Effect of bilateral stimulation of the subthalamic nucleus on parkinsonian dysarthria

Never was the effect of bilateral stimulation of the subthalamic nucleus (STN) evaluated quantitatively on all the components of speech production, that is articulation, respiration and phonation, at the same time. It is the purpose of this study which uses force measurements of the articulatory organs and acoustic analysis in 16 parkinsonian patients. With STN stimulation, reaction and movement time of the articulatory organs decreased and their maximal strength, as well as their precision increased. We also noted a large beneficial effect on voice with a significant improvement in respiratory and phonatory functions.

[1]  A. Lang,et al.  Posteroventral medial pallidotomy in advanced Parkinson's disease. , 1997, Advances in neurology.

[2]  A Benazzouz,et al.  Stimulation of subthalamic nucleus alleviates tremor in Parkinson's disease , 1997, The Lancet.

[3]  A. Benabid,et al.  Effect on parkinsonian signs and symptoms of bilateral subthalamic nucleus stimulation , 1995, The Lancet.

[4]  A L Benabid,et al.  Subthalamic nucleus or internal pallidal stimulation in young onset Parkinson's disease. , 1998, Brain : a journal of neurology.

[5]  A. Marchal,et al.  Speech production and speech modelling , 1990 .

[6]  H. Milner-Brown,et al.  Electrical properties of motor units in Parkinsonism and a possible relationship with bradykinesia , 1979, Journal of neurology, neurosurgery, and psychiatry.

[7]  J. Ryalls,et al.  A Comparison of the Prosodic Characteristics of the Speech of People with Parkinson’s Disease and Friedreich’s Ataxia with Neurologically Normal Speakers , 1998, Folia Phoniatrica et Logopaedica.

[8]  A. Benabid,et al.  Electrical stimulation of the subthalamic nucleus in advanced Parkinson's disease. , 1998, The New England journal of medicine.

[9]  A. Benabid,et al.  Effect of stimulation of the subthalamic nucleus on oral control of patients with parkinsonism , 1999, Journal of neurology, neurosurgery, and psychiatry.

[10]  M. Van der Linden,et al.  The interpretation of dysprosody in patients with Parkinson's disease. , 1991, Journal of neurology, neurosurgery, and psychiatry.

[11]  L. Golbe.  Pallidotomy for Parkinson's disease: hitting the target? , 1998, The Lancet.

[12]  D. Brooks,et al.  Core assessment program for intracerebral transplantations (CAPIT) , 1992, Movement disorders : official journal of the Movement Disorder Society.

[13]  T. Pring,et al.  Speech therapy and Parkinson's disease: a review and further data. , 1990, The British journal of disorders of communication.

[14]  T. Ohmoto,et al.  Long-term follow-up results of bilateral thalamotomy for parkinsonism. , 1976, Applied neurophysiology.

[15]  A. Aronson,et al.  Motor Speech Disorders , 2014 .

[16]  Michèle Gentil,et al.  Organization of the Articulatory System: Peripheral Mechanisms and Central Coordination , 1990 .

[17]  M. Hariz,et al.  Leksell's posteroventral pallidotomy in the treatment of Parkinson's disease. , 1992, Journal of neurosurgery.

[18]  S. Stellar,et al.  Mortality and morbidity in cryothalamectomy for parkinsonism. A statistical study of 2868 consecutive operations. , 1968, Journal of neurosurgery.

[19]  A. Lang,et al.  An investigation of the effects of subthalamic nucleus stimulation on acoustic measures of voice , 2000, Movement disorders : official journal of the Movement Disorder Society.

[20]  C. Markham,et al.  Deficits in orofacial sensorimotor function in Parkinson's disease , 1986, Annals of neurology.

[21]  A. Benabid,et al.  Effect of Bilateral Stimulation of the Subthalamic Nucleus on Parkinsonian Voice , 2001, Brain and Language.

[22]  A. Aronson,et al.  The Dysarthrias: Physiology, Acoustics, Perception, Management , 1985 .

[23]  Aileen K. Ho,et al.  Sequence Heterogeneity in Parkinsonian Speech , 1998, Brain and Language.

[24]  J. Dostrovsky,et al.  Effect of GPi pallidotomy on motor function in Parkinson's disease , 1995, The Lancet.

[25]  T Hehr,et al.  Oral diadochokinesis in neurological dysarthrias. , 1995, Folia phoniatrica et logopaedica : official organ of the International Association of Logopedics and Phoniatrics.