G Protein-coupled Receptor Kinase 2 (GRK2) Promotes Breast Tumorigenesis Through a HDAC6-Pin1 Axis
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A. Berjón | Xiao Zhen Zhou | K. Lu | M. Mendiola | V. Lafarga | Verónica Rivas | K. Stamatakis | P. Penela | F. Mayor | D. Hardisson | Laura Nogués | Clara Reglero | María Neves | Paula Ramos | Alicia Salcedo | X. Zhou
[1] R. Johnstone,et al. New and emerging HDAC inhibitors for cancer treatment. , 2014, The Journal of clinical investigation.
[2] James D. Robinson,et al. G protein-coupled receptor kinase 2 (GRK2) is a Rho-activated scaffold protein for the ERK MAP kinase cascade. , 2013, Cellular signalling.
[3] S. Loi,et al. Targeting the PI3K/AKT/mTOR and Raf/MEK/ERK pathways in the treatment of breast cancer. , 2013, Cancer treatment reviews.
[4] G. Dorn,et al. Developmental and tumoral vascularization is regulated by G protein-coupled receptor kinase 2. , 2013, The Journal of clinical investigation.
[5] Jeffrey W. Peng,et al. Interdomain Interactions Support Interdomain Communication in Human Pin1 , 2013, Biochemistry.
[6] J. Renoir,et al. Estrogen receptor signaling as a target for novel breast cancer therapeutics. , 2013, Biochemical pharmacology.
[7] A. Giordano,et al. The Prolyl Isomerase Pin1 Acts Synergistically with CDK2 to Regulate the Basal Activity of Estrogen Receptor α in Breast Cancer , 2013, PloS one.
[8] S. Kwon,et al. Histone deacetylase 6 plays a role as a distinct regulator of diverse cellular processes , 2012, The FEBS journal.
[9] V. Lafarga,et al. The interplay between G protein-coupled receptor kinase 2 (GRK2) and histone deacetylase 6 (HDAC6) at the crossroads of epithelial cell motility , 2012, Cell adhesion & migration.
[10] Ana Lluch,et al. Molecular biology in breast cancer: intrinsic subtypes and signaling pathways. , 2012, Cancer treatment reviews.
[11] C. Brandl,et al. Non-catalytic participation of the Pin1 peptidyl-prolyl isomerase domain in target binding , 2012, Front. Physio..
[12] J. Engele,et al. Grk2 is an Essential Regulator of CXCR7 Signalling in Astrocytes , 2012, Cellular and Molecular Neurobiology.
[13] Y. Onodera,et al. ['Molecular biology' of breast cancer]. , 2012, Nihon rinsho. Japanese journal of clinical medicine.
[14] L. Rhodes,et al. Targeting triple-negative breast cancer cells with the histone deacetylase inhibitor panobinostat , 2012, Breast Cancer Research.
[15] K. Lorenz,et al. Raf Kinase Inhibitor Protein (RKIP) Dimer Formation Controls Its Target Switch from Raf1 to G Protein-coupled Receptor Kinase (GRK) 2* , 2012, The Journal of Biological Chemistry.
[16] T. Daigle,et al. GRK2: multiple roles beyond G protein-coupled receptor desensitization. , 2012, Trends in pharmacological sciences.
[17] V. Lafarga,et al. A novel GRK2/HDAC6 interaction modulates cell spreading and motility , 2012, The EMBO journal.
[18] U. Moll,et al. SAHA shows preferential cytotoxicity in mutant p53 cancer cells by destabilizing mutant p53 through inhibition of the HDAC6-Hsp90 chaperone axis , 2011, Cell Death and Differentiation.
[19] N. Bertos,et al. Breast cancer - one term, many entities? , 2011, The Journal of clinical investigation.
[20] Y. Liou,et al. Prolyl isomerase Pin1 as a molecular switch to determine the fate of phosphoproteins. , 2011, Trends in biochemical sciences.
[21] Antonio Rosato,et al. A Pin1/mutant p53 axis promotes aggressiveness in breast cancer. , 2011, Cancer cell.
[22] T. Hupp,et al. How phosphorylation controls p53 , 2011, Cell cycle.
[23] D. Hanahan,et al. Hallmarks of Cancer: The Next Generation , 2011, Cell.
[24] Cristina Murga,et al. The complex G protein‐coupled receptor kinase 2 (GRK2) interactome unveils new physiopathological targets , 2010, British journal of pharmacology.
[25] P. Khanal,et al. The Prolyl Isomerase Pin1 Enhances HER-2 Expression and Cellular Transformation via Its Interaction with Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Kinase 1 , 2010, Molecular Cancer Therapeutics.
[26] T. Yao,et al. The Microtubule-associated Histone Deacetylase 6 (HDAC6) Regulates Epidermal Growth Factor Receptor (EGFR) Endocytic Trafficking and Degradation* , 2010, The Journal of Biological Chemistry.
[27] Verónica Rivas,et al. G protein–coupled receptor kinase 2 (GRK2) modulation and cell cycle progression , 2009, Proceedings of the National Academy of Sciences.
[28] Y. Kalaidzidis,et al. Regulation of Epidermal Growth Factor Receptor Trafficking by Lysine Deacetylase HDAC6 , 2009, Science Signaling.
[29] M. Mann,et al. Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions , 2009, Science.
[30] John D. Minna,et al. Molecular Profiling of Breast Cancer Cell Lines Defines Relevant Tumor Models and Provides a Resource for Cancer Gene Discovery , 2009, PloS one.
[31] K. Chin,et al. Protein Acetylation and Histone Deacetylase Expression Associated with Malignant Breast Cancer Progression , 2009, Clinical Cancer Research.
[32] Miou Zhou,et al. 17β-Estradiol-Mediated Neuroprotection and ERK Activation Require a Pertussis Toxin-Sensitive Mechanism Involving GRK2 and β-Arrestin-1 , 2009, The Journal of Neuroscience.
[33] K. Horie-Inoue,et al. Association of estrogen receptor alpha and histone deacetylase 6 causes rapid deacetylation of tubulin in breast cancer cells. , 2009, Cancer research.
[34] Mads Thomassen,et al. Gene expression meta-analysis identifies metastatic pathways and transcription factors in breast cancer , 2008, BMC Cancer.
[35] M. Caron,et al. Smoothened signaling in vertebrates is facilitated by a G protein-coupled receptor kinase. , 2008, Molecular biology of the cell.
[36] Xiao-Fan Wang,et al. The cytoplasmic deacetylase HDAC6 is required for efficient oncogenic tumorigenesis. , 2008, Cancer research.
[37] Yi Tang,et al. Acetylation Is Indispensable for p53 Activation , 2008, Cell.
[38] O. Barreiro,et al. G protein‐coupled receptor kinase 2 positively regulates epithelial cell migration , 2008, The EMBO journal.
[39] E. Rozengurt. Mitogenic signaling pathways induced by G protein‐coupled receptors , 2007, Journal of cellular physiology.
[40] J. Rosen,et al. Modelling breast cancer: one size does not fit all , 2007, Nature Reviews Cancer.
[41] J. Leal,et al. Mice expressing myrAKT1 in the mammary gland develop carcinogen-induced ER-positive mammary tumors that mimic human breast cancer. , 2007, Carcinogenesis.
[42] R. Gainetdinov,et al. Physiological roles of G protein-coupled receptor kinases and arrestins. , 2007, Annual review of physiology.
[43] P. Penela,et al. Mdm2 is involved in the ubiquitination and degradation of G‐protein‐coupled receptor kinase 2 , 2006, The EMBO journal.
[44] Priti Garg,et al. Modeling breast cancer in vivo and ex vivo reveals an essential role of Pin1 in tumorigenesis , 2004, The EMBO journal.
[45] J. Frasor,et al. Selective Estrogen Receptor Modulators , 2004, Cancer Research.
[46] K. Lu. Prolyl isomerase Pin1 as a molecular target for cancer diagnostics and therapeutics. , 2003, Cancer cell.
[47] A. Ryo,et al. Prolyl isomerase Pin1: a catalyst for oncogenesis and a potential therapeutic target in cancer , 2003, Journal of Cell Science.
[48] Sam W. Lee,et al. PIN1 Is an E2F Target Gene Essential for Neu/Ras-Induced Transformation of Mammary Epithelial Cells , 2002, Molecular and Cellular Biology.
[49] R. Roskoski. The ErbB/HER family of protein-tyrosine kinases and cancer. , 2014, Pharmacological research.
[50] Jeffrey A. Jones,et al. Gene targeting in ischemic heart disease and failure: translational and clinical studies. , 2013, Biochemical pharmacology.
[51] Virginia Espina,et al. Molecular Profiling , 2012, Methods in Molecular Biology.
[52] M. Maggiolini,et al. G protein-coupled receptors: novel targets for drug discovery in cancer , 2010, Nature Reviews Drug Discovery.