DNA-PK: the means to justify the ends?

[1]  David J. Chen,et al.  DNA-PKcs Is Required for Activation of Innate Immunity by Immunostimulatory DNA , 2009, Cell.

[2]  E. Hendrickson,et al.  Mutations to Ku reveal differences in human somatic cell lines. , 2008, DNA repair.

[3]  K. Valerie,et al.  Coordinate 5′ and 3′ endonucleolytic trimming of terminally blocked blunt DNA double-strand break ends by Artemis nuclease and DNA-dependent protein kinase , 2008, Nucleic acids research.

[4]  D. Ramsden,et al.  End-bridging is required for pol μ to efficiently promote repair of noncomplementary ends by nonhomologous end joining , 2008, Nucleic acids research.

[5]  M. Lieber,et al.  Mechanistic flexibility as a conserved theme across 3 billion years of nonhomologous DNA end-joining. , 2008, Genes & development.

[6]  M. Lieber,et al.  The Mechanism of Human Nonhomologous DNA End Joining* , 2008, Journal of Biological Chemistry.

[7]  V. Yamazaki,et al.  DNA double-strand break and chromosomal rejoining defects with misrejoining in Nijmegen breakage syndrome cells. , 2008, DNA repair.

[8]  K. Schwarz,et al.  Flexibility in the order of action and in the enzymology of the nuclease, polymerases, and ligase of vertebrate non-homologous DNA end joining: relevance to cancer, aging, and the immune system , 2008, Cell Research.

[9]  David J. Chen,et al.  The endless tale of non-homologous end-joining , 2008, Cell Research.

[10]  G. Teoh,et al.  Ku86 exists as both a full-length and a protease-sensitive natural variant in multiple myeloma cells , 2008, Cancer Cell International.

[11]  G. Chu,et al.  Crystal structure of human XLF: a twist in nonhomologous DNA end-joining. , 2007, Molecular cell.

[12]  Barbara Corneo,et al.  Rag mutations reveal robust alternative end joining , 2007, Nature.

[13]  Michael M. Murphy,et al.  IgH class switching and translocations use a robust non-classical end-joining pathway , 2007, Nature.

[14]  K. Schwarz,et al.  Single-stranded DNA ligation and XLF-stimulated incompatible DNA end ligation by the XRCC4-DNA ligase IV complex: influence of terminal DNA sequence , 2007, Nucleic acids research.

[15]  K. Valerie,et al.  Phosphorylation in the serine/threonine 2609–2647 cluster promotes but is not essential for DNA-dependent protein kinase-mediated nonhomologous end joining in human whole-cell extracts , 2007, Nucleic acids research.

[16]  G. Chu,et al.  Cernunnos/XLF promotes the ligation of mismatched and noncohesive DNA ends , 2007, Proceedings of the National Academy of Sciences.

[17]  Burkhard Jakob,et al.  Autophosphorylation of DNA-PKCS regulates its dynamics at DNA double-strand breaks , 2007, The Journal of cell biology.

[18]  Qi Ding,et al.  trans Autophosphorylation at DNA-Dependent Protein Kinase's Two Major Autophosphorylation Site Clusters Facilitates End Processing but Not End Joining , 2007, Molecular and Cellular Biology.

[19]  David J. Chen,et al.  Ataxia Telangiectasia Mutated (ATM) Is Essential for DNA-PKcs Phosphorylations at the Thr-2609 Cluster upon DNA Double Strand Break* , 2007, Journal of Biological Chemistry.

[20]  M. Lieber,et al.  XRCC4:DNA ligase IV can ligate incompatible DNA ends and can ligate across gaps , 2007, The EMBO journal.

[21]  L. Pearl,et al.  Structural model of full‐length human Ku70–Ku80 heterodimer and its recognition of DNA and DNA‐PKcs , 2007, EMBO reports.

[22]  K. Myung,et al.  The Lethality of Ku86 (XRCC5) Loss-of-Function Mutations in Human Cells is Independent of p53 (TP53) , 2007, Radiation research.

[23]  Qi Ding,et al.  The DNA-Dependent Protein Kinase Catalytic Subunit Is Phosphorylated In Vivo on Threonine 3950, a Highly Conserved Amino Acid in the Protein Kinase Domain , 2006, Molecular and Cellular Biology.

[24]  Yunmei Ma,et al.  DNA-PKcs Dependence of Artemis Endonucleolytic Activity, Differences between Hairpins and 5′ or 3′ Overhangs* , 2006, Journal of Biological Chemistry.

[25]  C. Delteil,et al.  Interplay between Ku, Artemis, and the DNA-dependent Protein Kinase Catalytic Subunit at DNA Ends* , 2006, Journal of Biological Chemistry.

[26]  P. Jeggo,et al.  DNA‐PK autophosphorylation facilitates Artemis endonuclease activity , 2006, The EMBO journal.

[27]  B. Chen,et al.  ATR-Dependent Phosphorylation of DNA-Dependent Protein Kinase Catalytic Subunit in Response to UV-Induced Replication Stress , 2006, Molecular and Cellular Biology.

[28]  Laurence H Pearl,et al.  Three-dimensional structure of the human DNA-PKcs/Ku70/Ku80 complex assembled on DNA and its implications for DNA DSB repair. , 2006, Molecular cell.

[29]  Michael M. Murphy,et al.  XRCC4 suppresses medulloblastomas with recurrent translocations in p53-deficient mice. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[30]  David Jung,et al.  Mechanism and control of V(D)J recombination at the immunoglobulin heavy chain locus. , 2006, Annual review of immunology.

[31]  M. Jovanović,et al.  Terminal DNA structure and ATP influence binding parameters of the DNA-dependent protein kinase at an early step prior to DNA synapsis , 2006, Nucleic acids research.

[32]  S. Jackson,et al.  XLF Interacts with the XRCC4-DNA Ligase IV Complex to Promote DNA Nonhomologous End-Joining , 2006, Cell.

[33]  A. Fischer,et al.  Cernunnos, a Novel Nonhomologous End-Joining Factor, Is Mutated in Human Immunodeficiency with Microcephaly , 2006, Cell.

[34]  K. Meek,et al.  The leucine rich region of DNA-PKcs contributes to its innate DNA affinity , 2005, Nucleic acids research.

[35]  S. Lees-Miller,et al.  Autophosphorylation of DNA-Dependent Protein Kinase Regulates DNA End Processing and May Also Alter Double-Strand Break Repair Pathway Choice , 2005, Molecular and Cellular Biology.

[36]  David J. Chen,et al.  Homologous recombination and nonhomologous end-joining repair pathways regulate fragile site stability. , 2005, Genes & development.

[37]  Yunmei Ma,et al.  The DNA-dependent Protein Kinase Catalytic Subunit Phosphorylation Sites in Human Artemis* , 2005, Journal of Biological Chemistry.

[38]  S. Lees-Miller,et al.  DNA-PK-dependent phosphorylation of Ku70/80 is not required for non-homologous end joining. , 2005, DNA repair.

[39]  T. Kunkel,et al.  A gradient of template dependence defines distinct biological roles for family X polymerases in nonhomologous end joining. , 2005, Molecular cell.

[40]  David J. Chen,et al.  Independent and sequential recruitment of NHEJ and HR factors to DNA damage sites in mammalian cells , 2005, The Journal of cell biology.

[41]  Yunmei Ma,et al.  The Artemis:DNA-PKcs endonuclease cleaves DNA loops, flaps, and gaps. , 2005, DNA repair.

[42]  Stephen P. Jackson,et al.  Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage , 2005, Nature.

[43]  C. Delteil,et al.  DNA-dependent Protein Kinase and XRCC4-DNA Ligase IV Mobilization in the Cell in Response to DNA Double Strand Breaks* , 2005, Journal of Biological Chemistry.

[44]  Laurence H Pearl,et al.  Three-dimensional structure and regulation of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs). , 2005, Structure.

[45]  Qi Ding,et al.  Inhibition of homologous recombination by variants of the catalytic subunit of the DNA-dependent protein kinase (DNA-PKcs). , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[46]  J. Turchi,et al.  Differential activation of DNA-PK based on DNA strand orientation and sequence bias , 2005, Nucleic acids research.

[47]  P. Calsou,et al.  Involvement of Poly(ADP-ribose) Polymerase-1 and XRCC1/DNA Ligase III in an Alternative Route for DNA Double-strand Breaks Rejoining* , 2004, Journal of Biological Chemistry.

[48]  Yunmei Ma,et al.  A biochemically defined system for mammalian nonhomologous DNA end joining. , 2004, Molecular cell.

[49]  Martin Kühne,et al.  A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci. , 2004, Molecular cell.

[50]  L. Pearl,et al.  Electron microscopy studies on DNA recognition by DNA-PK. , 2004, Micron.

[51]  Qi Ding,et al.  Non-homologous End Joining Requires That the DNA-PK Complex Undergo an Autophosphorylation-dependent Rearrangement at DNA Ends* , 2004, Journal of Biological Chemistry.

[52]  D. Ramsden,et al.  The DNA‐dependent protein kinase: the director at the end , 2004, Immunological reviews.

[53]  M. Jovanović,et al.  Identification of DNA-PKcs phosphorylation sites in XRCC4 and effects of mutations at these sites on DNA end joining in a cell-free system. , 2004, DNA repair.

[54]  David J. Chen,et al.  DNA-PKcs function regulated specifically by protein phosphatase 5. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[55]  Qi Ding,et al.  Autophosphorylation-dependent remodeling of the DNA-dependent protein kinase catalytic subunit regulates ligation of DNA ends. , 2004, Nucleic acids research.

[56]  J. Hoeijmakers,et al.  The role of DNA dependent protein kinase in synapsis of DNA ends , 2003, Nucleic acids research.

[57]  Qi Ding,et al.  DNA-PK phosphorylation sites in XRCC4 are not required for survival after radiation or for V(D)J recombination. , 2003, DNA repair.

[58]  Pablo Chacón,et al.  Visualization of DNA‐induced conformational changes in the DNA repair kinase DNA‐PKcs , 2003, The EMBO journal.

[59]  S. Lees-Miller,et al.  Repair of DNA double strand breaks by non-homologous end joining. , 2003, Biochimie.

[60]  W. Dynan,et al.  Distinct Pathways of Nonhomologous End Joining That Are Differentially Regulated by DNA-dependent Protein Kinase-mediated Phosphorylation* , 2003, Journal of Biological Chemistry.

[61]  J. Nickoloff,et al.  Interactive competition between homologous recombination and non-homologous end joining. , 2003, Molecular cancer research : MCR.

[62]  Timothy Woods,et al.  Autophosphorylation of the Catalytic Subunit of the DNA-Dependent Protein Kinase Is Required for Efficient End Processing during DNA Double-Strand Break Repair , 2003, Molecular and Cellular Biology.

[63]  Kai Rothkamm,et al.  Pathways of DNA Double-Strand Break Repair during the Mammalian Cell Cycle , 2003, Molecular and Cellular Biology.

[64]  D. Ramsden,et al.  Polymerase Mu Is a DNA-Directed DNA/RNA Polymerase , 2003, Molecular and Cellular Biology.

[65]  S. Soubeyrand,et al.  Threonines 2638/2647 in DNA-PK are essential for cellular resistance to ionizing radiation. , 2003, Cancer research.

[66]  A. Trumpp,et al.  Conditional Mutation of Rb Causes Cell Cycle Defects without Apoptosis in the Central Nervous System , 2003, Molecular and Cellular Biology.

[67]  K. Schwarz,et al.  The embryonic lethality in DNA ligase IV-deficient mice is rescued by deletion of Ku: implications for unifying the heterogeneous phenotypes of NHEJ mutants. , 2002, DNA repair.

[68]  M. Frank-Vaillant,et al.  Transient stability of DNA ends allows nonhomologous end joining to precede homologous recombination. , 2002, Molecular cell.

[69]  W. Dynan,et al.  Subnuclear Localization of Ku Protein: Functional Association with RNA Polymerase II Elongation Sites , 2002, Molecular and Cellular Biology.

[70]  D. Ramsden,et al.  Association of DNA Polymerase μ (pol μ) with Ku and Ligase IV: Role for pol μ in End-Joining Double-Strand Break Repair , 2002, Molecular and Cellular Biology.

[71]  J. Griffith,et al.  Synapsis of DNA ends by DNA‐dependent protein kinase , 2002, The EMBO journal.

[72]  David J. Chen,et al.  Autophosphorylation of the DNA-dependent protein kinase catalytic subunit is required for rejoining of DNA double-strand breaks. , 2002, Genes & development.

[73]  S. West,et al.  Involvement of human polynucleotide kinase in double‐strand break repair by non‐homologous end joining , 2002, The EMBO journal.

[74]  Yunmei Ma,et al.  Hairpin Opening and Overhang Processing by an Artemis/DNA-Dependent Protein Kinase Complex in Nonhomologous End Joining and V(D)J Recombination , 2002, Cell.

[75]  David J. Chen,et al.  DNA-dependent protein kinase suppresses double-strand break-induced and spontaneous homologous recombination , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[76]  Qi Ding,et al.  DNA-PKcs mutations in dogs and horses: allele frequency and association with neoplasia. , 2002, Gene.

[77]  E. Hendrickson,et al.  Ku86 is essential in human somatic cells , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[78]  N. Ellis,et al.  Ku DNA end-binding protein modulates homologous repair of double-strand breaks in mammalian cells. , 2001, Genes & development.

[79]  P. Dhar,et al.  Genetic Analysis of the DNA-dependent Protein Kinase Reveals an Inhibitory Role of Ku in Late S–G2 Phase DNA Double-strand Break Repair* , 2001, The Journal of Biological Chemistry.

[80]  H. Koyama,et al.  DNA ligase IV-deficient cells are more resistant to ionizing radiation in the absence of Ku70: Implications for DNA double-strand break repair , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[81]  A. Pastink,et al.  Genomic integrity and the repair of double-strand DNA breaks. , 2001, Mutation research.

[82]  M. Dark,et al.  SCID in Jack Russell Terriers: A New Animal Model of DNA-PKcs Deficiency1 , 2001, The Journal of Immunology.

[83]  J. Walker,et al.  Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair , 2001, Nature.

[84]  Wen-rong Gong,et al.  Activation and autoregulation of DNA-PK from structured single-stranded DNA and coding end hairpins , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[85]  S. Lees-Miller,et al.  Protein Phosphatases Regulate DNA-dependent Protein Kinase Activity* , 2001, The Journal of Biological Chemistry.

[86]  David J. Chen,et al.  RETRACTED: DNA-PKcs Is Required for Activation of Innate Immunity by Immunostimulatory DNA , 2000, Cell.

[87]  J. Turchi,et al.  Cisplatin-DNA adducts inhibit translocation of the Ku subunits of DNA-PK. , 2000, Nucleic acids research.

[88]  K. Meek,et al.  Both V(D)J recombination and radioresistance require DNA-PK kinase activity, though minimal levels suffice for V(D)J recombination. , 2000, Nucleic acids research.

[89]  O. Hammarsten,et al.  Activation of DNA-dependent Protein Kinase by Single-stranded DNA Ends* , 2000, The Journal of Biological Chemistry.

[90]  W. Dynan,et al.  Geometry of a complex formed by double strand break repair proteins at a single DNA end: recruitment of DNA-PKcs induces inward translocation of Ku protein. , 1999, Nucleic acids research.

[91]  M. Bogue,et al.  Modulation of terminal deoxynucleotidyltransferase activity by the DNA-dependent protein kinase. , 1999, Journal of immunology.

[92]  A. Kimzey,et al.  Photocross-linking of an Oriented DNA Repair Complex , 1999, The Journal of Biological Chemistry.

[93]  David J. Chen,et al.  Requirement for the Kinase Activity of Human DNA-Dependent Protein Kinase Catalytic Subunit in DNA Strand Break Rejoining , 1999, Molecular and Cellular Biology.

[94]  M. Gellert,et al.  DNA binding of Xrcc4 protein is associated with V(D)J recombination but not with stimulation of DNA ligase IV activity , 1999, The EMBO journal.

[95]  David J. Chen,et al.  The DNA-dependent Protein Kinase Catalytic Activity Regulates DNA End Processing by Means of Ku Entry into DNA* , 1999, The Journal of Biological Chemistry.

[96]  M. Lieber.  The biochemistry and biological significance of nonhomologous DNA end joining: an essential repair process in multicellular eukaryotes , 1999, Genes to cells : devoted to molecular & cellular mechanisms.

[97]  D. Chan,et al.  DNA-dependent protein kinase phosphorylation sites in Ku 70/80 heterodimer. , 1999, Biochemistry.

[98]  S. Jackson,et al.  DNA-dependent protein kinase. , 1997, The international journal of biochemistry & cell biology.

[99]  F. Alt,et al.  A Critical Role for DNA End-Joining Proteins in Both Lymphogenesis and Neurogenesis , 1998, Cell.

[100]  F. Alt,et al.  Late embryonic lethality and impaired V (D)J recombination in mice lacking DNA ligase IV , 1998, Nature.

[101]  G. Chu,et al.  Failure of Hairpin-Ended and Nicked DNA To Activate DNA-Dependent Protein Kinase: Implications for V(D)J Recombination , 1998, Molecular and Cellular Biology.

[102]  S. Jackson,et al.  DNA end-joining: from yeast to man. , 1998, Trends in biochemical sciences.

[103]  Y. Yamaguchi-Iwai,et al.  Homologous recombination and non‐homologous end‐joining pathways of DNA double‐strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells , 1998, The EMBO journal.

[104]  O. Hammarsten,et al.  DNA-dependent protein kinase: DNA binding and activation in the absence of Ku. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[105]  R. Leber,et al.  The XRCC4 Gene Product Is a Target for and Interacts with the DNA-dependent Protein Kinase* , 1998, The Journal of Biological Chemistry.

[106]  Shengfang Jin,et al.  Binding of Ku and c-Abl at the Kinase Homology Region of DNA-dependent Protein Kinase Catalytic Subunit* , 1997, The Journal of Biological Chemistry.

[107]  M. Lieber,et al.  Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammalian cells , 1997, Nature.

[108]  K. Meek,et al.  A kinase-negative mutation of DNA-PK(CS) in equine SCID results in defective coding and signal joint formation. , 1997, Journal of immunology.

[109]  S. E. Lee,et al.  Evidence for DNA-PK-dependent and -independent DNA double-strand break repair pathways in mammalian cells as a function of the cell cycle , 1997, Molecular and cellular biology.

[110]  P. Jeggo,et al.  Identification of a nonsense mutation in the carboxyl-terminal region of DNA-dependent protein kinase catalytic subunit in the scid mouse. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[111]  F Liang,et al.  Chromosomal double-strand break repair in Ku80-deficient cells. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[112]  D. Chan,et al.  DNA‐dependent protein kinase catalytic subunit: a target for an ICE‐like protease in apoptosis. , 1996, The EMBO journal.

[113]  D. Chan,et al.  The DNA-dependent Protein Kinase Is Inactivated by Autophosphorylation of the Catalytic Subunit (*) , 1996, The Journal of Biological Chemistry.

[114]  F. Alt,et al.  The XRCC4 gene encodes a novel protein involved in DNA double-strand break repair and V(D)J recombination , 1995, Cell.

[115]  M. Connelly,et al.  DNA-dependent protein kinase catalytic subunit: A relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product , 1995, Cell.

[116]  P. Jeggo,et al.  DNA-dependent protein kinase activity is absent in xrs-6 cells: implications for site-specific recombination and DNA double-strand break repair. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[117]  G. Chu,et al.  A DNA end-binding factor involved in double-strand break repair and V(D)J recombination , 1994, Molecular and cellular biology.

[118]  C. Anderson,et al.  Human cells contain a DNA-activated protein kinase that phosphorylates simian virus 40 T antigen, mouse p53, and the human Ku autoantigen , 1990, Molecular and cellular biology.

[119]  J. Steitz,et al.  Characterization of the DNA-binding protein antigen Ku recognized by autoantibodies from patients with rheumatic disorders. , 1986, The Journal of biological chemistry.

[120]  T. Hunt,et al.  Double‐stranded DNA induces the phosphorylation of several proteins including the 90 000 mol. wt. heat‐shock protein in animal cell extracts. , 1985, The EMBO journal.