论文信息 - Simultaneous Determination of Ebastine and Its Active Metabolite (Carebastine) in Human Plasma Using LC–MS–MS - 字舞流文

Simultaneous Determination of Ebastine and Its Active Metabolite (Carebastine) in Human Plasma Using LC–MS–MS

Dongyang Liu | Ji Jiang | P. Hu | Sheng Feng | Peng Wang

[1] P. Taylor. Matrix effects: the Achilles heel of quantitative high-performance liquid chromatography-electrospray-tandem mass spectrometry. , 2005, Clinical biochemistry.

[2] Kwang-Hyeon Liu,et al. Simultaneous determination of ebastine and its three metabolites in plasma using liquid chromatography-tandem mass spectrometry. , 2004, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[3] Y. Mizuki,et al. Simultaneous determination of the histamine H1-receptor antagonist ebastine and its two metabolites, carebastine and hydroxyebastine, in human plasma using high-performance liquid chromatography. , 2001, Journal of chromatography. B, Biomedical sciences and applications.

[4] J. Bousquet,et al. A 12‐week, placebo‐controlled study of the efficacy and safety of ebastine, 10 and 20 mg once daily, in the treatment of perennial allergic rhinitis , 1999, Allergy.

[5] S. Imaoka,et al. Involvement of CYP2J2 and CYP4F12 in the metabolism of ebastine in human intestinal microsomes. , 2002, The Journal of pharmacology and experimental therapeutics.