Diffusion-controlled enzyme-catalyzed molecular communication system for targeted drug delivery

In this paper, the prodrug activation capability of enzymes is used to model and study a molecular communication (MC) system for targeted drug delivery (TDD). Specifically, we string together fundamental ideas from nano-robotics, particle diffusion and enzyme-catalyzed kinetics, to present an MC-based TDD model using a set of ordinary differential equations (ODE). We also derived closed-form analytical expressions for the input and output information of the system, and present their corresponding numerical results. Results show that the ratio of the receiver surface area to the enzyme concentration is important to the system's performance in terms of the deliverable potent drug concentration at the targeted site.

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