Role of secondary low-energy electrons in the concomitant chemoradiation therapy of cancer.

Solid films of DNA with and without the chemotherapeutic agent cisplatin bonded to guanine were bombarded with electrons of 1, 10, 100, and 60,000 eV causing single and double strand breaks. In the presence of cisplatin this damage was increased by factors varying from 1.3 to 4.4 owing to an increase in bond dissociation triggered by the formation of transient anions. This mechanism may lie at the basis of the efficiency of concomitant cisplatin-radiation therapy.

[1]  A. Neugut,et al.  Is the prevalence of colorectal neoplasm higher in patients with coronary artery disease? , 2008, Nature Clinical Practice Oncology.

[2]  P. Ayotte,et al.  Charge stabilization by chloromethane molecules on multilayer Kr films , 1996 .

[3]  R. Richmond,et al.  Studies on radiosensitization of Escherichia coli cells by cis-platinum complexes. , 1979, International journal of radiation oncology, biology, physics.

[4]  Pierre Cloutier,et al.  Single, double, and multiple double strand breaks induced in DNA by 3-100 eV electrons. , 2003, Journal of the American Chemical Society.

[5]  L. Dewit,et al.  Combined treatment of radiation and cisdiamminedichloroplatinum (II): a review of experimental and clinical data. , 1987, International journal of radiation oncology, biology, physics.

[6]  Qing-Bin Lu,et al.  Electron transfer reaction mechanism of cisplatin with DNA at the molecular level. , 2007, Molecular pharmaceutics.

[7]  Piotr Skurski,et al.  Damage to Model DNA Fragments by 0.25−1.0 eV Electrons Attached to a Thymine π* Orbital , 2004 .

[8]  R. Bose.  Biomolecular targets for platinum antitumor drugs. , 2002, Mini reviews in medicinal chemistry.

[9]  Pierre Cloutier,et al.  DNA strand breaks induced by 0-4 eV electrons: the role of shape resonances. , 2004, Physical review letters.

[10]  D. Hunting,et al.  Resonant formation of DNA strand breaks by low-energy (3 to 20 eV) electrons. , 2000, Science.

[11]  J. Brown,et al.  The effect of treatment in fractionated schedules with the combination of X-irradiation and six cytotoxic drugs on the RIF-1 tumor and normal mouse skin. , 1985, International journal of radiation oncology, biology, physics.

[12]  T. Boulikas,et al.  Systemic Lipoplatin infusion results in preferential tumor uptake in human studies. , 2005, Anticancer research.

[13]  P. Eifel.  Concurrent chemotherapy and radiation therapy as the standard of care for cervical cancer , 2006, Nature Clinical Practice Oncology.

[14]  S. Pimblott,et al.  Production of low-energy electrons by ionizing radiation , 2007 .