The CD28 signaling pathway regulates glucose metabolism.

[1]  P. Linsley,et al.  Modulation of TCR-induced transcriptional profiles by ligation of CD28, ICOS, and CTLA-4 receptors , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[2]  J. Lord,et al.  Cytokine‐mediated inhibition of apoptosis in non‐transformed T cells and neutrophils can be dissociated from protein kinase B activation , 2002, European journal of immunology.

[3]  E. Kelly,et al.  IL-2 and Related Cytokines Can Promote T Cell Survival by Activating AKT1 , 2002, The Journal of Immunology.

[4]  S. Krauss,et al.  Signaling takes a breath--new quantitative perspectives on bioenergetics and signal transduction. , 2001, Immunity.

[5]  David R. Plas,et al.  Growth Factors Can Influence Cell Growth and Survival through Effects on Glucose Metabolism , 2001, Molecular and Cellular Biology.

[6]  A. Shaw,et al.  Cutting Edge: Distinct Motifs Within CD28 Regulate T Cell Proliferation and Induction of Bcl-XL1 , 2001, The Journal of Immunology.

[7]  C. Thompson,et al.  Akt and Bcl-xL Promote Growth Factor-independent Survival through Distinct Effects on Mitochondrial Physiology* , 2001, The Journal of Biological Chemistry.

[8]  K. Okkenhaug,et al.  A point mutation in CD28 distinguishes proliferative signals from survival signals , 2001, Nature Immunology.

[9]  M. Kubo,et al.  Novel Role of Phosphatidylinositol 3-Kinase in CD28-mediated Costimulation* , 2001, The Journal of Biological Chemistry.

[10]  C. June,et al.  Critical Requirement for the Membrane-Proximal Cytosolic Tyrosine Residue for CD28-Mediated Costimulation In Vivo1 , 2001, The Journal of Immunology.

[11]  R. Parsons,et al.  PTEN: life as a tumor suppressor. , 2001, Experimental cell research.

[12]  A. Weiss,et al.  Akt provides the CD28 costimulatory signal for up-regulation of IL-2 and IFN-γ but not TH2 cytokines , 2001, Nature Immunology.

[13]  A. Laurence,et al.  The T cell antigen receptor activates phosphatidylinositol 3‐kinase‐regulated serine kinases protein kinase B and ribosomal S6 kinase 1 , 2000, FEBS letters.

[14]  M. V. Vander Heiden,et al.  In the absence of extrinsic signals, nutrient utilization by lymphocytes is insufficient to maintain either cell size or viability. , 2000, Molecular cell.

[15]  M. V. Heiden,et al.  The CD28 and CTLA-4 receptors associate with the serine/threonine phosphatase PP2A. , 2000, Immunity.

[16]  P. Schwartzberg,et al.  Deficiency of PTEN in Jurkat T Cells Causes Constitutive Localization of Itk to the Plasma Membrane and Hyperresponsiveness to CD3 Stimulation , 2000, Molecular and Cellular Biology.

[17]  Michael J. Parsons,et al.  Protein Kinase B Regulates T Lymphocyte Survival, Nuclear Factor κb Activation, and Bcl-XL Levels in Vivo , 2000, The Journal of experimental medicine.

[18]  N. Sonenberg,et al.  Opposite Translational Control of GLUT1 and GLUT4 Glucose Transporter mRNAs in Response to Insulin , 1999, The Journal of Biological Chemistry.

[19]  M. Birnbaum,et al.  Signaling Pathways Mediating Insulin‐Stimulated Glucose Transport , 1999, Annals of the New York Academy of Sciences.

[20]  Richard A. Roth,et al.  Regulation of GLUT1 Gene Transcription by the Serine/Threonine Kinase Akt1* , 1999, The Journal of Biological Chemistry.

[21]  J. Woodgett,et al.  Protein Kinase B/Akt Participates in GLUT4 Translocation by Insulin in L6 Myoblasts , 1999, Molecular and Cellular Biology.

[22]  J. Allison,et al.  CTLA-4-Mediated inhibition of early events of T cell proliferation. , 1999, Journal of immunology.

[23]  B. Hemmings,et al.  Regulation of protein kinase cascades by protein phosphatase 2A. , 1999, Trends in biochemical sciences.

[24]  J. Bluestone,et al.  Regulation of cytotoxic T lymphocyte-associated molecule-4 by Src kinases. , 1999, Journal of immunology.

[25]  J. Bluestone,et al.  Molecular basis of T cell inactivation by CTLA-4. , 1998, Science.

[26]  Y. Yazaki,et al.  Potential Role of Protein Kinase B in Insulin-induced Glucose Transport, Glycogen Synthesis, and Protein Synthesis* , 1998, The Journal of Biological Chemistry.

[27]  P. Blair,et al.  Cutting Edge: CTLA-4 Ligation Delivers a Unique Signal to Resting Human CD4 T Cells That Inhibits Interleukin-2 Secretion but Allows Bcl-XL Induction , 1998, The Journal of Immunology.

[28]  M. Quon,et al.  Physiological role of Akt in insulin-stimulated translocation of GLUT4 in transfected rat adipose cells. , 1997, Molecular endocrinology.

[29]  M. V. Heiden,et al.  Bcl-xL Regulates the Membrane Potential and Volume Homeostasis of Mitochondria , 1997, Cell.

[30]  B. Hemmings,et al.  Ligation of the T cell co‐stimulatory receptor CD28 activates the serine‐threonine protein kinase protein kinase B , 1997, European journal of immunology.

[31]  N. Hay,et al.  The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal. , 1997, Genes & development.

[32]  M. Birnbaum,et al.  Expression of a Constitutively Active Akt Ser/Thr Kinase in 3T3-L1 Adipocytes Stimulates Glucose Uptake and Glucose Transporter 4 Translocation* , 1996, The Journal of Biological Chemistry.

[33]  J. Bluestone,et al.  CTLA-4 ligation blocks CD28-dependent T cell activation [published erratum appears in J Exp Med 1996 Jul 1;184(1):301] , 1996, The Journal of experimental medicine.

[34]  T. Mak,et al.  Regulation of T Cell Receptor Signaling by Tyrosine Phosphatase SYP Association with CTLA-4 , 1996, Science.

[35]  D. Fearon,et al.  CD28-mediated costimulation in the absence of phosphatidylinositol 3-kinase association and activation , 1995, Molecular and cellular biology.

[36]  G. Mills,et al.  CD28 delivers costimulatory signals independently of its association with phosphatidylinositol 3-kinase. , 1995, Journal of immunology.

[37]  H. Schneider,et al.  Selective CD28pYMNM mutations implicate phosphatidylinositol 3-kinase in CD86-CD28-mediated costimulation. , 1995, Immunity.

[38]  J. Allison,et al.  CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation , 1995, The Journal of experimental medicine.

[39]  D. Olive,et al.  Binding of phosphatidyl-inositol-3-OH kinase to CD28 is required for T-cell signalling , 1994, Nature.

[40]  A. August,et al.  CD28 of T lymphocytes associates with phosphatidylinositol 3-kinase. , 1994, International immunology.

[41]  L. Cantley,et al.  T-cell antigen CD28 interacts with the lipid kinase phosphatidylinositol 3-kinase by a cytoplasmic Tyr(P)-Met-Xaa-Met motif. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[42]  J. Imboden,et al.  Stimulation of CD28 triggers an association between CD28 and phosphatidylinositol 3-kinase in Jurkat T cells , 1994, The Journal of experimental medicine.

[43]  P. Pilch,et al.  The insulin receptor: structure, function, and signaling. , 1994, The American journal of physiology.

[44]  I. Mérida,et al.  Protein and lipid kinase activation cascades in interleukin-2 receptor signalling. , 1993, Seminars in immunology.

[45]  G. Freeman,et al.  Characterization of CTLA-4 structure and expression on human T cells. , 1993, Journal of immunology.

[46]  C. Thompson,et al.  T-cell proliferation involving the CD28 pathway is associated with cyclosporine-resistant interleukin 2 gene expression , 1987, Molecular and cellular biology.

[47]  S A Kaplan,et al.  The insulin receptor. , 1984, The Journal of pediatrics.

[48]  T. Dexter,et al.  Haemopoietic cell growth factor mediates cell survival via its action on glucose transport. , 1984, The EMBO journal.

[49]  M. Weidemann,et al.  Phytohaemagglutinin stimulation of rat thymus lymphocytes glycolysis. , 1976, Biochimica et biophysica acta.

[50]  S. Balcerzak,et al.  Alterations in hexose monophosphate shunt during lymphoblastic transformation. , 1974, Cellular immunology.

[51]  D. Roos,et al.  Changes in the carbohydrate metabolism of mitogenically stimulated human peripheral lymphocytes. I. Stimulation by phytohaemagglutinin. , 1970, Biochimica et biophysica acta.

[52]  C. J. Hedeskov.  Early effects of phytohaemagglutinin on glucose metabolism of normal human lymphocytes. , 1968, The Biochemical journal.

[53]  A. J. Hale,et al.  Observations on the Proliferation of Human Leucocytes Cultured with Phytohaemagglutinin , 1963, British journal of haematology.