Discovery and initial validation of α 1‐B glycoprotein fragmentation as a differential urinary biomarker in pediatric steroid‐resistant nephrotic syndrome

Purpose: In this cross‐sectional pilot study we set out to discover a non‐invasive biomarker that could distinguish steroid‐resistant nephrotic syndrome (SRNS) from steroid‐sensitive nephrotic syndrome (SSNS).

[1]  M. Bhasin,et al.  Optimizing a Proteomics Platform for Urine Biomarker Discovery* , 2010, Molecular & Cellular Proteomics.

[2]  S. Vyas,et al.  Long-term outcome of children with steroid-resistant nephrotic syndrome treated with tacrolimus , 2010, Pediatric Nephrology.

[3]  E. Silverman,et al.  Neutrophil gelatinase-associated lipocalin is a predictor of the course of global and renal childhood-onset systemic lupus erythematosus disease activity. , 2009, Arthritis and rheumatism.

[4]  A. Papagianni,et al.  Urinary levels of epidermal growth factor, interleukin‐6 and monocyte chemoattractant protein‐1 may act as predictor markers of renal function outcome in immunoglobulin A nephropathy , 2009, Nephrology.

[5]  V. Thongboonkerd,et al.  Are protease inhibitors required for gel-based proteomics of kidney and urine? , 2009, Journal of proteome research.

[6]  M. Masellis,et al.  Proteomic analysis of urine from proteinuric patients shows a proteolitic activity directed against albumin. , 2009, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[7]  Susan L Furth,et al.  New equations to estimate GFR in children with CKD. , 2009, Journal of the American Society of Nephrology : JASN.

[8]  A. Fisher,et al.  Peroxiredoxin-6 protects against mitochondrial dysfunction and liver injury during ischemia-reperfusion in mice. , 2009, American journal of physiology. Gastrointestinal and liver physiology.

[9]  G. Ross,et al.  Using proteomics to identify preprocedural risk factors for contrast induced nephropathy , 2008, Proteomics. Clinical applications.

[10]  R. Woroniecki,et al.  Urinary Cytokines and Steroid Responsiveness in Idiopathic Nephrotic Syndrome of Childhood , 2007, American Journal of Nephrology.

[11]  R. Craver,et al.  Presenting features and short-term outcome according to pathologic variant in childhood primary focal segmental glomerulosclerosis. , 2007, Clinical journal of the American Society of Nephrology : CJASN.

[12]  D. Stablein,et al.  Contributions of the Transplant Registry: The 2006 Annual Report of the North American Pediatric Renal Trials and Collaborative Studies (NAPRTCS) * , 2007, Pediatric transplantation.

[13]  M. Somers,et al.  Focal and segmental glomerulosclerosis in children: a longitudinal assessment , 2007, Pediatric Nephrology.

[14]  F. Scolari,et al.  Active focal segmental glomerulosclerosis is associated with massive oxidation of plasma albumin. , 2007, Journal of the American Society of Nephrology : JASN.

[15]  D. Gipson,et al.  Therapeutic approach to FSGS in children , 2007, Pediatric Nephrology.

[16]  F. Scolari,et al.  Repetitive Fragmentation Products of Albumin and α1-Antitrypsin in Glomerular Diseases Associated with Nephrotic Syndrome , 2006 .

[17]  S. Hailpern,et al.  Urinary Proteome of Steroid-Sensitive and Steroid-Resistant Idiopathic Nephrotic Syndrome of Childhood , 2006, American Journal of Nephrology.

[18]  T. Libermann,et al.  Urine proteomic profiling of pediatric nephrotic syndrome , 2006, Pediatric Nephrology.

[19]  R J Falk,et al.  Clinical and pathologic characteristics of focal segmental glomerulosclerosis pathologic variants. , 2006, Kidney international.

[20]  D. Gipson,et al.  Differential risk of remission and ESRD in childhood FSGS , 2006, Pediatric Nephrology.

[21]  G. Ross,et al.  Early Prediction of Acute Renal Injury Using Urinary Proteomics , 2005, American Journal of Nephrology.

[22]  Ethan M Balk,et al.  K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification. , 2002, American journal of kidney diseases : the official journal of the National Kidney Foundation.

[23]  A. Bagga,et al.  Treatment of focal glomerulosclerosis with pulse steroids and oral cyclophosphamide , 2001, Pediatric Nephrology.

[24]  A. Papagianni,et al.  Factors influencing the course and the response to treatment in primary focal segmental glomerulosclerosis. , 2000, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[25]  I. Ebihara,et al.  The Urinary Podocyte as a Marker for the Differential Diagnosis of Idiopathic Focal Glomerulosclerosis and Minimal-Change Nephrotic Syndrome , 2000, American Journal of Nephrology.

[26]  R. Portman,et al.  Changing patterns in the histopathology of idiopathic nephrotic syndrome in children. , 1999, Kidney international.

[27]  D. Cattran,et al.  Long-term outcome in children and adults with classic focal segmental glomerulosclerosis. , 1998, American journal of kidney diseases : the official journal of the National Kidney Foundation.

[28]  M. Schwartz,et al.  Primary focal segmental glomerular sclerosis in adults: prognostic value of histologic variants. , 1995, American journal of kidney diseases : the official journal of the National Kidney Foundation.

[29]  N. Ishioka,et al.  Amino acid sequence of human plasma alpha 1B-glycoprotein: homology to the immunoglobulin supergene family. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[30]  Q. Mac,et al.  Urine NGAL and IL-18 are Predictive Biomarkers for Delayed Graft Function Following Kidney Transplantation , 2006 .

[31]  M. Devita,et al.  Increasing incidence of focal segmental glomerulosclerosis and an examination of demographic patterns. , 2005, Clinical nephrology.

[32]  S. Korbet Clinical picture and outcome of primary focal segmental glomerulosclerosis. , 1999, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.