Eruptive xanthomas as a marker for metabolic disorders: A specific form of xanthoma that reflects hypertriglyceridemia

Eruptive xanthomas are skin manifestations associated with hypertriglyceridemia. Accordingly, the improvement of hypertriglyceridemia can ameliorate this condition. We report a case of a patient with type 2 diabetes mellitus who was diagnosed with this skin lesion. Clinicians should be aware that eruptive xanthomas could indicate metabolic disorders associated with atherosclerosis.

[1]  Ming-Jiuan Wu,et al.  Angiopoietin-Like Protein 3 (ANGPTL3) Modulates Lipoprotein Metabolism and Dyslipidemia , 2021, International journal of molecular sciences.

[2]  P. K. Sharma Atherosclerosis. , 2020, The Journal of the Association of Physicians of India.

[3]  U. Laufs,et al.  The Diagnosis and Treatment of Hypertriglyceridemia. , 2019, Deutsches Arzteblatt international.

[4]  R. Giugliano,et al.  Association Between Triglyceride Lowering and Reduction of Cardiovascular Risk Across Multiple Lipid-Lowering Therapeutic Classes: A Systematic Review and Meta-Regression Analysis of Randomized Controlled Trials. , 2019, Circulation.

[5]  H. Katagiri,et al.  Eruptive xanthomas in a patient with soft-drink diabetic ketosis and apolipoprotein E4/2. , 2019, Endocrine journal.

[6]  Deepak L. Bhatt,et al.  Cardiovascular Risk Reduction with Icosapent Ethyl for Hypertriglyceridemia , 2019, The New England journal of medicine.

[7]  S. Yamashita,et al.  Guidelines for Diagnosis and Treatment of Familial Hypercholesterolemia 2017 , 2018, Journal of atherosclerosis and thrombosis.

[8]  Gillian Roga,et al.  Eruptive xanthoma: Warning sign of systemic disease , 2016, Cleveland Clinic Journal of Medicine.

[9]  M. Kashif,et al.  A case report and literature review , 2016 .

[10]  P. Toth Triglyceride-rich lipoproteins as a causal factor for cardiovascular disease , 2016, Vascular health and risk management.

[11]  S. Acikgoz,et al.  First and only symptom of undiagnosed diabetes mellitus: eruptive xanthoma , 2015, BMJ Case Reports.

[12]  S. Nayak,et al.  Familial hypercholesterolemia presenting with multiple nodules of the hands and elbow , 2015, Clinical case reports.

[13]  S. Massoud,et al.  Eruptive xanthoma , 2015, Cleveland Clinic Journal of Medicine.

[14]  V. Dixit,et al.  Adipose tissue as an immunological organ , 2015, Obesity.

[15]  A. Žák,et al.  Xanthomas: clinical and pathophysiological relations. , 2014, Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia.

[16]  W. Placek,et al.  Eruptive xanthomas , 2013, Postepy dermatologii i alergologii.

[17]  L. Rui,et al.  Leptin signaling and leptin resistance , 2013, Frontiers of Medicine.

[18]  T. Kadowaki,et al.  Adiponectin receptor as a key player in healthy longevity and obesity-related diseases. , 2013, Cell metabolism.

[19]  S. Yamashita,et al.  Correlation of fasting serum apolipoprotein B‐48 with coronary artery disease prevalence , 2012, European journal of clinical investigation.

[20]  T. Njo,et al.  Exploring the value of apoB48 as a marker for atherosclerosis in clinical practice , 2012, European journal of clinical investigation.

[21]  J. Graaf,et al.  Serum triglycerides and risk of cardiovascular disease. , 2012, Biochimica et biophysica acta.

[22]  G. Shulman,et al.  Mechanisms for Insulin Resistance: Common Threads and Missing Links , 2012, Cell.

[23]  G. Francis,et al.  Incidence of pancreatitis, secondary causes, and treatment of patients referred to a specialty lipid clinic with severe hypertriglyceridemia: a retrospective cohort study , 2011, Lipids in Health and Disease.

[24]  L. Wells,et al.  Hexosamine flux, the O-GlcNAc modification, and the development of insulin resistance in adipocytes , 2010, Molecular and Cellular Endocrinology.

[25]  G. Hotamisligil,et al.  Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease , 2010, Cell.

[26]  J. Schaefer Unraveling hyperlipidemia type III (dysbetalipoproteinemia), slowly , 2009, European Journal of Human Genetics.

[27]  Eric Boerwinkle,et al.  Rare loss-of-function mutations in ANGPTL family members contribute to plasma triglyceride levels in humans. , 2008, The Journal of clinical investigation.

[28]  H. Katagiri,et al.  ANGPTL3 is increased in both insulin-deficient and -resistant diabetic states. , 2004, Biochemical and biophysical research communications.

[29]  M. Matsuda,et al.  Angiopoietin-like protein 3, a hepatic secretory factor, activates lipolysis in adipocytes. , 2003, Biochemical and biophysical research communications.

[30]  H. Iso,et al.  Serum triglycerides and risk of coronary heart disease among Japanese men and women. , 2001, American journal of epidemiology.

[31]  R. Havel Postprandial hyperlipidemia and remnant lipoproteins. , 1994, Current opinion in lipidology.

[32]  S. Yamashita,et al.  Management of type IIb dyslipidemia. , 2012, Journal of atherosclerosis and thrombosis.