The National Morbidity, Mortality, and Air Pollution Study. Part I: Methods and methodologic issues.

The Health Effects Institute, established in 1980, is an independent and unbiased source of information on the health effects of motor vehicle emissions. HEI supports research on all major pollutants, including regulated pollutants (such as carbon monoxide, ozone, nitrogen dioxide, and particulate matter) and unregulated pollutants (such as diesel engine exhaust, methanol, and aldehydes). To date, HEI has supported more than 200 projects at institutions in North America and Europe and has published over 100 research reports. Typically, HEI receives half its funds from the US Environmental Protection Agency and half from 28 manufacturers and marketers of motor vehicles and engines in the US. Occasionally, funds from other public and private organizations either support special projects or provide resources for a portion of an HEI study. Regardless of funding sources, HEI exercises complete autonomy in setting its research priorities and in reaching its conclusions. An independent Board of Directors governs HEI. The Institute's Research and Review Committees serve complementary scientific purposes and draw distinguished scientists as members. The results of HEI-funded studies are made available as Research Reports, which contain both the Investigators' Report and the Review Committee's evaluation of the work's scientific quality and regulatory relevance.

[1]  J. Schwartz,et al.  Air Pollution and Hospital Admissions for Cardiovascular Disease in Tucson , 1997, Epidemiology.

[2]  Jeffrey E. Harris,et al.  Bayes Methods for Combining the Results of Cancer Studies in Humans and other Species , 1983 .

[3]  B G Armstrong,et al.  Analysis of case-control data with covariate measurement error: application to diet and colon cancer. , 1989, Statistics in medicine.

[4]  J D Spengler,et al.  Respiratory health and PM10 pollution. A daily time series analysis. , 1991, The American review of respiratory disease.

[5]  B. Brunekreef,et al.  Personal sampling of particles in adults: relation among personal, indoor, and outdoor air concentrations. , 1998, American journal of epidemiology.

[6]  Adrian F. M. Smith,et al.  Sampling-Based Approaches to Calculating Marginal Densities , 1990 .

[7]  J Schwartz,et al.  What are people dying of on high air pollution days? , 1994, Environmental research.

[8]  R. Wyzga,et al.  Air pollution and mortality: issues and uncertainties. , 1995, Journal of the Air & Waste Management Association.

[9]  N. Laird,et al.  Meta-analysis in clinical trials. , 1986, Controlled clinical trials.

[10]  J. Schwartz,et al.  Mortality and air pollution in London: a time series analysis. , 1990, American journal of epidemiology.

[11]  J. Neyman,et al.  Correction for Bias Introduced by a Transformation of Variables , 1960 .

[12]  H. Schimmel,et al.  Proceedings: The relation of air pollution to mortality. , 1976, Journal of occupational medicine. : official publication of the Industrial Medical Association.

[13]  R. Wolpert,et al.  Combining Information From Related Regressions , 1997 .

[14]  Grace L. Yang,et al.  Asymptotics In Statistics , 1990 .

[15]  S. Zeger,et al.  Longitudinal data analysis using generalized linear models , 1986 .

[16]  Joel Schwartz,et al.  REVIEW OF EPIDEMIOLOGICAL EVIDENCE OF HEALTH EFFECTS OF PARTICULATE AIR POLLUTION , 1995 .

[17]  Walter R. Gilks,et al.  BUGS - Bayesian inference Using Gibbs Sampling Version 0.50 , 1995 .

[18]  Martin Abba Tanner,et al.  Tools for Statistical Inference: Observed Data and Data Augmentation Methods , 1993 .

[19]  J. Neher,et al.  Health effects of outdoor air pollution. , 1994, American family physician.

[20]  S. Zeger,et al.  Frequency Domain Log‐linear Models; Air Pollution and Mortality , 1999 .

[21]  J. Schwartz HEALTH EFFECTS OF AIR POLLUTION FROM TRAFFIC: OZONE AND PARTICULATE MATTER , 1997 .

[22]  D Krewski,et al.  Effects of low ambient levels of ozone and sulfates on the frequency of respiratory admissions to Ontario hospitals. , 1994, Environmental research.

[23]  J. Schwartz,et al.  Air pollution and daily mortality: a review and meta analysis. , 1994, Environmental research.

[24]  J Schwartz,et al.  Air pollution and daily mortality in Birmingham, Alabama. , 1993, American journal of epidemiology.

[25]  M Lippmann,et al.  Respiratory hospital admissions and summertime haze air pollution in Toronto, Ontario: consideration of the role of acid aerosols. , 1994, Environmental research.

[26]  S L Zeger,et al.  Harvesting-resistant estimates of air pollution effects on mortality. , 1999, Epidemiology.

[27]  C. Pope,et al.  Respiratory disease associated with community air pollution and a steel mill, Utah Valley. , 1989, American journal of public health.

[28]  R. D. Morris,et al.  Air pollution and hospital admissions for cardiovascular disease in Detroit, Michigan. , 1995, American journal of epidemiology.

[29]  D. Costa,et al.  Oxidant Generation and Lung Injury after Particulate Air Pollutant Exposure Increase with the Concentrations of Associated Metals , 1996 .

[30]  G. Thurston,et al.  Air Pollution Epidemiology: Considerations in Time-Series Modeling , 1995 .

[31]  D. Rubin,et al.  Inference from Iterative Simulation Using Multiple Sequences , 1992 .

[32]  T. N. Sriram Asymptotics in Statistics–Some Basic Concepts , 2002 .

[33]  J. Schwartz,et al.  Particulate air pollution and daily mortality in Detroit. , 1991, Environmental research.

[34]  W. Pierson,et al.  Particulate air pollution and hospital emergency room visits for asthma in Seattle. , 1993, The American review of respiratory disease.

[35]  D J Spiegelhalter,et al.  Bayesian approaches to random-effects meta-analysis: a comparative study. , 1995, Statistics in medicine.

[36]  Giovanni Parmigiani,et al.  Meta-Analysis of Migraine Headache Treatments: Combining Information from Heterogeneous Designs , 1999 .

[37]  D. Lindley,et al.  Bayes Estimates for the Linear Model , 1972 .

[38]  J Schwartz,et al.  Oxygen saturation, pulse rate, and particulate air pollution: A daily time-series panel study. , 1999, American journal of respiratory and critical care medicine.

[39]  J. Gamble,et al.  Health and respirable particulate (PM10) air pollution: a causal or statistical association? , 1996, Environmental health perspectives.

[40]  J. Hodgkin,et al.  Chronic obstructive pulmonary disease symptom effects of long-term cumulative exposure to ambient levels of total suspended particulates and sulfur dioxide in California Seventh-Day Adventist residents. , 1987, Archives of environmental health.

[41]  U. Epa Air Quality Criteria for Particulate Matter , 1996 .

[42]  C. Chatfield,et al.  Fourier Analysis of Time Series: An Introduction , 1977, IEEE Transactions on Systems, Man, and Cybernetics.

[43]  F Dominici,et al.  Combining Contingency Tables with Missing Dimensions , 2000, Biometrics.

[44]  J Schwartz,et al.  Short term fluctuations in air pollution and hospital admissions of the elderly for respiratory disease. , 1995, Thorax.

[45]  S. Greenland,et al.  Effects of nondifferential exposure misclassification in ecologic studies. , 1992, American Journal of Epidemiology.

[46]  N. Breslow,et al.  Approximate inference in generalized linear mixed models , 1993 .

[47]  S Richardson,et al.  A Bayesian approach to measurement error problems in epidemiology using conditional independence models. , 1993, American journal of epidemiology.

[48]  D. Dockery,et al.  An association between air pollution and mortality in six U.S. cities. , 1993, The New England journal of medicine.

[49]  James V. Zidek,et al.  CAUSALITY, MEASUREMENT ERROR AND MULTICOLLINEARITY IN EPIDEMIOLOGY , 1996 .

[50]  J. Schwartz,et al.  Air pollution and daily mortality in Erfurt, east Germany, 1980-1989. , 1993, Environmental health perspectives.

[51]  B Rosner,et al.  Correction of logistic regression relative risk estimates and confidence intervals for systematic within-person measurement error. , 2006, Statistics in medicine.

[52]  R. Wyzga,et al.  Air pollution and mortality: the implications of uncertainties in regression modeling and exposure measurement. , 1997, Journal of the Air & Waste Management Association.

[53]  L. Wallace,et al.  Indoor particles: a review. , 1996, Journal of the Air & Waste Management Association.

[54]  Donald Geman,et al.  Stochastic Relaxation, Gibbs Distributions, and the Bayesian Restoration of Images , 1984, IEEE Transactions on Pattern Analysis and Machine Intelligence.

[55]  D. Krewski,et al.  Adjusting for temporal variation in the analysis of parallel time series of health and environmental variables. , 1998, Journal of exposure analysis and environmental epidemiology.

[56]  C. Pope,et al.  Daily mortality and PM10 pollution in Utah Valley. , 1992, Archives of environmental health.

[57]  J. Xue,et al.  Personal exposure to airborne particles and metals: results from the Particle TEAM study in Riverside, California. , 1996, Journal of exposure analysis and environmental epidemiology.

[58]  Re Waller,et al.  Principles of Exposure Measurement in Epidemiology , 1994 .

[59]  P. S. Gilmour,et al.  Free radical activity and pro-inflammatory effects of particulate air pollution (PM10) in vivo and in vitro. , 1996, Thorax.

[60]  J Schwartz,et al.  Air Pollution and Hospital Admissions for Respiratory Disease , 1996, Epidemiology.

[61]  A. Raftery,et al.  How Many Iterations in the Gibbs Sampler , 1991 .

[62]  P. Lioy,et al.  The personal, indoor and outdoor concentrations of PM-10 measured in an industrial community during the winter , 1990 .

[63]  D. Thomas,et al.  Exposure measurement error: influence on exposure-disease. Relationships and methods of correction. , 1993, Annual review of public health.

[64]  D. Costa,et al.  Bioavailable transition metals in particulate matter mediate cardiopulmonary injury in healthy and compromised animal models. , 1997, Environmental health perspectives.

[65]  B Rosner,et al.  Correction of logistic regression relative risk estimates and confidence intervals for random within-person measurement error. , 1992, American journal of epidemiology.

[66]  P. Dellaportas,et al.  BAYESIAN ANALYSIS OF ERRORS-IN-VARIABLES REGRESSION MODELS , 1995 .

[67]  J M Davis,et al.  Assessing the human health risk of atmospheric particles. , 1999, Novartis Foundation symposium.

[68]  G A Allen,et al.  Effects of ozone and other pollutants on the pulmonary function of adult hikers. , 1998, Environmental health perspectives.

[69]  D. Dockery,et al.  Acute respiratory effects of particulate air pollution. , 1994, Annual review of public health.

[70]  J. Schwartz,et al.  Is Daily Mortality Associated Specifically with Fine Particles? , 1996, Journal of the Air & Waste Management Association.

[71]  L. Tierney Markov Chains for Exploring Posterior Distributions , 1994 .

[72]  J Schwartz,et al.  Air pollution and hospital admissions for the elderly in Birmingham, Alabama. , 1994, American journal of epidemiology.

[73]  D. Spiegelhalter,et al.  Modelling Complexity: Applications of Gibbs Sampling in Medicine , 1993 .

[74]  N. Best,et al.  Convergence Diagnosis and Output Analysis Software for Gibbs sampling output Version 0.30 , 1995 .

[75]  A P Verhoeff,et al.  Air Pollution and Daily Mortality in Amsterdam , 1996, Epidemiology.

[76]  D. Fairley,et al.  The relationship of daily mortality to suspended particulates in Santa Clara County, 1980-1986. , 1990, Environmental health perspectives.

[77]  B. Silverman,et al.  Nonparametric Regression and Generalized Linear Models: A roughness penalty approach , 1993 .

[78]  J C Wakefield,et al.  Hierarchical models for multicentre binary response studies. , 1990, Statistics in medicine.

[79]  B. Brunekreef,et al.  Childhood exposure to PM10: relation between personal, classroom, and outdoor concentrations. , 1997, Occupational and environmental medicine.

[80]  E. Luebeck,et al.  A critical review of the evidence on particulate air pollution and mortality. , 1996, Epidemiology.

[81]  Nancy Paul Silliman,et al.  Hierarchical Selection Models with Applications in Meta-Analysis , 1997 .

[82]  J Schwartz,et al.  Particulate air pollution and chronic respiratory disease. , 1993, Environmental research.

[83]  S. Zeger,et al.  Markov regression models for time series: a quasi-likelihood approach. , 1988, Biometrics.

[84]  D. Ruppert,et al.  Measurement Error in Nonlinear Models , 1995 .

[85]  S L Zeger,et al.  Air pollution and mortality in Philadelphia, 1974-1988. , 1997, American journal of epidemiology.

[86]  Raymond J. Carroll,et al.  Approximate Quasi-likelihood Estimation in Models with Surrogate Predictors , 1990 .

[87]  F. Lipfert Clean air skepticism. , 1997, Science.

[88]  A. Peters,et al.  Increased plasma viscosity during an air pollution episode: a link to mortality? , 1997, The Lancet.

[89]  Suresh H. Moolgavkar,et al.  Air Pollution and Daily Mortality in Philadelphia , 1995, Epidemiology.

[90]  M. Glickman,et al.  Statistical Methods for Profiling Providers of Medical Care: Issues and Applications , 1997 .

[91]  J. Schwartz,et al.  Air pollution and daily admissions for chronic obstructive pulmonary disease in 6 European cities: results from the APHEA project. , 1997, The European respiratory journal.

[92]  J Schwartz,et al.  Increased mortality in Philadelphia associated with daily air pollution concentrations. , 1992, The American review of respiratory disease.

[93]  R. Prentice Covariate measurement errors and parameter estimation in a failure time regression model , 1982 .

[94]  Leonard A. Stefanski,et al.  The effects of measurement error on parameter estimation , 1985 .

[95]  D. Costa,et al.  Cardiac arrhythmia induction after exposure to residual oil fly ash particles in a rodent model of pulmonary hypertension. , 1998, Toxicological sciences : an official journal of the Society of Toxicology.

[96]  W. K. Hastings,et al.  Monte Carlo Sampling Methods Using Markov Chains and Their Applications , 1970 .

[97]  W. Wong,et al.  The calculation of posterior distributions by data augmentation , 1987 .

[98]  Bani K. Mallick,et al.  Semiparametric errors-in-variables models A Bayesian approach , 1996 .

[99]  J Schwartz,et al.  Air pollution and hospital admissions for the elderly in Detroit, Michigan. , 1994, American journal of respiratory and critical care medicine.

[100]  D. Dockery,et al.  Particulate air pollution as a predictor of mortality in a prospective study of U.S. adults. , 1995, American journal of respiratory and critical care medicine.

[101]  Health effects of outdoor air pollution. Part 2. Committee of the Environmental and Occupational Health Assembly of the American Thoracic Society. , 1996, American journal of respiratory and critical care medicine.