Intravenous regional analgesia using bupivacaine

Intravenous regional analgesia using bupivacaine (Marcain) was employed as the anaesthetic technique in a series of 50 cases undergoing a variety of surgical procedures on the upper limb. A short pilot study was undertaken to determine the optimal dosage and concentration of bupivacaine. This was found to be 1-5 mg/kg in 0-2% concentration and proved suitable for all patients regardless of age or physical condition. The use of bupivacaine produced highly successful results in 98% of cases. Onset of analgesia was very rapid (3-5 minutes) and profound muscular relaxation occurred in approximately half of the cases. The degree of muscle relaxation was, however, always adequate for the successful reduction of fractures. Only one patient exhibited an adverse reaction to the dose of bupivacaine used and this was limited to a brief period of slight drowsiness. The results of this series suggest that bupivacaine may provide advantages over previously used local analgesic agents for intravenous regional analgesia and that it may be the agent of choice for this useful technique.

[1]  M. Ghoneim,et al.  Plasma protein binding of bupivacaine and its interaction with other drugs in man. , 1975, British journal of anaesthesia.

[2]  M. Kew,et al.  The cardiovascular complications of intravenous regional anaesthesia. , 1972, The British journal of surgery.

[3]  F. Reynolds.  A COMPARISON OF THE POTENTIAL TOXICITY OF BUPIVACAINE, LIGNOCAINE AND MEPIVACAINE DURING EPIDURAL BLOCKADE FOR SURGERY , 1971 .

[4]  O. Secher.  Physical and chemical data on anaesthetics. , 1971, Acta anaesthesiologica Scandinavica. Supplementum.

[5]  G. Tucker,et al.  Binding of Anilide‐type Local Anesthetics in Human Plasma: I. Relationships between Binding, Physicochemical Properties, and Anesthetic Activity , 1970, Anesthesiology.

[6]  W. H. Harris.  CHOICE OF ANESTHETIC AGENTS FOR INTRAVENOUS REGIONAL ANESTHESIA , 1969, Acta anaesthesiologica Scandinavica. Supplementum.

[7]  C. Holmes.  THE HISTORY AND DEVELOPMENT OF INTRAVENOUS REGIONAL ANAESTHESIA , 1969, Acta anaesthesiologica Scandinavica. Supplementum.

[8]  D. Jewitt,et al.  LIGNOCAINE IN THE MANAGEMENT OF ARRHYTHMIAS AFTER ACUTE MYOCARDIAL INFARCTION , 1968 .

[9]  W. H. Harris,et al.  Methemoglobin formation and oxygen transport following intravenous regional anesthesia using prilocaine. , 1968, Anesthesiology.

[10]  P. de Temmerman,et al.  [Intravenous regional anesthesia]. , 1967, Acta anaesthesiologica Belgica.

[11]  C. Sorbie,et al.  Intravenous regional anaesthesia. , 1966, Nursing mirror and midwives journal.

[12]  A. Merrifield,et al.  INTRAVENOUS REGIONAL ANALGESIA. LIGNOCAINE BLOOD LEVELS , 1966 .

[13]  B. Widman.  Some circulatory and respiratory effects of intravenously infused local anaesthetics. , 1966, Acta anaesthesiologica Scandinavica. Supplementum.

[14]  W. H. Harris,et al.  Regional anesthesia by the intravenous route. , 1965, JAMA.

[15]  M. Brunner,et al.  REGIONAL INTRAVENOUS ANESTHESIA. , 1965, JAMA.

[16]  A. Merrifield,et al.  Intravenous regional analgesia: lignocaine blood levels , 1965 .

[17]  C. Monty,et al.  Experiences with Intravenous Regional Anæsthesia , 1965, Proceedings of the Royal Society of Medicine.

[18]  C. Sorbie,et al.  Regional Anaesthesia by the Intravenous Route , 1965, British medical journal.

[19]  B. R. Kennedy,et al.  Intravenous Regional Analgesia: an Appraisal , 1965, British medical journal.

[20]  D. Dickler,et al.  Intravenous Regional Anesthesia with Chloroprocaine , 1965 .

[21]  J. P. Adams,et al.  INTRAVENOUS REGIONAL ANESTHESIA IN HAND SURGERY. , 1964, The Journal of bone and joint surgery. American volume.

[22]  S. A. Fleming,et al.  Intravenous regional anaesthesia , 1964, Canadian Anaesthetists' Society journal.

[23]  J. Hoyle.  Tourniquet for intravenous regional analgesia , 1964, Anaesthesia.

[24]  W. H. Harris,et al.  Regional anesthesia with intravenous Iidocaine , 1963, JAMA.

[25]  Holmes Cm.  INTRAVENOUS REGIONAL ANALGESIA A USEFUL METHOD OF PRODUCING ANALGESIA OF THE LIMBS , 1963 .

[26]  P. Bromage,et al.  CONCENTRATIONS OF LIGNOCAINE IN THE BLOOD AFTER INTRAVENOUS, INTRAMUSCULAR, EPIDURAL AND ENDOTRACHEAL ADMINISTRATION , 1963 .

[27]  D. Moore,et al.  Oxygen: the antidote for systemic toxic reactions from local anesthetic drugs. , 1960, JAMA.

[28]  F. Foldes,et al.  Comparison of toxicity of intravenously given local anesthetic agents in man. , 1960, Journal of the American Medical Association.