Blood lactate diagnostics in exercise testing and training.

A link between lactate and muscular exercise was seen already more than 200 years ago. The blood lactate concentration (BLC) is sensitive to changes in exercise intensity and duration. Multiple BLC threshold concepts define different points on the BLC power curve during various tests with increasing power (INCP). The INCP test results are affected by the increase in power over time. The maximal lactate steady state (MLSS) is measured during a series of prolonged constant power (CP) tests. It detects the highest aerobic power without metabolic energy from continuing net lactate production, which is usually sustainable for 30 to 60 min. BLC threshold and MLSS power are highly correlated with the maximum aerobic power and athletic endurance performance. The idea that training at threshold intensity is particularly effective has no evidence. Three BLC-orientated intensity domains have been established: (1) training up to an intensity at which the BLC clearly exceeds resting BLC, light- and moderate-intensity training focusing on active regeneration or high-volume endurance training (Intensity < Threshold); (2) heavy endurance training at work rates up to MLSS intensity (Threshold ≤ Intensity ≤ MLSS); and (3) severe exercise intensity training between MLSS and maximum oxygen uptake intensity mostly organized as interval and tempo work (Intensity > MLSS). High-performance endurance athletes combining very high training volume with high aerobic power dedicate 70 to 90% of their training to intensity domain 1 (Intensity < Threshold) in order to keep glycogen homeostasis within sustainable limits.

[1]  Masao Udo,et al.  Significance of the contribution of aerobic and anaerobic components to several distance running performances in female athletes , 2004, European Journal of Applied Physiology and Occupational Physiology.

[2]  Ralph Beneke,et al.  The effect of training on running economy and performance in recreational athletes. , 2005, Medicine and science in sports and exercise.

[3]  G A Brooks,et al.  Systemic lactate kinetics during graded exercise in man. , 1985, The American journal of physiology.

[4]  W. Kindermann,et al.  Lactate Kinetics and Individual Anaerobic Threshold* , 1981, International journal of sports medicine.

[5]  B R Londeree,et al.  Effect of training on lactate/ventilatory thresholds: a meta-analysis. , 1997, Medicine and science in sports and exercise.

[6]  T M McLellan,et al.  The transition from aerobic to anaerobic metabolism. , 1980, Research quarterly for exercise and sport.

[7]  Takayoshi Yoshida,et al.  Blood lactate parameters related to aerobic capacity and endurance performance , 2004, European Journal of Applied Physiology and Occupational Physiology.

[8]  L. Hermansen,et al.  Production and removal of lactate during exercise in man. , 1972, Acta physiologica Scandinavica.

[9]  S. Seiler,et al.  Lactate profile changes in relation to training characteristics in junior elite cyclists. , 2010, International journal of sports physiology and performance.

[10]  R. Beneke,et al.  Anaerobic threshold, individual anaerobic threshold, and maximal lactate steady state in rowing. , 1995, Medicine and science in sports and exercise.

[11]  W. Hollmann,et al.  Justification of the 4-mmol/l Lactate Threshold , 1985, International journal of sports medicine.

[12]  S. Perrey,et al.  Exercise Physiology: from a Cellular to an Integrative Approach , 2010 .

[13]  R. Beneke Mechanische und metabolische Belastung beim Radfahren - eine Analyse aus physiologischer und biomechanischer Sicht , 2001 .

[14]  P. Flore,et al.  Influence of moderate cold exposure on blood lactate during incremental exercise , 2004, European Journal of Applied Physiology and Occupational Physiology.

[15]  H. Akimune On a new type of negative deuterium ion source using a silicon semiconductor , 1983 .

[16]  R M Nicholson,et al.  Indices of lactate threshold and their relationship with 10-km running velocity. , 2001, Medicine and science in sports and exercise.

[17]  Pierre-Marie Lepretre,et al.  Training and bioenergetic characteristics in elite male and female Kenyan runners. , 2003, Medicine and science in sports and exercise.

[18]  H. A. Davis,et al.  Anaerobic threshold and lactate turnpoint , 2004, European Journal of Applied Physiology and Occupational Physiology.

[19]  Andrew E Kilding,et al.  Validity of a single-visit protocol to estimate the maximum lactate steady state. , 2005, Medicine and science in sports and exercise.

[20]  M. Kushmerick,et al.  Lactic acidosis in vivo: testing the link between lactate generation and H+ accumulation in ischemic mouse muscle. , 2010, Journal of applied physiology.

[21]  E. Coyle,et al.  Blood lactate threshold in some well-trained ischemic heart disease patients. , 1983, Journal of applied physiology: respiratory, environmental and exercise physiology.

[22]  R. Beneke,et al.  Carbohydrate and fat metabolism related to blood lactate in boys and male adolescents , 2008, European Journal of Applied Physiology.

[23]  H. Hebestreit,et al.  Predicting maximal lactate steady state in children and adults. , 2009, Pediatric exercise science.

[24]  A Geyssant,et al.  Effects of training on performance in competitive swimming. , 1995, Canadian journal of applied physiology = Revue canadienne de physiologie appliquee.

[25]  R. Mazzeo Physiological Responses to Exercise at Altitude , 2008, Sports medicine.

[26]  P. Flore,et al.  Influence of cold exposure on blood lactate response during incremental exercise , 2004, European Journal of Applied Physiology and Occupational Physiology.

[27]  O. Bang The lactate content of the blood during and after muscular exercise in man , 1936 .

[28]  D. Bishop,et al.  The relationship between plasma lactate parameters, Wpeak and 1-h cycling performance in women. , 1998, Medicine and science in sports and exercise.

[29]  T. Jansen,et al.  The first demonstration of lactic acid in human blood in shock by Johann Joseph Scherer (1814–1869) in January 1843 , 2007, Intensive Care Medicine.

[30]  Ralph Beneke,et al.  Methodological aspects of maximal lactate steady state—implications for performance testing , 2003, European Journal of Applied Physiology.

[31]  J. Keul,et al.  The significance of the aerobic-anaerobic transition for the determination of work load intensities during endurance training , 1979, European Journal of Applied Physiology and Occupational Physiology.

[32]  H. A. Davis,et al.  Blood lactate concentrations during incremental work before and after maximum exercise. , 1979, British journal of sports medicine.

[33]  G. Brooks Lactate production under fully aerobic conditions: the lactate shuttle during rest and exercise. , 1986, Federation proceedings.

[34]  K. Braumann,et al.  Estimation of an individual equilibrium between lactate production and catabolism during exercise. , 1993, Medicine and science in sports and exercise.

[35]  C. Bouchard,et al.  Variability in the response of HDL cholesterol to exercise training in the HERITAGE Family Study. , 2002, International journal of sports medicine.

[36]  J. Harvey,et al.  Treadmill Velocity Best Predicts 5000-m Run Performance. , 2009, International journal of sports medicine.

[37]  B. Sjödin,et al.  Onset of Blood Lactate Accumulation and Marathon Running Performance , 1981, International journal of sports medicine.

[38]  C. N. H. Long,et al.  Muscular Exercise, Lactic Acid, and the Supply and Utilisation of Oxygen , 1924 .

[39]  S. V. von Duvillard,et al.  Effect of test interruptions on blood lactate during constant workload testing. , 2003, Medicine and science in sports and exercise.

[40]  V. Di Salvo,et al.  Evolution of physiological and haematological parameters with training load in elite male road cyclists: a longitudinal study. , 2007, The Journal of sports medicine and physical fitness.

[41]  R. Föhrenbach Leistungsdiagnostik, Trainingsanalyse und -steuerung bei Läuferinnen und Läufern verschiedener Laufdisziplinen , 1986 .

[42]  Stephen Seiler,et al.  Autonomic recovery after exercise in trained athletes: intensity and duration effects. , 2007, Medicine and science in sports and exercise.

[43]  Sally Davis,et al.  Joint position statement , 1999 .

[44]  Alejandro Lucia,et al.  How do endurance runners actually train? Relationship with competition performance. , 2005, Medicine and science in sports and exercise.

[45]  K. Nazar,et al.  Early effects of short-term aerobic training. Physiological responses to graded exercise. , 2003, The Journal of sports medicine and physical fitness.

[46]  David Bishop,et al.  Incremental Exercise Test Design and Analysis , 2007, Sports medicine.

[47]  H. Heck,et al.  Laktat in der Leistungsdiagnostik , 1990 .

[48]  Luc Léger,et al.  Methods to Determine Aerobic Endurance , 2002, Sports medicine.

[49]  R. Beneke,et al.  Maximal lactate-steady-state independent of performance. , 2000, Medicine and science in sports and exercise.

[50]  R. Beneke Maximal lactate steady state concentration (MLSS): experimental and modelling approaches , 2002, European Journal of Applied Physiology.

[51]  G. Brooks,et al.  Cell–cell and intracellular lactate shuttles , 2009, The Journal of physiology.

[52]  H. Bergmeyer Methoden der enzymatischen Analyse , 1962 .

[53]  L. Jorfeldt Metabolism of L(plus)-lactate in human skeletal muscle during exercise. , 1970, Acta physiologica Scandinavica. Supplementum.

[54]  R. Thayer,et al.  Comparison of effects of two interval-training programmes on lactate and ventilatory thresholds. , 1994, British journal of sports medicine.

[55]  H Heck,et al.  A Theory of the Metabolic Origin of “Anaerobic Threshold” , 1986, International journal of sports medicine.

[56]  T D Noakes,et al.  Why does exercise terminate at the maximal lactate steady state intensity? , 2007, British Journal of Sports Medicine.

[57]  Espen Tønnessen,et al.  Intervals, Thresholds, and Long Slow Distance: the Role of Intensity and Duration in Endurance Training , 2009 .

[58]  R. Beneke,et al.  Dependence of the maximal lactate steady state on the motor pattern of exercise , 2001, British journal of sports medicine.

[59]  J. Keul,et al.  Stage duration and increase of work load in incremental testing on a cycle ergometer , 1997, European Journal of Applied Physiology and Occupational Physiology.

[60]  Stephen Seiler,et al.  What is best practice for training intensity and duration distribution in endurance athletes? , 2010, International journal of sports physiology and performance.

[61]  R. Beneke,et al.  The limits of human performance. , 2008, Essays in biochemistry.

[62]  S. Grant,et al.  The relationship between 3 km running performance and selected physiological variables. , 1997, Journal of sports sciences.

[63]  Markus Amann,et al.  Predictive validity of ventilatory and lactate thresholds for cycling time trial performance , 2006, Scandinavian journal of medicine & science in sports.

[64]  L. Mcnaughton,et al.  Peak power output, the lactate threshold, and time trial performance in cyclists. , 2001, Medicine and science in sports and exercise.

[65]  S. Seiler,et al.  Training methods and intensity distribution of young world-class rowers. , 2009, International journal of sports physiology and performance.

[66]  W. Dawson American College of Sports Medicine, American Dietetic Association, and Dietitians of Canada: Nutrition and athletic performance (joint position statement) , 2002 .

[67]  M. Febbraio,et al.  Muscle metabolism during exercise and heat stress in trained men: effect of acclimation. , 1994, Journal of applied physiology.

[68]  M. Schuhmacher,et al.  Biological monitoring of metals and organic substances in hazardous-waste incineration workers , 2002, International archives of occupational and environmental health.

[69]  J. Bristow,et al.  Myocardial Lactate Metabolism: Evidence of Lactate Release During Net Chemical Extraction in Man , 1981, Circulation.

[70]  S. V. von Duvillard,et al.  Determination of maximal lactate steady state response in selected sports events. , 1996, Medicine and science in sports and exercise.

[71]  P. Watt,et al.  Maximal lactate steady state as a training stimulus. , 2008, International journal of sports medicine.

[72]  Nicholas E Kimber,et al.  Energy balance during an ironman triathlon in male and female triathletes. , 2002, International journal of sport nutrition and exercise metabolism.

[73]  M. Udo,et al.  Physiological characteristics related to endurance running performance in female distance runners. , 1993, Journal of sports sciences.

[74]  J. Doust,et al.  Physiological and performance effects of low- versus mixed-intensity rowing training. , 2008, Medicine and science in sports and exercise.

[75]  K. S. Seiler,et al.  Quantifying training intensity distribution in elite endurance athletes: is there evidence for an “optimal” distribution? , 2006, Scandinavian journal of medicine & science in sports.

[76]  N. Secher,et al.  Lactate fuels the human brain during exercise , 2008, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[77]  C. Knoepfli-Lenzin,et al.  Time to exhaustion at maximal lactate steady state is similar for cycling and running in moderately trained subjects , 2009, European Journal of Applied Physiology.

[78]  K. Nazar,et al.  Early effects of short-term endurance training on hormonal responses to graded exercise. , 2005, Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.

[79]  J. Slawinski,et al.  Physical and training characteristics of top-class marathon runners. , 2001, Medicine and science in sports and exercise.

[80]  O. Faude,et al.  Lactate Threshold Concepts , 2009, Sports medicine.

[81]  R. Beneke,et al.  Haemolysis caused by alterations of α- and β-spectrin after 10 to 35 min of severe exercise , 2005, European Journal of Applied Physiology.

[82]  B. Saltin,et al.  Skeletal muscle glucose uptake during dynamic exercise in humans: role of muscle mass. , 1988, The American journal of physiology.

[83]  J. Juchmes,et al.  Critical analysis of the “anaerobic threshold” during exercise at constant workloads , 2004, European Journal of Applied Physiology and Occupational Physiology.