Boron Trifluoride‐Catalyzed Synthesis of 3‐Alkylidene‐3H‐indole N‐Oxides via Tandem Reaction of Propargylic Alcohols and Nitrosobenzenes

An atom-economical synthesis of 3-alkylidene-3H-indole N-oxides has been developed via a tandem reaction of propargylic alcohols and nitrosobenzenes in the presence of boron trifluoride etherate (BF3⋅Et2O) as catalyst. This method offers great potential for the synthesis of biologically important 3-alkylidene-3H-indole N-oxides and related derivatives.

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