Plasma-cell dyscrasia and peripheral neuropathy with a monoclonal antibody to peripheral-nerve myelin.

PERIPHERAL neuropathy has been associated with plasma-cell dyscrasia, 1 but it is not known whether the monoclonal immunoglobulins react with peripheral-nerve antigens. We report on a patient with a peripheral neuropathy associated with an IgMk monoclonal protein, in whom pathological and immunological studies indicated that the IgMk antibody was directed against peripheral-nerve myelin, as shown by complement fixation and immunoabsorption. Case Report The patient was a 45-year-old man admitted for evaluation of a slowly progressive sensory-motor neuropathy of 11 years' duration. On examination there was moderate to severe weakness and atrophy of the muscles of the hands and distal parts of . . .

[1]  K. Dellagi,et al.  Cross-idiotypic antigens among monoclonal immunoglobulin M from patients with Waldenström's macroglobulinemia and polyneuropathy. , 1979, The Journal of clinical investigation.

[2]  G. Boysen,et al.  Familial amyloidosis with cranial neuropathy and corneal lattice dystrophy. , 1979, Journal of neurology, neurosurgery, and psychiatry.

[3]  D. Silberberg,et al.  Experimental allergic neuritis induced by sensitization with galactocerebroside. , 1979, Science.

[4]  J. Fitting,et al.  Neuropathy, amyloidosis, and monoclonal gammopathy. , 1979, Journal of neurology, neurosurgery, and psychiatry.

[5]  M. Swash,et al.  Significance of immunoglobulin deposition in peripheral nerve in neuropathies associated with paraproteinaemia. , 1979, Journal of neurology, neurosurgery, and psychiatry.

[6]  D. Darriet,et al.  Polyneuropathy in Waldenström's macroglobulinemia. Deposition of M component on myelin sheaths. , 1978, Archives of neurology.

[7]  W. Schlaepfer,et al.  PROTEIN COMPOSITION OF AXONS and MYELIN FROM RAT and HUMAN PERIPHERAL NERVES , 1978, Journal of neurochemistry.

[8]  C. Warlow,et al.  Peripheral neuropathy and solitary plasmacytoma. , 1978, Journal of neurology, neurosurgery, and psychiatry.

[9]  F. Jennekens,et al.  Plasma proteins in human peripheral nerve , 1977, Journal of the Neurological Sciences.

[10]  F Buchthal,et al.  Peroneal muscular atrophy (PMA) and related disorders. II. Histological findings in sural nerves. , 1977, Brain : a journal of neurology.

[11]  G. Chazot,et al.  [Neurological manifestations in monoclonal gammapathies. Pure neurological manifestations. Immunofluorescence study]. , 1976, Revue neurologique.

[12]  F. Buchthal,et al.  Unmyelinated fibres and Schwann cells of sural nerve in neuropathy. , 1976, Brain : a journal of neurology.

[13]  H. Wiśniewski,et al.  Recurrent experimental allergic polyganglioradiculoneuritis. Multiple demyelinating episodes in rhesus monkey sensitized with rabbit sciatic nerve myelin. , 1974, Archives of neurology.

[14]  R. Dawson,et al.  SOME PROPERTIES OF A MAJOR STRUCTURAL GLYCOPROTEIN OF SCIATIC NERVE , 1974, Journal of neurochemistry.

[15]  K. Lowitzsch,et al.  Polyneuropathy in Waldenström's macroglobulinaemia. , 1974, Journal of the neurological sciences.

[16]  P. Burnett,et al.  Isolation and characterization of a protein from sciatic nerve myelin responsible for experimental allergic neuritis. , 1972, Nature: New biology.

[17]  L. Levine,et al.  Quantitative micro-complement fixation and its use in the study of antigenic structure by specific antigen-antibody inhibition. , 1961, Journal of immunology.