Manual ischemic stroke lesion segmentation in MR image data is a time-consuming task subject to inter-rater variability. Reliable automated lesion segmentation is of high interest for clinical trials and research in ischemic stroke. However, recent segmentation challenges (e.g. ISLES 2015) illustrate that current state-of-the-art approaches still lack accuracy and ischemic stroke segmentation remains a complicated problem. Within this context, low rank-&-sparse matrix decomposition (also known as robust PCA, RPCA) and RPCA-based non-linear subject-toatlas registration could provide valuable segmentation prior information. The aim of this study is to evaluate the suitability of RPCA and RPCAbased registration for ischemic stroke segmentation in follow-up FLAIR MR data sets. Building on a top-ranked segmentation approach of ISLES 2015, the performance of RPCA sparse component image information as random forest (RF) feature is evaluated. A comprehensive feature-byfeature comparison of the segmentation performance with and without RPCA sparse component information as RF feature illustrate the potential of low rank-&-sparse decomposition to improve stroke segmentation.