Optical assessment of the in vivo tympanic membrane status using a handheld optical coherence tomography-based otoscope

Abstract Objective: Conventional otoscopes and oto-endoscopes, which are used to examine the tympanic membrane (TM), do not provide tomographic information. Optical coherence tomography (OCT) non-invasively reveals the depth-resolved internal microstructure of the TM with very high spatial resolution. We designed this study to examine the TMs with middle ear diseases using a handheld otoscope employing 860 nm spectral domain (SD)-OCT, combined with video camera and to demonstrate the clinical applicability of this system. Design: A total of 120 patients with otologic symptoms were enrolled. TM images were obtained using the handheld OCT-based otoscope (860 nm central wave length, 15 μm axial resolution, 15 μm lateral resolution, and 7 mm scanning range using relay lens). Both OCT and oto-endoscope images were compared according to the clinical characteristics such as perforation, retraction, and postoperative healing process. Results: The objective grade about the thickness of perforation margins and the accurate information about the extent of TM retraction that was not distinguishable by oto-endoscopic exam could be identified using this system. The postoperative healing process of TMs could be also followed using the OCT device. Conclusion: These analyses from the surgeon-oriented perspective suggest another useful application of the handheld OCT device.

[1]  Steve D. M. Brown,et al.  Panel 1: Biotechnology, biomedical engineering and new models of otitis media. , 2019, International journal of pediatric otorhinolaryngology.

[2]  N. M. Perez,et al.  Recovery from tympanic membrane perforation: Effects on membrane thickness, auditory thresholds, and middle ear transmission , 2019, Hearing Research.

[3]  K. Devaraja.  Myringitis: An update , 2018, Journal of otology.

[4]  Manohar Bance,et al.  Long-range, wide-field swept-source optical coherence tomography with GPU accelerated digital lock-in Doppler vibrography for real-time, in vivo middle ear diagnostics. , 2016, Biomedical optics express.

[5]  Nathan D. Shemonski,et al.  Real-time automated thickness measurement of the in vivo human tympanic membrane using optical coherence tomography. , 2015, Quantitative imaging in medicine and surgery.

[6]  Guillermo L. Monroy,et al.  Noninvasive depth‐resolved optical measurements of the tympanic membrane and middle ear for differentiating otitis media , 2015, The Laryngoscope.

[7]  Seung-ha Oh,et al.  Prevalence and Risk Factors of Chronic Otitis Media: The Korean National Health and Nutrition Examination Survey 2010–2012 , 2015, PloS one.

[8]  S. Boppart,et al.  Erratum: Optical Coherence Tomography for the Diagnosis and Evaluation of Human Otitis Media , 2015, Journal of Korean medical science.

[9]  Jeehyun Kim,et al.  Optical Coherence Tomography for the Diagnosis and Evaluation of Human Otitis Media , 2015, Journal of Korean medical science.

[10]  Tatsunori Sakamoto,et al.  In Vivo Imaging of Mouse Cochlea by Optical Coherence Tomography , 2014, Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology.

[11]  Jeehyun Kim,et al.  Development of Real-Time Dual-Display Handheld and Bench-Top Hybrid-Mode SD-OCTs , 2014, Sensors.

[12]  C. Schultz,et al.  Tissue clearing for optical anatomy. , 2013, Angewandte Chemie.

[13]  Cac T. Nguyen,et al.  Noninvasive in vivo optical detection of biofilm in the human middle ear , 2012, Proceedings of the National Academy of Sciences.

[14]  John S. Oghalai,et al.  Quantitative imaging of cochlear soft tissues in wild-type and hearing-impaired transgenic mice by spectral domain optical coherence tomography , 2011, Optics express.

[15]  V. Sciacca,et al.  Risk factors for otitis media with effusion: case-control study in Sicilian schoolchildren. , 2011, International journal of pediatric otorhinolaryngology.

[16]  Jeehyun Kim,et al.  Handheld Optical Coherence Tomography Scanner for Primary Care Diagnostics , 2011, IEEE Transactions on Biomedical Engineering.

[17]  Stephen A. Boppart,et al.  Non-invasive optical interferometry for the assessment of biofilm growth in the middle ear , 2010, Biomedical optics express.

[18]  Gabriele Lohmann,et al.  Image restoration and spatial resolution in 7‐tesla magnetic resonance imaging , 2010, Magnetic resonance in medicine.

[19]  Zhongping Chen,et al.  Imaging the Human Tympanic Membrane Using Optical Coherence Tomography In Vivo , 2008, Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology.

[20]  J. Patel,et al.  Incidence of Acute Otitis Media and Sinusitis Complicating Upper Respiratory Tract Infection: The Effect of Age , 2007, Pediatrics.

[21]  M. Neff.  AAP, AAFP, AAO-HNS release guideline on diagnosis and management of otitis media with effusion. , 2004, American family physician.

[22]  M. Neff.  AAP, AAFP release guideline on diagnosis and management of acute otitis media. , 2004, American family physician.

[23]  J. Fujimoto,et al.  High-resolution imaging of the middle ear with optical coherence tomography: a feasibility study. , 2001, Archives of otolaryngology--head & neck surgery.