Adherence to treatment in adolescents.

Health care professionals must be alert to the high prevalence of low adherence to treatment during adolescence. Low adherence increases morbidity and medical complications, contributes to poorer quality of life and an overuse of the health care system. Many different factors have an impact on adherence. However, critical factors to consider in teens are their developmental stage and challenges, emotional issues and family dysfunction. Direct and indirect methods have been described to assess adherence. Eliciting an adherence history is the most useful way for clinicians to evaluate adherence, and could be the beginning of a constructive dialogue with the adolescent. Interventions to improve adherence are multiple - managing mental health issues appropriately, building a strong relationship, customizing the treatment regimen if possible, empowering the adolescent to deal with adherence issues, providing information, ensuring family and peer support, and motivational enhancement therapy. Evaluation of adherence at regular intervals should be an important aspect of health care for adolescents.

[1]  John Weinman,et al.  Self-regulation and Self-management in Asthma: Exploring The Role of Illness Perceptions and Treatment Beliefs in Explaining Non-adherence to Preventer Medication , 2002 .

[2]  S. Dunn,et al.  Non‐compliance in children post‐liver transplant. Who are the culprits? , 2004, Pediatric transplantation.

[3]  R. Yehuda,et al.  Medication adherence in pediatric and adolescent liver transplant recipients. , 2004, Pediatrics.

[4]  N. White,et al.  Behavior therapy for families of adolescents with diabetes: Effects on directly observed family interactions , 1999 .

[5]  M. Rapoff,et al.  Adherence to Pediatric Medical Regimens , 1999, Issues in Clinical Child Psychology.

[6]  A. La Greca,et al.  Parenting styles, regimen adherence, and glycemic control in 4- to 10-year-old children with diabetes. , 2001, Journal of pediatric psychology.

[7]  M. Sarwal,et al.  A typology of non‐adherence in pediatric renal transplant recipients , 2003, Pediatric transplantation.

[8]  J. Salomon,et al.  Patient-Reported Compliance with Cystic Fibrosis Therapy , 1981, Clinical pediatrics.

[9]  Melanie L. McGrath,et al.  Typologies of Nonadherence in Cystic Fibrosis , 1990, Journal of developmental and behavioral pediatrics : JDBP.

[10]  H. Kraemer,et al.  Compliance with anticonvulsant therapy by epileptic youth. Relationships to psychosocial aspects of adolescent development. , 1986, Journal of adolescent health care : official publication of the Society for Adolescent Medicine.

[11]  M. Zevon,et al.  Compliance of pediatric and adolescent cancer patients , 1986, Cancer.

[12]  L. D'Angelo,et al.  A family group approach to increasing adherence to therapy in HIV-infected youths: results of a pilot project. , 2003, AIDS patient care and STDs.

[13]  M A Fischl,et al.  Antiretroviral Therapy in Adults Updated Recommendations of the International AIDS Society–USA Panel , 2000 .

[14]  K. Ruccione,et al.  Research triangulation to derive meaning‐based quality‐of‐life theory: Adolescent Resilience Model and instrument development , 1999, International journal of cancer. Supplement = Journal international du cancer. Supplement.

[15]  I. Litt,et al.  Compliance with therapeutic regimens. , 1984, Journal of adolescent health care : official publication of the Society for Adolescent Medicine.

[16]  A. Moscicki,et al.  Barriers to HAART adherence among human immunodeficiency virus-infected adolescents. , 2003, Archives of pediatrics & adolescent medicine.

[17]  D. Drotar,et al.  Association of observed family relationship quality and problem-solving skills with treatment adherence in older children and adolescents with cystic fibrosis. , 2004, Journal of pediatric psychology.

[18]  D. Murphy,et al.  Antiretroviral medication adherence among the REACH HIV-infected adolescent cohort in the USA , 2001, AIDS care.

[19]  L. Peterson,et al.  Family variables and disease management in juvenile rheumatoid arthritis. , 1989, Journal of pediatric psychology.

[20]  L. Aiken,et al.  The health belief model and adolescents with insulin-dependent diabetes mellitus. , 1992, Health psychology : official journal of the Division of Health Psychology, American Psychological Association.

[21]  G. Fritz,et al.  Medication adherence in pediatric asthma: reasoning, responsibility, and behavior. , 2003, Journal of pediatric psychology.

[22]  J. Abbott,et al.  Ways of coping with cystic fibrosis: implications for treatment adherence. , 2001, Disability and rehabilitation.

[23]  R. Brian Haynes,et al.  Compliance in Health Care , 1979 .

[24]  M. Rapoff Assessing and enhancing adherence to medical regimens for juvenile rheumatoid arthritis. , 2002, Pediatric annals.

[25]  L. Osterberg,et al.  Adherence to medication. , 2005, The New England journal of medicine.

[26]  A. Asadi-Pooya Drug compliance of children and adolescents with epilepsy , 2005, Seizure.

[27]  J. Hamilton,et al.  Deteriorating Diabetes Control during Adolescence: Physiological or Psychosocial? , 2002, Journal of pediatric endocrinology & metabolism : JPEM.

[28]  C. Rey,et al.  Compliance thérapeutique chez l'adolescent malade chronique , 1995 .

[29]  A. La Greca,et al.  Peer Relations of Youth with Pediatric Conditions and Health Risks: Promoting Social Support and Healthy Lifestyles , 2002, Journal of developmental and behavioral pediatrics : JDBP.

[30]  S. Hanauer,et al.  Medication nonadherence and the outcomes of patients with quiescent ulcerative colitis. , 2003, The American journal of medicine.

[31]  B. Bender,et al.  Relations among asthma knowledge, treatment adherence, and outcome. , 2003, The Journal of allergy and clinical immunology.

[32]  I. B. Pless,et al.  [Compliance in adolescents with chronic disease]. , 1991, Archives francaises de pediatrie.

[33]  H. Kyngäs,et al.  Compliance of young diabetics with health regimens. , 1992, Journal of advanced nursing.

[34]  M. J. Kupst The Adolescent Resilience Model and Interventions to Promote Resilience—Critique , 2004 .

[35]  Noncompliance in children with renal transplants. , 1978, Pediatrics.

[36]  E. Soliday,et al.  Health beliefs and pediatric emergency department after-care adherence , 2000, Annals of behavioral medicine : a publication of the Society of Behavioral Medicine.

[37]  C. Rand,et al.  Measurement of children's asthma medication adherence by self report, mother report, canister weight, and Doser CT. , 2000, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.

[38]  J. Kamps,et al.  Empirically supported treatments in pediatric psychology: regimen adherence. , 2001, Journal of pediatric psychology.

[39]  S. Beratis Noncompliance with iron chelation therapy in patients with β thalassaemia , 1989 .

[40]  D. Sindhusake,et al.  Effect of peer led programme for asthma education in adolescents: cluster randomised controlled trial , 2001, BMJ : British Medical Journal.

[41]  R S Woodward,et al.  The effect of prescribed daily dose frequency on patient medication compliance. , 1990, Archives of internal medicine.

[42]  L. Laffel,et al.  The Impact of Physiological, Therapeutic and Psychosocial Variables on Glycemic Control in Youth with Type 1 Diabetes Mellitus , 2004, Journal of pediatric endocrinology & metabolism : JPEM.

[43]  E. Abrams,et al.  The reliability of reports of medical adherence from children with HIV and their adult caregivers. , 2003, Journal of pediatric psychology.

[44]  J. Lavigne,et al.  Psychosocial Aspects of Compliance in Children and Adolescents with Asthma , 1989, Journal of developmental and behavioral pediatrics : JDBP.

[45]  W. Gaebel Towards the improvement of compliance: the significance of psycho‐education and new antipsychotic drugs , 1997, International clinical psychopharmacology.

[46]  D. Murphy,et al.  The TREAT (Therapeutic Regimens Enhancing Adherence in Teens) program: theory and preliminary results. , 2001, The Journal of adolescent health : official publication of the Society for Adolescent Medicine.

[47]  S. Johnson,et al.  A longitudinal analysis of adherence and health status in childhood diabetes. , 1992, Journal of pediatric psychology.

[48]  T. Nevins Non‐compliance and its management in teenagers , 2002, Pediatric transplantation.

[49]  Y. Frishberg,et al.  Is Noncompliance Among Adolescent Renal Transplant Recipients Inevitable? , 2005, Pediatrics.

[50]  M. Robin DiMatteo,et al.  Patient Adherence and Medical Treatment Outcomes: A Meta-Analysis , 2002, Medical care.

[51]  Philip L. Smith,et al.  The impact of cognitive distortions, stress, and adherence on metabolic control in youths with type 1 diabetes. , 2004, The Journal of adolescent health : official publication of the Society for Adolescent Medicine.

[52]  B. Lask,et al.  Motivating children and adolescents to improve adherence. , 2003, The Journal of pediatrics.

[53]  B Wise,et al.  Antiretroviral therapy in adults. , 1996, Journal of the American Academy of Nurse Practitioners.

[54]  J. Weinman,et al.  Patients' beliefs about prescribed medicines and their role in adherence to treatment in chronic physical illness. , 1999, Journal of psychosomatic research.

[55]  V. Helgeson,et al.  The role of friendship in the lives of male and female adolescents: does diabetes make a difference? , 2007, The Journal of adolescent health : official publication of the Society for Adolescent Medicine.

[56]  G. Walco,et al.  Therapeutic adherence to oral medication regimens by adolescents with cancer. II. Clinical and psychologic correlates. , 1992, The Journal of pediatrics.

[57]  M. Dimatteo,et al.  The role of effective communication with children and their families in fostering adherence to pediatric regimens. , 2004, Patient education and counseling.