inflammatory Bowel Disease on Azathioprine , 2000, Digestion.

[569]  M. T. Abreu-Martin,et al.  High level perinuclear antineutrophil cytoplasmic antibody (pANCA) in ulcerative colitis patients before colectomy predicts the development of chronic pouchitis after ileal pouch-anal anastomosis , 2001, Gut.

[570]  D. Foell,et al.  Faecal S100A12 as a non-invasive marker distinguishing inflammatory bowel disease from irritable bowel syndrome , 2007, Gut.

[571]  D. Rampton,et al.  Thrombosis and inflammatory bowel disease. , 2005, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[572]  P. Nyström,et al.  Use of air enema radiography to assess depth of ulceration during acute attacks of ulcerative colitis , 1996, The Lancet.

[573]  P. Rutgeerts,et al.  The risk of post‐operative complications associated with infliximab therapy for Crohn's disease: a controlled cohort study , 2004, Alimentary pharmacology & therapeutics.

[574]  D. Jewell,et al.  The efficacy of azathioprine for the treatment of inflammatory bowel disease: a 30 year review , 2002, Gut.

[575]  G. Mantzaris,et al.  Intravenous tobramycin and metronidazole as an adjunct to corticosteroids in acute, severe ulcerative colitis. , 1994, The American journal of gastroenterology.

[576]  R. Playford,et al.  Use of the ‘nutriceutical’, bovine colostrum, for the treatment of distal colitis: results from an initial study , 2002, Alimentary pharmacology & therapeutics.

[577]  S. Laurberg,et al.  Female fecundity before and after operation for familial adenomatous polyposis , 2003, The British journal of surgery.

[578]  J. Baker,et al.  Treatment of left‐sided ulcerative colitis with butyrate enemas: a controlled trial , 1996, Alimentary pharmacology & therapeutics.

[579]  P. Bello,et al.  International Study Group , 2004 .

[580]  T. Hibi,et al.  Treatment of ulcerative colitis patients by long-term administration of germinated barley foodstuff: multi-center open trial. , 2003, International journal of molecular medicine.

[581]  P. Rutgeerts,et al.  Laboratory markers in IBD: useful, magic, or unnecessary toys? , 2006, Gut.

[582]  K. Van Steen,et al.  Deficient host-bacteria interactions in inflammatory bowel disease? The toll-like receptor (TLR)-4 Asp299gly polymorphism is associated with Crohn’s disease and ulcerative colitis , 2004, Gut.

[583]  P. Lionetti,et al.  The use of ciclosporin in paediatric inflammatory bowel disease: an Italian experience , 2002, Alimentary pharmacology & therapeutics.

[584]  S. Travis,et al.  Management of acute severe colitis. , 2005, British medical bulletin.

[585]  V. Gross,et al.  Patient education in inflammatory bowel disease does not influence patients knowledge and long-term psychosocial well-being. , 2005, Zeitschrift fur Gastroenterologie.

[586]  H. Leufkens,et al.  5-Aminosalicylate use and colorectal cancer risk in inflammatory bowel disease: a large epidemiological study , 2005, Gut.

[587]  G. Järnerot,et al.  The influence of demographic and disease-related factors on health-related quality of life in patients with ulcerative colitis , 2003, European journal of gastroenterology & hepatology.

[588]  J. Satsangi,et al.  Toward an integrated clinical, molecular and serological classification of inflammatory bowel disease: report of a Working Party of the 2005 Montreal World Congress of Gastroenterology. , 2005, Canadian journal of gastroenterology = Journal canadien de gastroenterologie.

[589]  R. Spiller,et al.  Increased rectal mucosal enteroendocrine cells, T lymphocytes, and increased gut permeability following acuteCampylobacter enteritis and in post-dysenteric irritable bowel syndrome , 2000, Gut.

[590]  Beltrami,et al.  Musculoskeletal manifestations in inflammatory bowel disease. , 2000, European journal of internal medicine.

[591]  P. Rutgeerts,et al.  Effectiveness of concomitant immunosuppressive therapy in suppressing the formation of antibodies to infliximab in Crohn’s disease , 2007, Gut.

[592]  P. Schmitz-Moormann,et al.  Does quantitative histology of rectal biopsy improve the differential diagnosis of Crohn's disease and ulcerative colitis in adults? , 1988, Pathology, research and practice.

[593]  R. Urban,et al.  Corticosteroid-induced cataracts. , 1986, Survey of ophthalmology.

[594]  A. Gangl,et al.  Diagnosing colitis: a prospective study on essential parameters for reaching a diagnosis. , 2003, Endoscopy.

[595]  I. Engström,et al.  Inflammatory Bowel Disease in Children and Adolescents: a Somatic and Psychiatric Investigation , 1991, Acta paediatrica Scandinavica.

[596]  B. Levin,et al.  A controlled trial of azathioprine in the management of chronic ulcerative colitis. , 1975, Gastroenterology.

[597]  T. Ohkusa,et al.  Effectiveness of antibiotic combination therapy in patients with active ulcerative colitis: A randomized, controlled pilot trial with long-term follow-up , 2005, Scandinavian journal of gastroenterology.

[598]  A. Imaoka,et al.  Randomized placebo‐controlled trial assessing the effect of bifidobacteria‐fermented milk on active ulcerative colitis , 2004, Alimentary pharmacology & therapeutics.

[599]  M. Dougados,et al.  ASAS/EULAR recommendations for the management of ankylosing spondylitis , 2005, Annals of the rheumatic diseases.

[600]  R. Maunder,et al.  Supportive-Expressive Group Psychotherapy for Persons with Inflammatory Bowel Disease , 2001, Canadian journal of psychiatry. Revue canadienne de psychiatrie.

[601]  D. Thompson,et al.  Guided self-management and patient-directed follow-up of ulcerative colitis: a randomised trial , 2001, The Lancet.

[602]  J. Connor,et al.  Long-Term Outcome and Quality of Life After Continent Ileostomy , 2006, Diseases of the colon and rectum.

[603]  J. Jass,et al.  Observer study of the grading of dysplasia in ulcerative colitis: comparison with clinical outcome. , 1989, Human pathology.

[604]  S. Levenstein,et al.  Psychological stress and disease activity in ulcerative colitis: a multidimensional cross-sectional study. , 1994, The American journal of gastroenterology.

[605]  J. Marshall,et al.  Rectal corticosteroids versus alternative treatments in ulcerative colitis: a meta-analysis. , 1997, Gut.

[606]  J. Chen,et al.  Clinical therapeutic effect of drug-separated moxibustion on chronic diarrhea and its immunologic mechanisms. , 1997, Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan.

[607]  P. Mcclean,et al.  A prospective audit of paediatric colonoscopy under general anaesthesia , 1999, Acta paediatrica.

[608]  H. Adami,et al.  Ulcerative colitis and colorectal cancer. A population-based study. , 1990, The New England journal of medicine.

[609]  Judy H. Cho,et al.  The genetics of inflammatory bowel disease. , 2003, Gastroenterology.

[610]  R. Lynn,et al.  Variations in initial assessment and management of inflammatory bowel disease across Great Britain and Ireland , 2003, Archives of disease in childhood.

[611]  T. Sørensen,et al.  Familial occurrence of inflammatory bowel disease. , 1991, The New England journal of medicine.

[612]  Louis J. Cohen,et al.  Infliximab in Pediatric Ulcerative Colitis: Two-year Follow-up , 2003, Journal of pediatric gastroenterology and nutrition.

[613]  S. van der Linden,et al.  Combining information obtained from magnetic resonance imaging and conventional radiographs to detect sacroiliitis in patients with recent onset inflammatory back pain , 2005, Annals of the rheumatic diseases.

[614]  V. Fazio,et al.  Fertility is reduced after restorative proctocolectomy with ileal pouch anal anastomosis: a study of 300 patients. , 2004, Surgery.

[615]  S. Cucchiara,et al.  Gut-associated bacterial microbiota in paediatric patients with inflammatory bowel disease , 2006, Gut.

[616]  S. Travis,et al.  Remission in Trials of Ulcerative Colitis: What Does It Mean? INFLAMMATORY BOWEL DISEASE: A PRACTICAL APPROACH, SERIES #26 , 2006 .

[617]  S. Travis,et al.  Guidelines for the management of inflammatory bowel disease in adults , 2004, Gut.

[618]  B. Göke,et al.  Infliximab for acute, not steroid-refractory ulcerative colitis: a randomized pilot study , 2004, European journal of gastroenterology & hepatology.

[619]  A. Katz,et al.  Short- and Long-term Response to and Weaning from Infliximab Therapy in Pediatric Ulcerative Colitis , 2007, Journal of pediatric gastroenterology and nutrition.

[620]  A. Gent,et al.  Search for enteric microbial pathogens in patients with ulcerative colitis. , 1992, Digestion.

[621]  Marshall B. Kapp,et al.  A Therapeutic Approach , 2009 .

[622]  D. Robertson,et al.  Personality profile and affective state of patients with inflammatory bowel disease. , 1989, Gut.

[623]  Philip R. Cohen,et al.  Sweet’s Syndrome , 2002, American journal of clinical dermatology.

[624]  R. Lovegrove,et al.  Comparison of short-term outcomes of laparoscopic vs open approaches to ileal pouch surgery , 2007, International Journal of Colorectal Disease.

[625]  S. Galandiuk,et al.  Smoking and inflammatory bowel disease: a meta-analysis. , 2006, Mayo Clinic proceedings.

[626]  B. Levin,et al.  Dysplasia-associated lesion or mass (DALM) detected by colonoscopy in long-standing ulcerative colitis: An indication for colectomy , 1981 .

[627]  M J Goldacre,et al.  Depression and anxiety in people with inflammatory bowel disease , 2001, Journal of epidemiology and community health.

[628]  S. Salem,et al.  Non-specific ulcerative colitis in Bedouin Arabs. , 1967, Lancet.

[629]  W. Kraaz,et al.  Azodisal sodium in the treatment of ulcerative colitis. A study of tolerance and relapse-prevention properties. , 1986, Gastroenterology.

[630]  A. Forbes,et al.  Pancolonic indigo carmine dye spraying for the detection of dysplasia in ulcerative colitis , 2004, Gut.

[631]  German and Austrian ImipenemCilastatin Study Group,et al.  Treatment of distal ulcerative colitis with short-chain fatty acid enemas a placebo-controlled trial , 1996, Digestive Diseases and Sciences.

[632]  M. Kimmey,et al.  Ursodiol Use Is Associated with Lower Prevalence of Colonic Neoplasia in Patients with Ulcerative Colitis and Primary Sclerosing Cholangitis , 2001, Annals of Internal Medicine.

[633]  L. Mortelmans,et al.  Intravenous cyclosporine versus intravenous corticosteroids as single therapy for severe attacks of ulcerative colitis. , 2001, Gastroenterology.

[634]  S. Riley,et al.  Why do patients with ulcerative colitis relapse? , 1990, Gut.

[635]  C. Delaney,et al.  Equivalent Function, Quality of Life and Pouch Survival Rates After Ileal Pouch-Anal Anastomosis for Indeterminate and Ulcerative Colitis , 2002, Annals of surgery.

[636]  A. Peña,et al.  Treatment of extraintestinal manifestations in inflammatory bowel disease , 2003, Current treatment options in gastroenterology.

[637]  N. LeLeiko,et al.  Cyclosporine as an Alternative to Surgery in Children with Inflammatory Bowel Disease , 1994, Journal of pediatric gastroenterology and nutrition.

[638]  D. Jewell,et al.  Pharmacotherapy for inducing and maintaining remission in pouchitis. , 1998, The Cochrane database of systematic reviews.

[639]  A. Forbes,et al.  Infliximab for the treatment of pyoderma gangrenosum: a randomised, double blind, placebo controlled trial , 2005, Gut.

[640]  R. Playford,et al.  Combined PET/CT colonography: is this the way forward? , 2005, Gut.

[641]  P. Lakatos,et al.  Risk factors for ulcerative colitis‐associated colorectal cancer in a Hungarian cohort of patients with ulcerative colitis: Results of a population‐based study , 2006, Inflammatory bowel diseases.

[642]  E. Loftus.  Clinical epidemiology of inflammatory bowel disease: Incidence, prevalence, and environmental influences. , 2004, Gastroenterology.

[643]  M. Sata,et al.  Curcumin maintenance therapy for ulcerative colitis: randomized, multicenter, double-blind, placebo-controlled trial. , 2006, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[644]  A. Rösen‐Wolff,et al.  CARD15 Genotype and Phenotype Analysis in 55 Pediatric Patients With Crohn Disease From Saxony, Germany , 2003, Journal of pediatric gastroenterology and nutrition.

[645]  D. Jewell,et al.  The management of acute severe ulcerative colitis. , 1991, Annals of medicine.

[646]  J. O'Conner,et al.  AN EVALUATION OF THE EFFECTIVENESS OF PSYCHOTHERAPY IN THE TREATMENT OF ULCERATIVE COLITIS. , 1964, Annals of internal medicine.

[647]  H. Tilg,et al.  The second European evidence-based Consensus on the diagnosis and management of Crohn's disease: Special situations. , 2010, Journal of Crohn's & colitis.

[648]  L. Denson,et al.  Role of fecal calprotectin as a biomarker of intestinal inflammation in inflammatory bowel disease , 2006, Inflammatory bowel diseases.

[649]  V. Tolia.  Sulfasalazine desensitization in children and adolescents with chronic inflammatory bowel disease. , 1992, American Journal of Gastroenterology.

[650]  P. Rutgeerts,et al.  Familial Crohn's Disease in Belgium: Pedigrees, Temporal Relationships Among Cases, and Family Histories , 2007, Journal of clinical gastroenterology.

[651]  J. Helzer,et al.  A controlled study of the association between ulcerative colitis and psychiatric diagnoses , 1982, Digestive Diseases and Sciences.

[652]  F. Carbonnel,et al.  Impact of cessation of smoking on the course of ulcerative colitis , 2001, American Journal of Gastroenterology.

[653]  B. Warner,et al.  Restorative proctocolectomy with ileal pouch-anal anastomosis in very young patients with refractory ulcerative colitis. , 2003, Journal of pediatric surgery.

[654]  M. Vatn,et al.  Are There Any Differences in Phenotype or Disease Course Between Familial and Sporadic Cases of Inflammatory Bowel Disease? Results of a Population-Based Follow-Up Study , 2007, The American Journal of Gastroenterology.

[655]  A. Mcintyre,et al.  Double-blind crossover trial of metronidazole versus placebo in chronic unremitting pouchitis , 1994, Digestive diseases and sciences.

[656]  M. Singer,et al.  Predictors of disease-related concerns and other aspects of health-related quality of life in outpatients with inflammatory bowel disease , 2004, European journal of gastroenterology & hepatology.

[657]  R. Baldassano,et al.  Children with early-onset inflammatory bowel disease (IBD): analysis of a pediatric IBD consortium registry. , 2005, The Journal of pediatrics.

[658]  M. Milla,et al.  Intermittent therapy with high-dose 5-aminosalicylic acid enemas for maintaining remission in ulcerative proctosigmoiditis , 1990, Diseases of the colon and rectum.

[659]  R. Kozarek,et al.  Methotrexate induces clinical and histologic remission in patients with refractory inflammatory bowel disease. , 1989, Annals of internal medicine.

[660]  A. Andriulli,et al.  Case Report: Fatal Ulcerative Panenteritis Following Colectomy in a Patient with Ulcerative Colitis , 1999, Digestive Diseases and Sciences.

[661]  S. Leveson,et al.  Ileitis in Ulcerative Colitis: Is It a Backwash? , 2005, Diseases of the colon and rectum.

[662]  N. Hyman,et al.  Urgent Subtotal Colectomy for Severe Inflammatory Bowel Disease , 2005, Diseases of the colon and rectum.

[663]  M. Grootenhuis,et al.  Health‐Related Quality of Life and Psychosocial Functioning of Adolescents With Inflammatory Bowel Disease , 2005, Inflammatory bowel diseases.

[664]  A. Cox,et al.  The interleukin 1 receptor antagonist gene allele 2 as a predictor of pouchitis following colectomy and IPAA in ulcerative colitis. , 2001, Gastroenterology.

[665]  P. Lakatos.  Recent trends in the epidemiology of inflammatory bowel diseases: up or down? , 2006, World journal of gastroenterology.

[666]  J. Schölmerich,et al.  Mangelzustände und Komplikationen bei chronisch entzündlichen Darmerkrankungen , 2009, Medizinische Klinik.

[667]  Soundy,et al.  The double muscularis mucosa in ulcerative colitis: is it all new? , 1998, Histopathology.

[668]  H. Lindahl,et al.  Restorative proctocolectomy for ulcerative colitis in children--is the J-pouch better than straight pull-through? , 1996, Journal of pediatric surgery.

[669]  D. Ginard,et al.  Review article: colorectal cancer surveillance in ulcerative colitis – what should we be doing? , 2006, Alimentary pharmacology & therapeutics.

[670]  R. Löfberg,et al.  Early predictors of glucocorticosteroid treatment failure in severe and moderately severe attacks of ulcerative colitis , 1998, European journal of gastroenterology & hepatology.

[671]  W. Harmsen,et al.  Early Postoperative Complications are not Increased in Patients with Crohn's Disease Treated Perioperatively with Infliximab or Immunosuppressive Therapy , 2004, American Journal of Gastroenterology.

[672]  R. Giacomelli,et al.  Mucosal 5-aminosalicylic acid concentration inversely correlates with severity of colonic inflammation in patients with ulcerative colitis , 2000, Gut.

[673]  A. Forbes,et al.  Pre‐pouch ileitis: a disease of the ileum in ulcerative colitis after restorative proctocolectomy , 2006, Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland.

[674]  H. Drummond,et al.  Allelic variations of the multidrug resistance gene determine susceptibility and disease behavior in ulcerative colitis. , 2005, Gastroenterology.

[675]  N. Shepherd,et al.  An assessment of inflammation in the reservoir after restorative proctocolectomy with ileoanal ileal reservoir , 1986, International Journal of Colorectal Disease.

[676]  L. Påhlman,et al.  Health-Related Quality of Life and Psychological Distress in a Population-based Sample of Swedish Patients with Inflammatory Bowel Disease , 2002, Scandinavian journal of gastroenterology.

[677]  J. Schölmerich,et al.  [Initial symptoms, extra-intestinal manifestations and course of pregnancy in chronic inflammatory bowel diseases]. , 1998, Medizinische Klinik.

[678]  A. Forbes,et al.  European evidence-based Consensus on the management of ulcerative colitis: Special situations. , 2008, Journal of Crohn's & colitis.

[679]  Kimberly A. Reske,et al.  Incidence of Clostridium difficile infection in inflammatory bowel disease. , 2007, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[680]  K. Batts,et al.  Nicotine tartrate liquid enemas for mildly to moderately active left‐sided ulcerative colitis unresponsive to first‐line therapy: a pilot study , 1997, Alimentary pharmacology & therapeutics.

[681]  V. Fazio,et al.  Clinical Approach to Diseases of Ileal Pouch-Anal Anastomosis , 2005, The American Journal of Gastroenterology.

[682]  M. Davoli,et al.  Clinical and laboratory indicators of extent of ulcerative colitis. Serum C-reactive protein helps the most. , 1988, Journal of clinical gastroenterology.

[683]  S. Katz.  Osteoporosis in patients with inflammatory bowel disease: risk factors, prevention, and treatment. , 2006, Reviews in gastroenterological disorders.

[684]  E. Kouroumalis,et al.  Role of Appendicitis and Appendectomy in the Pathogenesis of Ulcerative Colitis: A Critical Review , 2002, Inflammatory bowel diseases.

[685]  S. Schwarzenberg,et al.  Role of Serology and Routine Laboratory Tests in Childhood Inflammatory Bowel Disease , 2002, Inflammatory bowel diseases.

[686]  O. Zmora,et al.  Outcome of Patients With Indeterminate Colitis Undergoing a Double-Stapled Ileal Pouch-Anal Anastomosis , 2004, Diseases of the colon and rectum.

[687]  M. Vatn,et al.  Change in the extent of colonoscopic and histological involvement in ulcerative colitis over time. , 1999 .

[688]  L. Illescas,et al.  [ULCERATIVE COLITIS: A 52 YEARS RETROSPECTIVE STUDY] , 1999, Revista de gastroenterologia del Peru : organo oficial de la Sociedad de Gastroenterologia del Peru.

[689]  A. Axon,et al.  Randomised controlled trial of azathioprine withdrawal in ulcerative colitis. , 1992, BMJ.

[690]  M. Panos,et al.  Toxic megacolon: the knee-elbow position relieves bowel distension. , 1993, Gut.

[691]  Alastair Forbes,et al.  Severity of inflammation is a risk factor for colorectal neoplasia in ulcerative colitis. , 2004, Gastroenterology.

[692]  A. Paerregaard,et al.  [Chronic inflammatory bowel disease in children. An epidemiological study from eastern Denmark 1998-2000]. , 2002, Ugeskrift for laeger.

[693]  V. Fazio,et al.  Effect of Withdrawal of Nonsteroidal Anti-Inflammatory Drug Use on Ileal Pouch Disorders , 2007, Digestive Diseases and Sciences.

[694]  R. Wright,et al.  Serial rectal biopsy in ulcerative colitis during the course of a controlled therapeutic trial of various diets , 1966, The American Journal of Digestive Diseases.

[695]  Y. Jeng,et al.  Characteristics and trends in incidence of inflammatory bowel disease in Taiwanese children. , 2004, Journal of the Formosan Medical Association = Taiwan yi zhi.

[696]  A. Andoh,et al.  A new prebiotic from germinated barley for nutraceutical treatment of ulcerative colitis , 2002, Journal of gastroenterology and hepatology.

[697]  J. Becker,et al.  Pathologic Features and Clinical Significance of “Backwash” Ileitis in Ulcerative Colitis , 2005, The American journal of surgical pathology.

[698]  B. Dallapiccola,et al.  Relationship between CARD15, SLC22A4/5, and DLG5 polymorphisms and early-onset inflammatory bowel diseases: an Italian multicentric study. , 2006, Inflammatory bowel diseases.

[699]  E. Ceriati,et al.  Role of cyclosporin in preventing or delaying colectomy in children with severe ulcerative colitis , 2007, Langenbeck's Archives of Surgery.

[700]  W. Sandborn,et al.  Systematic review: the management of pouchitis , 2006, Alimentary pharmacology & therapeutics.

[701]  P. Munkholm,et al.  Sweet’s Syndrome – An Extraintestinal Manifestation in Inflammatory Bowel Disease , 2005, Digestion.

[702]  D. Jewell,et al.  Peripheral arthropathies in inflammatory bowel disease: their articular distribution and natural history , 1998, Gut.

[703]  A. Senagore,et al.  Short-chain fatty acid enemas: A cost-effective alternative in the treatment of nonspecific proctosigmoiditis , 1992, Diseases of the colon and rectum.

[704]  M. Schwab,et al.  Serum Procalcitonin Differentiates Inflammatory Bowel Disease and Self-limited Colitis , 2004, Inflammatory bowel diseases.

[705]  Elaine McColl,et al.  Predictors of Quality of Life in Ulcerative Colitis.: The Importance of Symptoms and Illness Representations , 2005, Inflammatory bowel diseases.

[706]  W. Johnson,et al.  The risk of rectal carcinoma following colectomy in ulcerative colitis , 1983, Diseases of the colon and rectum.

[707]  S. Chew,et al.  Functional outcome and quality of life after ileal pouch−anal anastomosis in children and adults , 2003, ANZ journal of surgery.

[708]  J. Church,et al.  Vaginal Delivery After Ileal Pouch-Anal Anastomosis: A Word of Caution , 2005, Diseases of the colon and rectum.

[709]  I. Talbot,et al.  Patterns of distribution of endoscopic and histological changes in the ileal reservoir after restorative proctocolectomy for ulcerative colitis A long-term follow-up study , 1998, International Journal of Colorectal Disease.

[710]  K. Fellermann,et al.  Response of Refractory Colitis to Intravenous or Oral Tacrolimus (FK506) , 2002, Inflammatory bowel diseases.

[711]  J. Waye.  The role of colonoscopy in the differential diagnosis of inflammatory bowel disease. , 1977, Gastrointestinal endoscopy.

[712]  P. Rutgeerts,et al.  The role of C-reactive protein as an inflammatory marker in gastrointestinal diseases , 2005, Nature Clinical Practice Gastroenterology &Hepatology.

[713]  M. Vatn,et al.  Outcome of four weeks’ intervention with probiotics on symptoms and endoscopic appearance after surgical reconstruction with a J-configurated ileal-pouch-anal-anastomosis in ulcerative colitis , 2005, Scandinavian journal of gastroenterology.

[714]  A. Serck-Hanssen,et al.  Routine and blind histological diagnoses on colonoscopic biopsies compared to clinical-colonoscopic observations in patients without and with colitis. , 1976, Scandinavian journal of gastroenterology.

[715]  F. Autschbach,et al.  Backwash ileitis is strongly associated with colorectal carcinoma in ulcerative colitis. , 2001, Gastroenterology.

[716]  A. Ekbom,et al.  Appendectomy and protection against ulcerative colitis. , 2001, The New England journal of medicine.

[717]  P. Brigidi,et al.  Antibiotic combination therapy in patients with chronic, treatment‐resistant pouchitis , 1999, Alimentary pharmacology & therapeutics.

[718]  E. Montgomery,et al.  Histopathology of Ulcerative Colitis in Initial Rectal Biopsy in Children , 2002, The American journal of surgical pathology.

[719]  J. Cotter,et al.  Ulcerative colitis in northern Portugal and Galicia in Spain , 2010, Inflammatory bowel diseases.

[720]  S. Laurberg,et al.  Fertility after ileal pouch–anal anastomosis in women with ulcerative colitis , 1999, The British journal of surgery.

[721]  Russell W Read,et al.  Uveitis: Advances in understanding of pathogenesis and treatment , 2006, Current rheumatology reports.

[722]  M. Vatn,et al.  Clinical course during the first 10 years of ulcerative colitis: results from a population-based inception cohort (IBSEN Study) , 2009, Scandinavian journal of gastroenterology.

[723]  S. Travis,et al.  Sweet's syndrome: an unusual cutaneous feature of Crohn's disease or ulcerative colitis. The South West Gastroenterology Group. , 1997, European journal of gastroenterology & hepatology.

[724]  C. Benoni,et al.  Does smoking influence the risk of pouchitis following ileal pouch anal anastomosis for ulcerative colitis? , 2006, Scandinavian journal of gastroenterology.

[725]  W. Sandborn,et al.  Serious infections and mortality in association with therapies for Crohn's disease: TREAT registry. , 2006, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[726]  S. Truelove,et al.  A controlled therapeutic trial of long-term maintenance treatment of ulcerative colitis with sulphasalazine (Salazopyrin) , 1973, Gut.

[727]  P. Marteau,et al.  An unusual cause of soft tissue infection , 2005, Gut.

[728]  J. Murray,et al.  Long-term results of the ileoanal pouch procedure. , 1993, Archives of surgery.

[729]  L. Braslow.  Pouchitis and extraintestinal manifestations of inflammatory bowel disease after ileal pouch-anal anastomosis. , 1991, Annals of surgery.

[730]  S. Gallus,et al.  Role of early ultrasound in detecting inflammatory intestinal disorders and identifying their anatomical location within the bowel , 2003, Alimentary pharmacology & therapeutics.

[731]  S. Riley,et al.  Microscopic activity in ulcerative colitis: what does it mean? , 1991, Gut.

[732]  J. Goldblum,et al.  Clostridium Difficile-Associated Pouchitis , 2006, Digestive Diseases and Sciences.

[733]  F. Carbonnel,et al.  Effects of appendicectomy on the course of ulcerative colitis , 2002, Gut.

[734]  J. Hampe,et al.  Lack of association between the C3435T MDR1 gene polymorphism and inflammatory bowel disease in two independent Northern European populations. , 2003, Gastroenterology.

[735]  A. Hungin,et al.  Quality of life in patients with established inflammatory bowel disease: a UK general practice survey , 2004, Alimentary pharmacology & therapeutics.

[736]  A. Bousvaros,et al.  Pediatric Patients With Untreated Ulcerative Colitis May Present Initially With Unusual Morphologic Findings , 2004, The American journal of surgical pathology.

[737]  G. Holmes,et al.  Treatment of ulcerative colitis with fish oil supplementation: a prospective 12 month randomised controlled trial. , 1992, Gut.

[738]  D. Bjorkman,et al.  The efficacy of oral 5-ASAs in the treatment of active ulcerative colitis: a systematic review. , 2003, Reviews in gastroenterological disorders.

[739]  D. Rodeberg,et al.  Pediatric ileal pouch-anal anastomosis: functional outcomes and quality of life. , 2003, Journal of pediatric surgery.

[740]  I. Ekman,et al.  Thirty Years of Experience Living With a Continent Ileostomy , 2005, Journal of wound, ostomy, and continence nursing : official publication of The Wound, Ostomy and Continence Nurses Society.

[741]  D. Elkind.  Children and adolescents , 1970 .

[742]  J. Lewis,et al.  Corticosteroids and immunomodulators: postoperative infectious complication risk in inflammatory bowel disease patients. , 2003, Gastroenterology.

[743]  J. Sanderson,et al.  Low back pain, sacroiliitis, and the relationship with HLA-B27 in Crohn's disease. , 2003, The Journal of rheumatology.

[744]  R. Odze,et al.  Effect of topical 5-aminosalicylic acid (5-ASA) therapy on rectal mucosal biopsy morphology in chronic ulcerative colitis. , 1993, The American journal of surgical pathology.

[745]  Tariq Ahmad,et al.  Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci , 2010, Nature Genetics.

[746]  V. Trimble,et al.  Randomised comparison of olsalazine and mesalazine in prevention of relapses in ulcerative colitis , 1992, The Lancet.

[747]  S. Kane,et al.  Colon cancer surveillance in chronic ulcerative colitis: historical cohort study. , 1990, The American journal of gastroenterology.

[748]  R G Newcombe,et al.  Transdermal nicotine for active ulcerative colitis. , 1994, The New England journal of medicine.

[749]  J. H. Baron,et al.  Variation Between Observers in Describing Mucosal Appearances in Proctocolitis* , 1964, British medical journal.

[750]  K. Soares-Weiser,et al.  Cyclosporine A for induction of remission in severe ulcerative colitis. , 2005, The Cochrane database of systematic reviews.

[751]  A. Axon,et al.  Double blind controlled trial of oral vancomycin as adjunctive treatment in acute exacerbations of idiopathic colitis. , 1985, Gut.

[752]  A. Munakata,et al.  Spatial distribution and histogenesis of colorectal Paneth cell metaplasia in idiopathic inflammatory bowel disease , 2001, Journal of gastroenterology and hepatology.

[753]  E. Chuang,et al.  A Phase II dose ranging, double‐blind, placebo‐controlled study of alicaforsen enema in subjects with acute exacerbation of mild to moderate left‐sided ulcerative colitis , 2006, Alimentary pharmacology & therapeutics.

[754]  H. Goto,et al.  Cytomegalovirus infection in severe ulcerative colitis patients undergoing continuous intravenous cyclosporine treatment in Japan. , 2007, World journal of gastroenterology.

[755]  S. Truelove,et al.  Cortisone in ulcerative colitis; final report on a therapeutic trial. , 1955, British medical journal.

[756]  W. Sandborn,et al.  Inflammatory bowel disease: clinical aspects and established and evolving therapies , 2007, The Lancet.

[757]  N. Borruel,et al.  The opinion of patients with inflammatory bowel disease on healthcare received. , 2004, Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva.

[758]  Hebden,et al.  Limited exposure of the healthy distal colon to orally‐dosed formulation is further exaggerated in active left‐sided ulcerative colitis , 2000, Alimentary Pharmacology and Therapeutics.

[759]  J. Debatin,et al.  Magnetic resonance colonography for the detection of inflammatory diseases of the large bowel: quantifying the inflammatory activity , 2005, Gut.

[760]  M. Grootenhuis,et al.  Coping Strategies and Quality of Life of Adolescents with Inflammatory Bowel Disease , 2004, Quality of Life Research.

[761]  C. Lees,et al.  A retrospective analysis of the efficacy and safety of infliximab as rescue therapy in acute severe ulcerative colitis , 2007, Alimentary pharmacology & therapeutics.

[762]  H. Goebell,et al.  [The course and prognosis of ulcerative colitis]. , 1989, Medizinische Klinik.

[763]  A. Griffiths,et al.  Development of a quality-of-life index for pediatric inflammatory bowel disease: dealing with differences related to age and IBD type. , 1999, Journal of pediatric gastroenterology and nutrition.

[764]  K. Batts,et al.  Recurrence of primary sclerosing cholangitis following liver transplantation , 1999, Hepatology.

[765]  J. Markowitz,et al.  Atypical rectosigmoid histology in children with newly diagnosed ulcerative colitis. , 1993, The American journal of gastroenterology.

[766]  S. Murch,et al.  High‐dose azathioprine in children with inflammatory bowel disease , 2003, Alimentary pharmacology & therapeutics.

[767]  H. Tulchinsky,et al.  Long-Term Failure After Restorative Proctocolectomy for Ulcerative Colitis , 2003, Annals of surgery.