Radiofrequency and Extremely Low-Frequency Electromagnetic Field Effects on the Blood-Brain Barrier

During the last century, mankind has introduced electricity and during the very last decades, the microwaves of the modern communication society have spread a totally new entity—the radiofrequency fields—around the world. How does this affect biology on Earth? The mammalian brain is protected by the blood-brain barrier, which prevents harmful substances from reaching the brain tissue. There is evidence that exposure to electromagnetic fields at non thermal levels disrupts this barrier. In this review, the scientific findings in this field are presented. The result is a complex picture, where some studies show effects on the blood-brain barrier, whereas others do not. Possible mechanisms for the interactions between electromagnetic fields and the living organisms are discussed. Demonstrated effects on the blood-brain barrier, as well as a series of other effects upon biology, have caused societal anxiety. Continued research is needed to come to an understanding of how these possible effects can be neutralized, or at least reduced. Furthermore, it should be kept in mind that proven effects on biology also should have positive potentials, e.g., for medical use.

[1]  Simulation of the effect of inhomogeneities in TEM transmission cells using the FDTD-method , 1992 .

[2]  K. Fritze,et al.  Effect of global system for mobile communication (GSM) microwave exposure on blood-brain barrier permeability in rat , 1997, Acta Neuropathologica.

[3]  Kanako Wake,et al.  Biological effect on blood cerebrospinal fluid barrier due to radio frequency electromagnetic fields exposure of the rat brain in vivo , 2007 .

[4]  L. Salford,et al.  Electromagnetic field calculations used for exposure experiments on small animals in TEM cells , 1993 .

[5]  J. Elder,et al.  Measurement of blood-brain barrier permeation in rats during exposure to 2450-MHz microwaves. , 1982, Bioelectromagnetics.

[6]  C. Nordborg,et al.  Nerve cell injury in the brain of stroke-prone spontaneously hypertensive rats , 2004, Acta Neuropathologica.

[7]  L. Salford,et al.  Permeability of the blood‐brain barrier induced by 915 MHz electromagnetic radiation, continuous wave and modulated at 8, 16, 50, and 200 Hz , 1994, Microscopy research and technique.

[8]  J. H. Merritt,et al.  Studies on blood-brain barrier permeability after microwave-radiation , 1978, Radiation and environmental biophysics.

[9]  E. Albert,et al.  Reversible microwave effects on the blood-brain barrier , 1981, Brain Research.

[10]  Gert Frølund Pedersen,et al.  Possible exposures from future mobile communications systems , 2002 .

[11]  Martin Raff,et al.  Cell Junctions, Cell Adhesion, and the Extracellular Matrix , 2002 .

[12]  J. Herbertz Comment on the ICNIRP guidelines for limiting exposure to time-varying electric, magnetic, and electromagnetic fields (up to 300 GHz) , 1998, Health physics.

[13]  Val Gebski,et al.  Effect of long‐term mobile communication microwave exposure on vascular permeability in mouse brain , 2002, Pathology.

[14]  Rony Seger,et al.  Mechanism of short-term ERK activation by electromagnetic fields at mobile phone frequencies. , 2007, The Biochemical journal.

[15]  国際非電離放射線防護委員会 ICNIRP statement on the "Guidelines for limiting exposure to time-varying electric, magnetic, and electromagnetic fields (up to 300 GHz)". , 2009, Health physics.

[16]  A. H. Frey,et al.  NEURAL FUNCTION AND BEHAVIOR: DEFINING THE RELATIONSHIP , 1975, Annals of the New York Academy of Sciences.

[17]  I. Bates Permeability of the blood-brain barrier , 1985 .

[18]  J. Ali,et al.  Blood-brain barrier permeation in the rat during exposure to low-power 1.7-GHz microwave radiation. , 1985, Bioelectromagnetics.

[19]  J. C. Lin,et al.  Microwave hyperthermia-induced blood-brain barrier alterations. , 1982, Radiation research.

[20]  Dariusz Leszczynski,et al.  Non-thermal activation of the hsp27/p38MAPK stress pathway by mobile phone radiation in human endothelial cells: molecular mechanism for cancer- and blood-brain barrier-related effects. , 2002, Differentiation; research in biological diversity.

[21]  Jacob Eberhardt,et al.  Cognitive impairment in rats after long‐term exposure to GSM‐900 mobile phone radiation , 2008, Bioelectromagnetics.

[22]  S. Tsirka,et al.  Nitric oxide mediates neurodegeneration and breakdown of the blood-brain barrier in tPA-dependent excitotoxic injury in mice , 2006, Journal of Cell Science.

[23]  Catrin Bauréus Koch,et al.  Interaction between weak low frequency magnetic fields and cell membranes , 2003, Bioelectromagnetics.

[24]  Frank S. Prato,et al.  Magnetic resonance imaging temporarily alters blood-brain barrier permeability in the rat , 1987, Neuroscience Letters.

[25]  W. R. Adey,et al.  Effect of Immobilization and Concurrent Exposure to a Pulse-Modulated Microwave Field on Core Body Temperature, Plasma ACTH and Corticosteroid, and Brain Ornithine Decarboxylase, Fos and Jun mRNA , 2001, Radiation research.

[26]  Val Gebski,et al.  EFFECT OF GLOBAL SYSTEM FOR MOBILE COMMUNICATION (GSM)‐LIKE RADIOFREQUENCY FIELDS ON VASCULAR PERMEABILITY IN MOUSE BRAIN , 2001, Pathology.

[27]  B. Barres,et al.  The Blood-Brain Barrier— Lessons from Moody Flies , 2005, Cell.

[28]  G. Hyland Physics and biology of mobile telephony , 2000, The Lancet.

[29]  Influence of 50 Hz Frequency Sinusoidal Magnetic Field on the Blood‐Brain Barrier Permeability of Diabetic Rats , 2004, Bioelectromagnetics.

[30]  S. Michaelson,et al.  Effect of 2450 MHz microwave energy on the blood—brain barrier to hydrophilic molecules. A. Effect on the permeability to sodium fluorescein , 1984, Brain Research Reviews.

[31]  F. Prato,et al.  Magnetic resonance imaging increases the blood-brain barrier permeability to 153-gadolinium diethylenetriaminepentaacetic acid in rats , 1990, Brain Research.

[32]  W. Thomas,et al.  Brain macrophages: on the role of pericytes and perivascular cells , 1999, Brain Research Reviews.

[33]  R. Quock,et al.  Microwave facilitation of methylatropine antagonism of central cholinomimetic drug effects. , 1986, Radiation research.

[34]  Y. Olsson,et al.  Observations on exsudation of fibronectin, fibrinogen and albumin in the brain after carotid infusion of hyperosmolar solutions , 2004, Acta Neuropathologica.

[35]  J. C. Lin,et al.  Cerebrovascular permeability to 86Rb in the rat after exposure to pulsed microwaves. , 1984, Bioelectromagnetics.

[36]  K. J. Oscar,et al.  Microwave alteration of the blood-brain barrier system of rats , 1977, Brain Research.

[37]  A. H. Frey,et al.  Headaches from cellular telephones: are they real and what are the implications? , 1998, Environmental health perspectives.

[38]  Lars Malmgren,et al.  Non-thermal effects of EMF upon the mammalian brain: the Lund experience , 2007 .

[39]  R. Quock,et al.  Microwave facilitation of domperidone antagonism of apomorphine-induced stereotypic climbing in mice. , 1987, Bioelectromagnetics.

[40]  E. Preston,et al.  Does magnetic resonance imaging compromise integrity of the blood-brain barrier? , 1989, Neuroscience Letters.

[41]  J. C. Lin,et al.  Studies on microwave and blood-brain barrier interaction. , 1980, Bioelectromagnetics.

[42]  D. House,et al.  A role for the magnetic field in the radiation-induced efflux of calcium ions from brain tissue in vitro. , 1985, Bioelectromagnetics.

[43]  H. Galla,et al.  Electromagnetic fields (GSM 1800) do not alter blood–brain barrier permeability to sucrose in models in vitro with high barrier tightness , 2005, Bioelectromagnetics.

[44]  J. Bladel,et al.  Electromagnetic Fields , 1985 .

[45]  J. Fröhlich,et al.  Blood–brain barrier and electromagnetic fields: Effects of scopolamine methylbromide on working memory after whole-body exposure to 2.45GHz microwaves in rats , 2005, Behavioural Brain Research.

[46]  A. Schirmacher,et al.  Electromagnetic fields (1.8 GHz) increase the permeability to sucrose of the blood-brain barrier in vitro. , 2000, Bioelectromagnetics.

[47]  E. Preston,et al.  Permeability of the blood-brain barrier to mannitol in the rat following 2450 MHz microwave irradiation , 1979, Brain Research.

[48]  T. Ohmoto,et al.  Acute effects of interstitial hyperthermia on normal monkey brain--magnetic resonance imaging appearance and effects on blood-brain barrier. , 1994, Neurologia medico-chirurgica.

[49]  Y. Olsson,et al.  A transient hypertensive opening of the blood-brain barrier can lead to brain damage , 1988, Acta Neuropathologica.

[50]  M. Salcman,et al.  Blood-brain barrier alteration after microwave-induced hyperthermia is purely a thermal effect: I. Temperature and power measurements. , 1991, Surgical neurology.

[51]  M Taki,et al.  Biological and morphological effects on the brain after exposure of rats to a 1439 MHz TDMA field. , 2000, Bioelectromagnetics.

[52]  S. Michaelson,et al.  Effect of 2450 MHz microwave energy on the blood-brain barrier to hydrophilic molecules. B. Effect on the permeability to HRP , 1984, Brain Research Reviews.

[53]  S. Rapoport,et al.  Local cerebral blood flow after microwave exposure , 1981, Brain Research.

[54]  Bertil R. R. Persson,et al.  Blood-Brain Barrier Permeability and Nerve Cell Damage in Rat Brain 14 and 28 Days After Exposure to Microwaves from GSM Mobile Phones , 2008, Electromagnetic biology and medicine.

[55]  M. Mancini,et al.  Pericyte coverage is greater in the retinal than in the cerebral capillaries of the rat. , 1987, Investigative ophthalmology & visual science.

[56]  L. S. Kinney,et al.  Multiple power-density windows and their possible origin. , 1989, Bioelectromagnetics.

[57]  Osamu Fujiwara,et al.  Lack of effects of 1439 MHz electromagnetic near field exposure on the blood–brain barrier in immature and young rats , 2005, Bioelectromagnetics.

[58]  Bertil R. R. Persson,et al.  Brain tumour development in rats exposed to electromagnetic fields used in wireless cellular communication , 1997, Wirel. Networks.

[59]  Volkert Hansen,et al.  Effects of Universal Mobile Telecommunications System (UMTS) Electromagnetic Fields on the Blood-Brain Barrier In Vitro , 2005, Radiation research.

[60]  Lars Malmgren,et al.  Nerve cell damage in mammalian brain after exposure to microwaves from GSM mobile phones. , 2003, Environmental health perspectives.

[61]  F. Prato,et al.  Blood‐brain barrier permeability in rats is altered by exposure to magnetic fields associated with magnetic resonance imaging at 1.5 T , 1994, Microscopy research and technique.

[62]  M. Schramm,et al.  Acute glutamate toxicity and its potentiation by serum albumin are determined by the Ca2+ concentration , 1991, Neuroscience Letters.

[63]  F. Fonnum,et al.  Neurotoxicity of albumin in vivo , 1994, Neuroscience Letters.

[64]  Lars Malmgren,et al.  Exposure to radiation from global system for mobile communications at 1,800 MHz significantly changes gene expression in rat hippocampus and cortex , 2008 .

[65]  Ivan Yu. Torshin,et al.  Physiology and Medicine , 1946, Bioinformatics in the post-genomic era.

[66]  S. Rapoport,et al.  Absence of microwave effect on blood-brain barrier permeability to [14C]sucrose in the conscious rat , 1982, Experimental Neurology.

[67]  W. Oldendorf,et al.  The large apparent work capability of the blood‐brain barrier: A study of the mitochondrial content of capillary endothelial cells in brain and other tissues of the rat , 1977, Annals of neurology.

[68]  G. Siest,et al.  A new aspect of the protective functions of the blood-brain barrier: activities of four drug-metabolizing enzymes in isolated rat brain microvessels. , 1988, Life sciences.

[69]  M. Taussig The Nervous System , 1991 .

[70]  R. Lufkin,et al.  MRI gradient fields increase brain mannitol space. , 1989, Magnetic resonance imaging.

[71]  C. Blackman,et al.  Reply to comments on “clarification and application of an ion parametric resonance model for magnetic field interactions with biological systems” , 1995 .

[72]  R. Fishman,et al.  Induction of brain edema following intracerebral injection of arachidonic acid , 1983, Annals of neurology.

[73]  D. Lange,et al.  Microwave irradiation of rats at 2.45 GHz activates pinocytotic-like uptake of tracer by capillary endothelial cells of cerebral cortex. , 1990, Bioelectromagnetics.

[74]  B. Bozóky,et al.  Immunohistochemical localization of extravasated serum albumin in the hippocampus of human subjects with partial and generalized epilepsies and epileptiform convulsions , 2004, Acta Neuropathologica.

[75]  S. Michaelson,et al.  Effect of 2450 MHz microwave energy on the blood-brain barrier to hydrophilic molecules. D. Brain temperature and blood-brain barrier permeability to hydrophilic tracers , 1984, Brain Research Reviews.

[76]  Bertil R. R. Persson,et al.  Blood‐brain barrier permeability in rats exposed to electromagnetic fields used in wireless communication , 1997, Wirel. Networks.