Development of a High-Throughput ex-Vivo Burn Wound Model Using Porcine Skin, and Its Application to Evaluate New Approaches to Control Wound Infection

Citation for published version (Harvard): Alves, DR, Booth, SP, Scavone, P, Schellenberger, P, Salvage, J, Dedi, C, Thet, NT, Jenkins, ATA, Waters, R, Ng, KW, Overall, ADJ, Metcalfe, AD, Nzakizwanayo, J & Jones, BV 2018, 'Development of a high-throughput exvivo burn wound model using porcine skin, and its application to evaluate new approaches to control wound infection', Frontiers in cellular and infection microbiology, vol. 8, 196. https://doi.org/10.3389/fcimb.2018.00196

[1]  S. Booth,et al.  Prototype Development of the Intelligent Hydrogel Wound Dressing and Its Efficacy in the Detection of Model Pathogenic Wound Biofilms. , 2016, ACS applied materials & interfaces.

[2]  A. Metcalfe,et al.  Bacteriophage Can Prevent Encrustation and Blockage of Urinary Catheters by Proteus mirabilis , 2015, Antimicrobial Agents and Chemotherapy.

[3]  L. Hansen,et al.  A novel bacteriophage cocktail reduces and disperses P seudomonas aeruginosa biofilms under static and flow conditions , 2015, Microbial biotechnology.

[4]  Amitava Das,et al.  Chronic Wound Biofilm Model. , 2015, Advances in wound care.

[5]  Benjamin A Lipsky,et al.  Biofilms and Wounds: An Overview of the Evidence. , 2015, Advances in wound care.

[6]  N. Gibran,et al.  Porcine models of cutaneous wound healing. , 2015, ILAR journal.

[7]  R. Donlan,et al.  Bacteriophage-Mediated Control of a Two-Species Biofilm Formed by Microorganisms Causing Catheter-Associated Urinary Tract Infections in an In Vitro Urinary Catheter Model , 2014, Antimicrobial Agents and Chemotherapy.

[8]  L. Hansen,et al.  Combined Use of Bacteriophage K and a Novel Bacteriophage To Reduce Staphylococcus aureus Biofilm Formation , 2014, Applied and Environmental Microbiology.

[9]  H. Elgharably,et al.  Mixed‐species biofilm compromises wound healing by disrupting epidermal barrier function , 2014, The Journal of pathology.

[10]  S. Morales,et al.  Bacteriophages and Biofilms , 2014, Antibiotics.

[11]  R. Massey,et al.  Staphylococcus aureus Interaction with Phospholipid Vesicles – A New Method to Accurately Determine Accessory Gene Regulator (agr) Activity , 2014, PloS one.

[12]  P. Stewart,et al.  Biofilms and Inflammation in Chronic Wounds. , 2013, Advances in wound care.

[13]  D. Lebeaux,et al.  From in vitro to in vivo Models of Bacterial Biofilm-Related Infections , 2013, Pathogens.

[14]  S. Fracalanzza,et al.  Impact of agr dysfunction on virulence profiles and infections associated with a novel methicillin-resistant Staphylococcus aureus (MRSA) variant of the lineage ST1-SCCmec IV , 2013, BMC Microbiology.

[15]  A. Fallarero,et al.  Combining biofilm matrix measurements with biomass and viability assays in susceptibility assessments of antimicrobials against Staphylococcus aureus biofilms , 2012, The Journal of Antibiotics.

[16]  S. Dowd,et al.  An In Vivo Polymicrobial Biofilm Wound Infection Model to Study Interspecies Interactions , 2011, PloS one.

[17]  M. Guggenheim,et al.  Validation of the Zürich burn-biofilm model. , 2011, Burns : journal of the International Society for Burn Injuries.

[18]  Michael R Hamblin,et al.  Animal models of external traumatic wound infections , 2011, Virulence.

[19]  S. Gorman,et al.  The use of lytic bacteriophages in the prevention and eradication of biofilms of Proteus mirabilis and Escherichia coli. , 2010, FEMS immunology and medical microbiology.

[20]  Weiling Fu,et al.  Bacteriophage Cocktail for the Prevention of Biofilm Formation by Pseudomonas aeruginosa on Catheters in an In Vitro Model System , 2009, Antimicrobial Agents and Chemotherapy.

[21]  S. Chhibber,et al.  Bacteriophage Treatment of Burn Wound Infection Caused by Pseudomonas aeruginosa PAO in BALB/c Mice , 2009 .

[22]  S. Chhibber,et al.  Efficacy of bacteriophage treatment in murine burn wound infection induced by klebsiella pneumoniae. , 2009, Journal of microbiology and biotechnology.

[23]  M. Rybak,et al.  Accessory gene regulator dysfunction: an advantage for Staphylococcus aureus in health-care settings? , 2009, The Journal of infectious diseases.

[24]  R. Donlan.  Preventing biofilms of clinically relevant organisms using bacteriophage. , 2009, Trends in microbiology.

[25]  Yan Sun,et al.  In vitro multispecies Lubbock chronic wound biofilm model , 2008, Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.

[26]  James J. Collins,et al.  Dispersing biofilms with engineered enzymatic bacteriophage , 2007, Proceedings of the National Academy of Sciences.

[27]  J. Fralick,et al.  Phage Therapy of Pseudomonas aeruginosa Infection in a Mouse Burn Wound Model , 2007, Antimicrobial Agents and Chemotherapy.

[28]  Marc Lecuit.  Faculty Opinions recommendation of Staphylococcus aureus Panton-Valentine leukocidin causes necrotizing pneumonia. , 2007 .

[29]  J. Soothill,et al.  Multiplication of therapeutically administered bacteriophages in Pseudomonas aeruginosa infected patients. , 2006, Burns : journal of the International Society for Burn Injuries.

[30]  R. Donlan,et al.  Using Bacteriophages To Reduce Formation of Catheter-Associated Biofilms by Staphylococcus epidermidis , 2006, Antimicrobial Agents and Chemotherapy.

[31]  D. Church,et al.  Burn Wound Infections , 2006, Clinical Microbiology Reviews.

[32]  L. Herwaldt,et al.  Prospective Analysis of Nosocomial Infection Rates, Antibiotic Use, and Patterns of Resistance in a Burn Population , 2006, Journal of burn care & research : official publication of the American Burn Association.

[33]  N. Yakandawala,et al.  A microplate spectrofluorometric assay for bacterial biofilms , 2006, Journal of Industrial Microbiology & Biotechnology.

[34]  K. Tait,et al.  The interaction of phage and biofilms. , 2004, FEMS microbiology letters.

[35]  S. McAllister,et al.  Pulsed-Field Gel Electrophoresis Typing of Oxacillin-Resistant Staphylococcus aureus Isolates from the United States: Establishing a National Database , 2003, Journal of Clinical Microbiology.

[36]  R. Weinstein,et al.  The epidemiology of burn wound infections: then and now. , 2003, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[37]  R. Novick.  Autoinduction and signal transduction in the regulation of staphylococcal virulence , 2003, Molecular microbiology.

[38]  J. Costerton,et al.  Biofilms: Survival Mechanisms of Clinically Relevant Microorganisms , 2002, Clinical Microbiology Reviews.

[39]  M. Pfaffl,et al.  A new mathematical model for relative quantification in real-time RT-PCR. , 2001, Nucleic acids research.

[40]  D. G. Armstrong,et al.  Wound Microbiology and Associated Approaches to Wound Management , 2001, Clinical Microbiology Reviews.

[41]  M. Yarmush,et al.  A Model of Infected Burn Wounds UsingEscherichia coli O18:K1:H7 for the Study of Gram-Negative Bacteremia and Sepsis , 2000, Infection and Immunity.

[42]  I. Sutherland,et al.  Bacteriophage and associated polysaccharide depolymerases – novel tools for study of bacterial biofilms , 1998, Journal of applied microbiology.

[43]  J. Kornblum,et al.  Cloning, characterization, and sequencing of an accessory gene regulator (agr) in Staphylococcus aureus , 1988, Journal of bacteriology.

[44]  M. Vaneechoutte,et al.  Experimental phage therapy of burn wound infection: difficult first steps. , 2014, International journal of burns and trauma.

[45]  M. O'Reilly,et al.  Regulation of exoprotein gene expression in Staphylococcus aureus by agr , 2004, Molecular and General Genetics MGG.

[46]  B. Spratt,et al.  Multilocus sequence typing for characterization of methicillin-resistant and methicillin-susceptible clones of Staphylococcus aureus. , 2000, Journal of clinical microbiology.