Single-dose tioconazole compared with 3-day clotrimazole treatment in vulvovaginal candidiasis

A total of 80 patients were equally randomized to receive a single dose of 6.5% tioconazole ointment or a 3-day course of 100-mg clotrimazole vaginal tablets for the treatment of vulvovaginal candidiasis. Of the 32 evaluable patients treated with tioconazole, 27 (84%) remained asymptomatic 4 weeks posttreatment, compared with 28 of 33 patients (85%) treated with clotrimazole. A total of 34 patients in each group could be evaluated for mycological response based on culture results 1 and 4 weeks after treatment. Twenty patients (59%) who received tioconazole and twenty-one patients (62%) who received clotrimazole remained culture negative 4 weeks after therapy. Of 40 patients who received tioconazole, 12 (30%) experienced local irritation or itching, compared with 2 of 40 patients (5%) treated with clotrimazole (P less than 0.01). Single-dose tioconazole ointment was as effective as a 3-day course of clotrimazole tablets, but significantly more patients in the tioconazole-treated group experienced local side effects.

[1]  E. Houang,et al.  Systemic absorption and persistence of tioconazole in vaginal fluid after insertion of a single 300-mg tioconazole ovule , 1985, Antimicrobial Agents and Chemotherapy.

[2]  J. Sobel Management of recurrent vulvovaginal candidiasis with intermittent ketoconazole prophylaxis. , 1985, Obstetrics and gynecology.

[3]  D. Stevens,et al.  Inhibition and killing of Candida albicans in vitro by five imidazoles in clinical use , 1984, Antimicrobial Agents and Chemotherapy.

[4]  L. Cohen Single dose treatment of vaginal candidosis: comparison of clotrimazole and isoconazole. , 1984, The British journal of venereal diseases.

[5]  L. Cohen Single dosetreatment ofvaginal candidosis: Comparison ofclotrimazole andisoconazole , 1984 .

[6]  R. Thin,et al.  Clotrimazole and econazole in the treatment of vaginal candidosis. A single-blind comparison. , 1983, The British journal of venereal diseases.

[7]  I. Milsom,et al.  Treatment of vaginal candidosis with a single 500-mg clotrimazole pessary. , 1982, The British journal of venereal diseases.

[8]  J. García-tamayo,et al.  Human genital candidiasis: histochemistry, scanning and transmission electron microscopy. , 1982, Acta cytologica.

[9]  R. Hurley Recurrent Candida infection. , 1981, Clinics in obstetrics and gynaecology.

[10]  W. Robertson A concentrated therapeutic regimen for vulvovaginal candidiasis. , 1980, JAMA.

[11]  F. Odds Laboratory evaluation of antifungal agents: a comparative study of five imidazole derivatives of clinical importance. , 1980, The Journal of antimicrobial chemotherapy.

[12]  R. Cartwright Opportunistic mycoses of various body sites. , 1980 .

[13]  D. Warnock,et al.  Epidemiological investigation of patients with vulvovaginal candidosis. Application of a resistogram method for strain differentiation of Candida albicans. , 1979, The British journal of venereal diseases.

[14]  D. Warnock,et al.  Effect of simultaneous oral and vaginal treatment on the rate of cure and relapse in vaginal candidosis. , 1979, The British journal of venereal diseases.

[15]  M. Leeming,et al.  Antifungal Activity of Tioconazole (UK-20,349), a New Imidazole Derivative , 1979, Antimicrobial Agents and Chemotherapy.

[16]  S. Jevons,et al.  Antifungal Activity ofTioconazole (UK-20,349), aNewImidazole Derivative , 1979 .

[17]  W. Robertson Vulvovaginal candidiasis treated with clotrimazole cream in seven days compared with fourteen-day treatment with miconazole cream. , 1978, American journal of obstetrics and gynecology.

[18]  A. Rogers,et al.  Recurrent Vaginal Candidiasis: Importance of an Intestinal Reservoir , 1977 .

[19]  A. B. Maclean Genital yeast infections. , 1977, British medical journal.

[20]  F. Odds Cure and Relapse with Antifungal Therapy , 1977, Proceedings of the Royal Society of Medicine.

[21]  G. Masterton,et al.  Three-day clotrimazole treatment in candidal vulvovaginitis. , 1977, The British journal of venereal diseases.

[22]  A. Rogers,et al.  Recurrent vaginal candidiasis. Importance of an intestinal reservoir. , 1977, JAMA.

[23]  J. Balmer Three-day therapy of vulvovaginal candidiasis with econazole: a multicentric study comprising 996 cases. , 1976, American journal of obstetrics and gynecology.

[24]  D. Warnock,et al.  VAGINAL CANDIDIASIS AND THE ROLE OF THE DIGESTIVE TRACT AS A SOURCE OF INFECTION , 1975, British journal of obstetrics and gynaecology.

[25]  G. Masterton,et al.  Six-day clotrimazole therapy in vaginal candidosis. , 1975, Current medical research and opinion.

[26]  M. J. Denny,et al.  Genital Yeast Infections , 1972, British medical journal.